Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence
Open accessAbstract
This integrative aimed to evaluate the effects and the potential mechanism of action of prebiotics, probiotics, and synbiotics on constipation-associated gastrointestinal symptoms and to identify issues that still need to be answered. A literature search was performed in the PubMed database. Animal models (n = 23) and clinical trials (n = 39) were included. In animal studies, prebiotic, probiotic, and synbiotic supplementation showed a decreased colonic transit time (CTT) and an increase in the number and water content of feces. In humans, inulin is shown to be the most promising prebiotic, while B. lactis and L. casei Shirota probiotics were shown to increase defecation frequency, the latter strain being more effective in improving stool consistency and constipation symptoms. Overall, synbiotics seem to reduce CTT, increase defecation frequency, and improve stool consistency with a controversial effect on the improvement of constipation symptoms. Moreover, some aspects of probiotic use in constipation-related outcomes remain unanswered, such as the best dose, duration, time of consumption (before, during, or after meals), and matrices, as well as their effect and mechanisms on the regulation of inflammation in patients with constipation, on polymorphisms associated with constipation, and on the management of constipation via 5-HT. Thus, more high-quality randomized control trials (RCTs) evaluating these lacking aspects are necessary to provide safe conclusions about their effectiveness in managing intestinal constipation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the included studies, the most common probiotics ingredients were Bifidobacterium and Lactobacillus, and the most common prebiotics ingredients were inulin, fructooligosaccharide and psyllium.
“In our included studies, the most popular probiotics ingredients were Bifidobacterium and Lactobacillus, while the most popular prebiotics ingredients were inulin, fructooligosaccharide and psyllium.51”
From Efficacy in bowel movement and change of gut microbiota on adult functional constipation patients treated with probiotics-containing products: a systematic review and meta-analysis (2024) · cites this paper as [51]
The Results sections (page unavailable) identify Bifidobacterium and Lactobacillus strains as the most frequently assessed probiotics and inulin as the most evaluated prebiotic in the review’s human studies. They mention fructooligosaccharides and psyllium, but do not identify either as among the most common prebiotic ingredients. The source also cannot establish which ingredients were most common in the citing authors’ own included studies. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works
Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820 · see citing works
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866 · see citing works
Effects of probiotics, prebiotics, and synbiotics on human health
Markowiak, P., & Śliżewska, K. (2017) · Nutrients · doi:10.3390/nu9091021 · Cited by 2,401 · see citing works
Sperber, A. D., Bangdiwala, S. I., Drossman, D. A., Ghoshal, U. C., Simren, M., Tack, J., Whitehead, W. E., Dumitrascu, D. L., Fang, X., Fukudo, S., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.04.014 · Cited by 2,263 · see citing works
Swanson, K. S., Gibson, G. R., Hutkins, R., Reimer, R. A., Reid, G., Verbeke, K., Scott, K. P., Holscher, H. D., Azad, M. B., Delzenne, N. M., et al. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0344-2 · Cited by 2,196 · see citing works
Chambers, E. S., Viardot, A., Psichas, A., Morrison, D. J., Murphy, K. G., Zac-Varghese, S. E. K., MacDougall, K., Preston, T., Tedford, C., Finlayson, G. S., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307913 · Cited by 1,424 · see citing works
A constipation scoring system to simplify evaluation and management of constipated patients
Agachan, F., Chen, T., Pfeifer, J., Reissman, P., & Wexner, S. D. (1996) · Diseases of the Colon & Rectum · doi:10.1007/bf02056950 · Cited by 1,258 · see citing works
American Gastroenterological Association Technical Review on Constipation
Bharucha, A. E., Pembérton, J. H., & Locke, G. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.028 · Cited by 914 · see citing works
Suares, N. C., & Ford, A. C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.164 · Cited by 906 · see citing works
Schmulson, M. J., & Drossman, D. A. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16214 · Cited by 788 · see citing works
Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.202 · Cited by 747 · see citing works
Mechanisms, evaluation, and management of chronic constipation
Bharucha, A. E., & Lacy, B. E. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.034 · Cited by 655 · see citing works
Prebiotic inulin-type fructans induce specific changes in the human gut microbiota
Vandeputte, D., Falony, G., Vieira-Silva, S., Wang, J., Sailer, M., Theis, S., Verbeke, K., & Raes, J. (2017) · Gut · doi:10.1136/gutjnl-2016-313271 · Cited by 554 · see citing works
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 535 · see citing works
The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
Caballero‐Franco, C., Keller, K., Simone, C. D., & Chadee, K. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00265.2006 · Cited by 493 · see citing works
Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K. (2017) · Advances in Nutrition · doi:10.3945/an.116.014407 · Cited by 468 · see citing works
Psychometric validation of a constipation symptom assessment questionnaire.
Frank, L., Kleinman, L., Farup, C., Taylor, L., & Miner, P. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750025327 · Cited by 459 · see citing works
An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation
Aziz, I., Whitehead, W. E., Palsson, O. S., Törnblom, H., & Simrén, M. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1708718 · Cited by 413 · cited 2× · see citing works
“junction protein expression, improve gut barrier function (4); increase Treg expression and stimulating IgA to enhance immunoglobulin A (IgA) secretion in Peyer’s patch (5); stimulate the proliferation of short-chain fatty acid (SCFA) bacterial producers (6); inhibit the colonization of pathogenic bacteria by competin…”
BackgroundMethodKHALIF, I., QUIGLEY, E., KONOVITCH, E., & MAXIMOVA, I. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.06.008 · Cited by 382 · see citing works
Gut Microbiota and Chronic Constipation: A Review and Update
Ohkusa, T., Koido, S., Nishikawa, Y., & Sato, N. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00019 · Cited by 357 · see citing works
Kim, K.-N., Yao, Y., & Ju, S.-Y. (2019) · Nutrients · doi:10.3390/nu11102512 · Cited by 329 · see citing works
Dimidi, E., Christodoulides, S., Fragkos, K. C., Scott, S. M., & Whelan, K. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.089151 · Cited by 316 · see citing works
Liu, F., Li, P., Chen, M., Luo, Y., Prabhakar, M., Zheng, H., He, Y., Qi, Q., Long, H., Zhang, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10722-2 · Cited by 297 · see citing works
Koebnick, C., Wagner, I., Leitzmann, P., Stern, U., & Zunft, H. F. (2003) · Canadian Journal of Gastroenterology · doi:10.1155/2003/654907 · Cited by 288 · see citing works
Bastard, Q. L., Chapelet, G., Javaudin, F., Lepelletier, D., Batard, É., & Montassier, E. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03721-w · Cited by 258 · see citing works
Systematic review of randomised controlled trials: probiotics for functional constipation.
Chmielewska, A., & Szajewska, H. (2010) · Europe PMC (PubMed Central) · doi:10.3748/wjg.v16.i1.69 · Cited by 237 · see citing works
Intestinal microbiota and chronic constipation
Zhao, Y., & Yu, Y. (2016) · SpringerPlus · doi:10.1186/s40064-016-2821-1 · Cited by 212 · see citing works
Waller, P. A., Gopal, P. K., Leyer, G. J., Ouwehand, A. C., Reifer, C., Stewart, M. E., & Miller, L. E. (2011) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2011.584895 · Cited by 195 · see citing works
Kim, S.-E., Choi, S. C., Park, K. S., Park, M. I., Shin, J. E., Lee, T. H., Jung, K. W., Koo, H. S., & Myung, S.-J. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14048 · Cited by 180 · see citing works
Dual role of microbiota-derived short-chain fatty acids on host and pathogen
Mirzaei, R., Dehkhodaie, E., Bouzari, B., Rahimi, M., Gholestani, A., Hosseini‐Fard, S. R., Keyvani, H., Teimoori, A., & Karampoor, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112352 · Cited by 165 · see citing works
Saxelin, M., Lassig, A., Karjalainen, H., Tynkkynen, S., Surakka, A., Vapaatalo, H., Järvenpää, S. K., Korpela, R., Mutanen, M. L., & Hatakka, K. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.10.009 · Cited by 164 · see citing works
Regulation of IgA Production by Intestinal Dendritic Cells and Related Cells
Tezuka, H., & Ohteki, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01891 · Cited by 157 · see citing works
Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women
Yang, Y.-X., He, M., Hu, G., Wei, J., Pages, P., Yang, X.-H., & Bourdu-Naturel, S. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6237 · Cited by 151 · see citing works
Serotonin Transporter Gene Polymorphism in Irritable Bowel Syndrome
Pata, C., Erdal, E. M., Derici, E., Yazar, A., Kanık, A., & Ulu, O. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05841.x · Cited by 146 · see citing works
Micka, A., Siepelmeyer, A., Holz, A., Theis, S., & Schön, C. (2016) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1212819 · Cited by 141 · see citing works
Constipation in Australian Women: Prevalence and Associated Factors
Chiarelli, P., Brown, W. J., & McElduff, P. (2000) · International Urogynecology Journal · doi:10.1007/s001920050073 · Cited by 128 · see citing works
Ibarra, A., Latreille-Barbier, M., Donazzolo, Y., Pelletier, X., & Ouwehand, A. C. (2018) · Gut Microbes · doi:10.1080/19490976.2017.1412908 · Cited by 121 · see citing works
Wang, L., Hu, L., Xu, Q., Yin, B., Fang, D., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020318 · Cited by 120 · see citing works
Müller, M., Hermes, G. D. A., Emanuel E., C., Holst, J. J., Zoetendal, E. G., Smidt, H., Troost, F., Schaap, F. G., Damink, S. O., Jocken, J. W. E., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1704141 · Cited by 120 · see citing works
Sichetti, M., Marco, S. D., Pagiotti, R., Traina, G., & Pietrella, D. (2018) · Nutrition · doi:10.1016/j.nut.2018.02.005 · Cited by 119 · see citing works
Health Professionals’ Knowledge of Probiotics: An International Survey
Fijan, S., Frauwallner, A., Varga, L., Langerholc, T., Rogelj, I., Lorber, M., Lewis, P., & Povalej, P. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16173128 · Cited by 110 · see citing works
Magro, D. O., de Oliveira, L. M. R., Bernasconi, I., de Souza Ruela, M., Credidio, L., Barcelos, I. K., Leal, R. F., Ayrizono, M. D. L. S., Fagundes, J. J., Teixeira, L. D. B., et al. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-75 · Cited by 105 · see citing works
Higashikawa, F., Noda, M., Awaya, T., Nomura, K., Oku, H., & Sugiyama, M. (2009) · Nutrition · doi:10.1016/j.nut.2009.05.008 · Cited by 104 · see citing works
Neural and non‐neural mediation of propionate‐induced contractile responses in the rat distal colon
Mitsui, R., Ono, S., Karaki, S.-I., & Kuwahara, A. (2005) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2005.00669.x · Cited by 99 · see citing works
Waitzberg, D. L., Logullo, L., Bittencourt, A. F., Torrinhas, R. S., Shiroma, G. M., Paulino, N. P., & Teixeira-da-Silva, M. L. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.010 · Cited by 92 · see citing works
Serotonin transporter gene polymorphism and irritable bowel syndrome
Park, J. M., Choi, M., Park, J., Oh, J. H., Cho, Y. K., Lee, I. S., Kim, S. W., Choi, K.-Y., & Chung, I. ‐. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00829.x · Cited by 91 · see citing works
Dimidi, E., Scott, S. M., & Whelan, K. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000934 · Cited by 89 · see citing works
Mazlyn, M. M., Nagarajah, L. H., Fatimah, A., Norimah, A. K., & Goh, K. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12168 · Cited by 87 · see citing works
Riezzo, G., Orlando, A., D’Attoma, B., Guerra, V., Valerio, F., Lavermicocca, P., & de Candia, S. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04970.x · Cited by 85 · see citing works
Dimidi, E., Zdanaviciene, A., Christodoulides, S., Taheri, S., Louis, P., Duncan, P. I., Emami, N., Crabbé, R., De Castro, C. A., McLean, P., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15073 · Cited by 80 · see citing works
Tompkins, T., Mainville, I., & Arcand, Y. (2011) · Beneficial Microbes · doi:10.3920/bm2011.0022 · Cited by 80 · see citing works
Effect ofLactobacillus plantarumNCU116 on loperamide-induced constipation in mice
Li, C., Nie, S., Zhu, K.-X., Xiong, T., Li, C., Gong, J., & Xie, M. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2015.1024204 · Cited by 79 · see citing works
Miller, L. E. (2017) · Annals of Gastroenterology · doi:10.20524/aog.2017.0192 · Cited by 79 · see citing works
Wang, J., Bai, X., Peng, C., Yu, Z., Li, B., Zhang, W., Sun, Z., & Zhang, H. (2020) · Journal of Dairy Science · doi:10.3168/jds.2020-18639 · Cited by 78 · see citing works
Action Mode of Gut Motility, Fluid and Electrolyte Transport in Chronic Constipation
Zhao, Q., Chen, Y., Xu, D., Yue, S., Fu, R., Yang, J., Xing, L.-M., & Tang, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.630249 · Cited by 78 · see citing works
Lan, J., Wang, K., Chen, G., Cao, G., & Yang, C. (2020) · Food & Function · doi:10.1039/d0fo00865f · Cited by 76 · see citing works
Riezzo, G., Chimienti, G., Orlando, A., D’Attoma, B., Clemente, C., & Russo, F. (2018) · Beneficial Microbes · doi:10.3920/bm2018.0050 · Cited by 75 · see citing works
Mechanisms of smooth muscle responses to inflammation
Shea‐Donohue, T., Notari, L., Sun, R., & Zhao, A. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01986.x · Cited by 73 · see citing works
Wang, G., Yang, S., Sun, S., Si, Q., Wang, L., Zhang, Q., Wu, G., Zhao, J., Zhang, H., & Chen, W. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00423 · Cited by 72 · see citing works
Makizaki, Y., Uemoto, T., Yokota, H., Yamamoto, M., Tanaka, Y., & Ohno, H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248584 · Cited by 72 · see citing works
Chu, J. R., Kang, S.-Y., Kim, S.-E., Lee, S.-J., Lee, Y., & Sung, M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i40.6129 · Cited by 70 · see citing works
Martoni, C. J., Evans, M., Chow, C. T., Chan, L. S., & Leyer, G. (2019) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12797 · Cited by 67 · see citing works
Novel aspects of enteric serotonergic signaling in health and brain-gut disease
Colle, A. D., Israelyan, N., & Margolis, K. G. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00173.2019 · Cited by 65 · see citing works
Wilms, E., An, R., Smolinska, A., Stevens, Y., Weseler, A. R., Elizalde, M., Drittij-Reijnders, M.-J., Ioannou, A., van Schooten, F., Smidt, H., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.034 · Cited by 65 · see citing works
Laxative effect of probiotic chocolate on loperamide-induced constipation in rats
Eor, J. Y., Tan, P. L., Lim, S. M., Choi, D. H., Yoon, S. M., Yang, S. Y., & Kim, S. H. (2018) · Food Research International · doi:10.1016/j.foodres.2018.09.062 · Cited by 65 · see citing works
Diagnosis and treatment of constipation: a clinical update based on the Rome IV criteria
Sobrado, C. W., Neto, I. J. F. C., Pinto, R. A., Sobrado, L. F., Nahas, S. C., & Cecconello, I. (2018) · Journal of Coloproctology · doi:10.1016/j.jcol.2018.02.003 · Cited by 62 · see citing works
Adhesive Bifidobacterium Induced Changes in Cecal Microbiome Alleviated Constipation in Mice
Wang, L., Chen, C., Cui, S., Lee, Y. K., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01721 · Cited by 62 · see citing works
Chen, Z., Peng, Y., Shi, Q., Chen, Y., Cao, L., Jia, J., Liu, C., & Zhang, J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.815156 · Cited by 61 · see citing works
Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study
Madempudi, R. S., Neelamraju, J., Ahire, J. J., Gupta, S. K., & Shukla, V. K. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09542-9 · Cited by 60 · see citing works
Efficacy of Synbiotics in Patients with Slow Transit Constipation: A Prospective Randomized Trial
Ding, C., Ge, X., Zhang, X., Tian, H., Wang, H., Gu, L., Gong, J., Zhu, W., & Li, N. (2016) · Nutrients · doi:10.3390/nu8100605 · Cited by 55 · see citing works
Lactobacillus plantarum YS-3 Prevents Activated Carbon-Induced Constipation in Mice
Zhao, X., Yi, R., Qian, Y., & Park, K.-Y. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2017.4109 · Cited by 55 · see citing works
Paula, J. A. D., Carmuega, E., & Weill, R. (2008) · PubMed · Cited by 54 · see citing works
Hayeeawaema, F., Wichienchot, S., & Khuituan, P. (2019) · Nutrition · doi:10.1016/j.nut.2019.110715 · Cited by 53 · see citing works
Kang, S., Park, M. Y., Brooks, I., Lee, J., Kim, S. H., Kim, J. Y., Oh, B., Kim, J. W., & Kwon, O. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110428 · Cited by 53 · see citing works
Su, H., Chen, J., Miao, S., Deng, K., Liu, J., Zeng, S., Zheng, B., & Lu, X. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110838 · Cited by 53 · see citing works
FAVRETTO, D. C., Pontin, B., & Moreira, T. R. (2013) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032013000200035 · Cited by 51 · see citing works
The Constipation-Relieving Property of d-Tagatose by Modulating the Composition of Gut Microbiota
Liang, Y., Wen, P., Wang, Y., Ouyang, D., Da, W., Chen, Y.-Z., Song, Y., Deng, J., Sun, Y., & Wang, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225721 · Cited by 50 · see citing works
Pinheiro, I., Robinson, L. E., Verhelst, A., Marzorati, M., Winkens, B., den Abbeele, P. V., & Possemiers, S. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1948-0 · Cited by 49 · see citing works
Liu, J., Gu, Z., Song, F., Zhang, H., Zhao, J., & Chen, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00299 · Cited by 49 · see citing works
Wang, R., Sun, J. G., Li, G., Zhang, M., Niu, T., Kang, X., Zhao, H., Chen, J., Sun, E., & Li, Y. (2020) · Beneficial Microbes · doi:10.3920/bm2020.0023 · Cited by 49 · see citing works
Wang, Y., Cao, Y.-N., Feng, L., Wang, B., Jiang, K., Li, S., Xu, X. J., Wang, W., & Zhao, J. (2018) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_333_17 · Cited by 47 · see citing works
Botelho, P. B., Ferreira, M. V. R., Araújo, A. D. M., Mendes, M. M., & Nakano, E. Y. (2020) · Nutrition · doi:10.1016/j.nut.2020.110890 · Cited by 47 · see citing works
Self-citationOu, Y., Chen, S., Ren, F., Zhang, M., Ge, S., Guo, H., Zhang, H., & Zhao, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00324 · Cited by 46 · see citing works
Synbiotic preparation in men suffering from functional constipation: a randomised controlled trial
Fateh, R., Iravani, S., Frootan, M., Saadat, S., & Rasouli, M. (2011) · Swiss Medical Weekly · doi:10.4414/smw.2011.13239 · Cited by 46 · see citing works
Minamida, K., Nishimura, M., Miwa, K., & Nishihira, J. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.972331 · Cited by 45 · see citing works
Schoemaker, M. H., Hageman, J. H. J., ten Haaf, D. S. M., Hartog, A., Scholtens, P. A. M. J., Boekhorst, J., Nauta, A., & Bos, R. (2022) · Nutrients · doi:10.3390/nu14020309 · Cited by 45 · see citing works
Sakai, T., Makino, H., Ishikawa, E., Oishi, K., & Kushiro, A. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2010.542408 · Cited by 44 · see citing works
An, H. M., Baek, E. H., Jang, S., Lee, D. K., Kim, M. J., Kim, J. R., Lee, K. O., Park, J. G., & Ha, N. J. (2010) · Nutrition Journal · doi:10.1186/1475-2891-9-5 · Cited by 44 · see citing works
Chronic Constipation: Gastroenterohepatologist’s Approach
Milosavljević, T., Popovic, D. D., Mijac, D. D., Alempijevic, T. M., Krstic, S., & Krstic, M. N. (2021) · Digestive Diseases · doi:10.1159/000516976 · Cited by 42 · see citing works
Anzawa, D., Mawatari, T., Tanaka, Y., Yamamoto, M., Genda, T., Takahashi, S., Nishijima, T., Kamasaka, H., Suzuki, S., & Kuriki, T. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1033 · Cited by 41 · see citing works
Riezzo, G., Orlando, A., D’Attoma, B., Linsalata, M., Martulli, M., & Russo, F. (2017) · Beneficial Microbes · doi:10.3920/bm2017.0049 · Cited by 37 · see citing works
Lim, Y. J., Jamaluddin, R., Hazizi, A. S., & Chieng, J. Y. (2018) · Nutrients · doi:10.3390/nu10070824 · Cited by 37 · see citing works
Riaz, S., Nawaz, S. K., & Hasnain, S. (2010) · Brazilian Journal of Microbiology · doi:10.1590/s1517-83822010000300015 · Cited by 36 · see citing works
Wang, Y. M., Ge, X. Z., Wang, W. Q., Wang, T., Cao, H., Wang, B. L., & Wang, B. M. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12615 · Cited by 35 · see citing works
Zhu, Y., Zheng, G., & Hu, Z. (2018) · Gene · doi:10.1016/j.gene.2018.08.059 · Cited by 34 · see citing works
Chen, S., Ou, Y., Zhao, L., Li, Y., Qiao, Z., Hao, Y., & Ren, F. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17085 · Cited by 34 · see citing works
Cost Effectiveness of Treatments for Chronic Constipation: A Systematic Review
Han, D., Iragorri, N., Clement, F. M., Lorenzetti, D., & Spackman, E. (2018) · PharmacoEconomics · doi:10.1007/s40273-018-0609-6 · Cited by 33 · see citing works
Tan, Q. W., Hu, J. Y., Zhou, Y., Wan, Y., Zhang, C., Liu, X., Long, X., Tan, F., & Zhao, X. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s309675 · Cited by 33 · see citing works
Bazzocchi, G., Giovannini, T., Giussani, C., Brigidi, P., & Turroni, S. (2014) · Techniques in Coloproctology · doi:10.1007/s10151-014-1201-5 · Cited by 32 · see citing works
Ba, Z., Lee, Y., Meng, H., Kris‐Etherton, P. M., Rogers, C. J., Lewis, Z. T., Mills, D. A., Furumoto, E. J., Rolon, M. L., Fleming, J. A., et al. (2021) · mSphere · doi:10.1128/msphere.00084-21 · Cited by 32 · see citing works
Gan, Y., Liang, J., Diao, W., Zhou, X., Mu, J., Pang, L., Tan, F., & Zhao, X. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1814 · Cited by 31 · see citing works
Zhao, X., Suo, H., Qian, Y., Li, G., LIU, Z.-H., & Li, J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3737 · Cited by 30 · see citing works
Screening of intestinal peristalsis-promoting probiotics based on a zebrafish model
Lü, Y., Zhang, J., Yi, H., Zhang, Z., & Zhang, L. (2019) · Food & Function · doi:10.1039/c8fo02523a · Cited by 28 · see citing works
Zhang, J., Chen, B., Liu, B., Zhou, X., Mu, J., Wang, Q., Zhao, X., & Yang, Z. (2018) · Medicina · doi:10.3390/medicina54050089 · Cited by 28 · see citing works
Moreira, T. R., LEONHARDT, D., & Conde, S. R. (2017) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.201700000-27 · Cited by 26 · see citing works
Cudmore, S., Doolan, A., Lacey, S., & Shanahan, F. (2017) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1244661 · Cited by 26 · see citing works
Kodani, M., Fukui, H., Tomita, T., Oshima, T., Watari, J., & Miwa, H. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8926 · Cited by 23 · see citing works
Chemical stability of fructans in apple beverages and their influence on chronic constipation
Glibowski, P., Skrzypek, M., Ćwiklińska, M., Drozd, M., & Kowalska, A. (2020) · Food & Function · doi:10.1039/c9fo02596k · Cited by 23 · see citing works
Pápai, G., Torres-Maravilla, E., Chain, F., Varga-Visi, É., Antal, O., Naár, Z., Bermúdez‐Humarán, L. G., Langella, P., & Martín, R. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09702-2 · Cited by 22 · see citing works
Fuyuki, A., Higurashi, T., Kessoku, T., Ashikari, K., Yoshihara, T., Misawa, N., Iwaki, M., Kobayashi, T., Ohkubo, H., Yoneda, M., et al. (2021) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2020-073 · Cited by 21 · see citing works
Probiotics in primary care: A survey of health professionals
Jordan, D., Johnson, N., & Thomas, L. V. (2015) · Practice Nursing · doi:10.12968/pnur.2015.26.11.550 · Cited by 19 · see citing works
Malpeli, A., González, S., Vicentin, D., Apás, A. L., & González, H. F. (2012) · PubMed · doi:10.3305/nh.2012.27.4.5770 · Cited by 19 · see citing works
Lee, C. S., Tan, P. L., Eor, J. Y., Choi, D. H., Park, M., Seo, S. K., Yoon, S., Yang, S., & Kim, S. H. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9518 · Cited by 17 · see citing works
Araújo, A. D. M., Botelho, P. B., Ribeiro, D. J. S., Magalhães, K. G., Nakano, E. Y., & Arruda, S. F. (2021) · Nutrition · doi:10.1016/j.nut.2021.111225 · Cited by 17 · see citing works
Self-citationSuzuki, N., Murakoshi, M., Ono, T., Morishita, S., Koide, M., Bae, M., Totsuka, M., Shimizu, M., Sugiyama, K., Nishino, H., et al. (2013) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.32.13 · Cited by 16 · see citing works
Effect of dual-type oligosaccharides on constipation in loperamide-treated rats
Han, S., Hong, K. B., Kim, E. Y., Ahn, S. H., & Suh, H. J. (2016) · Nutrition Research and Practice · doi:10.4162/nrp.2016.10.6.583 · Cited by 14 · see citing works
Lü, Y., Zhang, J., Zhou, X., Guan, M., Zhang, Z., Liang, X., Tong, L., Yi, H., Gong, P., Bai, L., et al. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14196 · Cited by 14 · see citing works
Araújo, M. M., Vogado, C. D. O., Mendes, M. M., Gonçalves, V. S. S., & Botelho, P. B. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab109 · Cited by 10 · see citing works
Self-citationRelationship between serotonin transporter gene polymorphism and constipation in cancer patients
Li, W., Huang, L., Cai, W., Cao, S., Yan, Y., Lu, S., Zhao, Y., & Lu, P. (2015) · Współczesna Onkologia · doi:10.5114/wo.2014.41391 · Cited by 7 · see citing works
The effect of sodium carboxymethyl starch with high degree of substitution on defecation
Lu, W.-D., Wu, M., Zhang, J., Huang, T., Du, S., & Cao, Y.-X. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257012 · Cited by 6 · see citing works
Gotoh, Y., Nanba, F., Shioya, N., Haruhi, S., & Suzuki, T. (2019) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.19-009 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [103]Shea-Donohue T Notari L Sun R Zhao A. Mechansims of smooth muscle repsonses to inflammation. Neurogastroenterol Motil. (2012) 24: 802– 11. 22908862 PMC4068333
Cited by
Sorted by citations
Smolińska, S., Popescu, F., & Zemelka‐Wiącek, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14113673 · Cited by 153 · see citing works
Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases
Hou, S., Yu, J., Li, Y., Zhao, D., & Zhang, Z. (2025) · Advanced Science · doi:10.1002/advs.202413197 · Cited by 93 · see citing works
Functional yogurt: a comprehensive review of its nutritional composition and health benefits
Pannerchelvan, S., Rios‐Solis, L., Wasoh, H., Sobri, Z. M., Wong, F. W. F., Mohamed, M. S., Mohamad, R., & Halim, M. (2024) · Food & Function · doi:10.1039/d4fo03671a · Cited by 75 · see citing works
Recent advances in prebiotics: Classification, mechanisms, and health applications
Ali, S., Hamayun, M., Siraj, M., Khan, S. A., Kim, H., & Lee, B. (2025) · Future Foods · doi:10.1016/j.fufo.2025.100680 · Cited by 70 · see citing works
López‐Gómez, L., Alcorta, A., & Abalo, R. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13101487 · Cited by 51 · see citing works
Zhang, C., Wang, L., Liu, X., Wang, G., Guo, X., Liu, X., Zhao, J., & Chen, W. (2023) · Nutrients · doi:10.3390/nu15194230 · Cited by 40 · see citing works
Supriya, R., Delfan, M., Saeidi, A., Samaie, S. S., Kiyumi, M. H. A., Escobar, K. A., Laher, I., Heinrich, K. M., Weiss, K., Knechtle, B., et al. (2023) · Nutrients · doi:10.3390/nu15234891 · Cited by 33 · see citing works
Shan, Y., Zheng, M., Liang, W., Ouyang, L., & Wang, S. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116840 · Cited by 28 · see citing works
Chronic constipation and gut microbiota: current research insights and therapeutic implications
Xu, X., Wang, Y., Long, Y., & Cheng, Y. (2024) · Postgraduate Medical Journal · doi:10.1093/postmj/qgae112 · Cited by 32 · see citing works
Ding, F., Hu, M., Ding, Y., Meng, Y., & Zhao, Y. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-074557 · Cited by 22 · see citing works
“Fei Ding http://orcid.org/0000-0002-9396-8023 Mengyang Hu http://orcid.org/0000-0001-6338-8151 Yifei Ding http://orcid.org/0000-0001-9920-2320 Yingying Meng http://orcid.org/0000-0002-8594-4734 Yanchao Zhao http://orcid.org/0000-0002-2710-0824”
Mukherjee, A., Farsi, D. N., García-Gutiérrez, E., Akan, E., Salas-Millán, J. Á., Angelovski, L., Bintsis, Τ., Gérard, A., Güley, Z., Kabakcı, S. A., et al. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1668889 · Cited by 25 · see citing works
Moravejolahkami, A. R., Chitsaz, A., Hassanzadeh, A., & Paknahad, Z. (2023) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2023.101794 · Cited by 20 · see citing works
Understanding the probiotic health benefits of Bifidobacterium animalis subsp. lactis, BB-12™
Collins, F. W. J., Vera-Jimenéz, N. I., & Wellejus, A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1605044 · Cited by 20 · see citing works
Li, J., Yuan, Z., Li, J., Liu, Z., Wang, Y., Cui, M., Suo, C., Li, J., Ding, D., Chen, X., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00851-6 · Cited by 16 · see citing works
Camacho‐Díaz, B. H., Arenas-Ocampo, M. L., Osorio‐Díaz, P., Jiménez–Aparicio, A. R., Alvarado-Jasso, G. M., Saavedra-Briones, E., Valdovinos-Díaz, M. A., & Gómez-Reyes, E. (2023) · Nutrients · doi:10.3390/nu15163526 · Cited by 15 · see citing works
Mishima, M. D. V., Martino, H. S. D., Kolba, N., Shah, D. D., Grancieri, M., dos Santos, K. M. O., Lima, J. P., da Silva, B. P., de Mejı́a, E. G., & Tako, E. (2023) · Nutrients · doi:10.3390/nu15081831 · Cited by 14 · see citing works
Tryptophan Metabolism in Postmenopausal Women with Functional Constipation
Błońska, A., Chojnacki, M., Macieja, A., Błasiak, J., Majsterek, I., Chojnacki, J., & Popławski, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010273 · Cited by 13 · see citing works
Garcı́a, G., Soto, J., Valenzuela, C., Bernal, M., Penié, J. B., Lorenzo, M. D. C. L., Kazlauskaite, R., Waslidge, N., Bavington, C. D., & Cano, R. J. (2025) · Microorganisms · doi:10.3390/microorganisms13071545 · Cited by 12 · see citing works
Deng, X., Shang, X., Zhou, L., Li, X., Guo, K., Xu, M., Hou, L., Hui, X., & Li, S. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-2028-4 · Cited by 12 · see citing works
Luk-in, S., Leepiyasakulchai, C., Saelee, C., Keeratichamroen, A., Srisangwan, N., Ponprachanuvut, P., Chammari, K., Chatsuwan, T., Wannigama, D. L., Shein, A. M. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-79465-1 · Cited by 11 · see citing works
Chojnacki, C. J., Mędrek-Socha, M., Błońska, A., Błasiak, J., Popławski, T., Chojnacki, J., & Gąsiorowska, A. (2024) · Nutrients · doi:10.3390/nu16071027 · Cited by 9 · see citing works
Zhang, C., Wang, L., Liu, X., Wang, G., Zhao, J., & Chen, W. (2024) · Food & Function · doi:10.1039/d4fo04660a · Cited by 9 · see citing works
Kassie, A. T., Zegeye, A. F., Bazezew, A. M., Mamo, E. Y., Geberu, D. M., & Tamir, T. T. (2025) · PLOS Global Public Health · doi:10.1371/journal.pgph.0004244 · Cited by 9 · see citing works
Lora, A. T., Penadés, B. F., Oliva, S. L., Arponen, S., Okutan, G., Niño, G. M. S., & Martín, I. S. M. (2023) · Gastroenterology report · doi:10.1093/gastro/goae101 · Cited by 8 · see citing works
Culqui, D. R., Sanz, P. R., Sanchez, R. P., Miranda, M. Y. S., Cruz-López, C. Y. S., & Rodríguez, J. A. M. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.08.003 · Cited by 9 · see citing works
Li, Y., Ma, Y., Li, J., Lü, Y., Liu, H., Gao, M., & Cao, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117149 · Cited by 7 · see citing works
Jang, J. H., Chang, Y. B., Kim, S. M., Han, K., Sim, W., Hong, K., Suh, H. J., & Han, S. (2024) · Food & Function · doi:10.1039/d4fo04237a · Cited by 6 · see citing works
Tian, Z., Tan, Z., Zhang, X., Xie, Q., Song, M., Chen, X., Ma, J., & Ren, Q. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c17817 · Cited by 4 · see citing works
Bui, G., Torres‐Fuentes, C., Pusceddu, M. M., Gareau, M. G., & Marco, M. L. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00259.2023 · Cited by 4 · see citing works
Zhang, C., Wang, L., Liu, X., Wang, G., Guo, X., Liu, X., Zhao, J., & Chen, W. (2024) · Beneficial Microbes · doi:10.1163/18762891-bja00011 · Cited by 4 · see citing works
Bai, X.-F., Xu, L., Wang, K., Chen, L., Bai, T.-Y., Li, P., Chu, W.-H., & Song, C. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10732-x · Cited by 3 · see citing works
Gui, X., Wu, L., Huang, K., Zeng, R., Zhao, X., Yang, A., Yin, X., Cai, S., Yi, J., & Chu, C. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117714 · Cited by 5 · see citing works
Wang, L., Cai, H., Yao, Q., Chen, Z., Li, W., Liu, C., & Cui, S. (2026) · Nutrients · doi:10.3390/nu18020184 · Cited by 3 · see citing works
Miryan, M., Tadıbı, V., Sadeghi, E., Najafi, F., Saber, A., Abbaspour, M., & Pasdar, Y. (2025) · Trials · doi:10.1186/s13063-025-08780-3 · Cited by 3 · see citing works
Tan, F., & Kong, C. (2025) · Biomolecules · doi:10.3390/biom15030358 · Cited by 3 · see citing works
Role of Human Microbiome in Development and Management of Head and Neck Squamous Cell Carcinoma
Palkovský, M., Modráčková, N., Bunešová, V., Liberko, M., Hlodáková, A., & Soumarová, R. (2025) · Cancers · doi:10.3390/cancers17132238 · Cited by 2 · see citing works
Kobayashi, K., Ogawa, M., Mochizuki, J., & Sashihara, T. (2026) · Scientific Reports · doi:10.1038/s41598-026-39631-z · Cited by 2 · see citing works
Jiang, C., Wang, K. Z., & Yao, Y. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11061-3 · Cited by 2 · see citing works
Coman, M. M., Egidi, N., Silvi, S., Leone, R. D., & Verdenelli, M. C. (2024) · Fermentation · doi:10.3390/fermentation10100518 · Cited by 1 · see citing works
Serkova, M., Avalueva, E., & Sitkin, S. (2024) · Almanac of Clinical Medicine · doi:10.18786/2072-0505-2024-52-026 · Cited by 2 · see citing works
Ahmad, M. T., khan, D., Khan, S., Ahmed, S., Amin, M. N., Gulshan, M. Z., Shah, S. K. A., Shafaqat, A., Zia, M., & Noor, M. (2025) · Indus journal of bioscience research. · doi:10.70749/ijbr.v3i1.483 · Cited by 1 · see citing works
Quan, V., & Carey, S. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.102849 · Cited by 1 · see citing works
Huang, M., Yang, F., Song, J.-C., Wang, X., Jiao, P.-P., Kang, M.-J., Guo, Q.-Q., Si, L.-Z., Zhang, S.-H., Luo, L.-S., et al. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102482 · Cited by 1 · see citing works
Dai, Q., Duan, Z., Fang, C., & Chen, R. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1735614 · Cited by 1 · see citing works
Li, H., Feng, X., Zhong, F., & Luo, X. (2026) · Nutrients · doi:10.3390/nu18111658 · Cited by 1 · see citing works
Laxative effect of prebiotics in chronic constipation: Mechanisms of action
Fraia, L. D., Christodoulides, S., & Patrikios, I. S. (2023) · Magna Scientia Advanced Biology and Pharmacy · doi:10.30574/msabp.2023.9.2.0046 · Cited by 1 · see citing works
The gut microbiome and its use as a target for novel therapeutic modalities
Allam, A. A., & Al-Shaar, A. (2023) · Microbes and Infectious Diseases /Microbes and Infectious Diseases · doi:10.21608/mid.2023.217801.1543 · Cited by 1 · see citing works
Progress of Probiotics in Treating Functional Constipation through Intestinal Flora
那, 日. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1351212
YILMAZ, K., & KARLI, K. (2023) · Kastamonu Üniversitesi Sağlık Bilimleri Fakültesi Dergisi · doi:10.59778/sbfdergisi.1314182 · Cited by 1 · see citing works
Soheilipour, M., Khosravi, L., Tabesh, E., Jafari, M., Rabiee, F., Ebrahimi, M. T., & Adibi, P. (2024) · Current Nutrition & Food Science · doi:10.2174/0115734013287079240219073109
Yokota, H., Makizaki, Y., Tanaka, Y., & Ohno, H. (2025) · Microbiology and Immunology · doi:10.1111/1348-0421.13230
Clinical Applications of Probiotics: A Comprehensive Review of Benefits and Challenges
Hassan, R. W. (2025) · Maaen Journal for Medical Sciences · doi:10.55810/2789-9136.1080
Hatami, A., Ahmadi‐Khorram, M., Rahmanian, R., Esfehani, A. J., Nattagh‐Eshtivani, E., Afshari, A., & Nematy, M. (2025) · Journal of Dietary Supplements · doi:10.1080/19390211.2025.2561132
Lactobacillus acidophilus C4 ameliorates constipation in mice
Yan, H., Jia, Q., Liu, J., Hua, X., Cui, Y., Jian, W., Tan, Y., Oduor, O. S., Thomas, P., Kawimbe, M., et al. (2026) · Microbiology spectrum · doi:10.1128/spectrum.02950-25
Chen, Y., Duan, W., Du, M., Guo, M., & Sun, Y. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1817279
Song, M., Zhou, B., Zhang, S., Liu, Y., Tian, Z., Zhang, X., Xie, Q., Ma, J., & Ren, Q. (2026) · Food & Function · doi:10.1039/d6fo03584a
Zhu, J., Zeng, B., Zhu, W., Liu, Y., Li, X., Zhang, Y., Xu, Z., Xu, Q., Wu, W., Li, J., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117850
- Authors
- Araújo, M. M., & Botelho, P. B.
- Affiliations
- Universidade de Brasília (BR)
- Corresponding author
- Botelho, Patrícia Borges
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2022-12-08
- Volume
- 9
- Pages
- 935830-935830
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC9773270
- OpenAlex
- W4311865063
- Cited by
- 58
- References
- 124
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 13 · 2023: 14
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, prebiotics, synbiotics, chronic constipation, colonic transit time, inulin, Bifidobacterium animalis subsp. lactis, Lactobacillus casei Shirota, stool frequency, stool consistency, serotonin, inflammation, genetic polymorphism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
