Cited by 26Physiological and biochemical adaptationsRedox biology and oxidative stressInsect Resistance and Genetics

Oxidative stress delays development and alters gene expression in the agricultural pest moth, Helicoverpa armigera

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Apirajkamol, Nonthakorn (Beatrice), James, Bill, Gordon, Karl H. J., Walsh, Tom K., McGaughran, Angela·2020·Ecology and Evolution

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Abstract

Abstract Stress is a widespread phenomenon that all organisms must endure. Common in nature is oxidative stress, which can interrupt cell homeostasis to cause cell damage and may be derived from respiration or from environmental exposure thought diet. As a result of the routine exposure from respiration, many organisms can mitigate the effects of oxidative stress, but less is known about responses to oxidative stress from other sources. Helicoverpa armigera is a major agricultural pest moth that causes significant damage to crops worldwide. Here, we examined the effects of oxidative stress on H. armigera by chronically exposing individuals to paraquat - a free radical producer - and measuring changes in development (weight, developmental rate, lifespan), and gene expression. We found that oxidative stress strongly affected development in H. armigera , with stressed samples spending more time as caterpillars than control samples (>24 vs. ∼15 days, respectively) and living longer overall. We found 1,618 up- and 761 down-regulated genes, respectively, in stressed vs. control samples. In the up-regulated gene set were genes associated with cell senescence and apoptosis and an over-representation of biological processes related to cuticle and chitin development, glycine metabolism, and oxidation-reduction. Oxidative stress clearly impacts physiology and biochemistry in H. armigera and the interesting finding of an extended lifespan in stressed individuals could demonstrate hormesis, the process whereby toxic compounds can actually be beneficial at low doses. Collectively, our findings provide new insights into genomic responses to oxidative stress in invertebrates.

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  1. Breed, M. D., & Moore, J. (2015). Animal behavior. San Diego, CA: Academic Press.

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Authors
Apirajkamol, N. (., James, B., Gordon, K. H. J., Walsh, T. K., & McGaughran, A.
Affiliations
  • Australian National University (AU)
  • Commonwealth Scientific and Industrial Research Organisation (AU)
Corresponding author
McGaughran, Angela
Venue
Ecology and Evolution
Publisher
Wiley
Published
2020-04-29
Volume
10
Issue
12
Pages
5680-5693
ISSN
2045-7758 (ISSN-L)
OpenAlex
W3021218637
Cited by
26
References
84
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 1
FWCI
1.19
Type
journal article
Language
en
Open access
Locations
  • Ecology and Evolution (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ANU Open Research (Australian National University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Commonwealth Scientific and Industrial Research Organisation
  • Australian Research Council (DE160100685)
Topics
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Keywords
oxidative stress, Helicoverpa armigera, paraquat, gene expression, insect development, lifespan, hormesis, glycine metabolism, redox metabolism, crop pests

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