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Cited by 242Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

The Role of Water Homeostasis in Muscle Function and Frailty: A Review

Open access
Lorenzo, Isabel, Serra-Prat, Mateu, Yébenes, Juan Carlos·2019·Nutrients
DOI 10.3390/nu11081857PMC PMC6723611
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Abstract

Water, the main component of the body, is distributed in the extracellular and intracellular compartments. Water exchange between these compartments is mainly governed by osmotic pressure. Extracellular water osmolarity must remain within very narrow limits to be compatible with life. Older adults lose the thirst sensation and the ability to concentrate urine, and this favours increased extracellular osmolarity (hyperosmotic stress). This situation, in turn, leads to cell dehydration, which has severe consequences for the intracellular protein structure and function and, ultimately, results in cell damage. Moreover, the fact that water determines cell volume may act as a metabolic signal, with cell swelling acting as an anabolic signal and cell shrinkage acting as a catabolic signal. Ageing also leads to a progressive loss in muscle mass and strength. Muscle strength is the main determinant of functional capacity, and, in elderly people, depends more on muscle quality than on muscle quantity (or muscle mass). Intracellular water content in lean mass has been related to muscle strength, functional capacity, and frailty risk, and has been proposed as an indicator of muscle quality and cell hydration. This review aims to assess the role of hyperosmotic stress and cell dehydration on muscle function and frailty.

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Figure 1 Summarizes the possible mechanisms by which water homeostasis alterations can affect muscle function and promote frailty. Reactive oxygen species (ROS).
Figure 1 Summarizes the possible mechanisms by which water homeostasis alterations can affect muscle function and promote frailty. Reactive oxygen species (ROS).CC BY · PubMed Central

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Research works printed but not linked: 4

  1. Goodman Gilman, A., Rall, T.W., Nies, A.S., and Taylor, P. (1990). Agents affecting volume and composition of body fluids. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Pergamon Press.
  2. Institute of Medicine, Food and Nutrition Board (2005). Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate, National Academies Press.
  3. Kondo, 2009, Thermoregulatory adaption in humans and its modifying factors, Glob. Environ. Res., 13, 35
  4. Barrett, K.E., Barman, S.M., Boitano, S., and Brooks, H. (2010). Hypothalamic regulation of hormonal functions. Ganong’s Review of Medical Physiology, McGraw-Hill Medic. [23th ed.].

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Metadata

Authors
Lorenzo, I., Serra-Prat, M., & Yébenes, J. C.
Affiliations
  • Maresme Health Consortium (ES)
  • Research Unit, Consorci Sanitari del Maresme, 08304 Mataró (Barcelona), Spain
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2019-08-09
Volume
11
Issue
8
Pages
1857
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu11081857
PMC
PMC6723611
OpenAlex
W2969066781
Cited by
239
References
107
Citations by year
2026: 31 · 2025: 45 · 2024: 68 · 2023: 40 · 2022: 18 · 2021: 21 · 2020: 16
FWCI
1.70
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Spanish Ministry of Health (Instituto de Salud Carlos III) (FIS PI 16/00750)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
water homeostasis, muscle function, frailty, hyperosmotic stress, cell dehydration, osmotic pressure, extracellular osmolarity, thirst, urine concentrating ability, aging, muscle quality, muscle strength, functional capacity, cell volume, intracellular water content, lean body mass
MeSH terms
Frailty, Organism Hydration Status, Animals, Body Composition, Energy Metabolism, Humans, Muscle Contraction, Osmotic Pressure, Water-Electrolyte Balance, Water-Electrolyte Imbalance, Muscle, Skeletal, Muscle Strength

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