The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
The Role of Water Homeostasis in Muscle Function and Frailty: A Review
Open accessAbstract
Water, the main component of the body, is distributed in the extracellular and intracellular compartments. Water exchange between these compartments is mainly governed by osmotic pressure. Extracellular water osmolarity must remain within very narrow limits to be compatible with life. Older adults lose the thirst sensation and the ability to concentrate urine, and this favours increased extracellular osmolarity (hyperosmotic stress). This situation, in turn, leads to cell dehydration, which has severe consequences for the intracellular protein structure and function and, ultimately, results in cell damage. Moreover, the fact that water determines cell volume may act as a metabolic signal, with cell swelling acting as an anabolic signal and cell shrinkage acting as a catabolic signal. Ageing also leads to a progressive loss in muscle mass and strength. Muscle strength is the main determinant of functional capacity, and, in elderly people, depends more on muscle quality than on muscle quantity (or muscle mass). Intracellular water content in lean mass has been related to muscle strength, functional capacity, and frailty risk, and has been proposed as an indicator of muscle quality and cell hydration. This review aims to assess the role of hyperosmotic stress and cell dehydration on muscle function and frailty.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Exercising in a dehydrated state is well-established to negatively affect both performance and health [97, 98].”
From Nutritional Strategies to Improve Post-exercise Recovery and Subsequent Exercise Performance: A Narrative Review (2025) · cites this paper as [97]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503
A global clinical measure of fitness and frailty in elderly people
Rockwood, K. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.050051 · Cited by 8,968
Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
Almilaji, A., Szteyn, K., Fein, E., Pakladok, T., Muñoz, C., Elvira, B., Towhid, S. T., Alesutan, I., Shumilina, E. V., Bock, C. –., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350083 · Cited by 8,700
Water as an active constituent in cell biology
Ball, P. (2008) · Chemical Reviews · doi:10.1021/cr068037a · Cited by 2,177
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E. M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., & on Behalf of the Health, A. A. B. C. S. I. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.1.72 · Cited by 1,692
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211
Excess mortality related to the August 2003 heat wave in France
Fouillet, A., Rey, G., Laurent, F., Pavillon, G., Bellec, S., Guihenneuc-Jouyaux, C., Clavel, J., Jougla, E., & Hémon, D. (2006) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-006-0089-4 · Cited by 1,023
Clark, B. C., & Manini, T. M. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.8.829 · Cited by 876
Dynapenia and aging: an update
Manini, T. M., & Clark, B. C. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr010 · Cited by 875
Delmonico, M. J., Harris, T. B., Lee, J., Visser, M., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Newman, A. B., & for the Health, A. A. B. C. S. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01140.x · Cited by 819
Cellular Response to Hyperosmotic Stresses
Burg, M. B., Ferraris, J. D., & Dmitrieva, N. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00056.2006 · Cited by 807
Dietary Reference Values for nutrients Summary report
(EFSA), E. F. S. A. (2017) · EFSA Supporting Publications · doi:10.2903/sp.efsa.2017.e15121 · Cited by 762
Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide
Bienert, G. P., & Chaumont, F. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.09.017 · Cited by 757
Water as an essential nutrient: the physiological basis of hydration
Jéquier, E., & Constant, F. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.111 · Cited by 751
Scientific Opinion on Dietary Reference Values for water
EFSA Panel on Dietetic Products, N. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1459 · Cited by 740
Aquaporin 4 and neuromyelitis optica
Papadopoulos, M. C., & Verkman, A. S. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70133-3 · Cited by 608
The role of cellular hydration in the regulation of cell function
Häussinger, D. (1996) · Biochemical Journal · doi:10.1042/bj3130697 · Cited by 592
An update on inflamm-aging: mechanisms, prevention, and treatment
Xia, S., Zhang, X., Zheng, S., Khanabdali, R., Kalionis, B., Wu, J., Wan, W., & Tai, X. (2016) · Journal of Immunology Research · doi:10.1155/2016/8426874 · Cited by 538
Cell volume change through water efflux impacts cell stiffness and stem cell fate
Guo, M., Pegoraro, A. F., Mao, A. S., Zhou, E. H., Arany, P. R., Han, Y., Burnette, D. T., Jensen, M. H., Kasza, K. E., Moore, J. R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705179114 · Cited by 530
Osmotic and nonosmotic control of vasopressin release
Schrier, R. W., Berl, T., & Anderson, R. J. (1979) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1979.236.4.f321 · Cited by 500
mTOR as a key regulator in maintaining skeletal muscle mass
Yoon, M.-S. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00788 · Cited by 495
Cellular hydration state: an important determinant of protein catabolism in health and disease
Häussinger, D. (1993) · The Lancet · doi:10.1016/0140-6736(93)90828-5 · Cited by 447
Mechanisms and Significance of Cell Volume Regulation
Lang, F. J. W. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719667 · Cited by 434
Source of chronic inflammation in aging
Sanada, F., Taniyama, Y., Muratsu, J., Otsu, R., Shimizu, H., Rakugi, H., & Morishita, R. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00012 · Cited by 413
Pallafacchina, G., Calabria, E., Serrano, A. L., Kalhovde, J. M., & Schiaffino, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142166599 · Cited by 402
Anabolic Resistance of Muscle Protein Synthesis with Aging
Burd, N. A., Gorissen, S. H., & van Loon, L. J. C. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318292f3d5 · Cited by 384
The Physiological Regulation of Thirst and Fluid Intake
McKinley, M. J., & Johnson, A. K. (2004) · Physiology · doi:10.1152/nips.01470.2003 · Cited by 376
Skeletal muscle and mortality results from the InCHIANTI study
Cesari, M., Pahor, M., Lauretani, F., Zamboni, V., Bandinelli, S., Bernabei, R., Guralnik, J. M., & Ferrucci, L. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln031 · Cited by 346
Sandri, M., Barberi, L., Bijlsma, A. Y., Blaauw, B., Dyar, K. A., Milan, G., Mammucari, C., Meskers, C. G. M., Pallafacchina, G., Paoli, A., et al. (2013) · Biogerontology · doi:10.1007/s10522-013-9432-9 · Cited by 340
KLEINER, S. M. (1999) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(99)00048-6 · Cited by 333
Treschan, T. A., Peters, J., & Warltier, D. C. (2006) · Anesthesiology · doi:10.1097/00000542-200609000-00026 · Cited by 320
The role of hyperosmotic stress in inflammation and disease
Brocker, C. N., Thompson, D. C., & Vasiliou, V. (2012) · BioMolecular Concepts · doi:10.1515/bmc-2012-0001 · Cited by 310
Human aquaporins: Regulators of transcellular water flow
Day, R. E., Kitchen, P., Owen, D. S., Bland, C. E., Marshall, L. J., Conner, A. C., Bill, R. M., & Conner, M. T. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.09.033 · Cited by 309
Léger, B., Derave, W., Bock, K. D., Hespel, P., & Russell, A. P. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0588 · Cited by 284
Water-loss dehydration and aging
Hooper, L., Bunn, D., Jimoh, F. O., & Fairweather-Tait, S. J. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.11.009 · Cited by 283
Korniluk, A., Koper, O., Kemona, H., & Dymicka-Piekarska, V. (2017) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-016-1464-0 · Cited by 282
Thirst and hydration: Physiology and consequences of dysfunction
Thornton, S. N. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.02.026 · Cited by 224
Hydrophilicity and the Viscosity of Interfacial Water
Goertz, M. P., Houston, J. E., & Zhu, X. (2007) · Langmuir · doi:10.1021/la062299q · Cited by 215
Body Fluid Dynamics: Back to the Future
Bhave, G., & Neilson, E. G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011080865 · Cited by 215
Narrative Review of Hydration and Selected Health Outcomes in the General Population
Liska, D. J., Mah, E., Brisbois, T. D., Barrios, P. L., Baker, L. B., & Spriet, L. L. (2019) · Nutrients · doi:10.3390/nu11010070 · Cited by 201
Aging and Disturbances of Thirst and Fluid Balance
Rolls, B. J., & Phillips, P. A. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1990.tb02915.x · Cited by 175
Hydration and outcome in older patients admitted to hospital (The HOOP prospective cohort study)
Elsharkawy, A. M., Watson, P., Neal, K. R., Ljungqvist, O. H., Maughan, R., Sahota, O., & Lobo, D. N. (2015) · Age and Ageing · doi:10.1093/ageing/afv119 · Cited by 167
Leib, D. E., Zimmerman, C. A., & Knight, Z. A. (2016) · Current Biology · doi:10.1016/j.cub.2016.11.019 · Cited by 161
Progressive cellular dehydration and proteolysis in critically ill patients
Finn, P., Plank, L. D., Clark, M. A., Connolly, A. B., & Hill, G. L. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91204-0 · Cited by 153
Malbrain, M. L. N. G., Huygh, J., Dąbrowski, W., Waele, J. J. D., Staelens, A. S., & Wauters, J. (2014) · Anestezjologia, Intensywna Terapia · doi:10.5603/ait.2014.0061 · Cited by 152
Age-Associated Abnormalities of Water Homeostasis
Cowen, L. E., Hodak, S. P., & Verbalis, J. G. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.005 · Cited by 149
Oral Hydration in Older Adults
Mentes, J. C. (2006) · AJN American Journal of Nursing · doi:10.1097/00000446-200606000-00023 · Cited by 148
Defining anabolic resistance: implications for delivery of clinical care nutrition
Morton, R. W., Traylor, D. A., Weijs, P. J. M., & Phillips, S. M. (2018) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000488 · Cited by 145
Role of NFAT5 in Inflammatory Disorders Associated with Osmotic Stress
Neuhofer, W. (2010) · Current Genomics · doi:10.2174/138920210793360961 · Cited by 136
Clark, B. C., Fernhall, B., & Ploutz‐Snyder, L. L. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01402.2005 · Cited by 135
Unraveling Water’s Entropic Mysteries: A Unified View of Nonpolar, Polar, and Ionic Hydration
Ben‐Amotz, D., & Underwood, R. (2008) · Accounts of Chemical Research · doi:10.1021/ar7001478 · Cited by 130
Frailty, Sarcopenia, and Hormones
Morley, J. E., & Malmstrom, T. K. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.006 · Cited by 128
Is inflammation a consequence of extracellular hyperosmolarity?
Schwartz, L. H., Guais, A., Pooya, M., & Abolhassani, M. (2009) · Journal of Inflammation · doi:10.1186/1476-9255-6-21 · Cited by 128
Effects of changes in hydration on protein, glucose and lipid metabolism in man: impact on health
Keller, U. B., Szinnai, G., Bilz, S., & Berneis, K. K. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601904 · Cited by 122
Tamma, G., Valenti, G., Grossini, E., Donnini, S., Marino, A., Marinelli, R. A., & Calamita, G. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1501847 · Cited by 122
What can we learn by studying enzymes in non–aqueous media?
Halling, P. J. (2004) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2004.1505 · Cited by 116
Vasopressin and disorders of water balance: the physiology and pathophysiology of vasopressin
Ball, S. G. (2007) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1258/000456307781646030 · Cited by 110
Stookey, J. D., Pieper, C. F., & Cohen, H. J. (2005) · Public Health Nutrition · doi:10.1079/phn2005829 · Cited by 107
Yamada, Y., Yoshida, T., Yokoyama, K., Watanabe, Y., Miyake, M., Yamagata, E., Yamada, M., Kimura, M., & Study, K.-K. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw125 · Cited by 104
Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival
Medraño-Fernández, I., Bestetti, S., Bertolotti, M., Bienert, G. P., Bottino, C., Laforenza, U., Rubartelli, A., & Sitia, R. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6636 · Cited by 99
Water in the Half Shell: Structure of Water, Focusing on Angular Structure and Solvation
Sharp, K. A., & Vanderkooi, J. M. (2009) · Accounts of Chemical Research · doi:10.1021/ar900154j · Cited by 93
Prevalence, risk factors and strategies to prevent dehydration in older adults
Wotton, K., Crannitch, K., & Munt, R. (2008) · Contemporary Nurse · doi:10.5172/conu.673.31.1.44 · Cited by 85
Serra‐Prat, M., Lorenzo, I., Palomera, E., Ramírez, S., & Yébenes, J. C. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-1129-y · Cited by 83
Self-citationStöllberger, C., Lutz, W., & Finsterer, J. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02581.x · Cited by 81
Fernández-Elías, V. E., ORTEGA, J. F., Nelson, R. K., & Mora‐Rodríguez, R. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3175-z · Cited by 78
Plank, L. D., & Hill, G. L. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06521.x · Cited by 77
Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise
CAMERA, D. M., West, D. W. D., Burd, N. A., Phillips, S. M., GARNHAM, A. P., Hawley, J. A., & Coffey, V. G. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00395.2012 · Cited by 73
Nosé, H., Morimoto, T., & Ogura, K. (1983) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.33.1019 · Cited by 72
Hydration, morbidity, and mortality in vulnerable populations
Maughan, R. J. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00531.x · Cited by 69
Hydration health literacy in the elderly
Picetti, D., Foster, S., Pangle, A. K., Schrader, A. M., George, M., Wei, J. Y., & Azhar, G. (2017) · Nutrition and Healthy Aging · doi:10.3233/nha-170026 · Cited by 65
The sensitivity of the human thirst response to changes in plasma osmolality: a systematic review
Hughes, F., Mythen, M. G., & Montgomery, H. (2018) · Perioperative Medicine · doi:10.1186/s13741-017-0081-4 · Cited by 63
Serra‐Prat, M., Lorenzo, I., Palomera, E., Yébenes, J. C., Campins, L., & Cabré, M. (2019) · Nutrients · doi:10.3390/nu11030661 · Cited by 63
Self-citationBody Water Spaces and Cellular Hydration during Healthy Aging
Ritz, P., & INVESTIGATORS (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06502.x · Cited by 62
Aquaporins, Vasopressin, and Aging: Current Perspectives
Tamma, G., Goswami, N., Reichmuth, J., Santo, N. G. D., & Valenti, G. (2014) · Endocrinology · doi:10.1210/en.2014-1812 · Cited by 56
Role of aquaporins in cell proliferation: What else beyond water permeability?
Galán‐Cobo, A., Ramírez‐Lorca, R., & Echevarrı́a, M. (2016) · Channels · doi:10.1080/19336950.2016.1139250 · Cited by 56
Why Do We have to Move Fluid to be Able to Breathe?
Fronius, M., Clauss, W. G., & Althaus, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00146 · Cited by 55
Campins, H., & Drake, M. J. (2010) · CRC Press eBooks · doi:10.1201/ebk1439803561 · Cited by 54
Vasopressin, from Regulator to Disease Predictor for Diabetes and Cardiometabolic Risk
Melander, O. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000446201 · Cited by 51
Vasopressin and the Regulation of Thirst
Bichet, D. G. (2018) · Annals of Nutrition and Metabolism · doi:10.1159/000488233 · Cited by 50
Molecular mechanisms of aquaporin biogenesis by the endoplasmic reticulum Sec61 translocon
Pitonzo, D., & Skach, W. R. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.04.021 · Cited by 49
Probing the role of water in protein conformation and function
Rand, R. P. (2004) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2004.1504 · Cited by 49
Cell hydration and mTOR‐dependent signalling
Schliess, F., Richter, L., Dahl, S. V., & Häussinger, D. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01547.x · Cited by 48
Osmoadaptation of Mammalian Cells - An Orchestrated Network of Protective Genes
Küper, C., Beck, F.-X., & Neuhofer, W. (2007) · Current Genomics · doi:10.2174/138920207781386979 · Cited by 45
Eisner, V., Criollo, A., Quiroga, C., Olea‐Azar, C., Santibanez, J. F., Troncoso, R., Chiong, M., Dı́az-Araya, G., Foncea, R. E., & Lavandero, S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.07.029 · Cited by 40
Cell electrical properties: reconsidering the origin of the electrical potential
Pollack, G. H. (2014) · Cell Biology International · doi:10.1002/cbin.10382 · Cited by 39
Aquaporin Expression in Normal and Pathological Skeletal Muscles: A Brief Review with Focus on AQP4
Wakayama, Y. (2010) · BioMed Research International · doi:10.1155/2010/731569 · Cited by 38
Hyperosmotic stress stimulates autophagy via polycystin-2
Peña‐Oyarzún, D., Troncoso, R., Kretschmar, C., Hernando, C., Budini, M., Morselli, E., Lavandero, S., & Criollo, A. (2017) · Oncotarget · doi:10.18632/oncotarget.18995 · Cited by 38
Enhörning, S., & Melander, O. (2018) · Annals of Nutrition and Metabolism · doi:10.1159/000488304 · Cited by 38
Gosmanov, A. R., Schneider, E. G., & Thomason, D. B. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00576.2002 · Cited by 37
Origins for the estimations of water requirements in adults
Vivanti, A. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.157 · Cited by 32
A review of the literature on how important water is to the world's elderly population
Davidhizar, R., Dunn, C. L., & Hart, A. (2004) · International Nursing Review · doi:10.1111/j.1466-7657.2004.00224.x · Cited by 31
Cell Volume Controls Protein Stability and Compactness of the Unfolded State
Wang, Y., Sukenik, S., Davis, C. M., & Gruebele, M. (2018) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b08216 · Cited by 30
The role of water in the mechanism of muscular contraction
Oplatka, A. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01158-3 · Cited by 24
Muscle strength in the Mataró aging study participants and its relationship to successful aging
Mataró Aging Study Group, Puig‐Domingo, M., Serra‐Prat, M., Merino, M. J. L., Pubill, M., Burdoy, E., & Papiol, M. (2008) · Aging Clinical and Experimental Research · doi:10.1007/bf03325150 · Cited by 23
Self-citationLearning (by) osmosis: an approach to teaching osmolarity and tonicity
Vujovic, P. Z., Chirillo, M. A., & Silverthorn, D. U. (2018) · AJP Advances in Physiology Education · doi:10.1152/advan.00094.2018 · Cited by 23
Impact of Mild Hypohydration on Muscle Endurance, Power, and Strength in Healthy, Active Older Men
Goulet, E. D. B., Mélançon, M. O., Lafrenière, D., Paquin, J., Maltais, M. L., & Morais, J. A. (2017) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001857 · Cited by 22
The TORC1 pathway to protein destruction
Chantranupong, L., & Sabatini, D. M. (2016) · Nature · doi:10.1038/nature18919 · Cited by 21
Tatlısu, M. A., Kaya, A., Keskin, M., Uzman, O., Börklü, E. B., Çinier, G., Hayıroğlu, M. İ., Tatlisu, K., & Eren, M. (2016) · Coronary Artery Disease · doi:10.1097/mca.0000000000000426 · Cited by 20
Contraction-Induced Changes in Hydrogen Bonding of Muscle Hydration Water
Yoo, H., Nagornyak, E., Das, R., Wexler, A. D., & Pollack, G. H. (2014) · The Journal of Physical Chemistry Letters · doi:10.1021/jz5000879 · Cited by 17
Isosmotic is not always isotonic: the five-minute version
Silverthorn, D. U. (2016) · AJP Advances in Physiology Education · doi:10.1152/advan.00080.2016 · Cited by 11
Kalman, D., & Lepeley, A. (2010) · Strength and conditioning journal · doi:10.1519/ssc.0b013e3181c21172 · Cited by 10
Abdel-Sater, K. A. (2018) · American Journal of Biomedical Sciences · doi:10.5099/aj180300167 · Cited by 7
Cell Volume Sensing and Regulation in Skeletal Muscle Cells
Rasgado-Flores, H., Theobald, J. L., Ruiz, J., Bitner, J. B., Markowitz, S., Zlatnick, D., Yee, P.-A., Yee, P.-P., Trais, L., Gohar, K., et al. (2006) · Springer eBooks · doi:10.1007/0-387-23752-6_25 · Cited by 2
Aquaporins in physiology and pathology
Lutosławska, G. (2014) · Cited by 2
Acuaporinas: moléculas revelación en cosmética y oncología cutánea
Osorio-Gómez, G., Bernabeu, J., Echevarrı́a, M., & Conejo‐Mir, J. (2009) · Piel · doi:10.1016/s0213-9251(09)70754-3 · Cited by 2
Flagged first, then by citations
Research works printed but not linked: 4
- Goodman Gilman, A., Rall, T.W., Nies, A.S., and Taylor, P. (1990). Agents affecting volume and composition of body fluids. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Pergamon Press.
- Institute of Medicine, Food and Nutrition Board (2005). Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate, National Academies Press.
- Kondo, 2009, Thermoregulatory adaption in humans and its modifying factors, Glob. Environ. Res., 13, 35
- Barrett, K.E., Barman, S.M., Boitano, S., and Brooks, H. (2010). Hypothalamic regulation of hormonal functions. Ganong’s Review of Medical Physiology, McGraw-Hill Medic. [23th ed.].
Cited by
Sorted by citations
ESPEN guideline on chronic intestinal failure in adults – Update 2023
Pironi, L., Cuerda, C., Jeppesen, P. B., Joly, F., Jonkers‐Schuitema, C. F., Krznarić, Ž., Lal, S., Lamprecht, G., Lichota, M., Mundi, M. S., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.07.019 · Cited by 225
Jeong, S., Lee, D. H., Rezende, L. F. M., & Giovannucci, E. L. (2023) · Scientific Reports · doi:10.1038/s41598-023-30527-w · Cited by 194
Diet for the prevention and management of sarcopenia
Calvani, R., Picca, A., Coelho‐Júnior, H. J., Tosato, M., Marzetti, E., & Landi, F. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155637 · Cited by 162
Hydration Status in Older Adults: Current Knowledge and Future Challenges
Li, S., Xiao, X., & Zhang, X. (2023) · Nutrients · doi:10.3390/nu15112609 · Cited by 154
Assessing the nutritional quality of Pleurotus ostreatus (oyster mushroom)
Effiong, M. E., Umeokwochi, C. P., Afolabi, I. S., & Chinedu, S. N. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1279208 · Cited by 136
Metadata
- Authors
- Lorenzo, I., Serra-Prat, M., & Yébenes, J. C.
- Affiliations
- Maresme Health Consortium (ES)
- Research Unit, Consorci Sanitari del Maresme, 08304 Mataró (Barcelona), Spain
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-08-09
- Volume
- 11
- Issue
- 8
- Pages
- 1857
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6723611
- OpenAlex
- W2969066781
- Cited by
- 239
- References
- 107
- Citations by year
- 2026: 31 · 2025: 45 · 2024: 68 · 2023: 40 · 2022: 18 · 2021: 21 · 2020: 16
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Spanish Ministry of Health (Instituto de Salud Carlos III) (FIS PI 16/00750)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- water homeostasis, muscle function, frailty, hyperosmotic stress, cell dehydration, osmotic pressure, extracellular osmolarity, thirst, urine concentrating ability, aging, muscle quality, muscle strength, functional capacity, cell volume, intracellular water content, lean body mass
- MeSH terms
- Frailty, Organism Hydration Status, Animals, Body Composition, Energy Metabolism, Humans, Muscle Contraction, Osmotic Pressure, Water-Electrolyte Balance, Water-Electrolyte Imbalance, Muscle, Skeletal, Muscle Strength
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
