New developments and novel therapeutic perspectives for vitamin C

Li, Yi; Schellhorn, Herb E.

doi:10.1093/jn/137.10.2171

Cited by 508Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

New developments and novel therapeutic perspectives for vitamin C

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Li, Yi, Schellhorn, Herb E.·2007·The Journal of Nutrition

DOI 10.1093/jn/137.10.2171

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Abstract

Vitamin C is required for collagen synthesis and biosynthesis of certain hormones and recommended dietary intake levels are largely based these requirements. However, to function effectively as an antioxidant (or a pro-oxidant), relatively high levels of this vitamin must be maintained in the body. The instability of vitamin C combined with its relatively poor intestinal absorption and ready excretion from the body reduce physiological availability of this vitamin. This inability to maintain high serum levels of vitamin C may have serious health implications and is particularly relevant in the onset and progression of degenerative disease, such as cancer and cardiovascular disease (CVD), which have a strong contributing oxidative damage factor. In this review, we examine recent studies on the regulation of transport mechanisms for vitamin C, related clinical ramifications, and potential implications in high-dose vitamin C therapy. We also evaluate recent clinical and scientific evidence on the effects of this vitamin on cancer and CVD, with focus on the key mechanisms of action that may contribute to the therapeutic potential of this vitamin in these diseases. Several animal models that could be utilized to address unresolved questions regarding the feasibility of vitamin C therapy are also discussed.

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The human body cannot produce endogenous vitamin C.
“Due to the inability of the human body to produce endogenous vitamin C, supplementation of the diet can be used to maintain adequate amounts of the nutrient [8].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [8]
Supplementation of the diet can be used to maintain adequate amounts of vitamin C.
“Due to the inability of the human body to produce endogenous vitamin C, supplementation of the diet can be used to maintain adequate amounts of the nutrient [8].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [8]

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Authors: Li, Y., & Schellhorn, H. E.
Affiliations: McMaster University (CA)
Corresponding author: Schellhorn, Herb E.
ORCID: Li, Yi
Schellhorn, Herb E.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2007-10
Volume: 137
Issue: 10
Pages: 2171-2184
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/137.10.2171
OpenAlex: W2147164761
Cited by: 508
References: 218
Citations by year: 2026: 22 · 2025: 21 · 2024: 40 · 2023: 22 · 2022: 42 · 2021: 37 · 2020: 35 · 2019: 34 · 2018: 27 · 2017: 25 · 2016: 24 · 2015: 25 · 2014: 20 · 2013: 23 · 2012: 31
FWCI: 20.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5610 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: vitamin C, vitamin C transport, antioxidants, pro-oxidants, vitamin C bioavailability, intestinal absorption, oxidative damage, cancer, cardiovascular disease, degenerative diseases, animal models
MeSH terms: Ascorbic Acid, Biological Transport, Cardiovascular Diseases, Humans, Neoplasms

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