Meal-Generated Oxidative Stress in Type 2 Diabetic Patients
Abstract
OBJECTIVE: Free radical production has been reported to be increased in diabetic patients and to be involved in the pathogenesis of diabetic complications. In this study, a standardized meal was administered to 10 type 2 diabetic patients and 10 healthy matched normal subjects to evaluate its effects on plasma oxidative stress generation. RESEARCH DESIGN AND METHODS: In diabetic patients, at baseline and after the meal, plasma malondialdehyde (MDA), vitamin C, protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual cooperation, were measured. RESULTS: After the meal, plasma MDA and vitamin C increased, while protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter decreased more significantly in the diabetic subjects than in control subjects. CONCLUSIONS: This finding shows that in the absorptive phase, free radicals are produced in diabetic patients. Since plasma glucose, but not insulin, rose significantly more in diabetic subjects than in control subjects, hyperglycemia may play an important role in the generation of postprandial oxidative stress in diabetic patients.
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From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [728]
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“High blood glucose in diabetic patients facilitates lipid peroxidation and decreases SH content, 23 whereas KDs are carbohydrate restricted and do not increase blood glucose in healthy subjects.”
Straface, E., Rivabene, R., Masella, R., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6340 · Cited by 49 · see citing works
Clinical relevance of the oxidative stress concept
Haffner, S. M. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80083-9 · Cited by 48 · see citing works
Variations in Postprandial Blood Glucose Responses and Satiety after Intake of Three Types of Bread
Lunde, M. S. H., Hjellset, V. T., Holmboe‐Ottesen, G., & Høstmark, A. T. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/437587 · Cited by 49 · see citing works
“, intake of a carbohydrate meal is followed by oxidative stress that is related to the level of hyperglycemia [34], and to fluctuations in blood glucose levels [14, 16, 35].”
BackgroundLipid peroxidation and atherosclerosis in type II diabetes
Oranje, W. A., & Wolffenbuttel, B. H. R. (1999) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(99)90050-1 · Cited by 46 · see citing works
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“Impairments in lipid (33) and glucose (34) handling may both lead to oxidative stress.”
BackgroundEffect of Catha edulis (khat) chewing on plasma lipid peroxidation
Al-Zubairi, A. S., Al‐Habori, M., & Al-Geiry, A. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00101-6 · Cited by 45 · see citing works
Insulin as an anti-inflammatory and antiatherosclerotic hormone
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Oxidative stress: The special case of diabetes
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Oral glucose loading attenuates endothelial function in normal individual
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Oxidative Stress in Diabetes Mellitus: Is There a Role for Hypoglycemic Drugs and/or Antioxidants?
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“Evidence implicates the role of oxidative stress in the different stages of the development of diabetes mellitus, starting from the pre-diabetes state, impaired glucose tolerance, postprandial hyperglycemia, mild diabetes and finally to overt diabetes mellitus (Ceriello et al., 1998).”
Postprandial insulin resistance as an early predictor of cardiovascular risk.
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Jax, T. W., Stirban, A. O., Terjung, A., Esmaeili, H. A., Berk, A., Thiemann, S., CHILTON, R. J., von Eynatten, M., & Marx, N. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0493-3 · Cited by 38 · see citing works
Energetic investment associated with vitellogenesis induces an oxidative cost of reproduction
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“Oxidative stress has also been implicated in the pathogenesis of atherosclerotic vascular disease [4] with several studies demonstrating that both acute postprandial hyperglycaemia and glucose loading induced oxidative stress in humans [5, 6].”
BackgroundThe response of γ vitamin E to varying dosages of α vitamin E plus vitamin C
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“Hyperglycemia may increase free radical production through mechanisms of lipoprotein glycation, glucose autooxidation, and polyol pathway activation [44].”
Postprandial hyperglycemia and endothelial function in type 2 diabetes: focus on mitiglinide
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“Postprandial acceleration of oxidative stress and inflammation has been observed in patients with type 2 diabetes [49,55-58].”
BackgroundStimulation of Urinary TGF-β and Isoprostanes in Response to Hyperglycemia in Humans
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“(37) that individuals with diabetes have an increased level of free radical generation after a standard meal compared with individuals without diabetes.”
BackgroundEffect of taxifolin on development of retinopathy in alloxan-induced diabetic rats
Ahiskali, I., Pinar, C. L., Kiki, M., Mammadov, R., Bilgin, A. Ö., Hacımüftüoğlu, A., Çankaya, M., Çimen, F. K., & Altuner, D. (2019) · Cutaneous and Ocular Toxicology · doi:10.1080/15569527.2019.1588289 · Cited by 35 · see citing works
- Authors
- Ceriello, A., Bortolotti, N., Motz, E., Crescentini, A., Lizzio, S., Russo, A., Tonutti, L., & Taboga, C.
- Affiliations
- University of Udine (IT)
- Diabetology Unit, Udine General Hospital Udine, Italy
- ORCID
- Ceriello, Antonio
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1998-09-01
- Volume
- 21
- Issue
- 9
- Pages
- 1529-1533
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2052825417
- Cited by
- 211
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 14
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- type 2 diabetes, oxidative stress, postprandial oxidative stress, free radicals, malondialdehyde, vitamin C, vitamin E, uric acid, protein thiol groups, antioxidant capacity, hyperglycemia, plasma glucose, insulin
- MeSH terms
- Analysis of Variance, Antioxidants, Ascorbic Acid, Blood Glucose, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Free Radicals, Humans, Male, Malondialdehyde, Middle Aged, Uric Acid, Vitamin E, Oxidative Stress, Postprandial Period
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