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Cited by 49Probiotics and Fermented FoodsInfant Nutrition and HealthViral gastroenteritis research and epidemiology

Systematic review with meta-analysis: Lactobacillus reuteri DSM 17938 for treating acute gastroenteritis in children. An update

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Patro-Gołąb, Bernadeta, Szajewska, Hania·2019·Nutrients
DOI 10.3390/nu11112762PMC PMC6893691
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Abstract

The effectiveness of Lactobacillus reuteri DSM 17938 (L. reuteri) for the management of acute gastroenteritis (AGE) has been recently questioned. We performed a systematic review to update evidence on L. reuteri for treating AGE in children. We searched MEDLINE, EMBASE, the Cochrane Library databases, and additional data sources from January 2016 (end of search for our 2016 systematic review) to August 2019. The primary outcomes were stool volume and duration of diarrhea. Four RCTs were included. None of them evaluated stool volume. Compared with placebo or no treatment, L. reuteri reduced diarrhea duration (four RCTs, n = 347, mean difference, MD −0.87 days, 95% CI [−1.43, −0.31]). L. reuteri use was also associated with a reduced duration of hospitalization (three RCTs, n = 284, MD −0.54 days, 95% CI [−1.09, 0.0]). The small effect sizes of limited clinical relevance and methodological limitations of the included trials should be noted when interpreting these findings.

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  • A systematic review of L reuteri DSM 17938 for treating acute gastroenteritis in children reported marked statistical heterogeneity and very low certainty of evidence for both duration of diarrhoea and duration of hospitalization.

    “A systematic review of L reuteri DSM 17938 for treating acute gastroenteritis in children reported marked statistical heterogeneity and very low certainty of evidence for both duration of diarrhoea and duration of hospitalization (Patro‐Gołab 2019).”

    From Probiotics for treating acute infectious diarrhoea (2020) · cites this paper as Patro‐Gołab 2019

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Cited by

Sorted by citations

Authors
Patro-Gołąb, B., & Szajewska, H.
Affiliations
Medical University of Warsaw (PL)
Corresponding author
Szajewska, Hania
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2019-11-14
Volume
11
Issue
11
Pages
2762
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu11112762
PMC
PMC6893691
OpenAlex
W2986401148
Cited by
49
References
5
Citations by year
2026: 4 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 5
FWCI
0.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
Keywords
Lactobacillus reuteri DSM 17938, acute gastroenteritis, childhood diarrhea, probiotics, diarrhea duration, length of hospital stay, stool volume
MeSH terms
Child, Preschool, Defecation, Diarrhea, Feces, Gastroenteritis, Hospitalization, Humans, Infant, Species Specificity, Probiotics, Limosilactobacillus reuteri

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