Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice
Open accessAbstract
Impaired early nutrition influences the risk of developing metabolic disorders in later life. We observed that transient postnatal overfeeding (OF) in mice induces long-term hepatic alterations, characterized by microsteatosis, fibrosis associated with oxidative stress (OS), and stress-induced premature senescence (SIPS). In this study, we investigated whether such changes can be reversed by moderate calorie restriction (CR). C57BL/6 male mice pups were maintained during lactation in litters adjusted to nine pups in the normal feeding (NF) group and three pups in the transient postnatal OF group. At six months of age, adult mice from the NF and OF groups were randomly assigned to an ad libitum diet or CR (daily energy supply reduced by 20%) for one month. In each group, at the age of seven months, analysis of liver structure, liver markers of OS (superoxide anion, antioxidant defenses), and SIPS (lipofuscin, p53, p21, p16, pRb/Rb, Acp53, sirtuin-1) were performed. CR in the OF group reduced microsteatosis, decreased levels of superoxide anion, and increased protein expression of catalase and superoxide dismutase. Moreover, CR decreased lipofuscin staining, p21, p53, Acp53, and p16 but increased pRb/Rb and sirtuin-1 protein expression. CR did not affect the NF group. These results suggest that CR reduces hepatic disorders induced by OF.
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A 20% reduction of calories in mice diet resulted in increased expression of SIRT1, decreased levels of superoxide radical anion, and increased expression of superoxide dismutase.
“It was also reported that a 20% reduction of calories in mice diet resulted in increased expression of SIRT1, decreased levels of superoxide radical anion, and increased expression of superoxide dismutase (Yzydorczyk et al. 2019).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Yzydorczyk et al. 2019
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- Authors
- Yzydorczyk, C., Li, N., Rigal, E., Chehade, H., Mosig, D., Armengaud, J. B., Rolle, T., Krishnasamy, A., Orozco, E., Siddeek, B., Juvet, C., Vergely, C., & Simeoni, U.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Université de Bourgogne (FR)
- DOHaD Laboratory, Woman-Mother-Child Department, Division of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland
- Corresponding author
- Yzydorczyk, Catherine
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-11-16
- Volume
- 11
- Issue
- 11
- Pages
- 2796
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6893580
- OpenAlex
- W2987052097
- Cited by
- 24
- References
- 51
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 4
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, cc-by)
- IRIS (submittedVersion, cc-by)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Centre Hospitalier Universitaire Vaudois (30034)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- caloric restriction, postnatal overfeeding, hepatic steatosis, liver fibrosis, oxidative stress, stress-induced premature senescence, SIRT1, p53, p16, retinoblastoma protein, lipofuscin, catalase, superoxide dismutase, early life nutrition, metabolic disorders
- MeSH terms
- Animals, Animals, Newborn, Catalase, Feeding Methods, Female, Liver, Liver Diseases, Male, Mice, Inbred C57BL, Superoxide Dismutase, Cellular Senescence, Oxidative Stress, Caloric Restriction, Mice
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