The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Vitamin D Deficiency and Sarcopenia in Older Persons
Open accessAbstract
Vitamin D deficiency is a common health problem worldwide, in particular among older people. Vitamin D regulates and modulates the physiology and function of multiple human systems, including the skeletal muscle. The effect of vitamin D on the muscle has been widely investigated, suggesting that this hormone can stimulate the proliferation and differentiation of skeletal muscle fibers, maintaining and improving muscle strength and physical performance. Older persons have a higher prevalence of low Vitamin D levels as a consequence of low dietary intake and reduced ultraviolet irradiation of the skin. Therefore, older people with vitamin D deficiency might be at risk of sarcopenia, a geriatric syndrome characterized by the progressive loss of skeletal muscle mass and strength often complicated by adverse events, such as falls, disability hospitalization and death. Several randomized clinical trials have been conducted to investigate the effect of oral vitamin D supplementation in older patients to prevent or treat sarcopenia, but results are still controversial. In this narrative review we summarize the biological, clinical and epidemiological evidence supporting the hypothesis of a causal association between Vitamin D deficiency and an increased risk of sarcopenia in older people.
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Cited by
Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial
Martínez-Arnau, F. M., Fonfría-Vivas, R., Buigues, C., Castillo, Y., Molina, P., Hoogland, A. J., van Doesburg, F., Pruimboom, L., Fernández-Garrido, J., & Cauli, O. (2020) · Nutrients · doi:10.3390/nu12040932 · Cited by 120
Geng, Q., Zhai, H., Wang, L., Wei, H., & Hou, S. (2023) · Medicine · doi:10.1097/md.0000000000034254 · Cited by 33
Organotypic cultures as aging associated disease models
Sanchez, M. M., Bagdasarian, I. A., Darch, W., & Morgan, J. T. (2022) · Aging · doi:10.18632/aging.204361 · Cited by 12
Metadata
- Authors
- Remelli, F., Vitali, A., Zurlo, A., & Volpato, S.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-11-21
- Volume
- 11
- Issue
- 12
- Pages
- 2861
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2990303184
- Cited by
- 348
- References
- 16
- FWCI
- 19.40
- Type
- journal article
- Language
- en
- Open access
- gold
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