The DOI matches its Crossref record; 269 of the 269 references it cites were found in a registry or an index.
A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models
Open accessAbstract
Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic homeostasis of this essential trace element. This review summarizes the key aspects of human zinc homeostasis and distribution. In particular, current knowledge on human intestinal zinc absorption and the influence of diet-derived factors on bioaccessibility and bioavailability as well as intrinsic luminal and basolateral factors with an impact on zinc uptake are discussed. Their investigation is increasingly performed using in vitro cellular intestinal models, which are continually being refined and keep gaining importance for studying zinc uptake and transport via the human intestinal epithelium. The vast majority of these models is based on the human intestinal cell line Caco-2 in combination with other relevant components of the intestinal epithelium, such as mucin-secreting goblet cells and in vitro digestion models, and applying improved compositions of apical and basolateral media to mimic the in vivo situation as closely as possible. Particular emphasis is placed on summarizing previous applications as well as key results of these models, comparing their results to data obtained in humans, and discussing their advantages and limitations.
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Cited by
Role of zinc in health and disease
Stiles, L. I., Ferrao, K., & Mehta, K. J. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01302-6 · Cited by 275
Nishito, Y., & Kambe, T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010227 · Cited by 117
Zinc for prevention and treatment of the common cold
Nault, D., Machingo, T. A., Shipper, A. G., Antiporta, D. A., Hamel, C., Nourouzpour, S., Konstantinidis, M., Phillips, E., Lipski, E. A., & Wieland, L. S. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014914.pub2 · Cited by 18
Metadata
- Authors
- Maares, M., & Haase, H.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-03-13
- Volume
- 12
- Issue
- 3
- Pages
- 762
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W3010944001
- Cited by
- 367
- References
- 269
- FWCI
- 22.85
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
