Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 1,298

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Trace elements in human physiology and pathology: zinc and metallothioneins

Tapiero, Haim, Tew, Kenneth D·2003·Biomedicine & Pharmacotherapy

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0753-3322(03)00081-7

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 11 references

Research works printed but not linked: 183

  1. Paulsen, 1997, A novel family of ubiquitous heavy metal ion transport proteins, J Membr Biol, 156, 99, 10.1007/s002329900192 · DOI · Paper page
  2. Palmiter, 1995, Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc, EMBO J, 14, 639, 10.1002/j.1460-2075.1995.tb07042.x · DOI · Paper page
  3. McMahon, 1998, Regulation of the zinc transporter ZnT-1 by dietary zinc, Proc Natl Acad Sci USA, 95, 4841, 10.1073/pnas.95.9.4841 · DOI · Paper page
  4. Palmiter, 1996, ZnT-3, a putative transporter of zinc into synaptic vesicles, Proc Natl Acad Sci USA, 93, 14934, 10.1073/pnas.93.25.14934 · DOI · Paper page
  5. Fleming, 1998, Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport, Proc Natl Acad Sci USA, 95, 1148, 10.1073/pnas.95.3.1148 · DOI · Paper page
  6. Berg, 1996, The galvanization of biology: a growing appreciation for the roles of zinc, Science, 271, 1081, 10.1126/science.271.5252.1081 · DOI · Paper page
  7. King, 2000, Zinc homeostasis in humans, J Nutr, 130, 1360S, 10.1093/jn/130.5.1360S · DOI · Paper page
  8. Van Wouwe, 1994, The role of the pancreas in the regulation of zinc status, Biol Trace Elem Res, 42, 143, 10.1007/BF02785385 · doi:10.1007/bf02785385
  9. De Lisle, 1996, Metallothioneins a component of exocrine pancreas secretion: implications for zinc homeostasis, Am J Physiol, 271, C1103, 10.1152/ajpcell.1996.271.4.C1103 · DOI
  10. Oberlas, 1996, Mechanism of zinc homeostasis, J Inorg Biochem, 62, 231, 10.1016/0162-0134(95)00157-3 · doi:10.1016/0162-0134(95)00157-3
  11. Johnson, 1993, Homeostatic control of zinc metabolism in men: zinc excretion and balance in men fed diets low in zinc, Am J Clin Nutr, 57, 557, 10.1093/ajcn/57.4.557 · DOI
  12. Fung, 1997, Zinc absorption in women during pregnancy and lactation: a longitudinal study, Am J Clin Nutr, 66, 80, 10.1093/ajcn/66.1.80 · DOI
  13. King, 2001, Effect of acute zinc depletion on zinc homeostasis and plasma zinc kinetics in men, Am J Clin Res, 74, 116
  14. Forbes, 1983, Bioavailability of trace mineral elements, Annu Rev Nutr, 3, 213, 10.1146/annurev.nu.03.070183.001241 · doi:10.1146/annurev.nu.03.070183.001241
  15. Hempe, 1992, Cysteine-rich intestinal protein and intestinal metallothioneins: an inverse relationship as a conceptual model for zinc absorption in rats, J Nutr, 122, 89, 10.1093/jn/122.1.89 · DOI
  16. Dore-Duffy, 1990, Zinc profiles in rheumatoid arthritis, Clin Exp Rheumatol, 8, 541
  17. De Kok, 1993, The uptake of zinc by erythrocytes under near-physical conditions, Biol Trace Elem Res, 38, 13, 10.1007/BF02783978 · doi:10.1007/bf02783978
  18. Tibaduiza, 1996, Zinc transport across and endothelium includes vesicular cotransport with albumin, J Cell Physiol, 167, 539, 10.1002/(SICI)1097-4652(199606)167:3<539::AID-JCP17>3.0.CO;2-Z · doi:10.1002/(sici)1097-4652(199606)167:3<539::aid-jcp17>3.0.co;2-z
  19. Gachot, 1991, Zinc uptake by proximal cells isolated from rabbit kidney: effect of cysteine and histidine, Pflügers Arch Physiol, 419, 583, 10.1007/BF00370299 · doi:10.1007/bf00370299
  20. Kirchgessner, 1983, Zinc absorption and excretion in relation to nutrition, Metal Ions Biol Syst, 15, 319
  21. Hempe, 1991, Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport, Proc Natl Acad Sci USA, 88, 9671, 10.1073/pnas.88.21.9671 · DOI
  22. Palmiter, 1996, ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration, EMBO J, 15, 1784, 10.1002/j.1460-2075.1996.tb00527.x · DOI · Paper page
  23. Vallee, 1993, The biochemical basis of zinc physiology, Physisol Rev, 73, 79, 10.1152/physrev.1993.73.1.79 · DOI · Paper page
  24. Prasad, 1963, Biochemical studies on dwarfism, hypogonadism and anemia, Arch Int M, 111, 407, 10.1001/archinte.1963.03620280007003 · DOI · Paper page
  25. Halstead, 1972, Zinc deficiency in man. The Shiraz experiment, Am J M, 53, 277, 10.1016/0002-9343(72)90169-6 · DOI · Paper page
  26. Sandstead, 1991, Zinc deficiency. A public health problem?, Am J Dis Child, 145, 853, 10.1001/archpedi.1991.02160080029016 · DOI · Paper page
  27. Moser-Veillon, 1990, Zinc: Consumption patterns and dietary recommendations, J Am Diet Assoc, 90, 1089, 10.1016/S0002-8223(21)01706-5 · DOI
  28. Calhoun, 1974, The role of zinc in bone metabolism, Orthopedics, 103, 212, 10.1097/00003086-197409000-00084 · DOI
  29. Yamaguchi, 1982, Stimulation of bone resorption by comparatively high dose of zinc in rats, J Pharm Dyn, 5, 501, 10.1248/bpb1978.5.501 · doi:10.1248/bpb1978.5.501
  30. Prasad, 1998, Zinc in human health: an update, J Trace Elem Exp M, 11, 63, 10.1002/(SICI)1520-670X(1998)11:2/3<63::AID-JTRA2>3.0.CO;2-5 · doi:10.1002/(sici)1520-670x(1998)11:2/3<63::aid-jtra2>3.0.co;2-5
  31. Cousins, 1988, Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin-1, FASEB J, 2, 2884, 10.1096/fasebj.2.13.2458983 · DOI · Paper page
  32. Cui, 1997, Induction of nitric oxide synthase in rat intestine by interleukin-1 my explain diarrhea associated with zinc deficiency, J Nutr, 127, 1729, 10.1093/jn/127.9.1729 · DOI
  33. Driscoll, 1993, The effect of dietary zinc deficiency in the rat on the lipid composition of the erythrocyte membrane Triton shell, Lipids, 27, 972, 10.1007/BF02535574 · DOI
  34. Avery, 1992, Zinc deficiency alters the protein composition of the membrane skeleton but not the extractability of oligomeric form of spectrin in rat erythrocyte membrane, J Nutr, 122, 428, 10.1093/jn/122.3.428 · DOI
  35. Johanning, 1990, Effect of zinc deficiency on enzyme activities in rat and pig erythrocyte membranes, Proc Soc Exp Biol M, 195, 224, 10.3181/00379727-195-43139 · DOI
  36. Ruz, 1992, Erythrocyte membranes, neutrophils and platelets as biopsy materials for the assessment of zinc status in humans, Br J Nutr, 68, 515, 10.1079/BJN19920109 · DOI
  37. Dakshinamurti, 1990, Neurobiology of pyridoxine, Ann NY Acad Sci, 585, 128, 10.1111/j.1749-6632.1990.tb28049.x · DOI · Paper page
  38. Yamada, 1990, Probable reaction mechanisms of flavokinase and FAD synthetase from rat liver, Arch Biochem Biophys, 278, 125, 10.1016/0003-9861(90)90240-Y · DOI
  39. Jay, 1987, Alterations in lipid membrane fluidity and the physical state of cell surface sialic acid in zinc-deficient rat erythrocyte ghosts, Biochim Biophys Acta, 897, 507, 10.1016/0005-2736(87)90449-4 · doi:10.1016/0005-2736(87)90449-4
  40. Keen, 1990, Zinc deficiency and immune function, Annu Rev Nutr, 10, 415, 10.1146/annurev.nu.10.070190.002215 · DOI · Paper page
  41. Xie, 1994, Modulation of GABA-mediated synaptic transmission by endogenous zinc in the immature rat hippocampus in vitro, J Physiol, 478, 75, 10.1113/jphysiol.1994.sp020231 · DOI
  42. Vinegar, 1990, Voltage-dependent block by zinc of single calcium channels in mouse myotubes, J Physiol, 425, 563, 10.1113/jphysiol.1990.sp018118 · DOI
  43. Vaillancourt, 1991, Glucocorticoid effects on zinc transport into colostrums and milk of lactating cows, Biol Trace Elem Res, 30, 185, 10.1007/BF02990353 · doi:10.1007/bf02990353
  44. Klug, 1998, Zinc fingers: a novel protein motif for nucleic acid recognition, TIBS, 7, 464
  45. Favier, 1992, The role of zinc in reproduction. Hormonal mechanisms, Biol Trace Elem Res, 32, 363, 10.1007/BF02784623 · DOI · Paper page
  46. Neve, 1992, Clinical implications of trace elements in endocrinology, Biol Trace Elem Res, 32, 173, 10.1007/BF02784602 · DOI
  47. Bray, 1990, The physiological role of zinc as an antioxidant, Free Radic Biol M, 8, 281, 10.1016/0891-5849(90)90076-U · DOI · Paper page
  48. Sakanashi, 1993, Zinc deficiency associated alterations in the chemotactic and respiratory burst responses of rat peripheral blood neutrophils, FASEB J, 7, A723
  49. Davis, 1998, Extracellular superoxide dismutase activity: a promising indicator of zinc status in humans, FASEB J, 12, A346
  50. Cousins, 1985, Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplamin, Phys Rev, 65, 238
  51. Kelly, 1986, The dihydroorotase domain of the multifunctional protein CAD, J Biol Chem, 261, 6073, 10.1016/S0021-9258(17)38494-6 · DOI
  52. Washabaugh, 1986, Dihydroorotase from Escherichia coli: sulphydryl group-metal interactions, J Biol Chem, 261, 5920, 10.1016/S0021-9258(17)38471-5 · DOI
  53. Conte, 1996, In vivo and in vitro iron replaced zinc finger generates free radicals and causes DNA damage, J Biol Chem, 271, 5125, 10.1074/jbc.271.9.5125 · DOI
  54. Hesketh, 1983, Zinc binding to tubulin, Int J Biochem, 15, 743, 10.1016/0020-711X(83)90202-1 · DOI
  55. Wu, 1994, A cysteine in the C-terminal region of alnyl-tRNA synthetase is important for aminoacylation activity, Biochemistry, 33, 12260, 10.1021/bi00206a032 · doi:10.1021/bi00206a032
  56. Padgette, 1988, Identification of the reactive cysteines of Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase and their nonessentiality for enzymatic catalysis, J Biol Chem, 263, 1798, 10.1016/S0021-9258(19)77947-2 · doi:10.1016/s0021-9258(19)77947-2
  57. Tse-Dinh, 1988, Escherichia coli DNA topoiisomerease I is a zinc metalloprotein with three repetitive zinc-binding domains, J Biol Chem, 263, 15857, 10.1016/S0021-9258(18)37526-4 · DOI
  58. Fu, 1996, Identification of cysteine residue essential for activity of protein farnesyltransferase. Cys 299 is exposed only upon removal of zinc from the enzyme, J Biol Chem, 271, 28541, 10.1074/jbc.271.45.28541 · DOI
  59. Gibbs, 1985, Investigation of the effect of metal ions on the reactivity of thiol groups in humans: aminolevulinate dehydratase, Biochem J, 225, 573, 10.1042/bj2250573 · DOI
  60. Powell, 2000, The antioxidant properties of zinc, J Nutr, 130, 1447S, 10.1093/jn/130.5.1447S · DOI · Paper page
  61. Chevion, 1988, A site specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals, Free Radic Biol M, 5, 27, 10.1016/0891-5849(88)90059-7 · DOI · Paper page
  62. Bhat, 1994, DNA breakage by tannic acid and Cu(II): sequence specificity of the reaction and involvement of active oxygen species, Mutat Res Environ Mutagen Rel Subj, 313, 39
  63. Stadtman, 1990, Metal-ion catalysed oxidation of proteins: biochemical mechanism and consequences, Free Radic Biol M, 9, 315, 10.1016/0891-5849(90)90006-5 · DOI · Paper page
  64. Har-el, 1992, Zinc(II) protects against metal-mediated free raical induced damage: studies on single and double-strand DNA breakage, Free Rad Res Commun, 12–13, 509
  65. Bagchi, 1997, Comparative in vitro oxygen radical scavenging ability of zinc methionine and selected zinc salts and antioxidants, Gen Pharmacol, 28, 85, 10.1016/S0306-3623(96)00178-4 · DOI
  66. Lovering, 1992, Restriction of the participation of copper in radical-generating systems by zinc, Free Rad Res Commun, 14, 217, 10.3109/10715769109088951 · doi:10.3109/10715769109088951
  67. Afanas Suslova, 1995, Study of antioxidant properties of metal aspartates, Analyst, 120, 859, 10.1039/an9952000859 · DOI
  68. Shinar, 1989, Oxidative damage to human red blood cells induced by copper and iron complexes in the presnceof asorbate, Biochim Biophys Acta, 1014, 66, 10.1016/0167-4889(89)90241-3 · doi:10.1016/0167-4889(89)90241-3
  69. Reid, 1987, Electron transfer from cytochrome b5 to iron and copper complexes, Biochemistry, 26, 7102, 10.1021/bi00396a035 · doi:10.1021/bi00396a035
  70. Persoon-Rothert, 1989, Isopoterenol-induced cytotoxicity in neonatal rat heart cell cultures is mediated by free radical formation, J Mol Cell Cardiol, 21, 1285, 10.1016/0022-2828(89)90674-3 · DOI
  71. Powell, 1994, Salicylate trapping of OH as a tool for studying post-ischemic oxidative injury in the isolated rat heart, Free Radic Res Commun, 21, 355, 10.3109/10715769409056588 · doi:10.3109/10715769409056588
  72. Powell, 1999, Promotion of copper excretion from the isolated perfused rat heart attenuates post ischemic cardiac oxidative injury, Am J Physiol, 277, H956
  73. Willie, 1997, Apoptosis: an overview, Br Med Bull, 53, 451, 10.1093/oxfordjournals.bmb.a011623 · DOI · Paper page
  74. Webb, 1997, Apoptosis: an overview of the process and its relevance in disease, Adv Pharmacol, 54, 1
  75. Thornberry, 1998, Caspases: enemies within, Science (Washington DC), 281, 1312, 10.1126/science.281.5381.1312 · DOI · Paper page
  76. Telford, 1995, Preferential induction of apoptosis in mouse CD4+CD8+TCRloCD3lo thymocytes by zinc, J Cell Physiol, 164, 259, 10.1002/jcp.1041640206 · DOI
  77. Perry, 1997, Zinc a potent inhibitor of the apoptotic protease caspase-3: a novel target for zinc in the inhibition of apoptosis, J Biol Chem, 272, 18530, 10.1074/jbc.272.30.18530 · DOI · Paper page
  78. Truong-Tran, 2000, Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death, J Nutr, 130, 1459S, 10.1093/jn/130.5.1459S · DOI · Paper page
  79. Srinivasula, 1996, The ced-3/interleukin 1 converting enzyme-like homolog Mch6and the lamin-cleaving enzyme Mch2α are substrates for the apoptotic mediator CPP32, J Biol Chem, 271, 27099, 10.1074/jbc.271.43.27099 · DOI · Paper page
  80. Takahashi, 1996, Cleavage of lamin A by Mch2α but not CPP32: multiple interleukin 1β-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis, Proc Natl Acad Sci USA, 93, 8395, 10.1073/pnas.93.16.8395 · DOI · Paper page
  81. Aiuchi, 1998, Zinc ions prevent processing of caspase-3 during apoptosis induced by geranylgeraniol in HL60 cells, J Biochem, 124, 300, 10.1093/oxfordjournals.jbchem.a022111 · doi:10.1093/oxfordjournals.jbchem.a022111
  82. Fukamachi, 1998, Zinc suppresses apoptosis of U937 cells induced by hydrogen peroxide through an increase in Bcl-2/Bax ratio, Biochem Biophys Res Commun, 246, 364, 10.1006/bbrc.1998.8621 · DOI
  83. Fraker, 1995, Possible roles for glucocorticoids and apoptosis in the suppression of lymphopoiesis during zinc deficiency. A review, J Am Coll Nutr, 14, 11, 10.1080/07315724.1995.10718467 · DOI
  84. Zalewski, 1993, Correlation of apoptosis with change in intracellular labile Zn(II) using Zinquin ((2-methyl-8-p-toluenesulphonamido-6-quinolytoxy)acetic acid) new specific fluorescent probe for Zn(II), Biochem J, 296, 403, 10.1042/bj2960403 · DOI · Paper page
  85. Maret, 1998, Thiolate ligands in metallothionein confer redoxactivity of zinc clusters, Proc Natl Acad Sci USA, 95, 3478, 10.1073/pnas.95.7.3478 · DOI · Paper page
  86. Wellinghausen, 1998, The significance of zinc for leukocyte biology, J Leukoc Biol, 64, 571, 10.1002/jlb.64.5.571 · DOI
  87. Bettger, 1993, Physiological roles of zinc in the plasma membrane of mammalian cells, J Nutr Biochem, 4, 194, 10.1016/0955-2863(93)90052-X · DOI
  88. Fraker, 2000, The dynamic link between the integrity of the immune system and zinc status, J Nutr, 130, 1399S, 10.1093/jn/130.5.1399S · DOI · Paper page
  89. Fabris, 1992, Immune system and aging: neuroimmunological implications, Int J Immunopathol Pharmacol, 5, 93, 10.1177/039463209200500204 · DOI
  90. Sunderman, 1995, The influence of inc on apoptosis, Ann Clin Lab Sci, 25, 134
  91. Singh, 1992, Effect of zinc on immune functions and host resistance against infection and tumor challenge, Immunopharm Immunotox, 14, 813, 10.3109/08923979209009237 · DOI
  92. Atassi, 1979, Potentiation of the anti-tumor activity of 2-formylpyridine thiosemicarbazone by metal chelation: 2-formylpyridine thiosemicarbazone zinc sulphate (NSC 294721), Eur J Cancer, 15, 451, 10.1016/0014-2964(79)90080-X · doi:10.1016/0014-2964(79)90080-x
  93. Jong, 1995, Trace element metabolic alterations of zinc and prostaglandins in both human and animal colonic tumor cells, J Am Coll Nutr, s14, 473
  94. Chvapil, 1976, Effect of zinc on cells and biomembranes, Med Clin N Am, 60, 799, 10.1016/S0025-7125(16)31862-4 · DOI · Paper page
  95. Takeyama, 1995, Effects of zinc on production of active oxygen species by rat neutrophils, Pharmacol Toxicol, 76, 50, 10.1111/j.1600-0773.1995.tb00102.x · doi:10.1111/j.1600-0773.1995.tb00102.x
  96. Baum, 1995, Micronutrients and HIV-disease progression, AIDS, 9, 1051, 10.1097/00002030-199509000-00010 · DOI · Paper page
  97. Novick, 1996, How does zinc modify the common cold?, Med Hypoth, 46, 295, 10.1016/S0306-9877(96)90259-5 · DOI
  98. Petrus, 1998, Randomized, double-masked, placebo-controlled clinical study of the effectiveness of zinc acetate lozenges on common cold symptoms in allergy tested subjects, Curr Ther Res, 59, 595, 10.1016/S0011-393X(98)85058-3 · DOI
  99. Abou-Mohamed, 1998, Zinc++ inhibits nitric oxide formation in response to polysaccharides: implications in its anti-inflammatory activity, Eur J Pharmacol, 341, 265, 10.1016/S0014-2999(97)01416-7 · DOI
  100. Scuderi, 1990, Differential effects of copper and zinc on human peripheral blood monocyte cytokine secretion, Cell Immunol, 126, 391, 10.1016/0008-8749(90)90330-T · DOI
  101. Cho, 1985, Effects of zinc sulphate on ethanol and indomethacine-induced ulceration and changes in prostaglandin E2 and histamine levels in the rat gastric glandular mucosa, Digestion, 32, 288, 10.1159/000199250 · doi:10.1159/000199250
  102. Wetterholum, 1994, Zinc and other divalent actions inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes, Arch Biochem Biophys, 311, 263, 10.1006/abbi.1994.1236 · doi:10.1006/abbi.1994.1236
  103. Santos-Neto, 1992, Zinc reverses the increased sensitivity of lymphocytes from aged subjects to the antiproliferative effect of prostaglandin E2, Clin Immunol Immunopathol, 64, 184, 10.1016/0090-1229(92)90198-W · DOI
  104. Kiefer, 1994, Functional characterization of carbonic anhydrase II variants with altered zinc binding sites, Biochemistry, 33, 15233, 10.1021/bi00255a003 · DOI
  105. Kadakia, 1992, Serum and tissue zinc concentrations in patients with endoscopic oesophagitis, Dig Dis Sci, 37, 513, 10.1007/BF01307572 · doi:10.1007/bf01307572
  106. Cho, 1987, Zinc deficiency: its role in gastric secretion and stress-induced gastric ulceration in rats, Pharmacol Biochem Behav, 26, 293, 10.1016/0091-3057(87)90121-3 · DOI
  107. Glenner, 1984, Alzheimer disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem Biophys Res Comm, 120, 885, 10.1016/S0006-291X(84)80190-4 · DOI · Paper page
  108. Prelli, 1988, Differences between vascular and plaque core amyloid in Alzheimer’s disease, J Neuro-Chem, 51, 648
  109. Fukahori, 1990, Effects of dietary zinc status on seizure susceptibility and hippocampal zinc content in the El (epilepsy) mouse, Brain Res, 529, 16, 10.1016/0006-8993(90)90806-M · DOI
  110. Mitchell, 1990, Diethyldithiocarbamate and dithizone augment the toxicity of kainic acid, Brain Res, 506, 327, 10.1016/0006-8993(90)91273-J · doi:10.1016/0006-8993(90)91273-j
  111. Chen, 1997, Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition, Mol Pharmacol, 51, 1015, 10.1124/mol.51.6.1015 · DOI · Paper page
  112. Paoletti, 1997, High affinity zinc inhibition of NMDA NR1-NR2A receptors, J Neurosci, 17, 5711, 10.1523/JNEUROSCI.17-15-05711.1997 · DOI · Paper page
  113. Traynelis, 1998, Control of voltage-independent zinc inhibition of NMDA receptors by the NR1-subunit, J Neurosci, 18, 6163, 10.1523/JNEUROSCI.18-16-06163.1998 · DOI · Paper page
  114. Fisher, 1998, The role of an α subtype M2–M3 His in regulating inhibition of GABAA receptor current by zinc and other divalent cations, J Neurosci, 18, 2944, 10.1523/JNEUROSCI.18-08-02944.1998 · DOI
  115. Vandenberg, 1998, Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions, Mol Pharmacol, 54, 189, 10.1124/mol.54.1.189 · DOI
  116. Noregaard, 1998, Delineation of an endogenous zinc-binding site in the human dopamine transporter, EMBO J, 17, 4266, 10.1093/emboj/17.15.4266 · DOI · Paper page
  117. Colvin, 1998, Characterization of a plasma membrane zinc transporter in rat brain, Neurosci Lett, 247, 147, 10.1016/S0304-3940(98)00302-4 · doi:10.1016/s0304-3940(98)00302-4
  118. Colvin, 2000, Evidence for a zinc/protonantiporter in rat brain, Neurochem Int, 36, 539, 10.1016/S0197-0186(99)00127-8 · doi:10.1016/s0197-0186(99)00127-8
  119. Koh, 1994, Zinc toxicity on cultured cortical neurons: involvement of N–methyl-D-aspartate receptors, Neuroscience, 60, 1049, 10.1016/0306-4522(94)90282-8 · DOI · Paper page
  120. Sensi, 1997, Measurement of intracellular free zinc in living cortical neurons: routes of entry, J Neurosci, 17, 9554, 10.1523/JNEUROSCI.17-24-09554.1997 · DOI · Paper page
  121. Erickson, 1997, Disruption of metallothionein-III gene in mice: Analysis of brain zinc, behavior, and neuron vulnerability to metals, aging and seizures, J Neurosci, 17, 1271, 10.1523/JNEUROSCI.17-04-01271.1997 · DOI
  122. Palmiter, 1998, The elusive functions of metallothioneins, Proc Natl Acad Sci USA, 95, 8230, 10.1073/pnas.95.15.8428 · DOI · Paper page
  123. Bush, 1994, Modulation of A beta adhesiveness and secretase site cleavage by zinc, J Biol Chem, 269, 12152, 10.1016/S0021-9258(17)32694-7 · DOI · Paper page
  124. Bush, 1994, The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily, J Biol Chem, 269, 26618, 10.1016/S0021-9258(18)47062-7 · DOI
  125. Cuajungco, 1997, Zinc and Alzheimer’s disease: is there a direct link?, Brain Res Rev, 23, 219, 10.1016/S0165-0173(97)00002-7 · DOI · Paper page
  126. Cornett, 1998, Imbalances of trace elements related to oxidative damage in Alzheimer’s disease brain, Neuro-toxicology, 19, 339
  127. Danscher, 1997, Increased amount of zinc in the hippocampus and amygdala of Alzheimer’s disease brains: a proton-induced X–ray emission spectroscopic analysis of cryostat sections from autopsy material, J Neurosci Methods, 76, 53, 10.1016/S0165-0270(97)00079-4 · DOI · Paper page
  128. Suh, 1998, Histologic evidence of a zinc role in Alzheimer’s disease, Soc Neurosci (Abstr), 24, 1217
  129. Corrigan, 1993, Hippocampal tin, aluminium and zinc in Alzheimer’s disease, BioMetals, 6, 149, 10.1007/BF00205853 · DOI
  130. Constantinidis, 1990, Alzheimer’s disease and the zinc theory, Encephale, 16, 231
  131. Lui, 1990, Metals and the liver in Alzheimer’s disease. An investigation of hepatic zinc, cadmium and metallothionein, J Am Geriatr Soc, 38, 633, 10.1111/j.1532-5415.1990.tb01421.x · DOI
  132. Markesbery, 1997, Oxidative stress hypothesis in Alzheimer disease, Free Radic Biol M, 23, 134, 10.1016/S0891-5849(96)00629-6 · DOI · Paper page
  133. Smith, 1997, Iron accumulation in Alzheimer disease is a source of redox-generated free radicals, Proc Natl Acad Sci USA, 94, 9866, 10.1073/pnas.94.18.9866 · DOI · Paper page
  134. Multhaup, 1996, The amyloid precursor protein of Alzheimer’s disease in the reduction of copper(II) to copper(I), Science, 271, 1406, 10.1126/science.271.5254.1406 · DOI · Paper page
  135. Multhaup, 1997, Amyloid precursor protein, copper and Alzheimer’s disease, Biomed Pharmacother, 51, 105, 10.1016/S0753-3322(97)86907-7 · DOI
  136. Deibel, 1996, Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer’s disease: possible relation to oxidative stress, J Neurol Sci, 143, 137, 10.1016/S0022-510X(96)00203-1 · DOI · Paper page
  137. Huang, 1997, Alzheimer Aβ peptides simultaneously reduce metals and produce reactive oxygen species, Soc Neurosci (Abstr), 23, 1663
  138. Bush, 1993, A novel zinc(II) binding site modulates the function of A4 amyloid protein precursor of Alzheimer’s disease, J Biol Chem, 268, 16109, 10.1016/S0021-9258(19)85394-2 · DOI · Paper page
  139. Multhaup, 1994, Interaction between the zinc (II) and heparin binding site of the Alzheimer’s disease =A4 amyloid precursor protein, FEBS Lett, 355, 151, 10.1016/0014-5793(94)01176-1 · DOI
  140. Jeandel, 1989, Lipid peroxidation and free radical scavengers in Alzheimer’s disease, Gerontology, 35, 275, 10.1159/000213037 · DOI · Paper page
  141. West, 1990, Human metallotionein genes; structure of the functional locus at 16q13, Genomics, 8, 513, 10.1016/0888-7543(90)90038-V · DOI
  142. Hamer, 1986, Metallothionein, Annu Rev Biochem, 55, 913, 10.1146/annurev.bi.55.070186.004405 · DOI · Paper page
  143. Bryan, 1994, Species variation in hepatic metallothionein, Toxicol Lett, 74, 23, 10.1016/0378-4274(94)90071-X · doi:10.1016/0378-4274(94)90071-x
  144. Bremmer, 1991, Nutritional and physiological significance of metallothionein, Meth Enzymol, 205, 25, 10.1016/0076-6879(91)05080-F · DOI
  145. Bremmer, 1990, Metallothionein and the trace minerals, Annu Rev Nutr, 10, 63, 10.1146/annurev.nu.10.070190.000431 · DOI · Paper page
  146. Sugiura, 1994, Metallothionein in platelets, Int Arch Allergy Immunol, 103, 341, 10.1159/000236652 · doi:10.1159/000236652
  147. Nartey, 1987, Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development, Pathology, 19, 233, 10.3109/00313028709066555 · DOI
  148. Panemangalore, 1983, Changes in intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development, Dev Biol, 97, 95, 10.1016/0012-1606(83)90067-2 · doi:10.1016/0012-1606(83)90067-2
  149. Tsujikawa, 1994, Induction and subcellular localization of metallothionein in regenerating rat liver, Eur J Cell Biol, 63, 240
  150. Summer, 1989, Metallothionein induction by nonsteroidal antiinflammatory drugs, Biol Trace Elem Res, 21, 165, 10.1007/BF02917248 · doi:10.1007/bf02917248
  151. Anstey, 1996, In vivo photoinduction of metallothionein in human skin by ultraviolet-irradiation, J Pathol., 136, 94
  152. Vasak, 1994, Metallothioneins, vol. 4, 2229
  153. Jiang, 1998, The glutathione-redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitoldehydrogenase, Proc Natl Acad Sci USA, 95, 3483, 10.1073/pnas.95.7.3483 · DOI · Paper page
  154. Kobayashi, 1994, Possible role of metallothionein in the cellular defense-mechanism against UVB-irradiation in neonatal human skin fibroblasts, Photochem Photobiol, 59, 650
  155. Feldman, 1978, Degradation of rat liver metallothioneins in vitro, Biochim Biophys Acta, 544, 638, 10.1016/0304-4165(78)90338-0 · DOI
  156. Hunziker, 1985, Isolation and characterization of six human hepatic isometallothioneins, Biochem J, 231, 375, 10.1042/bj2310375 · DOI
  157. Klaassen, 1999, Metallothionein: an intracellular protein to protect against cadmium toxicity, Annu Rev Pharmacol Toxicol, 39, 267, 10.1146/annurev.pharmtox.39.1.267 · DOI · Paper page
  158. Kang, 1999, The antioxidant function of metallothionein in the heart, Proc Soc Exp Biol M, 222, 263, 10.1046/j.1525-1373.1999.d01-143.x · DOI
  159. Klaassen, 1999, Metallothionein: an intracellular protein to protect against cadmium toxicity, Annu Rev Pharmacol Toxicol, 39, 267, 10.1146/annurev.pharmtox.39.1.267 · DOI · Paper page
  160. Lazo, 1995, Metallothionein and cell death by anticancer drugs, Annu Rev Pharmacol Toxicol, 35, 635, 10.1146/annurev.pa.35.040195.003223 · DOI
  161. Uchida, 1991, The growth inhibitory factor that is deficient in the Alzheimer‘s disease brain is a 68 amino acid metallothionein-like protein, Neuron, 7, 337, 10.1016/0896-6273(91)90272-2 · DOI · Paper page
  162. Palmiter, 1992, MT-III a brain-specific member of the metallothionein gene family, Proc Natl Acad Sci USA, 89, 6333, 10.1073/pnas.89.14.6333 · DOI · Paper page
  163. Pountney, 1994, Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain, FEBS Lett, 345, 193, 10.1016/0014-5793(94)00452-8 · doi:10.1016/0014-5793(94)00452-8
  164. Tsuji, 1992, Molecular cloning of human growth inhibitory factor cDNA and its down regulation in Alzheimer’s disease, EMBO J, 11, 4843, 10.1002/j.1460-2075.1992.tb05590.x · DOI · Paper page
  165. Cuajungco, 1998, Nitric oxide generators produce accumulation of chelatable zinc in hippocampal neuronal perikarya, Brain Res, 799, 118, 10.1016/S0006-8993(98)00463-6 · DOI
  166. Kroncke, 1999, Measurement of nitric oxide–mediated effects on zinc homeostasis and zinc finger transcription factors, Meth Enzymol, 301, 126, 10.1016/S0076-6879(99)01075-7 · DOI
  167. Quaife, 1994, Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia, Biochemistry, 33, 7250, 10.1021/bi00189a029 · DOI · Paper page
  168. Schmid, 1986, Cell specificity and an effect on ras on human metallothionein gene expression, Proc Natl Acad Sci USA, 83, 3346, 10.1073/pnas.83.10.3346 · DOI
  169. Jahroudi, 1990, Cell-type specific and differential regulation of the human metallothionein genes, J Biol Chem, 265, 6506, 10.1016/S0021-9258(19)39356-1 · DOI
  170. Samson, 1998, Molecular analyses of metallothionein gene regulation, Prog Nucleic Acid Res Mol Biol, 59, 257, 10.1016/S0079-6603(08)61034-X · DOI
  171. Andrews, 2000, Regulation of metallothionein gene expression by oxidative stress and metal ions, Biochem Pharmacol, 59, 95, 10.1016/S0006-2952(99)00301-9 · DOI · Paper page
  172. Cousins, 1994, Metal elements and gene expression, Annu Rev Nutr, 14, 449, 10.1146/annurev.nu.14.070194.002313 · DOI
  173. Maret, 1995, Metallothionein disulphide interactions, oxidative stress, and the mobilization of cellular zinc, Neurochem Int, 27, 111, 10.1016/0197-0186(94)00173-R · DOI · Paper page
  174. Jacob, 1998, Control of zinc transfer between thionein, metallothionein, and zinc proteins, Proc Natl Acad Sci USA, 95, 3489, 10.1073/pnas.95.7.3489 · DOI · Paper page
  175. Jiang, 1998, The ATP-Metallothionein complex, Proc Natl Acad Sci USA, 95, 9146, 10.1073/pnas.95.16.9146 · DOI
  176. Ebadi, 1995, Expression and regulation of brain metallothionein, Neurochem Int, 27, 1, 10.1016/0197-0186(94)00164-P · DOI
  177. Masters, 1994, Metallothionein-III is expressed in neurons that sequester zinc in synaptic vesicles, J Neurosci, 14, 5844, 10.1523/JNEUROSCI.14-10-05844.1994 · DOI · Paper page
  178. Reeves, 1995, Adaptation responses in rat to long-term feeding of high zinc diet: emphasis on intestinal metallothionein, J Nutr Biochem, 6, 48, 10.1016/0955-2863(94)00008-A · DOI
  179. Moffatt, 1996, Rat hepatocytes with elevated metallothionein expression are resistant to N′-methyl–N′-nitro-nitrosoguanidine cytotoxicity, Toxicol Appl Pharmacol, 136, 200, 10.1006/taap.1996.0025 · doi:10.1006/taap.1996.0025
  180. Kondo, 1995, Metallothionein null-cells have increased sensitivity to anticancer drugs, Cancer Res, 55, 2021
  181. Cai, 1995, Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro, Chem Biol Interact, 96, 143, 10.1016/0009-2797(94)03585-V · DOI
  182. Lynes, 1990, Extracellular metallothionein effects on lymphocyte activities, Mol Immunol, 27, 211, 10.1016/0161-5890(90)90132-J · DOI
  183. Borghesi, 1996, Interaction of metallothionein with murine lymphocytes-plasma membrane binding and proliferation, Toxicology, 108, 129, 10.1016/S0300-483X(95)03243-9 · doi:10.1016/s0300-483x(95)03243-9

Cited by

See all 1,298

Metadata

Authors
Tapiero, H., & Tew, K. D.
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2003-11
Volume
57
Issue
9
Pages
399-411
ISSN
0753-3322 (ISSN-L)
OpenAlex
W2031718525
Cited by
1,298
References
11
FWCI
17.37
Type
journal article
Language
en
Open access
closed
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Trace elements in human physiology and pathology: zinc and metallothioneins. https://app.cochat.ai/papers/10.1016/s0753-3322(03)00081-7
The paper
Tapiero, H., & Tew, K. D. (2003). Trace elements in human physiology and pathology: zinc and metallothioneins. Biomedicine & Pharmacotherapy. https://doi.org/10.1016/s0753-3322(03)00081-7

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.