Lactobacillus rhamnosus GG (ATCC 53103) for the Management of Infantile Colic: A Randomized Controlled Trial
Open accessAbstract
Background: The aim of this study was to investigate the efficacy of Lactobacillus rhamnosus ATCC 53103 together with the maternal diet avoidance of cow’s milk in treating infantile colic. Methods: Forty-five colicky breastfed infants were consecutively randomized to receive L. rhamnosus for 28 days at a dosage of 5 × 109 cfu per day or placebo. Faecal samples were collected from each subject before starting supplementation and at the end of the study period and were immediately analysed. Faecal calprotectin was detected via a quantitative assay. The total bacterial load and selected bacterial species were evaluated using real-time TaqMan PCR. Results: After supplementation for 28 days with Lactobacillus rhamnosus ATCC 53103, median full-force daily crying was reduced (104 versus 242 min, p < 0.001) and the values of faecal calprotectin decreased significantly (p = 0.026). Furthermore, the probiotic increased the abundance of Lactobacillus (p = 0.048) and total bacteria (p = 0.040); all these effects were not observed in the placebo group. Conclusion: Infants treated with Lactobacillus rhamnosus ATCC 53103 for 28 days, in association with the elimination of cow’s milk from the maternal diet, presented some interesting features related to the effect of this probiotic treatment: reductions in crying time and faecal calprotectin, with increased total bacteria and Lactobacillus. To validate these results, a double-blind, placebo-controlled trial on a larger cohort is required.
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L. rhamnosus ATCC 53103 (Sporit GG, Sporlac GG) significantly reduced infantile colic (104 vs. 242 minutes, p < 0.001) and increased gut Lactobacillus levels (p = 0.048).
“and L. rhamnosus ATCC 53103 (Sporit GG, Sporlac GG), which significantly reduced infantile colic (104 vs. 242 minutes, p < 0.001) and increased gut Lactobacillus levels (p = 0.048).47”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and <i>in vitro</i> assessment (2026) · cites this paper as [47]
The paper reports 104 versus 242 minutes of daily crying (p < 0.001) and increased faecal Lactobacillus (p = 0.048; Results, §3.3). It does not identify the study product as Sporit GG or Sporlac GG, and the treatment was given alongside maternal avoidance of cow’s milk (Study Design, §2.2). (LLM, conf=0.85)
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“Nevertheless, in order to substantiate these fi ndings, a double-blind, placebo-controlled trial involving a more extensive participant cohort is necessary (21).”
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“These studies demonstrated a significant reduction in crying time after the study period for subjects exclusively breast-fed and treated with Lactobacillus rhamnosus GG (LGG), compared to those who received a placebo (Pärtty et al ., 2017; Savino et al ., 2020; Sung et al ., 2018).”
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“In some studies, parents recorded the duration of their infant’s crying on a daily basis.[12] However, in the present study and Dorreh’s study,[17] the duration of crying was asked weekly from the parents.”
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“Sung et al.1,18, Nation et al.17 e Savino et al. 20 incluíram na pesquisa apenas crianças <13 semanas.”
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Andersen, D. B., Fog, J., Vestergaard, M. V., Rasmussen, I. S., Wilson, P., Overbeck, G., Jørgensen, L. B., Kragstrup, J., & Jensen, B. H. (2026) · Acta Paediatrica · doi:10.1111/apa.70489
Lactobacillus acidophilus for infant colic and microbiota modulation: a randomized clinical trial
Vaz, S. R., Tofoli, M. H. C., Avelino, M. A. G., Mota, J. F., Filho, H. B. D. A., & Costa, P. S. (2026) · BMC Pediatrics · doi:10.1186/s12887-026-06883-7
- Authors
- Savino, F., Montanari, P., Galliano, I., Daprà, V., & Bergallo, M.
- Affiliations
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- University of Turin (IT)
- Corresponding author
- Savino, Francesco
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-06-05
- Volume
- 12
- Issue
- 6
- Pages
- 1693
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7352391
- OpenAlex
- W3034084386
- Cited by
- 41
- References
- 39
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 5 · 2022: 14 · 2021: 3
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- infantile colic, Lactobacillus rhamnosus GG, probiotics, maternal diet, breastfeeding, fecal calprotectin, crying time, gut microbiota
- MeSH terms
- Gastrointestinal Microbiome, Adult, Animals, Breast Feeding, Colic, Diet, Feces, Female, Humans, Infant, Infant, Newborn, Male, Milk, Treatment Outcome, Dietary Supplements, Probiotics, Leukocyte L1 Antigen Complex, Lacticaseibacillus rhamnosus, Young Adult
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