Cited by 521Probiotics and Fermented FoodsReproductive tract infections researchAquaculture disease management and microbiota

Immunomodulatory Effects of Probiotics on Cytokine Profiles

Open access
Azad, Md. Abul Kalam, Sarker, Manobendro, Wan, Dan·2018·BioMed Research International

Abstract

Probiotics confer immunological protection to the host through the regulation, stimulation, and modulation of immune responses. Researchers have shifted their attention to better understand the immunomodulatory effects of probiotics, which have the potential to prevent or alleviate certain pathologies for which proper medical treatment is as yet unavailable. It has been scientifically established that immune cells (T- and B-cells) mediate adaptive immunity and confer immunological protection by developing pathogen-specific memory. However, this review is intended to present the recent studies on immunomodulatory effects of probiotics. In the early section of this review, concepts of probiotics and common probiotic strains are focused on. On a priority basis, the immune system, along with mucosal immunity in the human body, is discussed in this study. It has been summarized that a number of species of Lactobacillus and Bifidobacterium exert vital roles in innate immunity by increasing the cytotoxicity of natural killer cells and phagocytosis of macrophages and mediate adaptive immunity by interacting with enterocytes and dendritic, Th1, Th2, and Treg cells. Finally, immunomodulatory effects of probiotics on proinflammatory and anti-inflammatory cytokine production in different animal models have been extensively reviewed in this paper. Therefore, isolating new probiotic strains and investigating their immunomodulatory effects on cytokine profiles in humans remain a topical issue.

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  • An immunomodulatory effect of probiotics is attributed to the release of a large number of cytokines and chemokines from immune cells, which can further impact the innate and adaptive immune systems.

    “For example, an immunomodulatory effect of probiotics is attributed to the release of a large number of cytokines and chemokines from immune cells, which can further impact the innate and adaptive immune systems [122].”

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  1. [18]Ooi M. F. Mazlan N. Foo H. L. Effects of carbon and nitrogen sources on bacteriocin-inhibitory activity of postbiotic metabolites produced by Lactobacillus plantarum I-UL4 Malaysian Journal of Microbiology 2015 11 2 176 184 2-s2.0-84932613117
  2. [30]Dixit Y. Wagle A. Vakil B. Patents in the Field of Probiotics, Prebiotics, Synbiotics: A Review Journal of Food: Microbiology Safety & Hygiene 2016 01 02
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  6. [63]Murphy K. P. Janeway’s immunobiology 2011 8th London/New York: Garland Science, Taylor & Francis Group

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Authors
Azad, M. A. K., Sarker, M., & Wan, D.
Affiliations
  • Chinese Academy of Sciences (CN)
  • State University of Bangladesh (BD)
Corresponding author
Wan, Dan
Venue
BioMed Research International
Publisher
Wiley
Published
2018-10-23
Volume
2018
Pages
1-10
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
OpenAlex
W2897981765
Cited by
521
References
82
Citations by year
2026: 42 · 2025: 73 · 2024: 64 · 2023: 72 · 2022: 97 · 2021: 89 · 2020: 60 · 2019: 22 · 2018: 1
FWCI
4.33
Type
journal article
Language
en
Open access
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Key R&D Program of China (2016YFD0501201, 2016YFD0200900, 2016YFD0500504, 31702127)
  • National Natural Science Foundation of China (2016YFD0501201, 2016YFD0200900, 2016YFD0500504, 31702127)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
Keywords
probiotics, immunomodulation, cytokines, mucosal immunity, innate immunity, adaptive immunity, Lactobacillus, Bifidobacterium, natural killer cells, macrophage phagocytosis, dendritic cells, regulatory T cells, Th1/Th2 balance, inflammatory cytokines, anti-inflammatory cytokines, probiotic strains
MeSH terms
Animals, Humans, Immunity, Innate, Immunologic Factors, Lymphocytes, Cytokines, Immunity, Mucosal, Probiotics, Adaptive Immunity

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