Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy
Open accessAbstract
Honeybees produce royal jelly (RJ) from their cephalic glands. Royal jelly is a source of nutrition for the queen honey bee throughout its lifespan and is also involved in fertility and longevity. Royal jelly has long been considered beneficial to human health. We recently observed that RJ delayed impairment of motor function during aging, affecting muscle fiber size. However, how RJ affects skeletal muscle metabolism and the functional component of RJ is as of yet unidentified. We demonstrate that feeding mice with RJ daily prevents a decrease in myofiber size following denervation without affecting total muscle weight. RJ did not affect atrophy-related genes but stimulated the expression of myogenesis-related genes, including IGF-1 and IGF receptor. Trans-10-hydroxy-2-decenoic acid (10H2DA) and 10-hydroxydecanoic acid (10HDAA), two major fatty acids contained in RJ. After ingestion, 10H2DA and 10HDAA are metabolized into 2-decenedioic acid (2DA) and sebacic acid (SA) respectively. We found that 10H2DA, 10HDAA, 2DA, and SA all regulated myogenesis of C2C12 cells, murine myoblast cells. These novel findings may be useful for potential preventative and therapeutic applications for muscle atrophy disease included in Sarcopenia, an age-related decline in skeletal muscle mass and strength.
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Royal jelly attenuates denervation-induced skeletal muscle atrophy in C57BL/6J mice and stimulates myoblast proliferation and differentiation of C2C12 cells.
“It attenuates denervation-induced skeletal muscle atrophy in C57BL/6J mice and stimulates myoblast proliferation and differentiation of C2C12 cells [81].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [81]
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Self-citation
- Authors
- Shirakawa, T., Miyawaki, A., Matsubara, T., Okumura, N., Okamoto, H., Nakai, N., Rojasawasthien, T., Morikawa, K., Inoue, A., Goto, A., Washio, A., Tsujisawa, T., Kawamoto, T., & Kokabu, S.
- Affiliations
- Kyushu Dental University (JP)
- Institute for Bee Products and Health Science, Yamada Bee Company, Inc., Tomata, Okayama 708-0393, Japan
- Iwate Medical University (JP)
- Corresponding author
- Kokabu, Shoichiro
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-10-11
- Volume
- 12
- Issue
- 10
- Pages
- 3089
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7600733
- OpenAlex
- W3092520978
- Cited by
- 34
- References
- 56
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 10
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (18K09524, 18K09865)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Bee Products Chemical Analysis
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- royal jelly, protease treatment, denervation-induced muscle atrophy, skeletal muscle atrophy, sarcopenia, myogenesis, insulin-like growth factor I, IGF receptors, 10-hydroxydecanoic acid, sebacic acid, fatty acid metabolism, C2C12 myoblasts, aging, muscle fiber size
- MeSH terms
- Royal Jelly, Administration, Oral, Animals, Cells, Cultured, Decanoic Acids, Denervation, Fatty Acids, Fatty Acids, Monounsaturated, Insulin-Like Growth Factor I, Mice, Inbred C57BL, Muscular Atrophy, Peptide Hydrolases, Receptor, IGF Type 1, Muscle, Skeletal, Muscle Development, Myoblasts, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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