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The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19
Open accessAbstract
Investigation into the role of vitamin C in the prevention and treatment of pneumonia and sepsis has been underway for many decades. This research has laid a strong foundation for translation of these findings into patients with severe coronavirus disease (COVID-19). Research has indicated that patients with pneumonia and sepsis have low vitamin C status and elevated oxidative stress. Administration of vitamin C to patients with pneumonia can decrease the severity and duration of the disease. Critically ill patients with sepsis require intravenous administration of gram amounts of the vitamin to normalize plasma levels, an intervention that some studies suggest reduces mortality. The vitamin has pleiotropic physiological functions, many of which are relevant to COVID-19. These include its antioxidant, anti-inflammatory, antithrombotic and immuno-modulatory functions. Preliminary observational studies indicate low vitamin C status in critically ill patients with COVID-19. There are currently a number of randomized controlled trials (RCTs) registered globally that are assessing intravenous vitamin C monotherapy in patients with COVID-19. Since hypovitaminosis C and deficiency are common in low–middle-income settings, and many of the risk factors for vitamin C deficiency overlap with COVID-19 risk factors, it is possible that trials carried out in populations with chronic hypovitaminosis C may show greater efficacy. This is particularly relevant for the global research effort since COVID-19 is disproportionately affecting low–middle-income countries and low-income groups globally. One small trial from China has finished early and the findings are currently under peer review. There was significantly decreased mortality in the more severely ill patients who received vitamin C intervention. The upcoming findings from the larger RCTs currently underway will provide more definitive evidence. Optimization of the intervention protocols in future trials, e.g., earlier and sustained administration, is warranted to potentially improve its efficacy. Due to the excellent safety profile, low cost, and potential for rapid upscaling of production, administration of vitamin C to patients with hypovitaminosis C and severe respiratory infections, e.g., COVID-19, appears warranted.
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Cites
Wiersinga, W. J., Rhodes, A., Cheng, A. C., Peacock, S. J., & Prescott, H. C. (2020) · JAMA · doi:10.1001/jama.2020.12839 · Cited by 4,609
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
Blanco-Melo, D., Nilsson-Payant, B. E., Liu, W.-C., Uhl, S., Hoagland, D., Møller, R., Jordan, T. X., Oishi, K., Panis, M., Sachs, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.026 · Cited by 4,222
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Bastard, P., Rosen, L. B., Zhang, Q., Michailidis, E., Hoffmann, H.-H., Zhang, Y., Dorgham, K., Philippot, Q., Rosain, J., Béziat, V., et al. (2020) · Science · doi:10.1126/science.abd4585 · Cited by 2,662
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Zhang, Q., Bastard, P., Liu, Z., Le Pen, J., Moncada-Velez, M., Chen, J., Ogishi, M., Sabli, I. K. D., Hodeib, S., Korol, C., et al. (2020) · Science · doi:10.1126/science.abd4570 · Cited by 2,229
Middleton, E. A., He, X., Denorme, F., Campbell, R. A., Ng, D. C., Salvatore, S., Mostyka, M., Baxter-Stoltzfus, A., Borczuk, A., Loda, M. F., et al. (2020) · Blood · doi:10.1182/blood.2020007008 · Cited by 1,515
Fowler, A. A., Truwit, J. D., Hite, R. D., Morris, P. E., DeWilde, C., Priday, A., Fisher, B., Thacker, L. R., Natarajan, R., Brophy, D. F., et al. (2019) · JAMA · doi:10.1001/jama.2019.11825 · Cited by 836
Skendros, P., Mitsios, A., Chrysanthopoulou, A., Mastellos, D. C., Metallidis, S., Rafailidis, P., Ntinopoulou, M., Sertaridou, E., Tsironidou, V., Tsigalou, C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci141374 · Cited by 786
Tissue damage from neutrophil-induced oxidative stress in COVID-19
Laforge, M., Elbim, C., Frère, C., Hémadi, M., Massaad, C., Nuss, P., Benoliel, J. J., & Becker, C. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0407-1 · Cited by 587
Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis.
Nursing, M. R. I. C. U., Fowler, A. A., Syed, A. A., Knowlson, S., Sculthorpe, R., Farthing, D., DeWilde, C., Farthing, C. A., Larus, T. L., Martin, E., et al. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-32 · Cited by 573
Carr, A. C., Rosengrave, P. C., Bayer, S., Chambers, S., Mehrtens, J., & Shaw, G. M. (2017) · Critical Care · doi:10.1186/s13054-017-1891-y · Cited by 413
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Research works printed but not linked: 2
- Chen, Q., and Vissers, M. (2020). Vitamin C in pneumonia and sepsis. Vitamin C: New Biochemical and Functional Insights. Oxidative Stress and Disease, CRC Press/Taylor & Francis.
- Sawyer, 1989, Antioxidant therapy and survival in ARDS, Crit. Care Med., 17, S153
Cited by
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Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553
Vitamin C and Cardiovascular Disease: An Update
Morelli, M. B., Gambardella, J., Castellanos, V., Trimarco, V., & Santulli, G. (2020) · Antioxidants · doi:10.3390/antiox9121227 · Cited by 178
Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment
Lordan, R., Rando, H. M., & Greene, C. S. (2021) · mSystems · doi:10.1128/msystems.00122-21 · Cited by 137
Forcados, G. E., Muhammad, A. I., Oladipo, O. O., Makama, S., & Meseko, C. A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.654813 · Cited by 103
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey
Izzo, R., Trimarco, V., Mone, P., Aloè, T., Marzani, M. C., Diana, A., Fazio, G., Mallardo, M., Maniscalco, M., Marazzi, G., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106360 · Cited by 94
Metadata
- Authors
- Carr, A. C., & Rowe, S.
- Affiliations
- University of Otago (NZ)
- Liverpool School of Tropical Medicine (GB)
- Corresponding author
- Carr, Anitra C.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-10-27
- Volume
- 12
- Issue
- 11
- Pages
- 3286
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7693980
- OpenAlex
- W3095007644
- Cited by
- 155
- References
- 45
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 32 · 2022: 36 · 2021: 56 · 2020: 3
- FWCI
- 20.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LSTM Online Archive (Liverpool School of Tropical Medicine) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Medical Research Council (MR/T004045/1)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Keywords
- vitamin C, COVID-19 pandemic, hypovitaminosis C, scurvy, oxidative stress, intravenous vitamin C, pneumonia, sepsis, antioxidant activity, anti-inflammatory activity, antithrombotic activity, immunomodulation, critically ill patients, mortality, low-middle income countries
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Anti-Inflammatory Agents, Antioxidants, Ascorbic Acid, Ascorbic Acid Deficiency, Humans, Nutritional Status, Pneumonia, Viral, Vitamins, Critical Illness, Coronavirus Infections, Severe Acute Respiratory Syndrome, Pandemics
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