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Living with Food Hypersensitivity as an Adolescent Impairs Health Related Quality of Life Irrespective of Disease Severity: Results from a Population-Based Birth Cohort

Jonsson, Marina, Ekström, Sandra, Protudjer, Jennifer L. P., Bergström, Anna, Kull, Inger·2021·Nutrients
DOI 10.3390/nu13072357PMC PMC8308910
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Abstract

Food hypersensitivity (FHS) refers to food-related symptoms, with or without concurrent Immunoglobulin E (IgE) antibodies related to food(s). It remains unclear how different FHS phenotypes affect health-related quality of life (HRQoL). We examined self-reported HRQoL (with the generic instrument EQ-5D (dimensions and a Visual Analogue Scale (VAS), range 0–100) in association with phenotypes of FHS, and food-specific symptoms among adolescents (n = 2990) from a population-based birth cohort. Overall, 22% of the adolescents had FHS. Compared to adolescents without FHS, those with FHS reported more problems in the dimensions of pain/discomfort (p < 0.001), and anxiety/depression (p = 0.007). Females with FHS reported more problems than males in these dimensions (p < 0.001). Different FHS phenotypes (IgE-sensitization, allergic co-morbidity, and severity of symptoms) were not associated with differences in HRQoL. EQ-VAS scores were lowest for adolescents with symptoms for wheat vs. no wheat, median 80 vs. 89, p = 0.04) and milk vs. no milk (median 85 vs. 90, p = 0.03). Physician-diagnosed lactose intolerance median EQ-VAS was 80 vs. 90, p = 0.03 and also associated with more problems in the dimension of anxious/depression. In conclusion, FHS is associated with lower HRQoL in adolescence, irrespective of phenotypes, but differentially affects females vs. males, and those with vs. without symptoms for milk or wheat.

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Figure 1 The distribution of symptoms of different food items among adolescents with food hypersensitivity. Common foods: milk, egg, fish and wheat. Nuts and peanuts: peanut, hazelnut, almond, walnut/pecan, cashew/pistachio, Brazil nuts. Other foods: Shellfish, soy, sesame seed, apple/pear, peach/nectarine/plum/cherry, kiwi, banana and raw carrot.
Figure 1 The distribution of symptoms of different food items among adolescents with food hypersensitivity. Common foods: milk, egg, fish and wheat. Nuts and peanuts: peanut, hazelnut, almond, walnut/pecan, cashew/pistachio, Brazil nuts. Other foods: Shellfish, soy, sesame seed, apple/pear, peach/nectarine/plum/cherry, kiwi, banana and raw carrot.CC BY · PubMed Central
Figure 2 Median EQ VAS and Interquartile Range (IQR) in relation to FHS with specific symptoms to milk and wheat.
Figure 2 Median EQ VAS and Interquartile Range (IQR) in relation to FHS with specific symptoms to milk and wheat.CC BY · PubMed Central

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Citations

Cites

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Metadata

Authors
Jonsson, M., Ekström, S., Protudjer, J. L. P., Bergström, A., & Kull, I.
Venue
Nutrients
Publisher
MDPI AG
Published
2021-07-09
Volume
13
Issue
7
Pages
2357
ISSN
2072-6643
DOI
10.3390/nu13072357
PMC
PMC8308910
Cited by
11
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • the Swedish Asthma and Allergy research foundation (F2017-0007)
  • the Swedish Research Council for Health, Working Life and Welfare (2010-00451, 2017-00526)
  • Swedish Heart-Lung Foundation (20180579)
  • the European Research Council (757919)

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