Nutrient effects on motor neurons and the risk of amyotrophic lateral sclerosis
Open accessAbstract
Amyotrophic lateral sclerosis (ALS) is an incurable chronic progressive neurodegenerative disease with the progressive degeneration of motor neurons in the motor cortex and lower motor neurons in the spinal cord and the brain stem. The etiology and pathogenesis of ALS are being actively studied, but there is still no single concept. The study of ALS risk factors can help to understand the mechanism of this disease development and, possibly, slow down the rate of its progression in patients and also reduce the risk of its development in people with a predisposition toward familial ALS. The interest of researchers and clinicians in the protective role of nutrients in the development of ALS has been increasing in recent years. However, the role of some of them is not well-understood or disputed. The objective of this review is to analyze studies on the role of nutrients as environmental factors affecting the risk of developing ALS and the rate of motor neuron degeneration progression. Methods: We searched the PubMed, Springer, Clinical keys, Google Scholar, and E-Library databases for publications using keywords and their combinations. We analyzed all the available studies published in 2010–2020. Discussion: We analyzed 39 studies, including randomized clinical trials, clinical cases, and meta-analyses, involving ALS patients and studies on animal models of ALS. This review demonstrated that the following vitamins are the most significant protectors of ALS development: vitamin B12, vitamin E > vitamin C > vitamin B1, vitamin B9 > vitamin D > vitamin B2, vitamin B6 > vitamin A, and vitamin B7. In addition, this review indicates that the role of foods with a high content of cholesterol, polyunsaturated fatty acids, urates, and purines plays a big part in ALS development. Conclusion: The inclusion of vitamins and a ketogenic diet in disease-modifying ALS therapy can reduce the progression rate of motor neuron degeneration and slow the rate of disease progression, but the approach to nutrient selection must be personalized. The roles of vitamins C, D, and B7 as ALS protectors need further study.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Supplementation of pharmacological treatment with vitamins and changing the diet to a ketogenic diet could reduce the rate of motor neuron degeneration in ALS patients.
“Goncharova et al. (107), found that supplementation of pharmacological treatment with vitamins and changing the diet to a ketogenic diet could reduce the rate of motor neuron degeneration in ALS patients.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [107]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lips, P. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.02.016 · Cited by 1,173 · see citing works
Bueno, N. B., de Melo, I. S. V., de Oliveira, S. L., & da Rocha Ataide, T. (2013) · British Journal of Nutrition · doi:10.1017/s0007114513000548 · Cited by 778 · see citing works
Veech, R. L. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.09.007 · Cited by 759 · see citing works
Folate Production by Probiotic Bacteria
Rossi, M., Amaretti, A., & Raimondi, S. (2011) · Nutrients · doi:10.3390/nu3010118 · Cited by 653 · see citing works
Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity
Yoshii, K., Hosomi, K., Sawane, K., & Kunisawa, J. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00048 · Cited by 573 · see citing works
Vitamin B6 and Its Role in Cell Metabolism and Physiology
Parra, M., Stahl, S., & Hellmann, H. A. (2018) · Cells · doi:10.3390/cells7070084 · Cited by 536 · see citing works
Structure and function of biotin-dependent carboxylases
Tong, L. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1096-0 · Cited by 473 · see citing works
Risk factors for amyotrophic lateral sclerosis
Fang, F., Ingre, C., Roos, P. M., Kamel, F., & Piehl, F. (2015) · Clinical Epidemiology · doi:10.2147/clep.s37505 · Cited by 470 · see citing works
Microbial production of vitamin B12: a review and future perspectives
Fang, H., Kang, J., & Zhang, D. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0631-y · Cited by 466 · see citing works
Vitamin B12 deficiency from the perspective of a practicing hematologist
Green, R. (2017) · Blood · doi:10.1182/blood-2016-10-569186 · Cited by 415 · see citing works
Zempleni, J., Wijeratne, S. S. K., & Hassan, Y. I. (2009) · BioFactors · doi:10.1002/biof.8 · Cited by 366 · see citing works
Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases
Serriari, N., Eoche, M., Lamotte, L., Lion, J., Fuméry, M., Marcelo, P., Chatelain, D., Barre, A., Nguyen-Khac, É., Lantz, O. J., et al. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12277 · Cited by 335 · see citing works
Xu, L., Liu, T., Liu, L., Yao, X., Chen, L., Fan, D., Zhan, S., & Wang, S. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09652-y · Cited by 330 · see citing works
Alessandri, J., Guesnet, P., Vancassel, S., Astorg, P., Denis, I., Goustard, B., Aïd, S., Poumès‐Ballihaut, C., Champeil‐Potokar, G., & Lavialle, M. (2004) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2004063 · Cited by 283 · see citing works
Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism
Bruce, K. D., Zsombok, A., & Eckel, R. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00060 · Cited by 264 · see citing works
Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
Kocot, J., Luchowska-Kocot, D., Kiełczykowska, M., Musik, I., & Kurzepa, J. (2017) · Nutrients · doi:10.3390/nu9070659 · Cited by 245 · see citing works
Troesch, B., Eggersdorfer, M. L., Laviano, A., Rolland, Y., Smith, A. D., Warnke, I., Weimann, A., & Calder, P. C. (2020) · Nutrients · doi:10.3390/nu12092555 · Cited by 233 · see citing works
Lactic acid bacteria as a cell factory for riboflavin production
Thakur, K., Tomar, S. K., & De, S. (2015) · Microbial Biotechnology · doi:10.1111/1751-7915.12335 · Cited by 222 · see citing works
Vitamin D and the central nervous system
Wrzosek, M., Łukaszkiewicz, J., Wrzosek, M., Jakubczyk, A., Matsumoto, H., Piątkiewicz, P., Radziwoń-Zaleska, M., Wojnar, M., & Nowicka, G. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71003-x · Cited by 193 · see citing works
Cholesterol biosensors: A review
Narwal, V., Deswal, R., Batra, B., et al. (2018) · Steroids · doi:10.1016/j.steroids.2018.12.003 · Cited by 190 · see citing works
Pinto, J. T., & Zempleni, J. (2016) · Advances in Nutrition · doi:10.3945/an.116.012716 · Cited by 181 · see citing works
McSwiney, F. T., Wardrop, B., Hyde, P. N., Lafountain, R. A., Volek, J. S., & Doyle, L. (2018) · Metabolism · doi:10.1016/j.metabol.2017.10.010 · Cited by 172 · cited 1× · see citing works
“Specifically, a gluten-free diet [97,98] and a ketogenic diet [99] are considered as promising diets.”
BackgroundPremorbid body mass index and risk of amyotrophic lateral sclerosis
O’Reilly, É. J., Wang, H., Weisskopf, M. G., Fitzgerald, K. C., Falcone, G. J., McCullough, M. L., Thun, M. J., Park, Y., Kolonel, L. N., & Ascherio, A. (2012) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2012.735240 · Cited by 169 · see citing works
Ebara, S. (2017) · Congenital Anomalies · doi:10.1111/cga.12233 · Cited by 169 · see citing works
Vitamin D and the nervous system
Bivona, G., Gambino, C. M., Iacolino, G., & Ciaccio, M. (2019) · Neurological Research · doi:10.1080/01616412.2019.1622872 · Cited by 169 · see citing works
Vitamin E intake and risk of amyotrophic lateral sclerosis
Ascherio, A., Weisskopf, M. G., O’Reilly, É. J., Jacobs, E. J., McCullough, M. L., Calle, E. E., Cudkowicz, M., & Thun, M. J. (2004) · Annals of Neurology · doi:10.1002/ana.20316 · Cited by 165 · see citing works
Liu, D., Ke, Z., & Luo, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0079-9 · Cited by 155 · see citing works
Overlapping riboflavin supply pathways in bacteria
García-Angulo, V. A. (2016) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1192578 · Cited by 153 · see citing works
Genistein Is Neuroprotective in Murine Models of Familial Amyotrophic Lateral Sclerosis and Stroke
Trieu, V. N., & Uckun, F. M. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0577 · Cited by 149 · see citing works
Tocotrienol: The Natural Vitamin E to Defend the Nervous System?
Sen, C. K., Khanna, S., & Roy, S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1331.013 · Cited by 144 · see citing works
Nelson, L. M., Matkin, C. C., Longstreth, W. T., Jr., & McGuire, V. M. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010184 · Cited by 144 · see citing works
Wang, H., O’Reilly, É. J., Weisskopf, M. G., Logroscino, G., McCullough, M. L., Schatzkin, A. G., Kolonel, L. N., & Ascherio, A. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwq416 · Cited by 144 · see citing works
Veldink, J. H., Kalmijn, S., Groeneveld, G. J., Wunderink, W., Koster, A., de Vries, J. H. M., van der Luyt, J., Wokke, J. H. J., & van den Berg, L. H. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.083378 · Cited by 139 · see citing works
Dietary ω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis
Fitzgerald, K. C., O’Reilly, É. J., Falcone, G. J., McCullough, M. L., Park, Y., Kolonel, L. N., & Ascherio, A. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1214 · Cited by 135 · see citing works
Biotin deficiency enhances the inflammatory response of human dendritic cells
Agrawal, S., Agrawal, A., & Said, H. M. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00141.2016 · Cited by 129 · see citing works
1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis
Blasco, H., Corcia, P., Moreau, C., Veau, S., Fournier, C., Vourc’h, P., Emond, P., Gordon, P., Pradat, P., Praline, J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013223 · Cited by 127 · see citing works
Kephart, W., Pledge, C., Roberson, P., Mumford, P., Romero, M., Mobley, C., Martin, J., Young, K., Lowery, R., Wilson, J., et al. (2018) · Sports · doi:10.3390/sports6010001 · Cited by 107 · see citing works
Risk factors and emerging therapies in amyotrophic lateral sclerosis
Nowicka, N., Juranek, J., Juranek, J. K., & Wojtkiewicz, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112616 · Cited by 106 · see citing works
Huisman, M. H. B., Seelen, M., van Doormaal, P. T. C., de Jong, S. W., de Vries, J. H. M., van der Kooi, A. J., de Visser, M., Schelhaas, H. J., van den Berg, L. H., & Veldink, J. H. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1584 · Cited by 103 · see citing works
Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis
Nieves, J. W., Gennings, C., Factor-Litvak, P. R., Hupf, J. C., Singleton, J., Sharf, V., Oskarsson, B., Filho, J. A. M. F., Sorenson, E. J., D’Amico, E., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3401 · Cited by 100 · see citing works
Dietary omega-3 fatty acids for women
Bourre, J. M. (2007) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.09.015 · Cited by 97 · see citing works
Fitzgerald, K. C., O'Reilly, É. J., Fondell, E., Falcone, G. J., McCullough, M. L., Park, Y., Kolonel, L. N., & Ascherio, A. (2013) · Annals of Neurology · doi:10.1002/ana.23820 · Cited by 91 · see citing works
Zhang, X., Chen, S., Li, L., Wang, Q., & Le, W. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.02.020 · Cited by 88 · see citing works
Camu, W., Tremblier, B., Plassot, C., Alphandery, S., Salsac, C., Pageot, N., Morales, R. J., Scamps, F., Daurès, J., & Raoul, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.005 · Cited by 88 · see citing works
Cellular and physiological functions of C9ORF72 and implications for ALS/FTD
Pang, W., & Hu, F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15255 · Cited by 87 · see citing works
Elevated plasma homocysteine levels in patients with amyotrophic lateral sclerosis
Zoccolella, S., Simone, I. L., Lamberti, P. A., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000297193.53986.6f · Cited by 85 · see citing works
Nagano, S., Fujii, Y., Yamamoto, T., Taniyama, M., Fukada, K., Yanagihara, T., & Sakoda, S. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(02)00014-6 · Cited by 83 · see citing works
Kaji, R., Imai, T., Iwasaki, Y., Okamoto, K., Nakagawa, M., Ohashi, Y., Takase, T., Hanada, T., Shimizu, H., Tashiro, K., et al. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-319294 · Cited by 82 · see citing works
Nabokina, S. M., Inoue, K., Subramanian, V. S., Valle, J. E., Yuasa, H., & Said, H. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.528257 · Cited by 81 · see citing works
Gagliardi, D., Bresolin, N., Comi, G. P., & Corti, S. P. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03619-3 · Cited by 77 · see citing works
Vitamin D deficiency and its supplementation in patients with amyotrophic lateral sclerosis
Karam, C., Barrett, M. J., Imperato, T., MacGowan, D. J. L., & Scelsa, S. N. (2013) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2013.01.011 · Cited by 73 · see citing works
Nutrition and Dietary Supplements in Motor Neuron Disease
Rosenfeld, J., & Ellis, A. C. (2008) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2008.03.001 · Cited by 72 · see citing works
The effects of diet and sex in amyotrophic lateral sclerosis
Pape, J. A., & Grose, J. H. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2019.09.008 · Cited by 70 · see citing works
Nutritional status and risk of amyotrophic lateral sclerosis in Japan
Okamoto, K., Kihira, T., Kondo, T., Kobashi, G., Washio, M., Sasaki, S., Yokoyama, T., Miyake, Y., Sakamoto, N., Inaba, Y., et al. (2007) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960701472249 · Cited by 69 · see citing works
Dietary Vitamin B6 Deficiency Impairs Gut Microbiota and Host and Microbial Metabolites in Rats
Mayengbam, S., Chleilat, F., & Reimer, R. A. (2020) · Biomedicines · doi:10.3390/biomedicines8110469 · Cited by 68 · see citing works
Kim, Y., Nakatomi, R., Akagi, T., Hashikawa, T., & Takahashi, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502230200 · Cited by 66 · see citing works
Lipid Biomarkers for Amyotrophic Lateral Sclerosis
de Aguilar, J. G. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00284 · Cited by 62 · see citing works
Fruit and Vegetable Intake and Risk of Amyotrophic Lateral Sclerosis in Japan
Okamoto, K., Kihira, T., Kobashi, G., Washio, M., Sasaki, S., Yokoyama, T., Miyake, Y., Sakamoto, N., Inaba, Y., & Nagai, M. (2009) · Neuroepidemiology · doi:10.1159/000201563 · Cited by 61 · see citing works
Homocysteine levels and amyotrophic lateral sclerosis: A possible link
Zoccolella, S., Bendotti, C., Beghi, E., & Logroscino, G. (2010) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960902919360 · Cited by 60 · see citing works
Molecular Biology of Vitamin D Action
Ross, T. K., Darwish, H. M., & DeLuca, H. F. (1994) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61149-8 · Cited by 58 · see citing works
Amyotrophic lateral sclerosis and food intake
Pupillo, E., Bianchi, E., Chiò, A., Casale, F., Zecca, C., Tortelli, R., Beghi, E., Slalom, F., Parals, & Groups, A. F. S. (2017) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2017.1418002 · Cited by 54 · see citing works
Jannusch, K., Jockwitz, C., Bidmon, H. J., Moebus, S., Amunts, K., & Caspers, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00596 · Cited by 50 · see citing works
Paganoni, S., Nicholson, K. A., Chan, J. G. M., Shui, A. M., Schoenfeld, D., Sherman, A., Berry, J. D., Cudkowicz, M., & Atassi, N. (2017) · Muscle & Nerve · doi:10.1002/mus.25950 · Cited by 50 · see citing works
Folate bio-fortification of yoghurt and fermented milk: a review
Rad, A. H., Khosroushahi, A. Y., Khalili, M., et al. (2016) · Dairy Science and Technology · doi:10.1007/s13594-016-0286-1 · Cited by 47 · see citing works
Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis
Zhang, F., Zhang, Q., Ke, Y.-Q., Hao, J.-B., Lü, L., Lu, N., & Chen, X. (2018) · Scientific Reports · doi:10.1038/s41598-018-19609-2 · Cited by 45 · see citing works
Henriques, A., Blasco, H., Fleury, M., Corcia, P., Echaniz‐Laguna, A., Robelin, L., Rudolf, G., Lequeu, T., Bergaentzlé, M., Gachet, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131512 · Cited by 42 · see citing works
Ikeda, K., Iwasaki, Y., & Kaji, R. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.04.052 · Cited by 41 · see citing works
The neurotoxic effects of vitamin A and retinoids
de Oliveira, M. R. (2015) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201520140677 · Cited by 40 · see citing works
Vitamin E is necessary for zebrafish nervous system development
Head, B., Du, J. K. L., Tanguay, R. L., Kioussi, C., & Traber, M. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-71760-x · Cited by 39 · see citing works
Ojeda, L., Nogales, F., Murillo, L., & Carreras, O. (2017) · Biochemistry and Cell Biology · doi:10.1139/bcb-2017-0069 · Cited by 37 · see citing works
THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH VITAMIN E (TOCOPHEROLS)
Wechsler, I. S. (1940) · The American Journal of the Medical Sciences · doi:10.1097/00000441-194012000-00005 · Cited by 35 · see citing works
Netzahualcoyotzi, C., & Tapia, R. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0205-3 · Cited by 35 · see citing works
[Clinical trials of ultra-high-dose methylcobalamin in ALS].
Izumi, Y., & Kaji, R. (2007) · PubMed · Cited by 35 · see citing works
Vitamin D in amyotrophic lateral sclerosis
Libonati, L. (2017) · Functional Neurology · doi:10.11138/fneur/2017.32.1.035 · Cited by 35 · see citing works
Wang, M., Liu, Z., Sun, W., Yuan, Y., Jiao, B., Zhang, X., Shen, L. H., Jiang, H. F., Xia, K., Tang, B., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00488 · Cited by 35 · see citing works
Zhang, X., Chen, S., Li, L., Wang, Q., & Le, W. D. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.02.024 · Cited by 33 · see citing works
Parry, H. A., Kephart, W. C., Mumford, P. W., Romero, M. A., Mobley, C. B., Zhang, Y., Roberts, M. D., & Kavazis, A. N. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00975 · Cited by 32 · see citing works
Vitamin D is Not a Protective Factor in ALS
Blasco, H., Hounoum, B. M., Dufour‐Rainfray, D., et al. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12423 · Cited by 32 · see citing works
Correction:1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis
Blasco, H., Corcia, P., Moreau, C., et al. (2010) · PLoS ONE · doi:10.1371/annotation/2c2f8fce-a5be-40a3-af8f-48f119b2c593 · Cited by 32 · see citing works
RECOVERY IN AMYOTROPHIC LATERAL SCLEROSIS
Wechsler, I. S. (1940) · JAMA · doi:10.1001/jama.1940.02810110014007 · Cited by 29 · see citing works
Ikeda, M., Nagashima, T., Nakamura, E., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01322-17 · Cited by 27 · see citing works
Polyunsaturated Fatty Acid Metabolism in the Brain and Brain Cells
Joffre, C. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88232 · Cited by 25 · see citing works
Prediagnostic plasma polyunsaturated fatty acids and the risk of amyotrophic lateral sclerosis
O’Reilly, É. J., Bjørnevik, K., Furtado, J. D., Kolonel, L. N., Marchand, L. L., McCullough, M. L., Stevens, V. L., Shadyab, A. H., Snetselaar, L. G., Manson, J. E., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000008676 · Cited by 25 · see citing works
Evidence for the Importance of Vitamin D Status in Neurologic Conditions
Yeshokumar, A. K., Saylor, D. R., Kornberg, M. D., & Mowry, E. M. (2015) · Current Treatment Options in Neurology · doi:10.1007/s11940-015-0380-3 · Cited by 24 · see citing works
Healing of Amyotrophic Lateral Sclerosis: A Case Report
Mangelsdorf, I., Walach, H., & Mutter, J. (2017) · Complementary Medicine Research · doi:10.1159/000477397 · Cited by 23 · see citing works
Folate, vitamin B-12, and cognitive function in the Boston Puerto Rican Health Study
Boumenna, T., Scott, T. M., Lee, J., Palacios, N., & Tucker, K. L. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa293 · Cited by 23 · see citing works
Spasojević, I., Stević, Z., Nikolić‐Kokić, A., Jones, D. R., Blagojević, D. P., & Spasić, M. B. (2010) · Redox Report · doi:10.1179/174329210x12650506623320 · Cited by 21 · see citing works
Vitamin A and its natural derivatives
Redfern, C. P. F. (2020) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2020.02.002 · Cited by 21 · see citing works
Lanznaster, D., Bejan‐Angoulvant, T., Gandía, J., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00697 · Cited by 20 · see citing works
Rison, R. A., & Beydoun, S. R. (2010) · Journal of Medical Case Reports · doi:10.1186/1752-1947-4-298 · Cited by 18 · see citing works
Pre-diagnostic plasma urate and the risk of amyotrophic lateral sclerosis
O’Reilly, É. J., Bjørnevik, K., Schwarzschild, M. A., McCullough, M. L., Kolonel, L. N., Marchand, L. L., Manson, J. E., & Ascherio, A. (2017) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2017.1418005 · Cited by 18 · see citing works
High-dose pharmaceutical grade biotin (MD1003) in amyotrophic lateral sclerosis: A pilot study
Morales, R. J., Pageot, N., Bendarraz, A., Alphandery, S., Sedel, F., Seigle, S., & Camu, W. (2020) · EClinicalMedicine · doi:10.1016/j.eclinm.2019.100254 · Cited by 17 · see citing works
Riancho, J., Delgado‐Alvarado, M., Andreu, M. D., Paz‐Fajardo, L., Arozamena, S., Gil-Bea, F. J., & de Munaín, A. L. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15151 · Cited by 17 · see citing works
Thiamine deficiency in amyotrophic lateral sclerosis: Figure 1
Jesse, S., Thal, D. R., & Ludolph, A. C. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309435 · Cited by 14 · see citing works
Hoffman, H. I., Bradley, W. G., Chen, C. Y., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094528 · Cited by 9 · see citing works
A paradigm shift to treat psychoneurological disorders
Незнанов, Н. Г. (2021) · Personalized Psychiatry and Neurology · Cited by 9 · see citing works
Recent advances in biosynthesis of vitamin and enzyme from food grade bacteria
Shah, N., & Patel, A. R. (2014) · International Journal of Food and Fermentation Technology · doi:10.5958/2277-9396.2014.00008.7 · Cited by 8 · see citing works
ALSUntangled 55: vitamin E (α-tocopherol)
The Alsuntangled Group, & Richard, B. (2020) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2020.1754024 · Cited by 7 · see citing works
Biotin supplements and laboratory test results in neuropsychiatric practice and research
Rao, T. S., Christopher, R., & Andrade, C. (2017) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_454_17 · Cited by 5 · see citing works
Vitamin D and the Central Nervous System: Development, Protection, and Disease
Roman, S., & Mowry, E. M. (2018) · Contemporary Endocrinology · doi:10.1007/978-3-319-73742-3_12 · Cited by 3 · see citing works
Introductory Chapter: Feed Your Mind - How Does Nutrition Modulate Brain Function throughout Life?
Bosch‐Bouju, C. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.89349 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works
- Authors
- Goncharova, P. S., Davydova, T. K., Popova, T. E., Novitsky, M. A., Petrova, M. M., Gavrilyuk, O. A., Al-Zamil, M., Zhukova, N. G., Nasyrova, R. F., & Shnayder, N. A.
- Affiliations
- St.Petersburg V.M.Bekhterev Psychoneurological Research Institute (RU)
- Russian Academy of Sciences (RU)
- Center for Collective Using “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
- Krasnoyarsk State Medical University (RU)
- Peoples' Friendship University of Russia (RU)
- Department of Neurology and Neurosurgery, Siberian State Medical University, 634050 Tomsk, Russia
- Corresponding author
- Nasyrova, Regina F.
- Shnayder, Natalia A.
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-10-26
- Volume
- 13
- Issue
- 11
- Pages
- 3804
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC8622539
- OpenAlex
- W3209681582
- Cited by
- 35
- References
- 101
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- amyotrophic lateral sclerosis, motor neuron degeneration, dietary nutrients, vitamins, vitamin B12, vitamin E, vitamin C, vitamin D, vitamin B6, folic acid, biotin, vitamin A, cholesterol, polyunsaturated fatty acids, uric acid, purines, ketogenic diet, disease-modifying therapy, ALS risk factors, disease progression
- MeSH terms
- Nutrients, Amyotrophic Lateral Sclerosis, Animals, Diet, Disease Models, Animal, Humans, Motor Neurons, Nutritional Physiological Phenomena, Risk Factors, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
