Risk factors and emerging therapies in amyotrophic lateral sclerosis

Superoxide Dismutase

McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062 · see citing works

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

DeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936 · see citing works

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.010 · Cited by 4,409 · see citing works

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchiya, K., Yoshida, M., Hashizume, Y., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.093 · Cited by 2,732 · see citing works

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

Kwiatkowski, T. J., Bosco, D. A., LeClerc, A. L., Tamrazian, E., Vanderburg, C. R., Russ, C., Davis, A., Gilchrist, J. M., Kasarskis, E. J., Munsat, T. L., et al. (2009) · Science · doi:10.1126/science.1166066 · Cited by 2,526 · see citing works

Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212 · see citing works

Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage

Nuran Ercal, B. S. P., Hande Gurer-Orhan, B. S. P., & Nukhet Aykin-Burns, B. S. P. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394831 · Cited by 1,944 · see citing works

Amyotrophic Lateral Sclerosis

Rowland, L. P., & Shneider, N. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105313442207 · Cited by 1,851 · see citing works

Mutations of optineurin in amyotrophic lateral sclerosis

Maruyama, H., Morino, H., Ito, H., Izumi, Y., Kato, H., Watanabe, Y., Kinoshita, Y., Kamada, M., Nodera, H., Suzuki, H., et al. (2010) · Nature · doi:10.1038/nature08971 · Cited by 1,265 · see citing works

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Majounie, E., Renton, A. E., Mok, K., Dopper, E. G., Waite, A., Rollinson, S., Chiò, A., Restagno, G., Nicolaou, N., Simon-Sanchez, J., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70043-1 · Cited by 1,210 · see citing works

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Deng, H.-X., Chen, W., Hong, S.-T., Boycott, K. M., Gorrie, G. H., Siddique, N., Yang, Y., Fecto, F., Shi, Y., Zhai, H., et al. (2011) · Nature · doi:10.1038/nature10353 · Cited by 1,174 · see citing works

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

Pasinelli, P., & Brown, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1971 · Cited by 1,107 · see citing works

Amyotrophic lateral sclerosis

Wijesekera, L. C., & Leigh, P. N. (2009) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-4-3 · Cited by 1,051 · see citing works

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Rosen, D. (1993) · Nature · doi:10.1038/364362c0 · Cited by 922 · see citing works

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

Thurston, T. L. M., Ryzhakov, G., Bloor, S., von Muhlinen, N., & Randow, F. (2009) · Nature Immunology · doi:10.1038/ni.1800 · Cited by 872 · see citing works

Oxidative Stress in Neurodegenerative Diseases

Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800 · see citing works

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

Freischmidt, A., Wieland, T., Richter, B., Ruf, W., Schaeffer, V., Müller, K., Marroquin, N., Nordin, F., Hübers, A., Weydt, P., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4000 · Cited by 786 · see citing works

Incidence of amyotrophic lateral sclerosis in Europe

Logroscino, G., Traynor, B. J., Hardiman, O., Chio, A., Mitchell, D., Swingler, R. J., Millul, A., Benn, E., Beghi, E., & EURALS, F. (2010) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.183525 · Cited by 772 · see citing works

A comprehensive review of amyotrophic lateral sclerosis

Zarei, S., Carr, K., Reiley, L. E., Diaz, K., Guerra, O., Altamirano, P., Pagani, W., Lodin, D., Orozco, G., & Chinea, A. R. (2015) · Surgical Neurology International · doi:10.4103/2152-7806.169561 · Cited by 737 · see citing works

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

Ferraiuolo, L., Kirby, J., Grierson, A. J., Sendtner, M., & Shaw, P. J. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.152 · Cited by 615 · see citing works

Amyotrophic lateral sclerosis

Mitchell, J. D., & Borasio, G. D. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60944-1 · Cited by 583 · see citing works

Misfolded CuZnSOD and amyotrophic lateral sclerosis

Valentine, J. S., & Hart, P. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730423100 · Cited by 546 · see citing works

Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis

Zou, Z.-Y., Zhou, Z.-R., Che, C.-H., Liu, C.-Y., He, R.-L., & Huang, H.-P. (2017) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-315018 · Cited by 540 · see citing works

Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons

Duque, S., Joussemet, B., Riviere, C., Marais, T., Dubreil, L., Douar, A.-M., Fyfe, J., Moullier, P., Colle, M.-A., & Barkats, M. (2009) · Molecular Therapy · doi:10.1038/mt.2009.71 · Cited by 511 · see citing works

Antisense oligonucleotide therapy for neurodegenerative disease

Smith, R. A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25424 · Cited by 506 · see citing works

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease

Buratti, E. (2007) · Frontiers in bioscience · doi:10.2741/2727 · Cited by 493 · see citing works

Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs

Jaiswal, M. K. (2018) · Medicinal Research Reviews · doi:10.1002/med.21528 · Cited by 456 · see citing works

ALS clinical trials review: 20 years of failure. Are we any closer to registering a new treatment?

Petrov, D., Mansfield, C., Moussy, A., & Hermine, O. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00068 · Cited by 451 · see citing works

Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis

Rutherford, N. J., Zhang, Y., Baker, M. C., Gass, J. M., Finch, N. A., Xu, Y., Stewart, H. G., Kelley, B. J., Kuntz, K., Crook, R., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000193 · Cited by 450 · see citing works

Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

Lepore, A. C., Rauck, B., Dejea, C., Pardo, A. C., Rao, M. S., Rothstein, J. D., & Maragakis, N. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2210 · Cited by 441 · see citing works

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

Chiu, I., Chen, A., Zheng, Y., Kosaras, B., Tsiftsoglou, S., Vartanian, T., Brown, R. H., & Carroll, M. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0804610105 · Cited by 374 · see citing works

Amyotrophic lateral sclerosis associated with mutations in the CuZn superoxide dismutase gene

Andersen, P. M. (2006) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-996-0008-9 · Cited by 368 · see citing works

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

Harraz, M. M., Marden, J. J., Zhou, W., Zhang, Y., Williams, A. J., Sharov, V. S., Nelson, K., Luo, M., Paulson, H. L., Schöneich, C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34060 · Cited by 357 · see citing works

Microglia in ALS: The Good, The Bad, and The Resting

Henkel, J. S., Beers, D. R., Zhao, W., & Appel, S. H. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9171-5 · Cited by 353 · see citing works

Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis

Byrne, S., Walsh, C., Lynch, C., Bede, P., Elamin, M., Kenna, K. P., McLaughlin, R. L., & Hardiman, O. M. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.224501 · Cited by 351 · see citing works

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

Afroz, T., Hock, E., Ernst, P. J., Foglieni, C., Jambeau, M., Gilhespy, L. A. B., Laferrière, F., Maniecka, Z., Plückthun, A., Mittl, P. R. E., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00062-0 · Cited by 351 · see citing works

Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72

Cooper‐Knock, J., Hewitt, C., Highley, J. R., Brockington, A., Milano, A., Man, S., Martindale, J. E., Hartley, J. A., Walsh, T., Gelsthorpe, C., et al. (2012) · Brain · doi:10.1093/brain/awr365 · Cited by 329 · see citing works

Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis

D’Amico, E., Factor-Litvak, P. R., Santella, R. M., & Mitsumoto, H. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.029 · Cited by 324 · see citing works

Is SOD1 loss of function involved in amyotrophic lateral sclerosis?

Saccon, R. A., Bunton-Stasyshyn, R. K. A., Fisher, E., & Fratta, P. (2013) · Brain · doi:10.1093/brain/awt097 · Cited by 318 · see citing works

Amyotrophic Lateral Sclerosis: An Update for 2018

Oskarsson, B., Gendron, T. F., & Staff, N. P. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.04.007 · Cited by 315 · see citing works

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

Pottier, C., Bieniek, K. F., Finch, N., van de Vorst, M., Baker, M., Perkersen, R., Brown, P., Ravenscroft, T., van Blitterswijk, M., Nicholson, A. M., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1436-x · Cited by 312 · see citing works

Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

Cossetti, C., Iraci, N., Mercer, T. R., Leonardi, T., Alpi, E., Drago, D., Alfaro‐Cervelló, C., Saini, H. K., Davis, M. P. A., Schaeffer, J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.020 · Cited by 301 · see citing works

Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death

Kasarskis, E. J., Berryman, S., Vanderleest, J. G., Schneider, A., & McClain, C. J. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.1.130 · Cited by 293 · see citing works

Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis

Paganoni, S., Deng, J., Jaffa, M., Cudkowicz, M., & Wills, A.-M. A. (2011) · Muscle & Nerve · doi:10.1002/mus.22114 · Cited by 293 · see citing works

Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study

Laaksovirta, H., Peuralinna, T., Schymick, J. C., Scholz, S. W., Lai, S.-L., Myllykangas, L., Sulkava, R. O., Jansson, L., Hernandez, D. G., Gibbs, J. R., et al. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70184-8 · Cited by 260 · see citing works

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study

Fang, T., Al Khleifat, A., Meurgey, J.-H., Jones, A., Leigh, P. N., Bensimon, G., & Al-Chalabi, A. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30054-1 · Cited by 259 · see citing works

Potential occupational risks for neurodegenerative diseases

Park, R. M., Schulte, P. A., Bowman, J. D., Walker, J. T., Bondy, S. C., Yost, M. G., Touchstone, J. A., & Dosemeci, M. (2005) · American Journal of Industrial Medicine · doi:10.1002/ajim.20178 · Cited by 256 · see citing works

Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: Possible immune cell activation

Simkó, M., & Mattsson, M. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20198 · Cited by 256 · see citing works

Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

Larabi, A., Devos, J. M., Ng, S., Nanao, M., Round, A. R., Maniatis, T., & Panne, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.034 · Cited by 251 · see citing works

Occupational Exposures and Amyotrophic Lateral Sclerosis. A Population-based Case-Control Study

McGuire, V. M., Longstreth, W. T., Jr., Nelson, L. M., Koepsell, T. D., Checkoway, H., Morgan, M. S., & van Belle, G. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009070 · Cited by 235 · see citing works

Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis

Wang, M.-D., Little, J., Gomes, J., Cashman, N. R., & Krewski, D. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2016.06.015 · Cited by 233 · see citing works

Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial

Cudkowicz, M., van den Berg, L. H., Shefner, J. M., Mitsumoto, H., Mora, J. S., Ludolph, A. C., Hardiman, O. M., Bozik, M. E., Ingersoll, E. W., Archibald, D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70221-7 · Cited by 232 · see citing works

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

Elia, A. E., Lalli, S., Monsurrò, M. R., Sagnelli, A., Taiello, A. C., Reggiori, B., Bella, V. L., Tedeschi, G., & Albanese, A. (2015) · European Journal of Neurology · doi:10.1111/ene.12664 · Cited by 225 · see citing works

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

Paez-Colasante, X., Figueroa‐Romero, C., Sakowski, S. A., Goutman, S. A., & Feldman, E. L. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.57 · Cited by 224 · see citing works

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

Ou, Y.-H., Torres, M. J., Ram, R. R., Formstecher, É., Roland, C. L., Cheng, T., Brekken, R. A., Wurz, R. P., Tasker, A. S., Polverino, T., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.019 · Cited by 224 · see citing works

Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1

Tu, D., Zhu, Z., Zhou, A. Y., Yun, C., Lee, K., Toms, A. V., Li, Y., Dunn, G. P., Chan, E. M., Thai, T. C., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.033 · Cited by 215 · see citing works

Evolution of CuZn superoxide dismutase and the Greek Key β‐barrel structural motif

Getzoff, E. D., Tainer, J. A., Stempien, M. M., Bell, G. I., & Hallewell, R. A. (1989) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340050408 · Cited by 206 · see citing works

An Evidence-Based Medicine Approach to the Evaluation of the Role of Exogenous Risk Factors in Sporadic Amyotrophic Lateral Sclerosis

Armon, C. (2003) · Neuroepidemiology · doi:10.1159/000070562 · Cited by 205 · see citing works

An Analysis of Extended Survival in Patients With Amyotrophic Lateral Sclerosis Treated With Riluzole

Rivière, M., Meininger, V., Zeisser, P., & Munsat, T. L. (1998) · Archives of Neurology · doi:10.1001/archneur.55.4.526 · Cited by 198 · see citing works

A CASE-CONTROL STUDY OF AMYOTROPHIC LATERAL SCLEROSIS1

Deapen, D., & Henderson, B. E. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114308 · Cited by 184 · see citing works

Pathogenesis of amyotrophic lateral sclerosis

Morgan, S. L., & Orrell, R. W. (2016) · British Medical Bulletin · doi:10.1093/bmb/ldw026 · Cited by 179 · see citing works

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. C., & Cohen, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.267567 · Cited by 173 · see citing works

Dissociation of Human Copper-Zinc Superoxide Dismutase Dimers Using Chaotrope and Reductant

Doucette, P. A., Whitson, L. J., Cao, X., Schirf, V. R., Demeler, B., Valentine, J. S., Hansen, J. C., & Hart, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409744200 · Cited by 171 · see citing works

Premorbid body mass index and risk of amyotrophic lateral sclerosis

O’Reilly, É. J., Wang, H., Weisskopf, M. G., Fitzgerald, K. C., Falcone, G. J., McCullough, M. L., Thun, M. J., Park, Y., Kolonel, L. N., & Ascherio, A. (2012) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2012.735240 · Cited by 169 · see citing works

Exposure to chemicals and metals and risk of amyotrophic lateral sclerosis: A systematic review

Sutedja, N. A., Veldink, J. H., Fischer, K., Kromhout, H., Heederik, D. J. J., Huisman, M. H. B., Wokke, J. H. J., & van den Berg, L. H. (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960802455416 · Cited by 161 · see citing works

SOD1 in Amyotrophic Lateral Sclerosis: “Ambivalent” Behavior Connected to the Disease

Pansarasa, O., Bordoni, M., Diamanti, L., Sproviero, D., Gagliardi, S., & Cereda, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051345 · Cited by 160 · see citing works

Neurodegenerative Diseases in Welders and Other Workers Exposed to High Levels of Magnetic Fields

Håkansson, N., Gustavsson, P., Johansen, C., & Floderus, B. (2003) · Epidemiology · doi:10.1097/01.ede.0000078446.76859.c9 · Cited by 155 · see citing works

An outcome study of riluzole in amyotrophic lateral sclerosis

Traynor, B. J., Alexander, M. D., Corr, B., Frost, E., & Hardiman, O. M. (2003) · Journal of Neurology · doi:10.1007/s00415-003-1026-z · Cited by 152 · see citing works

TBK1 Mediates Crosstalk Between the Innate Immune Response and Autophagy

Weidberg, H., & Elazar, Z. (2011) · Science Signaling · doi:10.1126/scisignal.2002355 · Cited by 148 · see citing works

Potential Environmental Factors in Amyotrophic Lateral Sclerosis

Oskarsson, B., Horton, D. K., & Mitsumoto, H. (2015) · Neurologic Clinics · doi:10.1016/j.ncl.2015.07.009 · Cited by 143 · see citing works

Delayed Disease Onset and Extended Survival in the SOD1G93ARat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex

Thomsen, G. M., Gowing, G., Latter, J., Chen, M., Vit, J., Staggenborg, K., Avalos, P., Alkaslasi, M. R., Ferraiuolo, L., Likhite, S. B., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2037-14.2014 · Cited by 137 · see citing works

Riluzole, disease stage and survival in ALS

Dharmadasa, T., & Kiernan, M. C. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30091-7 · Cited by 135 · see citing works

Mitochondrial dysfunction in amyotrophic lateral sclerosis – a valid pharmacological target?

Muyderman, H., & Chen, T. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12476 · Cited by 134 · see citing works

Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases

Southwell, A. L., Skotte, N. H., Bennett, C. F., & Hayden, M. R. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.09.001 · Cited by 134 · see citing works

Advances in motor neurone disease

Bäumer, D., Talbot, K., & Turner, M. R. (2014) · Journal of the Royal Society of Medicine · doi:10.1177/0141076813511451 · Cited by 134 · see citing works

Frontotemporal Lobar Degeneration: Epidemiology, Pathology, Diagnosis and Management

Seltman, R. E., & Matthews, B. R. (2012) · CNS Drugs · doi:10.2165/11640070-000000000-00000 · Cited by 132 · see citing works

The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis

Tanaka, H., Shimazawa, M., Kimura, M., Takata, M., Tsuruma, K., Yamada, M., Takahashi, H., Hozumi, I., Niwa, J., Iguchi, Y., et al. (2012) · Scientific Reports · doi:10.1038/srep00573 · Cited by 127 · see citing works

The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on evidence and mechanisms

Mostafalou, S., & Abdollahi, M. R. (2018) · Toxicology · doi:10.1016/j.tox.2018.07.014 · Cited by 122 · see citing works

Amyotrophic lateral sclerosis and environmental factors

Bozzoni, V. (2016) · Functional Neurology · doi:10.11138/fneur/2016.31.1.007 · Cited by 118 · see citing works

Association Between Blood Lead and the Risk of Amyotrophic Lateral Sclerosis

Fang, F., Kwee, L. C., Allen, K. D., Umbach, D. M., Ye, W., Watson, M., Keller, J., Oddone, E. Z., Sandler, D. P., Schmidt, S., et al. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq063 · Cited by 117 · see citing works

Human Glial-Restricted Progenitor Transplantation into Cervical Spinal Cord of the SOD1G93A Mouse Model of ALS

Lepore, A. C., O'Donnell, J., Kim, A. S., Williams, T. L., Tuteja, A., Rao, M. S., Kelley, L. L., Campanelli, J. T., & Maragakis, N. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025968 · Cited by 116 · see citing works

Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation

Li, F., Xu, D., Wang, Y., Zhou, Z., Liu, J., Hu, S., Gong, Y., Yuan, J., & Pan, L. (2018) · Autophagy · doi:10.1080/15548627.2017.1391970 · Cited by 114 · see citing works

Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options

Körner, S., Hendricks, M., Kollewe, K., Zapf, A., Dengler, R., Silani, V., & Petri, S. (2013) · BMC Neurology · doi:10.1186/1471-2377-13-84 · Cited by 112 · see citing works

Aberrantly Increased Hydrophobicity Shared by Mutants of Cu,Zn-Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

Tiwari, A., Xu, Z., & Hayward, L. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504039200 · Cited by 108 · see citing works

Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis

Simpson, E. P., Yen, A. A., & Appel, S. H. (2003) · Current Opinion in Rheumatology · doi:10.1097/00002281-200311000-00008 · Cited by 107 · see citing works

Disease-modifying and symptomatic treatment of amyotrophic lateral sclerosis

Dorst, J., Ludolph, A. C., & Huebers, A. (2017) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285617734734 · Cited by 106 · see citing works

Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies

Cascella, R., Capitini, C., Fani, G., Dobson, C. M., Cecchi, C., & Chiti, F. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.737726 · Cited by 105 · see citing works

Edaravone for the treatment of amyotrophic lateral sclerosis

Yoshino, H. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1581610 · Cited by 104 · see citing works

Adipose Tissue Distribution Predicts Survival in Amyotrophic Lateral Sclerosis

Lindauer, E., Dupuis, L., Müller, H., Heiko Neumann, B., Ludolph, A. C., & Kassubek, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067783 · Cited by 102 · see citing works

Exposure to Electromagnetic Fields and Risk of Central Nervous System Disease in Utility Workers

Johansen, C. (2000) · Epidemiology · doi:10.1097/00001648-200009000-00009 · Cited by 100 · see citing works

Non‐neuronal Cells in ALS: Role of Glial, Immune cells and Blood‐CNS Barriers

Puentes, F., Malaspina, A., van Noort, J. M., & Amor, S. (2016) · Brain Pathology · doi:10.1111/bpa.12352 · Cited by 98 · see citing works

Randomized phase 2 trial of NP001, a novel immune regulator

Miller, R. G., Block, G. A., Katz, J., Barohn, R. J., Gopalakrishnan, V., Cudkowicz, M., Zhang, J. R., McGrath, M. S., Ludington, E. A., Appel, S. H., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000100 · Cited by 97 · see citing works

Paraoxonase gene polymorphisms and sporadic ALS

Słowik, A., Tomik, B., Wołkow, P. P., Partyka, D., Turaj, W., Malecki, M. T., Pera, J., Dziedzic, T., Szczudlik, A., & Figlewicz, D. A. (2006) · Neurology · doi:10.1212/01.wnl.0000219565.32247.11 · Cited by 93 · see citing works

Association of Mutations in TBK1 With Sporadic and Familial Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Freischmidt, A., Müller, K., Ludolph, A. C., Weishaupt, J. H., & Andersen, P. M. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3712 · Cited by 92 · see citing works

Edaravone and its clinical development for amyotrophic lateral sclerosis

Takei, K., Watanabe, K., Yuki, S., Akimoto, M., Sakata, T., & Palumbo, J. (2017) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2017.1353101 · Cited by 90 · see citing works

7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis

Korkmaz, O. T., Aytan, N., Carreras, I., Choi, J., Kowall, N. W., Jenkins, B. G., & Dedeoglu, A. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.02.058 · Cited by 89 · see citing works

Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy

Martier, R., Liefhebber, J. M. P., García‐Osta, A., Miniarikova, J., Cuadrado‐Tejedor, M., Espelosin, M., Ursúa, S., Petry, H., van Deventer, S. J. H., Evers, M. M., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.02.001 · Cited by 89 · see citing works

Current Challenges for the Advancement of Neural Stem Cell Biology and Transplantation Research

Reekmans, K., Praet, J., Daans, J., Reumers, V., Pauwels, P., der Linden, A. V., Berneman, Z. N., & Ponsaerts, P. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9266-2 · Cited by 86 · see citing works

Amyotrophic lateral sclerosis: toxins and environment

Mitchell, J. D. (2000) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820050515061 · Cited by 85 · see citing works

Edaravone: a new hope for deadly amyotrophic lateral sclerosis

Bhandari, R., Kuhad, A., & Kuhad, A. (2018) · Drugs of today · doi:10.1358/dot.2018.54.6.2828189 · Cited by 85 · see citing works

Riluzole exerts transient modulating effects on cortical and axonal hyperexcitability in ALS

Geevasinga, N., Menon, P., Ng, K., van den Bos, M. A. J., Byth, K., Kiernan, M. C., & Vucic, S. (2016) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2016.1188961 · Cited by 83 · see citing works

Paraoxonase gene mutations in amyotrophic lateral sclerosis

Ticozzi, N., LeClerc, A. L., Keagle, P. J., Glass, J. D., Wills, A.-M. A., van Blitterswijk, M., Bosco, D. A., Rodríguez‐Leyva, I., Gellera, C., Ratti, A., et al. (2010) · Annals of Neurology · doi:10.1002/ana.21993 · Cited by 78 · see citing works

Exposure to Environmental Toxicants and Pathogenesis of Amyotrophic Lateral Sclerosis: State of the Art and Research Perspectives

Trojsi, F., Monsurrò, M. R., & Tedeschi, G. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140815286 · Cited by 78 · see citing works

Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes.

Kamel, F., Umbach, D. M., Lehman, T. A., Park, L. P., Munsat, T. L., Shefner, J. M., Sandler, D. P., Hu, H., & Taylor, J. A. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6109 · Cited by 77 · see citing works

Caloric Restriction Shortens Lifespan through an Increase in Lipid Peroxidation, Inflammation and Apoptosis in the G93A Mouse, an Animal Model of ALS

Patel, B. P., Safdar, A., Raha, S., Tarnopolsky, M. A., & Hamadeh, M. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009386 · Cited by 76 · see citing works

Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life

Paris, G., Martinaud, O., Petit, A., Cuvelier, A., Hannequin, D., Roppenneck, P., & Vérin, É. (2012) · Journal of Oral Rehabilitation · doi:10.1111/joor.12019 · Cited by 76 · see citing works

Mitochondrial alterations in dorsal root ganglion cells in sporadic amyotrophic lateral sclerosis

Sasaki, S., Horie, Y., & Iwata, M. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0299-1 · Cited by 75 · see citing works

Association between Extremely Low-Frequency Electromagnetic Fields Occupations and Amyotrophic Lateral Sclerosis: A Meta-Analysis

Zhou, H., Chen, G., Chen, C., Yu, Y., & Xu, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048354 · Cited by 75 · see citing works

A Meta-Analysis of Observational Studies of the Association Between Chronic Occupational Exposure to Lead and Amyotrophic Lateral Sclerosis

Wang, M., Gomes, J., Cashman, N. R., Little, J., & Krewski, D. R. (2014) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000000323 · Cited by 74 · see citing works

Genetic susceptibility to environmental toxicants in ALS

Morahan, J. M., Yu, B., Trent, R. J., & Pamphlett, R. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30543 · Cited by 73 · see citing works

Stem Cell Technology for the Study and Treatment of Motor Neuron Diseases

Lunn, J. S., Sakowski, S. A., Federici, T., Glass, J. D., Boulis, N. M., & Feldman, E. L. (2011) · Regenerative Medicine · doi:10.2217/rme.11.6 · Cited by 72 · see citing works

MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS

Shvil, N., Banerjee, V., Zoltsman, G., Shani, T., Kahn, J., Abu‐Hamad, S., Papo, N., Engel, S., Bernhagen, J., & Israelson, A. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0130-4 · Cited by 70 · see citing works

Polymerase chain reaction and Southern blot-based analysis of the C9orf72 hexanucleotide repeat in different motor neuron diseases

Hübers, A., Marroquin, N., Schmoll, B., Vielhaber, S., Just, M., Mayer, B., Högel, J., Dorst, J., Mertens, T., Just, W., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.034 · Cited by 69 · see citing works

Neural stem cells: therapeutic potential for neurodegenerative diseases

Gincberg, G., Arien‐Zakay, H., Lazarovici, P., & Lelkes, P. I. (2012) · British Medical Bulletin · doi:10.1093/bmb/lds024 · Cited by 66 · see citing works

Aggregated SOD1 causes selective death of cultured human motor neurons

Benkler, C., O’Neil, A., Slepian, S., Qian, F., Weinreb, P. H., & Rubin, L. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-34759-z · Cited by 65 · see citing works

Oxidative stress: the lowest common denominator of multiple diseases

Matschke, V., Theiß, C., & Matschke, J. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.244780 · Cited by 65 · see citing works

Prospective Study of Occupation and Amyotrophic Lateral Sclerosis Mortality

Weisskopf, M. G., McCullough, M. L., Morozova, N., Calle, E. E., Thun, M. J., & Ascherio, A. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi343 · Cited by 64 · see citing works

Fatigue and activity dependent changes in axonal excitability in amyotrophic lateral sclerosis

Vucic, S., Krishnan, A. V., & Kiernan, M. C. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.112078 · Cited by 63 · see citing works

Current and emerging treatments for amyotrophic lateral sclerosis

Zoccolella (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s7788 · Cited by 62 · see citing works

Body mass index (BMI) as predictor of ALSFRS-R score decline in ALS patients

Reich‐Slotky, R., Andrews, J. A., Cheng, B., Buchsbaum, R., Levy, D., Kaufmann, P., & Thompson, J. L. P. (2013) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2013.770028 · Cited by 62 · see citing works

EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis

Rosenblum, L. T., & Trotti, D. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-55769-4_6 · Cited by 61 · see citing works

Association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis: A review

Li, C., & Sung, F. (2003) · American Journal of Industrial Medicine · doi:10.1002/ajim.10148 · Cited by 59 · see citing works

A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS

Bozik, M. E., Mitsumoto, H., Brooks, B. R., Rudnicki, S. A., Moore, D. H., Zhang, B., Ludolph, A., Cudkowicz, M., van den Berg, L. H., Mather, J. L., et al. (2014) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2014.943672 · Cited by 52 · see citing works

Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration

Edens, B. M., Miller, N., & Ma, Y. C. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00044 · Cited by 51 · see citing works

Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin

Amlie‐Wolf, A., Ryvkin, P., Tong, R., Dragomir, I. C., Suh, E. R., Xu, Y., Deerlin, V. M. V., Gregory, B. D., Kwong, L. K., Trojanowski, J. Q., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141836 · Cited by 50 · see citing works

Effect of Acute Extremely Low Frequency Electromagnetic Field Exposure on the Antioxidant Status and Lipid Levels in Rat Brain

Martínez-Sámano, J., Torres-Durán, P. V., Juárez-Oropeza, M. A., & Verdugo‐Díaz, L. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.04.003 · Cited by 49 · see citing works

“ALS reversals”: demographics, disease characteristics, treatments, and co-morbidities

Harrison, D. S., Mehta, P., van Es, M. A., Stommel, E. W., Drory, V. E., Nefussy, B., van den Berg, L. H., Crayle, J. I., Bedlack, R., & the Pooled Resource Open-Access ALS Clinical Trials Consortium (2018) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2018.1457059 · Cited by 46 · see citing works

Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1G93A ALS rat but has adverse side effects

Thomsen, G. M., Alkaslasi, M. R., Vit, J., Lawless, G., Godoy, M. I., Gowing, G., Shelest, O., & Svendsen, C. N. (2017) · Gene Therapy · doi:10.1038/gt.2017.9 · Cited by 44 · see citing works

Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomised, double blind, placebo controlled, phase III study

Lauria, G., Bella, E. D., Antonini, G., Borghero, G., Capasso, M., Caponnetto, C., Chiò, A., Corbo, M., Eleopra, R., Fazio, R., et al. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308996 · Cited by 41 · see citing works

FUS-regulated RNA metabolism and DNA damage repair

Zhou, Y., Liu, S., Öztürk, A., & Hicks, G. G. (2014) · Rare Diseases · doi:10.4161/rdis.29515 · Cited by 41 · see citing works

Riluzole therapy for motor neurone disease: An early Australian experience (1996–2002)

Zoing, M. C., Burke, D. J., Pamphlett, R., & Kiernan, M. C. (2006) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2004.04.011 · Cited by 40 · see citing works

GPNMB ameliorates mutant TDP‐43‐induced motor neuron cell death

Nagahara, Y., Shimazawa, M., Ohuchi, K., Itô, J., Takahashi, H., Tsuruma, K., Kakita, A., & Hara, H. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23999 · Cited by 39 · see citing works

Stem cells therapy for ALS

Mazzini, L., Vescovi, A. L., Cantello, R. M., Gelati, M., & Vercelli, A. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2016.1116516 · Cited by 38 · see citing works

Association between TBK1 mutations and risk of amyotrophic lateral sclerosis/frontotemporal dementia spectrum: a meta-analysis

Cui, R., Tuo, M., Li, P., & Zhou, C. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3246-0 · Cited by 37 · see citing works

Genetics of Amyotrophic Lateral Sclerosis

Siddique, N., & Siddique, T. (2008) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2008.05.001 · Cited by 33 · see citing works

Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives

Khairoalsindi, O. A., & Abuzinadah, A. R. (2018) · Neurology Research International · doi:10.1155/2018/6534150 · Cited by 31 · see citing works

Oxidative Stress as “Mother” of Many Human Diseases at Strong Clinical Impact

Cacciapuoti, F. (2016) · Journal of Cardiovascular Medicine and Cardiology · doi:10.17352/2455-2976.000020 · Cited by 28 · see citing works

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

Hanspal, M. A., Dobson, C. M., Yerbury, J. J., & Kumita, J. R. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.007 · Cited by 28 · see citing works

A Meta-Analysis on the Relationship of the PON Genes and Alzheimer Disease

Nie, Y., Luo, D., Yang, M., Wang, Y., Li, X., Gao, L., Liu, Y., & Liu, H. (2017) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988717731825 · Cited by 27 · see citing works

The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension

Keskin, I., Forsgren, E., Lehmann, M., Andersen, P. M., Brännström, T., Lange, D. J., Synofzik, M., Nordström, U., Zetterström, P., Marklund, S. L., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01986-1 · Cited by 27 · see citing works

Progress towards therapy in motor neuron disease

Kiernan, M. C. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.186 · Cited by 26 · see citing works

Dexpramipexole Is Ineffective in Two Models of ALS Related Neurodegeneration

Vieira, F. G., LaDow, E., Moreno, A. J., Kidd, J. D., Levine, B. A., Thompson, K., Gill, A., Finkbeiner, S. M., & Perrin, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091608 · Cited by 24 · see citing works

Early post-marketing experience with edaravone in an unselected group of patients with ALS

Abraham, A., Nefussy, B., Fainmesser, Y., Ebrahimi, Y., Karni, A., & Drory, V. E. (2019) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2019.1572191 · Cited by 24 · see citing works

Human glial progenitor engraftment and gene expression is independent of the ALS environment

Haidet-Phillips, A. M., Doreswamy, A., Gross, S. K., Tang, X., Campanelli, J. T., & Maragakis, N. J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.12.011 · Cited by 23 · see citing works

Capturing VCP: Another Molecular Piece in the ALS Jigsaw Puzzle

Shaw, C. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.040 · Cited by 22 · see citing works

Regulation of FMO and PON Detoxication Systems in ALS Human Tissues

Gagliardi, S., Abel, K. J., Bianchi, M., Milani, P., Bernuzzi, S., Corato, M. D., Ceroni, M., Cashman, J. R., & Cereda, C. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9356-1 · Cited by 19 · see citing works

Amyotrophic Lateral Sclerosis - Cell Based Therapy and Novel Therapeutic Development

Kim, C., Lee, H. C., & Sung, J. (2014) · Experimental Neurobiology · doi:10.5607/en.2014.23.3.207 · Cited by 19 · see citing works

The C9orf72 hexanucleotide repeat expansion in FTD and ALS

Bigio, E. H. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.58 · Cited by 15 · see citing works

Advances in the Research of Astrocyte Function in Neural Regeneration

Srikanth, M., Yao, L., & Asmatulu, R. (2018) · Springer eBooks · doi:10.1007/978-3-030-02104-7_1 · Cited by 1 · see citing works

Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System

Malik, A. R., & Willnow, T. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225671 · Cited by 170 · see citing works

The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders

Tripathi, M. K., Kartawy, M., & Amal, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101567 · Cited by 161 · see citing works

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

Peng, B., Yang, Q., B Joshi, R., Liu, Y., Akbar, M., Song, B.-J., Zhou, S., & Wang, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072316 · Cited by 156 · see citing works

Role of Edaravone as a Treatment Option for Patients with Amyotrophic Lateral Sclerosis

Cho, H., & Shukla, S. (2020) · Pharmaceuticals · doi:10.3390/ph14010029 · Cited by 124 · see citing works

Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)

Abati, E., Bresolin, N., Comi, G. P., & Corti, S. P. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1738390 · Cited by 104 · see citing works

Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease

Silvestro, S., Schepici, G., Bramanti, P., & Mazzon, E. (2020) · Molecules · doi:10.3390/molecules25215186 · Cited by 90 · see citing works

Neuropsychological and neurophysiological aspects of brain‐computer‐interface (BCI) control in paralysis

Chaudhary, U., Mrachacz‐Kersting, N., & Birbaumer, N. (2020) · The Journal of Physiology · doi:10.1113/jp278775 · Cited by 86 · see citing works

Nearly 30 Years of Animal Models to Study Amyotrophic Lateral Sclerosis: A Historical Overview and Future Perspectives

Bonifacino, T., Zerbo, R. A., Balbi, M., Torazza, C., Frumento, G., Fedele, E., Bonanno, G., & Milanese, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212236 · Cited by 78 · see citing works

CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro

Meijboom, K. E., Abdallah, A., Fordham, N. P., Nagase, H., Rodríguez, T., Kraus, C., Gendron, T. F., Krishnan, G., Esanov, R., Andrade, N. S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33332-7 · Cited by 72 · see citing works

Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis

Stoccoro, A., Smith, A. R., Mosca, L., Marocchi, A., Gerardi, F., Lunetta, C., Cereda, C., Gagliardi, S., Lunnon, K., Migliore, L., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00933-2 · Cited by 57 · see citing works

¹¹ C‐PK11195 PET–based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis

Tondo, G., Iaccarino, L., Cerami, C., Vanoli, G. E., Presotto, L., Masiello, V., Coliva, A., Salvi, F., Bartolomei, I., Mosca, L., et al. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51112 · Cited by 56 · see citing works

Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders

Gupta, R. V., Advani, D., Yadav, D., Ambasta, R. K., & Kumar, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03502-9 · Cited by 58 · see citing works

Skeletal Muscle-Restricted Expression of Human SOD1 in Transgenic Mice Causes a Fatal ALS-Like Syndrome

Martin, L. J., & Wong, M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.592851 · Cited by 49 · see citing works

p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles

Emanuele, S., Lauricella, M., D’Anneo, A., Carlisi, D., BLASIO, A. D., Liberto, D. D., & Giuliano, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145029 · Cited by 47 · see citing works

One-carbon epigenetics and redox biology of neurodegeneration

Coppedè, F. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.002 · Cited by 47 · see citing works

Role of Oxidative Stress on the Etiology and Pathophysiology of Amyotrophic Lateral Sclerosis (ALS) and Its Relation with the Enteric Nervous System

López‐Pingarrón, L., Almeida, H., Soria-Aznar, M., Reyes-Gonzales, M. C., Terrón, M. P., & García, J. J. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45040217 · Cited by 43 · see citing works

TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells

Ding, Q., Chaplin, J., Morris, M. J., Hilliard, M. A., Wolvetang, E. J., Ng, D. C. H., & Noakes, P. G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.611601 · Cited by 40 · see citing works

Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis

Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works

GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS

Tu, L., Zhang, T.-Z., Zhou, Y.-F., Zhou, Q., Gong, H., Liang, L., Hai, L.-N., You, N.-X., Su, Y., Chen, Y., et al. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.02.016 · Cited by 37 · see citing works

Nutrient effects on motor neurons and the risk of amyotrophic lateral sclerosis

Goncharova, P. S., Davydova, T. K., Popova, T. E., Novitsky, M. A., Petrova, M. M., Gavrilyuk, O. A., Al-Zamil, M., Zhukova, N. G., Nasyrova, R. F., & Shnayder, N. A. (2021) · Nutrients · doi:10.3390/nu13113804 · Cited by 35 · see citing works

Role of Polyphenols on Gut Microbiota and the Ubiquitin-Proteasome System in Neurodegenerative Diseases

Nargeh, H., Aliabadi, F., Ajami, M., & Pazoki–Toroudi, H. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c00923 · Cited by 31 · see citing works

A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Bioactive Peptides

Singh, K., Gupta, J. K., Kumar, S., & Soni, U. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037275221240327042353 · Cited by 30 · see citing works

The NGS technology for the identification of genes associated with the ALS. A systematic review

Pecoraro, V., Mandrioli, J., Carone, C., Chiò, A., Traynor, B. J., & Trenti, T. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13228 · Cited by 24 · see citing works

Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling

Arjmand, B., Hamidpour, S. K., Rabbani, Z. H., Tayanloo-Beik, A., Rahim, F., Aghayan, H. R., & Larijani, B. A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.788462 · Cited by 24 · see citing works

Stem cells in central nervous system diseases: Promising therapeutic strategies

Ying, C., Zhang, J., Zhang, H., Gao, S., Guo, X., Lin, J., Wu, H., & Hong, Y. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114543 · Cited by 22 · see citing works

Nanotheranostics revolutionizing neurodegenerative diseases: From precision diagnosis to targeted therapies

Joshi, R., Missong, H., Mishra, J., Kaur, S., Saini, S., Kandimalla, R. J. L., Reddy, P. H., Babu, A. M., Bhatti, G. K., & Bhatti, J. S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105067 · Cited by 23 · see citing works

In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches

Kukharsky, M. S., Skvortsova, V. I., Бачурин, С. О., & Buchman, V. L. (2020) · Medicinal Research Reviews · doi:10.1002/med.21725 · Cited by 21 · see citing works

FUS gene mutation in amyotrophic lateral sclerosis: a new case report and systematic review

Xiao, X., Li, M., Ye, Z., He, X., Wei, J. S., & Zha, Y. (2023) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2023.2272170 · Cited by 20 · see citing works

Neurodegenerative Marine Algae Bioactive Compounds: A Viable Cure to Treat Amyotrophic Lateral Sclerosis (ALS): A Review

Mani, A., Narayanan, M., & Rajinikanth, V. (2024) · Dubai Medical Journal · doi:10.18502/dmj.v7i3.17735 · Cited by 20 · see citing works

Amyotrophic lateral sclerosis (ALS) and the endocrine system: Are there any further ties to be explored?

Mentis, A. A., Bougea, A. M., & Chrousos, G. P. (2021) · Aging Brain · doi:10.1016/j.nbas.2021.100024 · Cited by 19 · see citing works

Incidence of amyotrophic lateral sclerosis in Sardinia, Italy: age–sex interaction and spatial–temporal variability

Borghero, G., Pierri, V., Vasta, R., Ercoli, T., Primicerio, G. C., Pili, F. M. G., Gigante, A. F., Rocchi, L., Chiò, A., & Defazio, G. (2022) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2022.2041670 · Cited by 19 · see citing works

Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS

Volonté, C., Morello, G., Spampinato, A. G., Amadio, S., Apolloni, S., D’Agata, V., & Cavallaro, S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101121 · Cited by 19 · see citing works

Amyotrophic Lateral Sclerosis and Air Pollutants in the Province of Ferrara, Northern Italy: An Ecological Study

Antonioni, A., Govoni, V., Brancaleoni, L., Donà, A., Granieri, E., Bergamini, M., Gerdol, R., & Pugliatti, M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20085591 · Cited by 18 · see citing works

Machine learning hypothesis-generation for patient stratification and target discovery in rare disease: our experience with Open Science in ALS

Geraci, J., Bhargava, R., Qorri, B., Leonchyk, P., Cook, D. J., Cook, M., Sie, F., & Pani, L. (2024) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2023.1199736 · Cited by 18 · see citing works

The Involvement of RAGE and Its Ligands during Progression of ALS in SOD1 G93A Transgenic Mice

Nowicka, N., Szymanska, K., Juranek, J. K., Zglejc‐Waszak, K., Korytko, A., Załęcki, M., Chmielewska‐Krzesińska, M., Wa̧sowicz, K., & Wojtkiewicz, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042184 · Cited by 18 · see citing works

The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation

Bajc Česnik, A., Motaln, H., & Rogelj, B. (2020) · Cells · doi:10.3390/cells9081791 · Cited by 17 · see citing works

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Madireddy, S., & Madireddy, S. (2019) · Journal of Neuroscience and Neurological Disorders · doi:10.29328/journal.jnnd.1001026 · Cited by 16 · see citing works

Exploring Multiple Sclerosis (MS) and Amyotrophic Lateral Scler osis (ALS) as Neurodegenerative Diseases and their Treatments: A Review Study

Deeb, O., & Nabulsi, M. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200924114827 · Cited by 16 · see citing works

Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review

Yuan, L., Yang, Y., Guo, Y., & Deng, H. (2025) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2025.05.008 · Cited by 15 · see citing works

Neurodegenerative disease and antioxidant biomarkers: A bidirectional Mendelian randomization study

Zhang, Q., Li, Q., Zhao, H., Shu, M., Luo, M., Li, Y., Ding, Y., Shi, S., Cheng, X., & Niu, Q. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1158366 · Cited by 14 · see citing works

Association of Single Nucleotide Polymorphism at rs2275294 in the ZNF512B Gene with Prognosis in Amyotrophic Lateral Sclerosis

Jiang, H., Yang, B., Wang, F., Li, K., Zhu, Y., Liu, B., Ren, H. J., Tian, S., Xu, Y., Pang, A., et al. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08634-y · Cited by 11 · see citing works

Dioxinodehydroeckol: A Potential Neuroprotective Marine Compound Identified by In Silico Screening for the Treatment and Management of Multiple Brain Disorders

Ahmad, F., Sachdeva, P., Sachdeva, B., Singh, G., Soni, H., Tandon, S., Rafeeq, M. M., Alam, M. Z., Baeissa, H. M., & Khalid, M. (2022) · Molecular Biotechnology · doi:10.1007/s12033-022-00629-3 · Cited by 10 · see citing works

Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice

Nowicka, N., Zglejc‐Waszak, K., Juranek, J. K., Korytko, A., Wa̧sowicz, K., Chmielewska‐Krzesińska, M., & Wojtkiewicz, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299567 · Cited by 9 · see citing works

Ensemble-imbalance-based classification for amyotrophic lateral sclerosis prognostic prediction: identifying short-survival patients at diagnosis

Papaiz, F., Júnior, M. E. T. D., Valentim, R. A. D. M., Pinto, R. D. M., de Morais, A. H. F., & Arrais, J. P. (2024) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-024-02484-5 · Cited by 9 · see citing works

Neurologic orphan diseases: Emerging innovations and role for genetic treatments

Kioutchoukova, I. P., Foster, D. T., Thakkar, R. N., Foreman, M. A., Burgess, B. J., Toms, R., Valero, E., & Lucke-Wold, B. P. (2023) · World Journal of Experimental Medicine · doi:10.5493/wjem.v13.i4.59 · Cited by 11 · see citing works

The preferences of people with amyotrophic lateral sclerosis on riluzole treatment in Europe

Ludolph, A. C., Grandjean, H., Reviers, E., Micheli, V. D., Bianchi, C., Cardosi, L., Russ, H., & Silani, V. (2023) · Scientific Reports · doi:10.1038/s41598-023-49424-3 · Cited by 9 · see citing works

Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis

Yang, B., Wu, Y., Wang, Y., Yang, H., Du, B., Wei, D., Xu, X., & Shi, X. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04416-3 · Cited by 9 · see citing works

The rs2619566, rs10260404, and rs79609816 Polymorphisms Are Associated With Sporadic Amyotrophic Lateral Sclerosis in Individuals of Han Ancestry From Mainland China

Zhang, J., Qiu, W., Hu, F., Zhang, X., Deng, Y., Nie, H., & Xu, R. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.679204 · Cited by 9 · see citing works

Locus-specific analysis of Transposable Elements during the progression of ALS in the SOD1G93A mouse model

Valdebenito‐Maturana, B., Arancibia, E., Riadi, G., Tapia, J. C., & Carrasco, M. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258291 · Cited by 9 · see citing works

Protective Effects of Choline against Inflammatory Cytokines and Characterization of Transport in Motor Neuron-like Cell Lines (NSC-34)

Latif, S., & Kang, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112374 · Cited by 8 · see citing works

A computational biology approach to identify potential protein biomarkers and drug targets for sporadic amyotrophic lateral sclerosis

Kumar, R., Malik, M. Z., Thanaraj, T. A., Bagabir, S. A., Haque, S., Tambuwala, M. M., & Haider, S. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110915 · Cited by 7 · see citing works

Oxidative stress and neurodegenerative diseases: Exploring natural antioxidants for therapeutic potential

Doke, R. R., Kallur, S., Suryawanshi, A. P., Utarade, A., Kandalkar, P., Morde, R., & Bhagwat, A. A. (2023) · IP International Journal of Comprehensive and Advanced Pharmacology · doi:10.18231/j.ijcaap.2023.026 · Cited by 6 · see citing works

Resting-State EEG Oscillations in Amyotrophic Lateral Sclerosis (ALS): Toward Mechanistic Insights and Clinical Markers

Chmiel, J., & Stępień–Słodkowska, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020545 · Cited by 7 · see citing works

Amyotrophic lateral sclerosis and the innate immune system: protocol for establishing a biobank and statistical analysis plan

Kjældgaard, A.-L., Pilely, K., Olsen, K. S., Lauritsen, A. Ø., Pedersen, S. W., Møller, K., & Garred, P. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-037753 · Cited by 6 · see citing works

Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank

Jin, W., Boss, J., Bakulski, K. M., Goutman, S. A., Feldman, E. L., Fritsche, L. G., & Mukherjee, B. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12644-2 · Cited by 5 · see citing works

Advancing Future Amyotrophic Lateral Sclerosis Medicines by Incorporating The Patient Voice Into Patient-Centered Holistic Measurement Strategies for Clinical and Real-World Studies: Results from Targeted Literature Reviews

Rofail, D., Chladek, M. R., Williams, B., Patel, N., Nowell, W. B., Karantzoulis, S., & Levy, O. (2025) · Neurology and Therapy · doi:10.1007/s40120-025-00740-y · Cited by 5 · see citing works

Amyotrophic lateral sclerosis

Vacca, V. M. (2020) · Nursing · doi:10.1097/01.nurse.0000662348.31823.44 · Cited by 5 · see citing works

Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry

Raymond, J., Howard, I. M., Berry, J., Larson, T., Horton, D. K., & Mehta, P. (2025) · Brain Sciences · doi:10.3390/brainsci15020143 · Cited by 4 · see citing works

Polyphenols and Stem Cells for Neuroregeneration in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Goyal, S., Seth, B., & Chaturvedi, R. K. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666211115154450 · Cited by 4 · see citing works

Plasma levels of soluble RAGE, AGEs and AOPPs at the early stage of amyotrophic lateral sclerosis: A preliminary study

Juranek, J. K., Osowski, A., Wojtkiewicz, J., & Banach, M. D. (2023) · Polymers in Medicine · doi:10.17219/pim/175544 · Cited by 4 · see citing works

Role of Receptor for Advanced Glycation End-Products in Endometrial Cancer: A Review

Zglejc‐Waszak, K., Jóźwik, M., Thoene, M. A., & Wojtkiewicz, J. (2024) · Cancers · doi:10.3390/cancers16183192 · Cited by 5 · see citing works

Predicting ALS progression using Autoregressive deep learning models

Papaiz, F., Júnior, M. E. T. D., Valentim, R. A. D. M., Fernandes, F. R. D. S., dos Santos, J. P. Q., de Morais, A. H. F., Correia, F. B., & Arrais, J. P. (2025) · Intelligence-Based Medicine · doi:10.1016/j.ibmed.2025.100247 · Cited by 3 · see citing works

The Effect of RAGE-Diaph1 Signaling Inhibition on the Progression of Peripheral Neuropathy in Diabetic Mice

Zglejc‐Waszak, K., Korytko, A., Kordas, B., Pomianowski, A., Lewczuk, B., Wojtkiewicz, J., Wa̧sowicz, K., Babińska, I., Mukherjee, K., & Juranek, J. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211182 · Cited by 3 · see citing works

Cutting-edge treatments in amyotrophic lateral sclerosis: the role of molecular pathogenesis in targeted therapies

Raoufinia, R., Alyari, G., Nia, A. T., Abbaszadegan, M. R., Mahmoudi, A., Shafaeibajestan, S., Saburi, E., Tavakol‐Afshari, J., Hassani, M., Jamali, F., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04781-w · Cited by 3 · see citing works

The influence of environmental risk factors in the development of ALS in the Mediterranean Island of Cyprus

Mitsi, E., Christodoulou, C. C., Nicolaou, P., Christodoulou, K., & Zamba‐Papanicolaou, E. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1264743 · Cited by 3 · see citing works

Examining ALS: reformed PCA and random forest for effective detection of ALS

Alqahtani, A., Alsubai, S., Sha, M., & Dutta, A. K. (2024) · Journal Of Big Data · doi:10.1186/s40537-024-00951-4 · Cited by 3 · see citing works

Hemizygous Granzyme A Mice Expressing the hSOD1G93A Transgene Show Slightly Extended Lifespan

Moreno‐Martínez, L., Santiago, L., de la Torre, M., Calvo, A. C., Pardo, J., & Osta, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113554 · Cited by 3 · see citing works

1,2-Dehydropyrrolizidine Alkaloids: Their Potential as a Dietary Cause of Sporadic Motor Neuron Diseases

Edgar, J. A., Molyneux, R. J., & Colegate, S. M. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00384 · Cited by 2 · see citing works

Headache types and characteristics in patients with Amyotrophic Lateral Sclerosis

Soliman, R., Fahmy, N. A., & Swelam, M. S. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-01987-4 · Cited by 2 · see citing works

Molecular therapeutic strategies in neurodegenerative diseases and injury

Tora, M. S., Texakalidis, P., Greven, A., Faraj, R. R., Gendreau, J. L., Liang, Z., Federici, T., & Boulis, N. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818084-6.00012-x · Cited by 2 · see citing works

Impact of occupational categories on the incidence of amyotrophic lateral sclerosis in Sardinia Island, Italy

Pierri, V., Borghero, G., Pili, F. M. G., Ercoli, T., Gigante, A. F., Lecca, L. I., Vasta, R., Campagna, M., Chiò, A., & Defazio, G. (2022) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2022.2153606 · Cited by 1 · see citing works

Racial and ethnic disparities in ALS: a longitudinal electronic health records study

Kuo, T., Reynolds, T., Chen, L., Park, C., Rascati, K. L., & Godley, P. J. (2025) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864251365001 · Cited by 1 · see citing works

Safety and efficacy of the Atalante exoskeleton in the rehabilitation of French patients with amyotrophic lateral sclerosis: a prospective, monocentric, open, uncontrolled, interventional protocol, EXALS

Trad, G., Lenglet, T., Ledoux, I., Querin, G., Blancho, S., Marchand‐Pauvert, V., Hogrel, J., & Pradat, P. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-109620 · Cited by 1 · see citing works

Targeting metabolic dysfunction in amyotrophic lateral sclerosis: therapeutic potential of GLP-1 receptor agonists

Helal, M. M., Almosilhy, N. A., Abo‐elnour, D. E., Jaffal, R., Allam, E. G., Almosilhy, M. A., Batarseh, S. F., & Meshref, M. M. (2026) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2026.2627901 · Cited by 2 · see citing works

Exploring the Lived Experiences of Individuals with Amyotrophic Lateral Sclerosis (ALS): A Qualitative Study and Conceptual Model of Signs, Symptoms, and Functional Impacts

Nowell, W. B., McGale, N., Levy, O. A., Wilding, S., Heinrich, P., Patel, N. C., Andrews, J. A., & Rofail, D. (2026) · Neurology and Therapy · doi:10.1007/s40120-026-00895-2 · Cited by 1 · see citing works

Mortality From Amyotrophic Lateral Sclerosis in Finland 1987–2022

Laine, M., Raitanen, J. A., & Auvinen, A. P. (2026) · European Journal of Neurology · doi:10.1111/ene.70586 · Cited by 1 · see citing works

Amyotrophic lateral sclerosis

Vacca, V. M. (2019) · Nursing Critical Care · doi:10.1097/01.ccn.0000612832.74020.6e · Cited by 1 · see citing works

Emerging Drugs for Amyotrophic Lateral Sclerosis

Boucher, M., & Mierzwinski‐Urban, M. (2022) · Canadian Journal of Health Technologies · doi:10.51731/cjht.2022.274 · Cited by 1 · see citing works

Fertility Does Not Alter Disease Progression in ALS Patients of Childbearing Age: A Three Centers Retrospective Analysis in Southern China

Yang, B., Huang, S., Zheng, Y., Hou, X., Lin, J., Peng, Y., Du, B., & Yao, X. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.895321 · Cited by 1 · see citing works

Esclerose Lateral Amiotrófica

Tozani, F. D. D., & de Siqueira, E. C. (2023) · Revista Eletrônica Acervo Médico · doi:10.25248/reamed.e12006.2023 · Cited by 1 · see citing works

Dynamic analysis of muscles and the internal structure of the peripheral nerve as biomarkers of amyotrophic lateral sclerosis: A pilot study with ultrasound imaging

López-Navarro, C., Serrano-Valero, M., Fages-Caravaca, E. M., Martínez-Payá, J. J., del Baño-Aledo, M. E., & Ríos-Díaz, J. (2023) · Neurología (English Edition) · doi:10.1016/j.nrleng.2021.10.007 · Cited by 1 · see citing works

Amyotrophic Lateral Sclerosis: When Nerve Cells Run Out of Power

Quatorze, M., Silva, F. S. G., Duarte, A. I., Cardoso, J. A., Caetano, C., Ramalho‐Santos, J., Oliveira, P. J., & Amaral, S. V. (2023) · Frontiers for Young Minds · doi:10.3389/frym.2023.974736 · Cited by 1 · see citing works

Effect of Leptin Treatment in a Mouse Model of Tdp-43 ProteinopathyPreprint

Ferrer-Donato, Á., Contreras, A., Fernández, P., & Fernández-Martos, C. M. (2021) · Preprints.org · doi:10.20944/preprints202104.0041.v1 · Cited by 1 · see citing works

Animal Models of ALS – Current and Future Perspectives

Déziel, R., Marriott, A. L., Kay, D. G., & Gill, D. A. (2021) · Wiley eBooks · doi:10.1002/9781119745532.ch8

Análisis dinámico muscular y de la estructura interna del nervio periférico como biomarcadores para la esclerosis lateral amiotrófica: estudio piloto mediante ecografía

López-Navarro, C., Serrano-Valero, M., Fages-Caravaca, E. M., Martínez-Payá, J. J., del Baño-Aledo, M. E., & Ríos-Díaz, J. (2022) · Neurología · doi:10.1016/j.nrl.2021.10.008

Analysis of STMN2 CA repeats in italian ALS patients shows no association

Doronzio, P. N., Lattante, S., Marangi, G., Martello, F., Conte, A., Bisogni, G., Bernardo, D., Patanella, A. K., Meleo, E., Zollino, M., et al. (2022) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2022.2102430

Electrophysiological Changes of Motor Neurons in a hESC Model of Sporadic and Familial Amyotrophic Lateral Sclerosis

Moon, E. F. (2022) · doi:10.14418/wes01.2.363

The role of TDP-43 protein in amyotrophic lateral sclerosis

Włodarczyk, P., Witczak, M., Gajewska, A., Chady, T., & Piotrowski, I. (2022) · Journal of Medical Science · doi:10.20883/medical.e710

No cause-effect relationships between psychiatric disorders and amyotrophic lateral sclerosis: a bidirectional Mendelian randomization studyPreprint

Huang, Z., Wen, Y., Tian, Y., Zou, H., Chen, A., Chen, J., Xie, H., Chen, J., Xiong, F., & Gao, X. (2023) · Research Square · doi:10.21203/rs.3.rs-2573779/v1

Effect of Pesticides on Nervous System or Neural Health

Chavan, S., & Mehta, M. (2022) · Asian Pacific Journal of Health Sciences · doi:10.21276/apjhs.2022.9.4s.49

Amyotrophic Lateral Sclerosis Patients’ Preferences on Riluzole Treatment in EuropePreprint

Ludolph, A. C., Grandjean, H., Reviers, E., Cardosi, L., Russ, H., & Silani, V. (2023) · Research Square · doi:10.21203/rs.3.rs-2701278/v1

Eficácia de intervenções imunomoduladoras para o tratamento da Esclerose Lateral Amiotrófica (ELA)

Neto, A. C. T., Macedo, G. M. L. B., Carnib, L. A. D. A., Carvalho, R. M. D., Rodrigues, É. P. D. S. M., Lima, J. B., Barreira, D. L. D. C., Maia, F. S. C. D. V., Vilarinho, A. V. D. S., Diniz, E. M. S., et al. (2023) · Brazilian Journal of Health Review · doi:10.34119/bjhrv6n3-141

Mesenchymal Stem Cells and their Applications against Neurodegenerative Disorders

Bahrini, I. (2023) · Springer eBooks · doi:10.1007/978-981-99-3848-3_5

Theme 05 - Human Cell Biology and Pathology

(2023) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2023.2260195

Association between DPP6 gene rs10260404 polymorphism and increased risk of sporadic amyotrophic lateral sclerosis (sALS): a meta-analysis

Miah, M. M., Zinnia, M. A., Tabassum, N., & Islam, A. B. M. M. K. (2024) · Neurological Sciences · doi:10.1007/s10072-024-07401-2

Rehabilitación basada en ejercicio físico en pacientes con esclerosis lateral amiotrófica

Gaitán-Caicedo, S. A., & Ruíz, D. M. C. (2024) · Revista Colombiana de Medicina Física y Rehabilitación · doi:10.28957/rcmfr.413

Gene Therapy for Neurodegeneration in Glaucoma

Karl, J. J., & Tseng, H. C. (2024) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-981-99-4436-1_21

Effect of Environmental Personal Exposure on Amyotrophic Lateral Sclerosis Disease Progression

Bosoni, P., Aiello, I., Manera, U., Gromicho, M., Alves, I., Camillo, B. D., de Carvalho, M. A., Chiò, A., Bellazzi, R., & Dagliati, A. (2025) · IEEE International Conference on Healthcare Informatics (ICHI) · doi:10.1109/ichi64645.2025.00029

A Qualitive Investigation of Geographic Disparities in Genetic Testing and Care Access for Amyotrophic Lateral Sclerosis: Insights From Patient Journey Mapping

Sethi, N., Levy, O. A., Richardson, A., Harari, O., & Sellati, R. (2026) · Patient Preference and Adherence · doi:10.2147/ppa.s566747

Corticospinal propagation of full-length TDP-43 toxicity drives brain-to-muscle pathologyPreprint

Marongiu, J., Crippa, V., Marzi, I., Porcedda, C., Gagliani, M. C., Brivio, A., Palmas, M. F., Etzi, M., Serra, M., Aminzadeh, K., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10681556/v1

Identifying Potential Risk Factors for Developing Amyotrophic Lateral Sclerosis

Chiò, A., & Traynor, B. J. (2011) · Neurodegenerative Disease Management · doi:10.2217/nmt.11.64 · Cited by 7 · see citing works

Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies

Gittings, L. M., & Sattler, R. (2020) · Faculty Reviews · doi:10.12703/b/9-12 · Cited by 26 · see citing works

Progress in Amyotrophic Lateral Sclerosis Gene Discovery

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