The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis
Open accessAbstract
Whether the gut microbiome in obesity is characterized by lower diversity and altered composition at the phylum or genus level may be more accurately investigated using high-throughput sequencing technologies. We conducted a systematic review in PubMed and Embase including 32 cross-sectional studies assessing the gut microbiome composition by high-throughput sequencing in obese and non-obese adults. A significantly lower alpha diversity (Shannon index) in obese versus non-obese adults was observed in nine out of 22 studies, and meta-analysis of seven studies revealed a non-significant mean difference (−0.06, 95% CI −0.24, 0.12, I2 = 81%). At the phylum level, significantly more Firmicutes and fewer Bacteroidetes in obese versus non-obese adults were observed in six out of seventeen, and in four out of eighteen studies, respectively. Meta-analyses of six studies revealed significantly higher Firmicutes (5.50, 95% 0.27, 10.73, I2 = 81%) and non-significantly lower Bacteroidetes (−4.79, 95% CI −10.77, 1.20, I2 = 86%). At the genus level, lower relative proportions of Bifidobacterium and Eggerthella and higher Acidaminococcus, Anaerococcus, Catenibacterium, Dialister, Dorea, Escherichia-Shigella, Eubacterium, Fusobacterium, Megasphera, Prevotella, Roseburia, Streptococcus, and Sutterella were found in obese versus non-obese adults. Although a proportion of studies found lower diversity and differences in gut microbiome composition in obese versus non-obese adults, the observed heterogeneity across studies precludes clear answers.
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ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions
Sterne, J. A., Hernán, M. A., Reeves, B. C., Savović, J., Berkman, N. D., Viswanathan, M., Henry, D., Altman, D. G., Ansari, M. T., Boutron, I., et al. (2016) · BMJ · doi:10.1136/bmj.i4919 · Cited by 20,329
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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
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The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?
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Cited by
Heinzel, S., Jureczek, J., Kainulainen, V., Nieminen, A. I., Suenkel, U., von Thaler, A.-K., Kaleta, C., Eschweiler, G. W., Brockmann, K., Aho, V. T. E., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-63893-0 · Cited by 36
Mishima, M. D. V., Da Silva, B. P., Gomes, M. J. C., Toledo, R. C. L., Mantovani, H. C., José, V. P. B. D. S., Costa, N. M. B., Tako, E., & Martino, H. S. D. (2022) · Nutrients · doi:10.3390/nu14224924 · Cited by 23
Tao, W., Yu, Y., Tan, D., Huang, X., Huang, J., Lin, C., & Yu, R. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1603442 · Cited by 9
Dumitru, C. N., Dumitru, A. O., Goroftei, L., Niculet, E., Ignat, M. D., Baroiu, L., Nechita, A., & Balan, G. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18060651 · Cited by 4
Metadata
- Authors
- Pinart, M., Dötsch, A., Schlicht, K., Laudes, M., Bouwman, J., Forslund, S. K., Pischon, T., & Nimptsch, K.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-12-21
- Volume
- 14
- Issue
- 1
- Pages
- 12
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W4200567941
- Cited by
- 398
- References
- 78
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pinart, M., Dötsch, A., Schlicht, K., Laudes, M., Bouwman, J., Forslund, S. K., Pischon, T., & Nimptsch, K. (2021). Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis. Nutrients. https://doi.org/10.3390/nu14010012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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