Inonotus hispidus protects against Hyperlipidemia by inhibiting oxidative stress and inflammation through Nrf2/NF-κB Signaling in high fat diet fed mice
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(Bull.: Fr.) P. Karst (IH) is an edible and medicinal parasitic mushroom. In this study, after a systematic analysis of its nutritional ingredients, the regulatory effects of IH on lipid metabolism were investigated in mice fed a high-fat diet (HFD). In HFD-fed mice, IH reversed the pathological state of the liver and the three types of fat and significantly decreased the levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), and leptin (LEP) and increased the level of high-density liptein cholesterol (HDL-C) in serum. Meanwhile, IH ameliorated liver damage by reducing alanine aminotransferase (ALT), aspartate aminotransferase (AST), interleukin (IL)-1β, IL-6, tumor necrosis factor-alpha (TNF-α), and plasminogen activator inhibitor-1 (PAI-1) levels in the liver and serum. Compared with HFD-fed mice, IH significantly modulated the gut microbiota, changed the relative abundances of microflora at different taxonomic levels, and regulated lipid levels. The results showed that 30 differential lipids were found. Results from Western blotting confirmed that IH regulated the nuclear factor erythroid-2 related factor 2 (Nrf2)/nuclear factor-kappa B (NF-κB) signaling pathway and oxidative stress. This study aimed to provide experimental evidence for the applicability of IH in obesity treatment.
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An edible therapeutic fungus was harnessed to treat mice subjected to a high-fat diet, resulting in reductions in the levels of alanine aminotransferase and aspartate aminotransferase in both the liver and blood, concomitant with alterations in the prevalence of microbial populations in murine subjects; by mitigating oxidative stress and inflammation through Nrf2/NF-κB signaling, this intervention
“Previously, an edible therapeutic fungus was harnessed to treat mice subjected to a high-fat diet, resulting in reductions in the levels of alanine aminotransferase and aspartate aminotransferase in both the liver and blood, concomitant with alterations in the prevalence of microbial populations in murine subjects. By mitigating oxidative stress and inflammation through Nrf2/NF-κB signaling, this”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Zhang et al., 2022
The Results (§3.3; page not provided) report lower ALT and AST in the liver and lower AST in serum after Inonotus hispidus treatment, but explicitly state that it did not affect serum ALT. The Results also report altered gut microbial abundances (§3.4) and reduced oxidative-stress and inflammatory markers alongside changes in Nrf2/NF-κB signaling (§3.6). Thus, the claim is supported except for the asserted reduction of both enzymes in blood. (LLM, conf=0.94)
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- Authors
- Zhang, Y., Hao, J., Liu, Z., Li, Z., Teng, L., & Wang, D.
- Affiliations
- Jilin University (CN)
- Corresponding author
- Wang, Di
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-08-24
- Volume
- 14
- Issue
- 17
- Pages
- 3477
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC9460493
- OpenAlex
- W4293221166
- Cited by
- 36
- References
- 76
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 3
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science and Technology Development Project in Jilin Province, China (20200708037YY, 20210401088YY, JJKH20211227KJ, CARS-20-08B, 2020C036-5, 2021C035-6, 2019C050-8)
- Science and Technology Research Project from the Education Department of Jilin Province in China (20200708037YY, 20210401088YY, JJKH20211227KJ, CARS-20-08B, 2020C036-5, 2021C035-6, 2019C050-8)
- China Agriculture Research System of MOF and MARA 421 (20200708037YY, 20210401088YY, JJKH20211227KJ, CARS-20-08B, 2020C036-5, 2021C035-6, 2019C050-8)
- Industrial Technology Research and Development Program of Jilin Province (20200708037YY, 20210401088YY, JJKH20211227KJ, CARS-20-08B, 2020C036-5, 2021C035-6, 2019C050-8)
- Project for Innovation Capacity Building of Jilin Province in China (20200708037YY, 20210401088YY, JJKH20211227KJ, CARS-20-08B, 2020C036-5, 2021C035-6, 2019C050-8)
- Topics
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- Inonotus hispidus, hyperlipidemia, high-fat diet, lipid metabolism, oxidative stress, inflammation, Nrf2 signaling, NF-κB signaling, gut microbiota, differential lipids, obesity, liver injury, cholesterol, triglycerides
- MeSH terms
- Inonotus, Animals, Cholesterol, Hyperlipidemias, Inflammation, Liver, Obesity, Signal Transduction, NF-kappa B, Oxidative Stress, NF-E2-Related Factor 2, Mice, Diet, High-Fat
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