Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
Open accessAbstract
Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it’s hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3–V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.
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A relevant contribution of gut microbiota is not restricted to neuroinflammatory and psychiatric disorders but also extends to brain development.
“Moreover, a relevant contribution of gut microbiota is not only restricted to neuroinflammatory and psychiatric disorders (23–32) but also to brain development (13).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [25]
Multiple sclerosis patients with active disease have an altered microbiota compared to patients in the remission phase, who have a microbiota more similar to healthy controls.
“Interestingly, even MS patients with active disease have an altered microbiota compared to patients in the remission phase, which in turn have a microbiota more similar to healthy controls (25, 134–138).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [25]
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Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · see citing works
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969 · see citing works
Self-citationInduction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works
Reagent and laboratory contamination can critically impact sequence-based microbiome analyses
Salter, S. J., Cox, M. J., Turek, E. M., Calus, S. T., Cookson, W. O., Moffatt, M. F., Turner, P., Parkhill, J., Loman, N. J., & Walker, A. W. (2014) · BMC Biology · doi:10.1186/s12915-014-0087-z · Cited by 3,463 · see citing works
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220 · see citing works
The gut microbiota influences blood-brain barrier permeability in mice
Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530 · see citing works
Immunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149 · see citing works
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works
Meta‐analyses of human gut microbes associated with obesity and IBD
Walters, W. A., Xu, Z., & Knight, R. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.09.039 · Cited by 836 · see citing works
IBD—what role do Proteobacteria play?
Mukhopadhya, I., Hansen, R., El-Omar, E. M., & Hold, G. L. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.14 · Cited by 810 · see citing works
Miyake, S., Kim, S., Suda, W., Oshima, K., Nakamura, M., Matsuoka, T., Chihara, N., Tomita, A., Sato, W., Kim, S.-W., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137429 · Cited by 809 · see citing works
Murri, M., Leiva, I., Gómez‐Zumaquero, J. M., Tinahones, F. J., Cardona, F., Soriguer, F., & Queipo‐Ortuño, M. I. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-46 · Cited by 767 · see citing works
The bile acid receptor FXR is a modulator of intestinal innate immunity
Vavassori, P., Mencarelli, A., Renga, B., Distrutti, E., & Fiorucci, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803978 · Cited by 655 · see citing works
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
Jenq, R. R., Ubeda, C., Taur, Y., Menezes, C. C., Khanin, R., Dudakov, J. A., Liu, C., West, M. L., Singer, N. V., Equinda, M. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112408 · Cited by 626 · see citing works
Bajaj, J. S., Hylemon, P. B., Ridlon, J. M., Heuman, D. M., Daita, K., White, M. B., Monteith, P., Noble, N. A., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00152.2012 · Cited by 525 · see citing works
Gut microbiota in multiple sclerosis: possible influence of immunomodulators
Cantarel, B. L., Waubant, E., Chehoud, C., Kuczynski, J., DeSantis, T. Z., Warrington, J., Venkatesan, A., Fraser, C. M., & Mowry, E. M. (2015) · Journal of Investigative Medicine · doi:10.1097/jim.0000000000000192 · Cited by 409 · see citing works
Hygiene Hypothesis and Autoimmune Diseases
Rook, G. A. W. (2011) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-011-8285-8 · Cited by 403 · see citing works
Environmental factors in multiple sclerosis
Ascherio, A. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.865866 · Cited by 331 · see citing works
Increased Risk for Demyelinating Diseases in Patients With Inflammatory Bowel Disease
Gupta, G., Gelfand, J. M., & Lewis, J. D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.022 · Cited by 266 · see citing works
Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration
Spence, R. D., & Voskuhl, R. R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.12.001 · Cited by 259 · see citing works
Plant Phenylpropanoids as Emerging Anti-Inflammatory Agents
Korkina, L. G., Kostyuk, V. A., Luca, C. D., & Pastore, S. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955711796575489 · Cited by 156 · see citing works
Labbé, A., Ganopolsky, J. G., Martoni, C., Prakash, S., & Jones, M. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115175 · Cited by 144 · see citing works
Yacyshyn, B., Meddings, J. B., Sadowski, D. C., & Bowen-Yacyshyn, M. B. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02100148 · Cited by 116 · see citing works
Concurrence of Inflammatory Bowel Disease and Multiple Sclerosis
Kimura, K. B., Hunter, S. F., Thollander, M. S., Loftus, E. V., Melton, L. J., O’Brien, P. C., Rodriguez, M., & Phillips, S. F. (2000) · Mayo Clinic Proceedings · doi:10.4065/75.8.802 · Cited by 111 · see citing works
Self-citationIM-TORNADO: A Tool for Comparison of 16S Reads from Paired-End Libraries
Jeraldo, P., Kalari, K. R., Chen, X., Bhavsar, J., Mangalam, A. K., White, B. A., Nelson, H., Kocher, J.-P. A., & Chia, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114804 · Cited by 99 · see citing works
Self-citationMoore, S. M., Khalaj, A. J., Kumar, S., Winchester, Z., Yoon, J., Yoo, T. S., Martinez‐Torres, L., Yasui, N., Katzenellenbogen, J. A., & Tiwari-Woodruff, S. K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411294111 · Cited by 97 · see citing works
The hygiene hypothesis and multiple sclerosis
Fleming, J. O., & Fábry, Z. (2007) · Annals of Neurology · doi:10.1002/ana.21092 · Cited by 79 · see citing works
Decoding multiple sclerosis: an update on genomics and future directions
Oksenberg, J. R. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.865867 · Cited by 66 · see citing works
Moussa, L., Bézirard, V., Salvador–Cartier, C., Bacquie, V., Lencina, C., Lévêque, M., Braniste, V., Ménard, S., Théodorou, V., & Houdeau, É. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049547 · Cited by 62 · see citing works
Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review
Nusrat, S., Gulick, E. E., Levinthal, D. J., & Bielefeldt, K. (2012) · ISRN Neurology · doi:10.5402/2012/376023 · Cited by 53 · see citing works
Schogor, A. L. B., Huws, S., dos Santos, G. T., Scollan, N. D., Hauck, B. D., Winters, A. L., Kim, E. J., & Petit, H. V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087949 · Cited by 46 · see citing works
Complete Genome Sequence of the Equol-Producing Bacterium Adlercreutzia equolifaciens DSM 19450 T
Toh, H., Oshima, K., Suzuki, T., Hattori, M., & Morita, H. (2013) · Genome Announcements · doi:10.1128/genomea.00742-13 · Cited by 29 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Confavreux C., Hutchinson M., Hours M. M., Cortinovis-Tourniaire P. & Moreau T. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group. The New England journal of medicine 339, 285– 291 (1998). 9682040
Cited by
Sorted by citations
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works
“Among its etiological factors, the imbalance between pro and anti-inflammatory cells in the immune system seems to play an important role, which is highly affected by the gut microbiota composition and can be aggravated by dysbiosis (104, 176, 177).”
BackgroundInteractions between the microbiota, immune and nervous systems in health and disease
Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4476 · Cited by 1,900 · see citing works
Dysbiosis and the immune system
Levy, M., Kolodziejczyk, A. A., Thaiss, C. A., & Elinav, E. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.7 · Cited by 1,769 · see citing works
The gut microbiome in neurological disorders
Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336 · see citing works
Inflammation in CNS neurodegenerative diseases
Stephenson, J., Nutma, E., van der Valk, P., & Amor, S. (2018) · Immunology · doi:10.1111/imm.12922 · Cited by 966 · see citing works
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota
Cignarella, F., Cantoni, C., Ghezzi, L., Salter, A., Dorsett, Y., Chen, L., Phillips, D., Weinstock, G. M., Fontana, L., Cross, A. H., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.006 · Cited by 568 · see citing works
The gut microbiome in human neurological disease: A review
Tremlett, H., Bauer, K. C., Appel‐Cresswell, S., Finlay, B. B., & Waubant, E. (2017) · Annals of Neurology · doi:10.1002/ana.24901 · Cited by 535 · see citing works
Differences in gut microbiota profile between women with active lifestyle and sedentary women
Bressa, C., Bailén-Andrino, M., Pérez-Santiago, J., González-Soltero, R., Pérez, M., Montalvo-Lominchar, M. G., Maté-Muñoz, J. L., Domínguez, R., Moreno, D., & Larrosa, M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171352 · Cited by 501 · see citing works
Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease
Qian, Y., Yang, X., Xu, S., Wu, C., Song, Y., Qin, N., Chen, S.-D., & Xiao, Q. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.016 · Cited by 409 · see citing works
The progress of gut microbiome research related to brain disorders
Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works
Self-citationFecal Microbiota Transplantation in Neurological Disorders
Vendrik, K. E. W., Ooijevaar, R. E., de Jong, P. R. C., Laman, J. D., van Oosten, B. W., van Hilten, J. J., Ducarmon, Q. R., Keller, J. J., Kuijper, E. J., & Contarino, M. F. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00098 · Cited by 413 · see citing works
Haran, J. P., Bhattarai, S. K., Foley, S. E., Dutta, P., Ward, D. V., Bucci, V., & McCormick, B. A. (2019) · mBio · doi:10.1128/mbio.00632-19 · Cited by 412 · see citing works
Kim, C. H. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-00987-1 · Cited by 420 · see citing works
Cosorich, I., Dalla-Costa, G., Sorini, C., Ferrarese, R., Messina, M. J., Dolpady, J., Radice, E., Mariani, A., Testoni, P. A., Canducci, F., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700492 · Cited by 338 · see citing works
Connecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex
Rizzetto, L., Fava, F., Tuohy, K. M., & Selmi, C. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.05.008 · Cited by 331 · see citing works
Host Genetics and Gut Microbiome: Challenges and Perspectives
Kurilshikov, A., Wijmenga, C., Fu, J., & Zhernakova, A. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.06.003 · Cited by 309 · see citing works
Changes of colonic bacterial composition in Parkinson's disease and other neurodegenerative diseases
Gerhardt, S., & Mohajeri, M. H. (2018) · Nutrients · doi:10.3390/nu10060708 · Cited by 298 · see citing works
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health
De Filippis, F., Pasolli, E., & Ercolini, D. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa015 · Cited by 303 · see citing works
Pellegrini, C., Antonioli, L., Colucci, R., Blandizzi, C., & Fornai, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1856-5 · Cited by 270 · see citing works
Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet
Zhang, Y., Zhou, S., Zhou, Y., Yu, L., Zhang, L., & Wang, Y. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.06.015 · Cited by 269 · see citing works
Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease
Mangalam, A., Shahi, S. K., Luckey, D., Karau, M., Marietta, E., Luo, N., Choung, R. S., Ju, J., Sompallae, R., Gibson-Corley, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.031 · Cited by 266 · see citing works
Self-citationGut microorganisms act together to exacerbate inflammation in spinal cords
Miyauchi, E., Kim, S.-W., Suda, W., Kawasumi, M., Onawa, S., Taguchi-Atarashi, N., Morita, H., Taylor, T. D., Hattori, M., & Ohno, H. (2020) · Nature · doi:10.1038/s41586-020-2634-9 · Cited by 268 · see citing works
Butyrate suppresses demyelination and enhances remyelination
Chen, T., Noto, D., Hoshino, Y., Mizuno, M., & Miyake, S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1552-y · Cited by 229 · see citing works
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
The role of the gut microbiota in multiple sclerosis
Correale, J., Hohlfeld, R., & Baranzini, S. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00697-8 · Cited by 207 · see citing works
The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis
Freedman, S. N., Shahi, S. K., & Mangalam, A. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0588-x · Cited by 168 · see citing works
Self-citationIntestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases
Opazo, M. C., Ortega-Rocha, E. M., Coronado-Arrázola, I., Bonifaz, L. C., Boudin, H., Neunlist, M., Bueno, S. M., Kalergis, A. M., & Riedel, C. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00432 · Cited by 179 · see citing works
Microbiota-gut brain axis involvement in neuropsychiatric disorders
Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., et al. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1638763 · Cited by 177 · see citing works
Investigation of probiotics in multiple sclerosis
Tankou, S. K., Regev, K., Healy, B. C., Cox, L. M., Tjon, E., Kivisakk, P., Vanande, I. P., Cook, S., Gandhi, R., Glanz, B., et al. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458517737390 · Cited by 156 · see citing works
Sodium in the microenvironment regulates immune responses and tissue homeostasis
Müller, D. N., Wilck, N., Haase, S., Kleinewietfeld, M., & Linker, R. A. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0113-4 · Cited by 149 · see citing works
A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis
Di Gioia, D., Bozzi Cionci, N., Baffoni, L., Amoruso, A., Pane, M., Mogna, L., Gaggìa, F., Lucenti, M. A., Bersano, E., Cantello, R., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01607-9 · Cited by 151 · see citing works
Weis, S., Schwiertz, A., Unger, M. M., Becker, A., Faßbender, K., Ratering, S., Kohl, M., Schnell, S., Schäfer, K.-H., & Egert, M. (2019) · npj Parkinson s Disease · doi:10.1038/s41531-019-0100-x · Cited by 145 · see citing works
The Gut-Brain Axis in Inflammatory Bowel Disease—Current and Future Perspectives
Günther, C., Rothhammer, V., Karow, M., Neurath, M., & Winner, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168870 · Cited by 123 · see citing works
Pröbstel, A.-K., & Baranzini, S. E. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0587-y · Cited by 110 · see citing works
The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
Winek, K., Dirnagl, U., & Meisel, A. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0475-x · Cited by 108 · see citing works
Chen, H., Ma, X., Liu, Y., Ma, L., Chen, Z., Lin, X., Si, L., Ma, X., & Chen, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01662 · Cited by 96 · see citing works
Self-citationProtection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis
Li, K., Wei, S., Hu, L., Yin, X., Mai, Y., Jiang, C., Peng, X., Cao, X., Huang, Z., Zhou, H., et al. (2020) · Mediators of Inflammation · doi:10.1155/2020/2058272 · Cited by 92 · see citing works
An investigation into physical frailty as a link between the gut microbiome and cognitive health
Verdi, S., Jackson, M. A., Beaumont, M., Bowyer, R. C. E., Bell, J. T., Spector, T. D., & Steves, C. J. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00398 · Cited by 82 · see citing works
Th17 cell pathogenicity in autoimmune disease
Park, E., & Ciofani, M. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01535-9 · Cited by 75 · see citing works
Microbial Immuno-Communication in Neurodegenerative Diseases
Main, B. S., & Minter, M. R. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00151 · Cited by 68 · see citing works
Cataldi, S., Bonavolontà, V., Poli, L., Clemente, F. M., De Candia, M., Carvutto, R., Silva, A. F., Badicu, G., Greco, G., & Fischetti, F. (2022) · Biology · doi:10.3390/biology11030479 · Cited by 68 · see citing works
Breaking down the gut microbiome composition in multiple sclerosis
Budhram, A., Parvathy, S., Kremenchutzky, M., & Silverman, M. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458516682105 · Cited by 51 · see citing works
Stanisavljević, S., Čepić, A., Bojić, S., Veljović, K., Mihajlović, S., Đedović, N., Jevtić, B., Momčilović, M., Lazarević, M., Mostarica Stojković, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37505-7 · Cited by 43 · see citing works
McMurran, C. E., Guzman de la Fuente, A., Penalva, R., Ben Menachem-Zidon, O., Dombrowski, Y., Falconer, J., Gonzalez, G. A., Zhao, C., Krause, F. N., Young, A. M. H., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905787116 · Cited by 39 · see citing works
Zhang, Y., Hao, J., Liu, Z., Li, Z., Teng, L., & Wang, D. (2022) · Nutrients · doi:10.3390/nu14173477 · Cited by 36 · see citing works
Nam, B., Kim, S. A., Park, S. D., Kim, H. J., Kim, J. S., Bae, C. H., Kim, J. Y., Nam, W., Lee, J. L., & Sim, J. H. (2020) · PLOS ONE · doi:10.1371/journal.pone.0231268 · Cited by 35 · see citing works
Gut microbiota in multiple sclerosis and animal models
Schumacher, S. M., Doyle, W. J., Hill, K., & Ochoa‐Repáraz, J. (2025) · The FEBS Journal · doi:10.1111/febs.17161 · Cited by 21 · see citing works
- Authors
- Chen, J., Chia, N., Kalari, K. R., Yao, J. Z., Novotna, M., Paz Soldan, M. M., Luckey, D. H., Marietta, E. V., Jeraldo, P. R., Chen, X., Weinshenker, B. G., Rodriguez, M., Kantarci, O. H., Nelson, H., Murray, J. A., & Mangalam, A. K.
- Affiliations
- Mayo Clinic (US)
- University of Iowa (US)
- Corresponding author
- Mangalam, Ashutosh K.
- ORCID
- Venue
- Scientific Reports
- Published
- 2016-06-27
- Volume
- 6
- Issue
- 1
- Pages
- 28484-28484
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4921909
- OpenAlex
- W2461582275
- Cited by
- 933
- References
- 32
- Citations by year
- 2026: 35 · 2025: 74 · 2024: 122 · 2023: 81 · 2022: 106 · 2021: 138 · 2020: 109 · 2019: 98 · 2018: 82 · 2017: 77 · 2016: 9
- FWCI
- 45.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Iowa Research Online (The University of Iowa) (submittedVersion)
- Iowa Research Online (University of Iowa) (submittedVersion, cc-by)
- Funders
- Mayo Clinic
- Center for Individualized Medicine, Mayo Clinic
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- multiple sclerosis, relapsing-remitting multiple sclerosis, gut microbiota, fecal microbiota, dysbiosis, microbial community composition, 16S rRNA gene sequencing, Haemophilus, Blautia, Dorea, Parabacteroides, Adlercreutzia, Prevotella, environmental risk factors, disease etiopathogenesis
- MeSH terms
- Gastrointestinal Microbiome, Adult, Female, Humans, Male, Multiple Sclerosis, RNA, Ribosomal, 16S, Gastrointestinal Tract, Microbiota, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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