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Genetic Determinants of 25-Hydroxyvitamin D Concentrations and Their Relevance to Public Health

Hyppönen, Elina, Vimaleswaran, Karani S., Zhou, Ang·2022·Nutrients
DOI 10.3390/nu14204408
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Abstract

Twin studies suggest a considerable genetic contribution to the variability in 25-hydroxyvitamin D (25(OH)D) concentrations, reporting heritability estimates up to 80% in some studies. While genome-wide association studies (GWAS) suggest notably lower rates (13–16%), they have identified many independent variants that associate with serum 25(OH)D concentrations. These discoveries have provided some novel insight into the metabolic pathway, and in this review we outline findings from GWAS studies to date with a particular focus on 35 variants which have provided replicating evidence for an association with 25(OH)D across independent large-scale analyses. Some of the 25(OH)D associating variants are linked directly to the vitamin D metabolic pathway, while others may reflect differences in storage capacity, lipid metabolism, and pathways reflecting skin properties. By constructing a genetic score including these 25(OH)D associated variants we show that genetic differences in 25(OH)D concentrations persist across the seasons, and the odds of having low concentrations (<50 nmol/L) are about halved for individuals in the highest 20% of vitamin D genetic score compared to the lowest quintile, an impact which may have notable influences on retaining adequate levels. We also discuss recent studies on personalized approaches to vitamin D supplementation and show how Mendelian randomization studies can help inform public health strategies to reduce adverse health impacts of vitamin D deficiency.

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Research works printed but not linked: 94

  1. Hunter, 2001, Genetic Contribution to Bone Metabolism, Calcium Excretion, and Vitamin D and Parathyroid Hormone Regulation, J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res., 16, 371, 10.1359/jbmr.2001.16.2.371 · DOI
  2. Orton, 2008, Evidence for Genetic Regulation of Vitamin D Status in Twins with Multiple Sclerosis, Am. J. Clin. Nutr., 88, 441, 10.1093/ajcn/88.2.441 · DOI
  3. Shea, 2009, Genetic and Non-Genetic Correlates of Vitamins K and D, Eur. J. Clin. Nutr., 63, 458, 10.1038/sj.ejcn.1602959 · DOI
  4. Wjst, 2007, A Genome-Wide Linkage Scan for 25-OH-D(3) and 1,25-(OH)2-D3 Serum Levels in Asthma Families, J. Steroid Biochem. Mol. Biol., 103, 799, 10.1016/j.jsbmb.2006.12.053 · DOI
  5. Berry, 2011, Determinants of Vitamin D Status: Focus on Genetic Variations, Curr. Opin. Nephrol. Hypertens., 20, 331, 10.1097/MNH.0b013e328346d6ba · DOI
  6. Jablonski, 2018, The Roles of Vitamin D and Cutaneous Vitamin D Production in Human Evolution and Health, Int. J. Paleopathol., 23, 54, 10.1016/j.ijpp.2018.01.005 · DOI
  7. Ahn, 2010, Genome-Wide Association Study of Circulating Vitamin D Levels, Hum. Mol. Genet., 19, 2739, 10.1093/hmg/ddq155 · DOI · Paper page
  8. Engelman, 2010, Genome-Wide Association Study of Vitamin D Concentrations in Hispanic Americans: The IRAS Family Study, J. Steroid Biochem. Mol. Biol., 122, 186, 10.1016/j.jsbmb.2010.06.013 · DOI
  9. Wang, 2010, Common Genetic Determinants of Vitamin D Insufficiency: A Genome-Wide Association Study, Lancet, 376, 180, 10.1016/S0140-6736(10)60588-0 · DOI · Paper page
  10. Lange, 2012, Genome-Wide Association Analysis of Circulating Vitamin D Levels in Children with Asthma, Hum. Genet., 131, 1495, 10.1007/s00439-012-1185-z · DOI
  11. Anderson, 2014, Genome-Wide Association Study of Vitamin D Levels in Children: Replication in the Western Australian Pregnancy Cohort (Raine) Study, Genes Immun., 15, 578, 10.1038/gene.2014.52 · DOI
  12. Sapkota, 2016, Genome-Wide Association Study of 25(OH) Vitamin D Concentrations in Punjabi Sikhs: Results of the Asian Indian Diabetic Heart Study, J. Steroid Biochem. Mol. Biol., 158, 149, 10.1016/j.jsbmb.2015.12.014 · DOI
  13. Manousaki, 2017, Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis, Am. J. Hum. Genet., 101, 227, 10.1016/j.ajhg.2017.06.014 · DOI
  14. Hong, 2018, Transethnic Evaluation Identifies Low-Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations, J. Clin. Endocrinol. Metab., 103, 1380, 10.1210/jc.2017-01802 · DOI
  15. Jiang, 2018, Genome-Wide Association Study in 79,366 European-Ancestry Individuals Informs the Genetic Architecture of 25-Hydroxyvitamin D Levels, Nat. Commun., 9, 260, 10.1038/s41467-017-02662-2 · DOI · Paper page
  16. Shi, 2018, Genome-Wide Association Study of Serum 25-Hydroxyvitamin D in US Women, Front. Genet., 9, 67, 10.3389/fgene.2018.00067 · DOI
  17. Kampe, A., Enlund-Cerullo, M., Valkama, S., Holmlund-Suila, E., Rosendahl, J., Hauta-Alus, H., Pekkinen, M., Andersson, S., and Makitie, O. (2019). Genetic Variation in GC and CYP2R1 Affects 25-Hydroxyvitamin D Concentration and Skeletal Parameters: A Genome-Wide Association Study in 24-Month-Old Finnish Children. PLoS Genet., 15. · DOI
  18. Manousaki, 2020, Genome-Wide Association Study for Vitamin D Levels Reveals 69 Independent Loci, Am. J. Hum. Genet., 106, 327, 10.1016/j.ajhg.2020.01.017 · DOI · Paper page
  19. Revez, 2020, Genome-Wide Association Study Identifies 143 Loci Associated with 25 Hydroxyvitamin D Concentration, Nat. Commun., 11, 1647, 10.1038/s41467-020-15421-7 · DOI · Paper page
  20. Traglia, 2020, Genetic Contributions to Maternal and Neonatal Vitamin D Levels, Genetics, 214, 1091, 10.1534/genetics.119.302792 · DOI
  21. Zheng, J.-S., Luan, J., Sofianopoulou, E., Sharp, S.J., Day, F.R., Imamura, F., Gundersen, T.E., Lotta, L.A., Sluijs, I., and Stewart, I.D. (2020). The Association between Circulating 25-Hydroxyvitamin D Metabolites and Type 2 Diabetes in European Populations: A Meta-Analysis and Mendelian Randomisation Analysis. PLoS Med., 17. · DOI
  22. Kim, 2021, Unveiling Genetic Variants Underlying Vitamin D Deficiency in Multiple Korean Cohorts by a Genome-Wide Association Study, Endocrinol. Metab., 36, 1189, 10.3803/EnM.2021.1241 · DOI
  23. Ong, 2021, A Comprehensive Re-Assessment of the Association between Vitamin D and Cancer Susceptibility Using Mendelian Randomization, Nat. Commun., 12, 246, 10.1038/s41467-020-20368-w · DOI
  24. Palmer, N.D., Lu, L., Register, T.C., Lenchik, L., Carr, J.J., Hicks, P.J., Smith, S.C., Xu, J., Dimitrov, L., and Keaton, J. (2021). Genome-Wide Association Study of Vitamin D Concentrations and Bone Mineral Density in the African American-Diabetes Heart Study. PLoS ONE, 16. · DOI
  25. Sallinen, 2021, Genetic Risk Score for Serum 25-Hydroxyvitamin D Concentration Helps to Guide Personalized Vitamin D Supplementation in Healthy Finnish Adults, J. Nutr., 151, 281, 10.1093/jn/nxaa391 · DOI
  26. Sampathkumar, 2021, Genetic Link Determining the Maternal-Fetal Circulation of Vitamin D, Front. Genet., 12, 721488, 10.3389/fgene.2021.721488 · DOI
  27. Zeng, 2021, Type 2 Diabetes Is Causally Associated With Reduced Serum Osteocalcin: A Genomewide Association and Mendelian Randomization Study, J. Bone Miner. Res., 36, 1694, 10.1002/jbmr.4330 · DOI
  28. Backman, 2021, Exome Sequencing and Analysis of 454,787 UK Biobank Participants, Nature, 599, 628, 10.1038/s41586-021-04103-z · DOI · Paper page
  29. Barton, 2021, Whole-Exome Imputation within UK Biobank Powers Rare Coding Variant Association and Fine-Mapping Analyses, Nat. Genet., 53, 1260, 10.1038/s41588-021-00892-1 · DOI · Paper page
  30. Benjamin, E.J., Dupuis, J., Larson, M.G., Lunetta, K.L., Booth, S.L., Govindaraju, D.R., Kathiresan, S., Keaney, J.F., Keyes, M.J., and Lin, J.-P. (2007). Genome-Wide Association with Select Biomarker Traits in the Framingham Heart Study. BMC Med. Genet., 8. · DOI
  31. Locke, 2019, Exome Sequencing of Finnish Isolates Enhances Rare-Variant Association Power, Nature, 572, 323, 10.1038/s41586-019-1457-z · DOI
  32. Sun, 2022, Analyses of Biomarker Traits in Diverse UK Biobank Participants Identify Associations Missed by European-Centric Analysis Strategies, J. Hum. Genet., 67, 87, 10.1038/s10038-021-00968-0 · DOI
  33. Richardson, 2022, Harnessing Whole Genome Polygenic Risk Scores to Stratify Individuals Based on Cardiometabolic Risk Factors and Biomarkers at Age 10 in the Lifecourse, Arterioscler. Thromb. Vasc. Biol., 42, ATVBAHA121316650, 10.1161/ATVBAHA.121.316650 · DOI
  34. Christakos, 2016, Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects, Physiol. Rev., 96, 365, 10.1152/physrev.00014.2015 · DOI · Paper page
  35. Aiba, 2006, Characterization of Rat and Human CYP2J Enzymes as Vitamin D 25-Hydroxylases, Steroids, 71, 849, 10.1016/j.steroids.2006.04.009 · DOI
  36. Zhou, 2022, Non-Linear Mendelian Randomization Analyses Support a Role for Vitamin D Deficiency in Cardiovascular Disease Risk, Eur. Heart J., 43, 1731, 10.1093/eurheartj/ehab809 · DOI
  37. Collins, 1999, Identification of a Common PEX1 Mutation in Zellweger Syndrome, Hum. Mutat., 14, 45, 10.1002/(SICI)1098-1004(1999)14:1<45::AID-HUMU6>3.0.CO;2-J · DOI
  38. Rush, 2016, Low Bone Mineral Density Is a Common Feature of Zellweger Spectrum Disorders, Mol. Genet. Metab., 117, 33, 10.1016/j.ymgme.2015.11.009 · DOI
  39. Guerrin, 2003, CDNA Cloning, Gene Organization and Expression Analysis of Human Peptidylarginine Deiminase Type I, Biochem. J., 370, 167, 10.1042/bj20020870 · DOI
  40. Enji, 2005, The Peptidylarginine Deiminases Expressed in Human Epidermis Differ in Their Substrate Specificities and Subcellular Locations, Cell. Mol. Life Sci. CMLS, 62, 1984, 10.1007/s00018-005-5196-y · DOI
  41. Jacobs, 2003, FoxO6, a Novel Member of the FoxO Class of Transcription Factors with Distinct Shuttling Dynamics *, J. Biol. Chem., 278, 35959, 10.1074/jbc.M302804200 · DOI · Paper page
  42. Zemva, 2012, Central FoxO3a and FoxO6 Expression Is Down-Regulated in Obesity Induced Diabetes but Not in Aging, Exp. Clin. Endocrinol. Diabetes Off. J. Ger. Soc. Endocrinol. Ger. Diabetes Assoc., 120, 340
  43. Vincent, 2000, The Human Homologue of Flamingo, EGFL2, Encodes a Brain-Expressed Large Cadherin-like Protein with Epidermal Growth Factor-like Domains, and Maps to Chromosome 1p13.3-P21.1, DNA Res., 7, 233, 10.1093/dnares/7.3.233 · DOI
  44. Kukita, 2004, RANKL-Induced DC-STAMP Is Essential for Osteoclastogenesis, J. Exp. Med., 200, 941, 10.1084/jem.20040518 · DOI · Paper page
  45. Kooijman, 2015, A Novel Common Variant in DCST2 Is Associated with Length in Early Life and Height in Adulthood, Hum. Mol. Genet., 24, 1155, 10.1093/hmg/ddu510 · DOI
  46. Borges, 2008, Population Studies of Vitamin D Binding Protein Microheterogeneity by Mass Spectrometry Lead to Characterization of Its Genotype-Dependent O-Glycosylation Patterns, J. Proteome Res., 7, 4143, 10.1021/pr8002936 · DOI
  47. Hezroni, 2015, Principles of Long Noncoding RNA Evolution Derived from Direct Comparison of Transcriptomes in 17 Species, Cell Rep., 11, 1110, 10.1016/j.celrep.2015.04.023 · DOI · Paper page
  48. Ghatnatti, 2021, Identification of Potential and Novel Target Genes in Pituitary Prolactinoma by Bioinformatics Analysis, AIMS Neurosci., 8, 254, 10.3934/Neuroscience.2021014 · DOI
  49. (2022, May 26). PubChem CPS1—Carbamoyl-Phosphate Synthase 1 (Human), Available online: https://pubchem.ncbi.nlm.nih.gov/gene/CPS1/human.
  50. Meech, 2019, The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms, Physiol. Rev., 99, 1153, 10.1152/physrev.00058.2017 · DOI · Paper page
  51. Wang, 2014, Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability, Endocrinology, 155, 2052, 10.1210/en.2013-2013 · DOI
  52. Biederer, 2006, Bioinformatic Characterization of the SynCAM Family of Immunoglobulin-like Domain-Containing Adhesion Molecules, Genomics, 87, 139, 10.1016/j.ygeno.2005.08.017 · DOI
  53. Yan, 2018, Cadm2 Regulates Body Weight and Energy Homeostasis in Mice, Mol. Metab., 8, 180, 10.1016/j.molmet.2017.11.010 · DOI
  54. Chun, 2012, New Perspectives on the Vitamin D Binding Protein, Cell Biochem. Funct., 30, 445, 10.1002/cbf.2835 · DOI
  55. Liang, 2009, Distinct Roles for CARMIL Isoforms in Cell Migration, Mol. Biol. Cell, 20, 5290, 10.1091/mbc.e08-10-1071 · DOI
  56. Canu, 1997, Cloning, Structural Organization Analysis, and Chromosomal Assignment of the Human Gene for the Neurosecretory Protein VGF, Genomics, 45, 443, 10.1006/geno.1997.4945 · DOI
  57. Benchoula, 2021, The Molecular Mechanism of Vgf in Appetite, Lipids, and Insulin Regulation, Pharmacol. Res., 172, 105855, 10.1016/j.phrs.2021.105855 · DOI
  58. Hahm, 2002, VGF Is Required for Obesity Induced by Diet, Gold Thioglucose Treatment, and Agouti and Is Differentially Regulated in Pro-Opiomelanocortin- and Neuropeptide Y-Containing Arcuate Neurons in Response to Fasting, J. Neurosci., 22, 6929, 10.1523/JNEUROSCI.22-16-06929.2002 · DOI
  59. Li, 2019, High LINC00536 Expression Promotes Tumor Progression and Poor Prognosis in Bladder Cancer, Exp. Cell Res., 378, 32, 10.1016/j.yexcr.2019.03.009 · DOI
  60. Fossati, 2019, Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons, Neuron, 104, 1081, 10.1016/j.neuron.2019.09.027 · DOI
  61. Cheng, 2004, Genetic Evidence That the Human CYP2R1 Enzyme Is a Key Vitamin D 25-Hydroxylase, Proc. Natl. Acad. Sci. USA, 101, 7711, 10.1073/pnas.0402490101 · DOI · Paper page
  62. Liu, 2018, The Coexistence of Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) at a Locus Can Result in Distorted Calculations of the Significance in Associating SNPs to Disease, Hum. Genet., 137, 553, 10.1007/s00439-018-1910-3 · DOI · Paper page
  63. Ng, 2018, The Role of Vitamin D in the Pathogenesis of Adolescent Idiopathic Scoliosis, Asian Spine J., 12, 1127, 10.31616/asj.2018.12.6.1127 · DOI
  64. Donato, 2013, Functions of S100 Proteins, Curr. Mol. Med., 13, 24, 10.2174/156652413804486214 · DOI · Paper page
  65. Smith, 2000, Obesity Resistance and Multiple Mechanisms of Triglyceride Synthesis in Mice Lacking Dgat, Nat. Genet., 25, 87, 10.1038/75651 · DOI · Paper page
  66. Eckhart, 2008, Histidase Expression in Human Epidermal Keratinocytes: Regulation by Differentiation Status and All-Trans Retinoic Acid, J. Dermatol. Sci., 50, 209, 10.1016/j.jdermsci.2007.12.009 · DOI
  67. Suchi, 1995, Molecular Cloning and Structural Characterization of the Human Histidase Gene (HAL), Genomics, 29, 98, 10.1006/geno.1995.1219 · DOI
  68. Welsh, 2008, A Role for Ultraviolet Radiation Immunosuppression in Non-Melanoma Skin Cancer as Evidenced by Gene-Environment Interactions, Carcinogenesis, 29, 1950, 10.1093/carcin/bgn160 · DOI
  69. Landeck, 2016, The Effect of Epidermal Levels of Urocanic Acid on 25-Hydroxyvitamin D Synthesis and Inflammatory Mediators upon Narrowband UVB Irradiation, Photodermatol. Photoimmunol. Photomed., 32, 214, 10.1111/phpp.12249 · DOI
  70. Azambuja, 2008, The search for non-chordate retinoic acid signaling: Lessons from chordates, J. Exp. Zoolog. B Mol. Dev. Evol., 310B, 54, 10.1002/jez.b.21139 · DOI
  71. Hartigan, 2005, PDILT, a Divergent Testis-Specific Protein Disulfide Isomerase with a Non-Classical SXXC Motif That Engages in Disulfide-Dependent Interactions in the Endoplasmic Reticulum, J. Biol. Chem., 280, 1376, 10.1074/jbc.M408651200 · DOI
  72. Kurogi, 2017, Sulfation of Vitamin D3 -Related Compounds-Identification and Characterization of the Responsible Human Cytosolic Sulfotransferases, FEBS Lett., 591, 2417, 10.1002/1873-3468.12767 · DOI
  73. Wong, 2018, Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans, Drug Metab. Dispos., 46, 367, 10.1124/dmd.117.078428 · DOI
  74. Prassas, 2015, Unleashing the Therapeutic Potential of Human Kallikrein-Related Serine Proteases, Nat. Rev. Drug Discov., 14, 183, 10.1038/nrd4534 · DOI
  75. Jones, 2012, 25-Hydroxyvitamin D-24-Hydroxylase (CYP24A1): Its Important Role in the Degradation of Vitamin D, Arch. Biochem. Biophys., 523, 9, 10.1016/j.abb.2011.11.003 · DOI · Paper page
  76. Shi, 2021, Importance of Extra-Renal CYP24A1 Expression for Maintaining Mineral Homeostasis, J. Endocr. Soc., 5, A234, 10.1210/jendso/bvab048.476 · DOI
  77. Murase, 2017, Group III Phospholipase A2 Promotes Colitis and Colorectal Cancer, Sci. Rep., 7, 12261, 10.1038/s41598-017-12434-z · DOI
  78. Karohl, 2010, Heritability and Seasonal Variability of Vitamin D Concentrations in Male Twins, Am. J. Clin. Nutr., 92, 1393, 10.3945/ajcn.2010.30176 · DOI
  79. Engelman, 2008, Genetic and Environmental Determinants of 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Hispanic and African Americans, J. Clin. Endocrinol. Metab., 93, 3381, 10.1210/jc.2007-2702 · DOI · Paper page
  80. Sutherland, 2021, Differences and Determinants of Vitamin D Deficiency among UK Biobank Participants: A Cross-Ethnic and Socioeconomic Study, Clin. Nutr., 40, 3436, 10.1016/j.clnu.2020.11.019 · DOI
  81. Koljonen, 2019, Genetic Variation of the Vitamin D Binding Protein Affects Vitamin D Status and Response to Supplementation in Infants, J. Clin. Endocrinol. Metab., 104, 5483, 10.1210/jc.2019-00630 · DOI
  82. Nissen, 2015, Common Variants in CYP2R1 and GC Genes Are Both Determinants of Serum 25-Hydroxyvitamin D Concentrations after UVB Irradiation and after Consumption of Vitamin D₃-Fortified Bread and Milk during Winter in Denmark, Am. J. Clin. Nutr., 101, 218, 10.3945/ajcn.114.092148 · DOI
  83. Nissen, 2014, Real-Life Use of Vitamin D3-Fortified Bread and Milk during a Winter Season: The Effects of CYP2R1 and GC Genes on 25-Hydroxyvitamin D Concentrations in Danish Families, the VitmaD Study, Genes Nutr., 9, 413, 10.1007/s12263-014-0413-7 · DOI
  84. Frost, P. (2022). The Problem of Vitamin D Scarcity: Cultural and Genetic Solutions by Indigenous Arctic and Tropical Peoples. Nutrients, 14. · DOI
  85. Lu, L., Bennett, D.A., Millwood, I.Y., Parish, S., McCarthy, M.I., Mahajan, A., Lin, X., Bragg, F., Guo, Y., and Holmes, M.V. (2018). Association of Vitamin D with Risk of Type 2 Diabetes: A Mendelian Randomisation Study in European and Chinese Adults. PLOS Med., 15. · DOI
  86. Vimaleswaran, 2014, Association of Vitamin D Status with Arterial Blood Pressure and Hypertension Risk: A Mendelian Randomisation Study, Lancet Diabetes Endocrinol., 2, 719, 10.1016/S2213-8587(14)70113-5 · DOI · Paper page
  87. Morris, 2011, A Potential Design Flaw of Randomized Trials of Vitamin Supplements, JAMA, 305, 1348, 10.1001/jama.2011.383 · DOI
  88. Scragg, 2018, Limitations of Vitamin D Supplementation Trials: Why Observational Studies Will Continue to Help Determine the Role of Vitamin D in Health, J. Steroid Biochem. Mol. Biol., 177, 6, 10.1016/j.jsbmb.2017.06.006 · DOI
  89. Sutherland, J.P., Zhou, A., and Hyppönen, E. (2022). Vitamin D Deficiency Increases Mortality Risk in the UK Biobank: A Non-Linear Mendelian Randomization Study. Ann. Intern. Med., in press. · DOI
  90. Sofianopoulou, 2021, Estimating Dose-Response Relationships for Vitamin D with Coronary Heart Disease, Stroke, and All-Cause Mortality: Observational and Mendelian Randomisation Analyses, Lancet Diabetes Endocrinol., 9, 837, 10.1016/S2213-8587(21)00263-1 · DOI
  91. Navale, 2022, Vitamin D and Brain Health: An Observational and Mendelian Randomization Study, Am. J. Clin. Nutr., 116, nqac107, 10.1093/ajcn/nqac107 · DOI
  92. Mokry, 2016, Genetically Decreased Vitamin D and Risk of Alzheimer Disease, Neurology, 87, 2567, 10.1212/WNL.0000000000003430 · DOI
  93. Wang, 2020, Circulating Vitamin D Levels and Alzheimer’s Disease: A Mendelian Randomization Study in the IGAP and UK Biobank, J. Alzheimers Dis. JAD, 73, 609, 10.3233/JAD-190713 · DOI
  94. Bjelakovic, G., Gluud, L.L., Nikolova, D., Whitfield, K., Wetterslev, J., Simonetti, R.G., Bjelakovic, M., and Gluud, C. (2014). Vitamin D Supplementation for Prevention of Mortality in Adults. Cochrane Database Syst. Rev., CD007470. · DOI · Paper page

Cited by

Metadata

Authors
Hyppönen, E., Vimaleswaran, K. S., & Zhou, A.
Venue
Nutrients
Publisher
MDPI AG
Published
2022-10-20
Volume
14
Issue
20
Pages
4408
ISSN
2072-6643
DOI
10.3390/nu14204408
Cited by
37
References
8
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
National Health and Medical Research Council (Australia) (GNT1123603)

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