The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota
Open accessAbstract
Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut homeostasis and their deficiency is involved in the pathogenesis of several disorders, including inflammatory bowel diseases, colorectal cancer, and cardiometabolic disorders. SCFAs are metabolites of specific bacterial taxa of the human gut microbiota, and their production is influenced by specific foods or food supplements, mainly prebiotics, by the direct fostering of these taxa. This Review provides an overview of SCFAs’ roles and functions, and of SCFA-producing bacteria, from their microbiological characteristics and taxonomy to the biochemical process that lead to the release of SCFAs. Moreover, we will describe the potential therapeutic approaches to boost the levels of SCFAs in the human gut and treat different related diseases.
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Cites
A metagenome-wide association study of gut microbiota in type 2 diabetes
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Obesity alters gut microbial ecology
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The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
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Self-citationThe role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
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The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
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“Finally, treatment with SCFAs, and especially with butyrate, is able to reduce gut inflammation, reducing the NF-κB signaling pathway and enhancing the expression of anti-inflammatory cytokines such as IL-10 [63].”
BackgroundTolhurst, G., Heffron, H., Lam, Y. S., Parker, H. E., Habib, A. M., Diakogiannaki, E., Cameron, J., Grosse, J., Reimann, F., & Gribble, F. M. (2012) · Diabetes · doi:10.2337/db11-1019 · Cited by 2,404
Cited by
Varghese, S., Rao, S., Khattak, A., Zamir, F., & Chaari, A. (2024) · Nutrients · doi:10.3390/nu16213663 · Cited by 152
Lagoumintzis, G., & Patrinos, G. P. (2023) · Human Genomics · doi:10.1186/s40246-023-00561-w · Cited by 132
Heinzel, S., Jureczek, J., Kainulainen, V., Nieminen, A. I., Suenkel, U., von Thaler, A.-K., Kaleta, C., Eschweiler, G. W., Brockmann, K., Aho, V. T. E., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-63893-0 · Cited by 36
Parenteral Nutrition, Inflammatory Bowel Disease, and Gut Barrier: An Intricate Plot
Covello, C., Becherucci, G., Di Vincenzo, F., Del Gaudio, A., Pizzoferrato, M., Cammarota, G., Gasbarrini, A., Scaldaferri, F., & Mentella, M. C. (2024) · Nutrients · doi:10.3390/nu16142288 · Cited by 21
Self-citation
Metadata
- Authors
- Fusco, W., Lorenzo, M. B., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M. C., Gasbarrini, A., Collado, M. C., Cammarota, G., & Ianiro, G.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2023-05-06
- Volume
- 15
- Issue
- 9
- Pages
- 2211
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W4381832905
- Cited by
- 1,243
- References
- 35
- FWCI
- 92.87
- Type
- journal article
- Language
- en
- Open access
- gold
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