Cited by 132Chronic Obstructive Pulmonary Disease (COPD) ResearchNutrition and Health in AgingMuscle Physiology and Disorders

Undernutrition in Patients with COPD and Its Treatment

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Itoh, Masayuki, Tsuji, Takao, Nemoto, Kenji, Nakamura, Hiroyuki, Aoshiba, Kazutetsu·2013·Nutrients

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lung and whole body caused mainly by tobacco smoking. Patients with advanced COPD are in a state of undernutrition, referred to as pulmonary cachexia; the exercise performance and quality of life (QOL) of these patients are deteriorated, the vital prognosis is unfavorable, and the medico-economic burden posed by poorly nourished COPD patients is high. The mainstays of COPD treatment are pharmacotherapy, mainly with bronchodilators, and non-pharmacotherapeutic approaches such as respiratory rehabilitation and nutrition counseling. Nutritional supplement therapy, consisting primarily of high calorie intake, has been demonstrated to be effective for maintaining and improving the muscle strength and exercise tolerance in poorly nourished COPD patients. The efficacy of intake of various nutrients, besides a high calorie intake, for amelioration of the disease state of COPD has also been reported. The roles of adipokines in the pathophysiology of COPD have begun to receive attention recently, and not only their regulatory effects on appetite and nutritional status, but also their influence on systemic inflammation have been increasingly clarified. We review the papers on COPD and nutrition and discuss the role of nutritional supplement therapy in the treatment of COPD.

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  • Undernutrition among adults can develop due to either starvation and/or disease-related inflammation, often due to acute injury or chronic disease.

    “However, undernutrition among adults can develop due to either starvation and/or disease-related inflammation, often due to acute injury or chronic disease (7, 8).”

    From Evolution of the diagnosis of malnutrition in adults: a primer for clinicians (2024) · cites this paper as [8]

    Section 3, “Causes of Undernutrition in COPD Patients” (page unavailable), identifies decreased dietary intake and inflammatory factors as possible contributors to undernutrition in patients with COPD, a chronic disease. It does not address starvation or acute injury, or establish the claim for adults generally. (LLM, conf=0.85)

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  1. [21]Breyer M.K. Rutten E.P. Locantore N.W. Watkins M.L. Miller B.E. Wouters E.F. Dysregulatedadipokine metabolism in chronic obstructive pulmonary disease Nat. Rev. Immunol. 2011 11 85 97 10.1038/nri2921 21252989 PMC3518031 · DOI · Paper page
  2. [26]Moore S.I. Huffnagle G.B. Chen G.H. White E.S. Mancuso P. Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae Infect. Immun. 2003 71 4182 4185 10.1128/IAI.71.7.4182-4185.2003 12819114 PMC161963 · DOI

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Authors
Itoh, M., Tsuji, T., Nemoto, K., Nakamura, H., & Aoshiba, K.
Affiliations
Tokyo Medical University Ibaraki Medical Center (JP)
Corresponding author
Aoshiba, Kazutetsu
Venue
Nutrients
Publisher
MDPI AG
Published
2013-04-18
Volume
5
Issue
4
Pages
1316-1335
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2141963607
Cited by
131
References
118
Citations by year
2026: 4 · 2025: 8 · 2024: 29 · 2023: 10 · 2022: 22 · 2021: 13 · 2020: 12 · 2019: 5 · 2018: 8 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 6
FWCI
0.93
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Japan Society for the Promotion of Science (24591140, 25461171)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
chronic obstructive pulmonary disease, malnutrition, dietary supplementation, hypercaloric diet, muscle strength, exercise tolerance, adipokines, systemic inflammation, nutrition counseling, pulmonary rehabilitation, bronchodilators, quality of life
MeSH terms
Animals, Cachexia, Energy Intake, Fruit, Humans, Nutritional Status, Vegetables, Treatment Outcome, Nutritional Support, Dietary Supplements, Pulmonary Disease, Chronic Obstructive, Malnutrition, Adipokines

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