The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects
Open accessAbstract
Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. The findings of the Hungarian intervention (randomized double-blind and cohort controlled) trials indicated that periconceptional folic acid (FA)-containing multivitamin supplementation prevented the major proportion (about 90%) of neural-tube defects (NTD) as well as a certain proportion (about 40%) of congenital heart defects. Finally the benefits and drawbacks of three main practical applications of folic acid/multivitamin treatment such as (i) dietary intake; (ii) periconceptional supplementation; and (iii) flour fortification are discussed. The conclusion arrived at is indeed confirmation of Benjamin Franklin’s statement: “An ounce of prevention is better than a pound of care”.
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Self-citationPrevention of neural tube defects: Results of the Medical Research Council vitamin study
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Prevention of Neural-Tube Defects with Folic Acid in China
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Prevention of Neural-Tube Defects with Folic Acid in China
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Impact of Folic Acid Fortification of the US Food Supply on the Occurrence of Neural Tube Defects
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Potential of Chlorella as a Dietary Supplement to Promote Human Health
Bito, T., Okumura, E., Fujishima, M., & Watanabe, F. (2020) · Nutrients · doi:10.3390/nu12092524 · Cited by 308
Kumar, A., Metwal, M., Kaur, S., Gupta, A. K., Puranik, S., Singh, S., Singh, M., Gupta, S., Babu, B. K., Sood, S., et al. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00934 · Cited by 299
Birth prevalence of congenital heart defects in Norway 1994-2009—A nationwide study
Leirgul, E., Fomina, T., Brodwall, K., Greve, G., Holmstrøm, H., Vollset, S. E., Tell, G. S., & Øyen, N. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.07.030 · Cited by 164
Yue, C., Ji, C., Zhang, H., Zhang, L. W., Tong, J., Jiang, Y., & Chen, T. (2017) · Environmental Toxicology · doi:10.1002/tox.22448 · Cited by 58
Maternal Folate Levels during Pregnancy and Offspring Brain Development in Late Childhood
Zou, R., El Marroun, H., Cecil, C., Jaddoe, V. W. V., Hillegers, M., Tiemeier, H., & White, T. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.11.025 · Cited by 44
Metadata
- Authors
- Czeizel, A., Dudás, I., Vereczkey, A., & Bánhidy, F.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2013-11-21
- Volume
- 5
- Issue
- 11
- Pages
- 4760-4775
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2032300647
- Cited by
- 349
- References
- 71
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- gold
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