The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Modulation of the Immune Response to Respiratory Viruses by Vitamin D
Open accessAbstract
Background: Vitamin D deficiency has been shown to be independently associated with increased risk of viral acute respiratory infection (ARI) in a number of observational studies, and meta-analysis of clinical trials of vitamin D supplementation for prevention of ARI has demonstrated protective effects. Several cellular studies have investigated the effects of vitamin D metabolites on immune responses to respiratory viruses, but syntheses of these reports are lacking. Scope: In this article, we review the literature reporting results of in vitro experiments investigating immunomodulatory actions of vitamin D metabolites in human respiratory epithelial cells infected with respiratory viruses. Key findings: Vitamin D metabolites do not consistently influence replication or clearance of rhinovirus, respiratory syncytial virus (RSV) or influenza A virus in human respiratory epithelial cell culture, although they do modulate expression and secretion of type 1 interferon, chemokines including CXCL8 and CXCL10 and pro-inflammatory cytokines, such as TNF and IL-6. Future research: More studies are needed to clarify the effects of vitamin D metabolites on respiratory virus-induced expression of cell surface markers mediating viral entry and bacterial adhesion to respiratory epithelial cells.
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Cited by
Martineau, A. R., Jolliffe, D. A., Hooper, R. L., Greenberg, L., Aloia, J. F., Bergman, P., Dubnov-Raz, G., Esposito, S., Ganmaa, D., Ginde, A. A., et al. (2017) · BMJ · doi:10.1136/bmj.i6583 · Cited by 2,040
Self-citationCalder, P., Carr, A., Gombart, A., & Eggersdorfer, M. (2020) · Nutrients · doi:10.3390/nu12041181 · Cited by 972
Jolliffe, D. A., Camargo, C. A., Sluyter, J. D., Aglipay, M., Aloia, J. F., Ganmaa, D., Bergman, P., Bischoff-Ferrari, H. A., Borzutzky, A., Damsgaard, C. T., et al. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00051-6 · Cited by 547
Self-citationMattioli, A. V., Sciomer, S., Cocchi, C., Maffei, S., & Gallina, S. (2020) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.05.020 · Cited by 540
The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147
Metadata
- Authors
- Greiller, C., & Martineau, A.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2015-05-29
- Volume
- 7
- Issue
- 6
- Pages
- 4240-4270
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2137836062
- Cited by
- 469
- References
- 13
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- gold
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