Distant Site Effects of Ingested Prebiotics
Open accessAbstract
The gut microbiome is being more widely recognized for its association with positive health outcomes, including those distant to the gastrointestinal system. This has given the ability to maintain and restore microbial homeostasis a new significance. Prebiotic compounds are appealing for this purpose as they are generally food-grade substances only degraded by microbes, such as bifidobacteria and lactobacilli, from which beneficial short-chain fatty acids are produced. Saccharides such as inulin and other fructo-oligosaccharides, galactooligosaccharides, and polydextrose have been widely used to improve gastrointestinal outcomes, but they appear to also influence distant sites. This review examined the effects of prebiotics on bone strength, neural and cognitive processes, immune functioning, skin, and serum lipid profile. The mode of action is in part affected by intestinal permeability and by fermentation products reaching target cells. As the types of prebiotics available diversify, so too will our understanding of the range of microbes able to degrade them, and the extent to which body sites can be impacted by their consumption.
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Mounting evidence suggests probiotics may play a significant role in skin health via regulating intestinal microbiota and metabolites and improving systemic immunity.
“Mounting evidence suggests that probiotics may play a significant role in skin health via regulating intestinal microbiota and metabolites and improving systemic immunity [79,138,139,140].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [138]
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References 141 · Cited by 112
- Authors
- Collins, S., & Reid, G.
- Affiliations
- Western University (CA)
- Corresponding author
- Reid, Gregor
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2016-08-26
- Volume
- 8
- Issue
- 9
- Pages
- 523
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5037510
- OpenAlex
- W2514744092
- Cited by
- 112
- References
- 141
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 30 · 2020: 10 · 2019: 10 · 2018: 7 · 2017: 11 · 2016: 1 · 2014: 1
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Scholarship@Western (Western University) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- prebiotics, gut microbiota, short-chain fatty acids, inulin, fructooligosaccharides, galactooligosaccharides, polydextrose, bone strength, cognitive function, immune function, skin, lipid profile, intestinal permeability, microbial fermentation, Bifidobacterium, lactobacilli
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Cognition, Fermentation, Humans, Immune System, Lipids, Nervous System, Skin, Bone Density, Bone Remodeling, Gastrointestinal Tract, Host-Pathogen Interactions, Prebiotics
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