The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
Vitamin C, Aging and Alzheimer’s Disease
Open accessAbstract
Accumulating evidence in mice models of accelerated senescence indicates a rescuing role of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell growth, oxidative stress, telomere attrition, disorganization of chromatin, and excessive secretion of inflammatory factors, and extend lifespan. Interestingly, ascorbic acid (AA) was also found to positively modulate inflamm-aging and immunosenescence, two hallmarks of biological aging. Moreover, ascorbic acid has been shown to epigenetically regulate genome integrity and stability, indicating a key role of targeted nutrition in healthy aging. Growing in vivo evidence supports the role of ascorbic acid in ameliorating factors linked to Alzheimer’s disease (AD) pathogenesis, although evidence in humans yielded equivocal results. The neuroprotective role of ascorbic acid not only relies on the general free radical trapping, but also on the suppression of pro-inflammatory genes, mitigating neuroinflammation, on the chelation of iron, copper, and zinc, and on the suppression of amyloid-beta peptide (Aβ) fibrillogenesis. Epidemiological evidence linking diet, one of the most important modifiable lifestyle factors, and risk of Alzheimer's disease is rapidly increasing. Thus, dietary interventions, as a way to epigenetically modulate the human genome, may play a role in the prevention of AD. The present review is aimed at providing an up to date overview of the main biological mechanisms that are associated with ascorbic acid supplementation/bioavailability in the process of aging and Alzheimer’s disease. In addition, we will address new fields of research and future directions.
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“In the brain, AA has been increasingly found to promote several beneficial effects on neurodegeneration by direct neuroprotection against OS [116].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [116]
In the citing paper
“Vitamin C or ascorbic acid (AA) is a powerful antioxidant that can have beneficial effects on delaying the aging process and age-related diseases thorough its action on redox oxidative and mitochondrial pathways, on the immune system, on inflamm-aging, on endothelial integrity, and on lipoprotein metabolism [114,115,116,117,118,119,120,121].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [116]
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Cites
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · cited 1×
“Inflamm-aging may be considered a biological background for both the aging process and the pathophysiological process of frailty in humans [7].”
BackgroundMetals, Toxicity and Oxidative Stress
Valko, M., Morris, H., & Cronin, M. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053764635 · Cited by 5,018 · cited 1×
“Interestingly, some in vitro studies investigated the pro-oxidant properties of ascorbate [109], which were mainly attributed to the release of metal ions from damaged cells.”
BackgroundChronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · cited 1×
“The free radical theory of aging allows an explanation of the molecular mechanisms underlying the aging process, at least partially, and the pathogenesis of age-related diseases, such as atherosclerosis, cardiovascular diseases, dementia, diabetes, and osteoporosis [3,4].”
BackgroundBloom (2014) · doi:10.1001/jamaneurol.2013.5847 · Cited by 2,194 · cited 1×
“Extracellular amyloid plaques are also responsible for the hyperphosphorylation of the cytoskeletal Tau protein [67].”
BackgroundVitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949 · cited 2×
“The increasing burden of this life-threatening condition [60] and the lack of disease-modifying drugs have guided the research towards preventive strategies, targeting AD modifiable risk factors [12].”
BackgroundOxidative Stress, Prooxidants, and Antioxidants: The Interplay
Rahal, A., Kumar, A., Singh, V., Yadav, B., Tiwari, R., Chakraborty, S., & Dhama, K. (2014) · BioMed Research International · doi:10.1155/2014/761264 · Cited by 1,806 · cited 1×
“A pro-oxidant or antioxidant effect of AA mainly relies on the concentration gradient and redox state of a cell [106].”
BackgroundProinflammatory Cytokines, Aging, and Age-Related Diseases
Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.009 · Cited by 1,094 · cited 2×
“mechanisms are responsible for altered T cell expression and the altered phenotype of immunological subpopulations [6].”
BackgroundDietary Intake of Antioxidants and Risk of Alzheimer Disease
Engelhart, M. J. (2002) · JAMA · doi:10.1001/jama.287.24.3223 · Cited by 1,080 · cited 1×
“The Rotterdam study showed the most consistent association between higher AA intake and reduced relative risk for AD in the largest population study [140] with the higher magnitude of association in people most depleted of AA (e.”
BackgroundMetals, oxidative stress and neurodegenerative disorders
Jomová, K., Vondráková, D., Lawson, M. K., & Valko, M. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0563-x · Cited by 1,074 · cited 4×
“AA repressed telomere shortening, decreased the production of pro-inflammatory cytokines, such as IL-6 and IL-8, downregulated the expression of markers of aging, such as cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 p16Ink4a and zinc finger transcriptional GATA4, and repressed the SASP (elevated s…”
BackgroundInfluentialIschiropoulos, H. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0755 · Cited by 1,025 · cited 1×
“The conjugated aromatic ring of tyrosine residues is also a target for free-radical attack, and accumulation of dityrosine and 3-nitrotyrosine has also been reported in the AD brain [77].”
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Diet and Inflammation in Cognitive Ageing and Alzheimer’s Disease
McGrattan, A., McGuinness, B., McKinley, M. C., Kee, F., Passmore, P., Woodside, J. V., & McEvoy, C. T. (2019) · Current Nutrition Reports · doi:10.1007/s13668-019-0271-4 · Cited by 414
Neuroinflammation in Alzheimer’s Disease
Onyango, I. G., Jauregui, G. V., Čarná, M., Bennett, J. P., & Stokin, G. B. (2021) · Biomedicines · doi:10.3390/biomedicines9050524 · Cited by 330
Plascencia‐Villa, G., & Perry, G. L. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8134 · Cited by 188
“Ascorbic acid supplementation showed neuroprotective properties, reducing free radicals and neuroinflammation, also iron chelation and Ab reduction (118).”
BackgroundDietary habits, lifestyle factors and neurodegenerative diseases
Popa‐Wagner, A., Dumbrava, D., Dumitrascu, D., Căpitănescu, B., Petcu, E. B., Surugiu, R., & Fang, W.-H. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266045 · Cited by 190
Promoting Successful Cognitive Aging: A Ten-Year Update
Krivanek, T. J., Gale, S. A., McFeeley, B. M., Nicastri, C. M., & Daffner, K. R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201462 · Cited by 189
“fatty acids [173, 174], antioxidant vitamins [175],”
Metadata
- Authors
- Monacelli, F., Acquarone, E., Giannotti, C., Borghi, R., & Nencioni, A.
- Affiliations
- University of Genoa (IT)
- Corresponding author
- Monacelli, Fiammetta
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-06-27
- Volume
- 9
- Issue
- 7
- Pages
- 670
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5537785
- OpenAlex
- W2724874603
- Cited by
- 243
- References
- 148
- Citations by year
- 2026: 9 · 2025: 29 · 2024: 37 · 2023: 31 · 2022: 38 · 2021: 34 · 2020: 27 · 2019: 22 · 2018: 14 · 2017: 2
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- vitamin C, aging, Alzheimer's disease, accelerated senescence, inflammaging, immunosenescence, telomere shortening, oxidative stress, epigenetic regulation, neuroinflammation, dietary supplementation, lifespan extension, healthy aging
- MeSH terms
- Aging, Alzheimer Disease, Animals, Ascorbic Acid, Brain, Disease Models, Animal, Humans, Vascular Diseases, Randomized Controlled Trials as Topic, Oxidative Stress, Nutrigenomics, Epigenomics, Plaque, Amyloid, Observational Studies as Topic
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