Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives

Naimi, Madina; Vlavcheski, Filip; Shamshoum, Hesham; Tsiani, Evangelia

doi:10.3390/nu9090968

Cited by 119Natural Antidiabetic Agents StudiesMedicinal Plant ResearchPhytochemicals and Antioxidant Activities

Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives

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Naimi, Madina, Vlavcheski, Filip, Shamshoum, Hesham, Tsiani, Evangelia·2017·Nutrients

DOI 10.3390/nu9090968PMC PMC5622728

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Abstract

Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic burden to health care systems around the globe, results from defects in insulin action (termed insulin resistance) combined with impaired insulin secretion. Current methods of prevention and treatments for insulin resistance and T2DM are lacking in number and efficacy and, therefore, there is a need for new preventative measures and targeted therapies. In recent years, chemicals found in plants/herbs have attracted attention for their use as functional foods or nutraceuticals for preventing and treating insulin resistance and T2DM. Rosemary is an evergreen shrub indigenous to the Mediterranean region and South America, which contains various polyphenols. Rosemary extract and its polyphenolic constituents have been reported to have antioxidant, anti-inflammatory, anticancer, and anti-hyperglycemic properties. The current review summarizes the existing in vitro and in vivo studies examining the anti-diabetic effects of rosemary extract and its polyphenolic components and highlights the known mechanism of action.

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Rosemary contains a large amount of polyphenols, especially carnosic acid, rosmarinic acid, and carnosol.
“According to Naimi et al. [34], rosemary contains a large amount of polyphenols, especially carnosic acid, rosmarinic acid and carnosol.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [34]

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Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216 · see citing works
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
Szkudelski, T. (2001) · Physiological Research · doi:10.33549/physiolres.930111 · Cited by 2,881 · see citing works
Lipases at interfaces: A review
Reis, P., Holmberg, K., Watzke, H. J., Leser, M. E., & Miller, R. (2008) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2008.06.001 · Cited by 801 · see citing works
Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition
Moreno, S., Scheyer, T., Romano, C. S., & Vojnov, A. A. (2006) · Free Radical Research · doi:10.1080/10715760500473834 · Cited by 705 · see citing works
Metformin-associated lactic acidosis: current perspectives on causes and risk
DeFronzo, R., Fleming, G. A., Chen, K., & Bicsak, T. A. (2016) · Metabolism · doi:10.1016/j.metabol.2015.10.014 · Cited by 658 · see citing works
Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation: Grand Rounds at University of California, San Francisco Medical Center
Bent, S. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0632-y · Cited by 611 · see citing works
Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials.
al-Sereiti, M. R., Abuamer, K. M., & Sen, P. (1999) · PubMed · Cited by 537 · see citing works
Characterization of Phenolic Composition in Lamiaceae Spices by LC-ESI-MS/MS
Hossain, M. B., Rai, D. K., Brunton, N. P., Martín‐Diana, A. B., & Barry‐Ryan, C. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102042g · Cited by 447 · see citing works
A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay
Vallverdú‐Queralt, A., Regueiro, J., Martínez‐Huélamo, M., de Alvarenga, J. F. R., Leal, L. N., & Lamuela-Raventós, R. M. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2013.12.106 · Cited by 399 · see citing works
In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits
Bakırel, T., Bakırel, U., Üstüner, O., Ülgen, S., & Yardibi, H. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.10.039 · Cited by 390 · see citing works
Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity
Kontogianni, V. G., Tomić, G., Nikolić, I., Nerantzaki, A. A., Sayyad, N., Stošić‐Grujičić, S., Stojanović, I., Gerothanassis, I. P., & Tzakos, A. G. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.07.091 · Cited by 364 · see citing works
Advance in Dietary Polyphenols as α-Glucosidases Inhibitors: A Review on Structure-Activity Relationship Aspect
Xiao, J., Kai, G., Yamamoto, K., & Chen, X. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.561379 · Cited by 340 · see citing works
Inhibitory effects of rosmarinic acid extracts on porcine pancreatic amylase in vitro.
McCue, P. P., & Shetty, K. (2004) · PubMed · Cited by 294 · see citing works
Carnosic acid, a new class of lipid absorption inhibitor from sage
Ninomiya, K., Matsuda, H., Shimoda, H., Nishida, N., Kasajima, N., Yoshino, T., Morikawa, T., & Yoshikawa, M. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.01.091 · Cited by 239 · see citing works
Degradation Study of Carnosic Acid, Carnosol, Rosmarinic Acid, and Rosemary Extract (Rosmarinus officinalisL.) Assessed Using HPLC
Zhang, Y., Smuts, J. P., Dodbiba, E., Rangarajan, R., Lang, J. C., & Armstrong, D. W. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302179c · Cited by 222 · see citing works
Rosemary (Rosmarinus officinalis): a study of the composition, antioxidant and antimicrobial activities of extracts obtained with supercritical carbon dioxide
Genena, A. K., Hense, H., Smânia, A., & de Souza, S. M. (2008) · Food Science and Technology · doi:10.1590/s0101-20612008000200030 · Cited by 195 · see citing works
Traditionally used plants in diabetes therapy: phytotherapeutics as inhibitors of alpha-amylase activity
Funke, I., & Melzig, M. F. (2006) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2006000100002 · Cited by 177 · see citing works
Rosemary (Rosmarinus officinalis) as a potential therapeutic plant in metabolic syndrome: a review
Hassani, F. V., Shirani, K., & Hosseinzadeh, H. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1256-0 · Cited by 149 · see citing works
Phenolic compounds from Rosemary (Rosmarinus officinalis L.) attenuate oxidative stress and reduce blood cholesterol concentrations in diet-induced hypercholesterolemic rats
Afonso, M. S., Silva, A. M. D. O. E., de Carvalho, E. B. T., Rivelli, D. P., Barros, S. B. D. M., Rogero, M. M., Lottenberg, A. M., Torres, R. P., & Mancini-Filho, J. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-19 · Cited by 147 · see citing works
Bioactive Compounds from Culinary Herbs Inhibit a Molecular Target for Type 2 Diabetes Management, Dipeptidyl Peptidase IV
Bower, A. M., Hernandez, L. M. R., Berhow, M. A., & de Mejı́a, E. G. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500639f · Cited by 137 · see citing works
Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism
Takahashi, T., Tabuchi, T., Tamaki, Y., Kosaka, K., Takikawa, Y., & Satoh, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.03.059 · Cited by 129 · see citing works
Dipeptidyl Peptidase‐4 Inhibitors and Cardiovascular Outcomes: Meta‐Analysis of Randomized Clinical Trials with 55,141 Participants
Wu, S., Hopper, I., Skiba, M. A., & Krum, H. (2014) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12075 · Cited by 128 · see citing works
Inhibition of hormone sensitive lipase and pancreatic lipase by Rosmarinus officinalis extract and selected phenolic constituents
Bustanji, Y. K., Issa, A., Mohammad, M., Hudaib, M., Tawah, K., AlKhatib, H. S., Almasri, I. M., & Alkhalidi, B. A. (2010) · Journal of Medicinal Plants Research · doi:10.5897/jmpr10.399 · Cited by 124 · see citing works
Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4
Inui, A., Cheng, K., Asakawa, A., Amitani, H., Amitani, M. S., Morinaga, A., Takimoto, Y., Kairupan, B. H. R., & Runtuwene, J. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s108539 · Cited by 124 · see citing works
Defects in Insulin Secretion and Action in the Pathogenesis of Type 2 Diabetes Mellitus
Tripathy, D., & Chávez, A. O. (2010) · Current Diabetes Reports · doi:10.1007/s11892-010-0115-5 · Cited by 123 · see citing works
Carnosic acid-rich rosemary (Rosmarinus officinalisL.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet
Ibarra, A., Cases, J., Roller, M., Chiralt, A., Coussaert, A., & Ripoll, C. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001620 · Cited by 118 · see citing works
Effects of rosmarinic acid against aﬂatoxin B1 and ochratoxin‐A‐induced cell damage in a human hepatoma cell line (Hep G2)
Renzulli, C., Galvano, F., Pierdomenico, L., Speroni, E., & Guerra, M. C. (2004) · Journal of Applied Toxicology · doi:10.1002/jat.982 · Cited by 117 · see citing works
Rosemary (Rosmarinus officinalisL.) Extract Regulates Glucose and Lipid Metabolism by Activating AMPK and PPAR Pathways in HepG2 Cells
Tu, Z., Moss‐Pierce, T., Ford, P. W., & Jiang, T. A. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400298c · Cited by 110 · see citing works
Inhibition of Gastric Lipase as a Mechanism for Body Weight and Plasma Lipids Reduction in Zucker Rats Fed a Rosemary Extract Rich in Carnosic Acid
Romo‐Vaquero, M., Yáñez-Gascón, M. J., Garcı́a-Villalba, R., Larrosa, M., Fromentin, E., Ibarra, A., Roller, M., Tomás-Barberán, F. A., Espı́n, J. C., & García‐Conesa, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039773 · Cited by 99 · see citing works
Chemistry and antioxidative factors in rosemary and sage
Ho, C., Wang, M., WEI, G., Huang, T., & Huang, M. (2000) · BioFactors · doi:10.1002/biof.5520130126 · Cited by 96 · see citing works
Pharmacologic Treatment of Type 2 Diabetes
Tran, L., Zielinski, A., Roach, A. H., Jende, J. A., Householder, A. M., Cole, E. E., Atway, S. A., Amornyard, M., Accursi, M. L., Shieh, S. W., et al. (2015) · Annals of Pharmacotherapy · doi:10.1177/1060028014558289 · Cited by 96 · see citing works
Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy
González‐Vallinas, M., Reglero, G., & de Molina, A. R. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1082110 · Cited by 94 · see citing works
An Evidence-Based Systematic Review of Rosemary ( Rosmarinus officinalis ) by the Natural Standard Research Collaboration
Ulbricht, C. E., Abrams, T. R., Brigham, A., Ceurvels, J., Clubb, J., Curtiss, W., Kirkwood, C. D., Giese, N., Hoehn, K., Iovin, R. C., et al. (2010) · Journal of Dietary Supplements · doi:10.3109/19390211.2010.525049 · Cited by 87 · see citing works
Use of rosemary extracts as a food additive - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
(EFSA), E. F. S. A. (2008) · EFSA Journal · doi:10.2903/j.efsa.2008.721 · Cited by 85 · see citing works
Hyperglycemic and insulin release inhibitory effects of Rosmarinus officinalis
Alhader, A. A., Hasan, Z. A., & Aqel, M. B. (1994) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(94)90046-9 · Cited by 79 · see citing works
Adverse Effects of Rosemary ( Rosmarinus officinalis L.) on Reproductive Function in Adult Male Rats
Nusier, M. K., Bataineh, H. N., & Daradkah, H. M. (2007) · Experimental Biology and Medicine · doi:10.3181/00379727-232-2320809 · Cited by 78 · see citing works
Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice
Wang, T., Takikawa, Y., Satoh, T., Yoshioka, Y., Kosaka, K., Tatemichi, Y., & Suzuki, K. (2010) · Hepatology Research · doi:10.1111/j.1872-034x.2010.00747.x · Cited by 74 · see citing works
The Effects of Rosemary (Rosmarinus officinalis) Leaves Powder on Glucose Level, Lipid Profile and Lipid Perodoxation
Labban, L., Mostafa, U. E.-S., & Ibrahim, Y. M. (2014) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2014.56044 · Cited by 74 · see citing works
Rosemary (Rosmarinus officinalisL.) Leaf Extract Limits Weight Gain and Liver Steatosis in Mice Fed a High-Fat Diet
Harach, T., Aprikian, O., Monnard, I., Moulin, J., Membrez, M., Béolor, J.-C., Raab, T., Macé, K., & Darimont, C. (2009) · Planta Medica · doi:10.1055/s-0029-1240612 · Cited by 70 · see citing works
Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program
Gaya, M., Repetto, M. V., Toneatto, J., Anesini, C. A., Piwien‐Pilipuk, G., & Moreno, S. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.03.021 · Cited by 69 · see citing works
A Pilot trial evaluating meta050, a proprietary combination of reduced iso-alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia
Lukaczer, D., Darland, G. K., Tripp, M. L., Liska, D. A., Lerman, R. H., Schiltz, B., & Bland, J. S. (2005) · Phytotherapy Research · doi:10.1002/ptr.1709 · Cited by 67 · see citing works
Rosemary tea consumption results to anxiolytic- and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity; phytochemical investigation and in silico studies
Ferlemi, A.-V., Katsikoudi, A., Kontogianni, V. G., Kellici, T. F., Iatrou, G., Lamari, F. N., Tzakos, A. G., & Margarity, M. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.04.013 · Cited by 65 · see citing works
Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats
Ramadan, K. S., Khalil, O. A., Danial, E. N., Alnahdi, H. S., & Ayaz, N. O. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0253-8 · Cited by 65 · see citing works
Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity
Cui, L., Kim, M. O., Seo, J. H., Kim, I. S., Kim, N. Y., Lee, S. H., Park, J., Kim, J.-W., & Lee, H. S. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.11.138 · Cited by 58 · see citing works
Carnosic acid (CA) prevents lipid accumulation in hepatocytes through the EGFR/MAPK pathway
Wang, T., Takikawa, Y., Tabuchi, T., Satoh, T., Kosaka, K., & Suzuki, K. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-012-0546-7 · Cited by 58 · see citing works
Preventive and protective properties of rosemary (Rosmarinus officinalis L.) in obesity and diabetes mellitus of metabolic disorders: a brief review
Sedighi, R., Zhao, Y., Yerke, A. M., & Sang, S. (2015) · Current Opinion in Food Science · doi:10.1016/j.cofs.2015.02.002 · Cited by 57 · see citing works
Comparative evaluation of antidiabetic activity of Rosmarinus officinalis L. and Chamomile recutita in streptozotocin induced diabetic rats
Emam, M. A. (2012) · Agriculture and Biology Journal of North America · doi:10.5251/abjna.2012.3.6.247.252 · Cited by 55 · see citing works
The Evaluation of Risk Factors Associated with Adverse Drug Reactions by Metformin in Type 2 Diabetes Mellitus
Okayasu, S., Kitaichi, K., Hori, A., Suwa, T., Horikawa, Y., Yamamoto, M., Takeda, J., & Itoh, Y. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.933 · Cited by 53 · see citing works
Antidiabetic activity of Rosmarinus officinalis and its relationship with the antioxidant property
Khalil, O. A. (2012) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp12.162 · Cited by 52 · see citing works
Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates rat intestinal SGLT1 levels with effects on blood glucose
Azevedo, M. F., Lima, C. F., Fernandes‐Ferreira, M., Almeida, M. J., Wilson, J. M., & Pereira‐Wilson, C. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000472 · Cited by 50 · see citing works
ROSMARINIC ACID AMELIORATES DIABETIC NEPHROPATHY IN UNINEPHRECTOMIZED DIABETIC RATS
Tavafi, M., Ahmadvand, H., Khalatbari, A., & Tamjidipoor, A. (2011) · Iranian journal of basic medical sciences. · doi:10.22038/ijbms.2011.5006 · Cited by 45 · see citing works
Effects of 50% Ethanol Extract from Rosemary ( Rosmarinus officinalis ) on α‐Glucosidase Inhibitory Activity and the Elevation of Plasma Glucose Level in Rats, and Its Active Compound
Koga, K., Shibata, H., Yoshino, K., & Nomoto, K. (2006) · Journal of Food Science · doi:10.1111/j.1750-3841.2006.00125.x · Cited by 42 · see citing works
Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis
Lipina, C., & Hundal, H. S. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.07.022 · Cited by 42 · see citing works
The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice
Sheyab, F. M. A., Abuharfeil, N. M., Salloum, L., Hani, R. B., & Awad, D. (2012) · Journal of Biology and Life Science · doi:10.5296/jbls.v3i1.906 · Cited by 42 · see citing works
Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation
Naimi, M., Tsakiridis, T. K., Stamatatos, T. C., Alexandropoulos, D. I., & Tsiani, E. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0430 · Cited by 40 · see citing works
Self-citation
Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes
Park, M.-Y., & Mun, S. T. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.5.516 · Cited by 39 · see citing works
Rosemary extracts improve flow‐mediated dilatation of the brachial artery and plasma PAI‐1 activity in healthy young volunteers
Sinkovič, A., Šuran, D., Lokar, L., Fliser, E., Škerget, M., Novak, Z., & Knez, Ž. (2010) · Phytotherapy Research · doi:10.1002/ptr.3276 · Cited by 37 · see citing works
Antidiabetic Screening of Commercial Botanical Products in 3T3-L1 Adipocytes and db/db Mice
Babish, J. G., Pacioretty, L. M., Bland, J. S., Minich, D. M., Hu, J., & Tripp, M. L. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2009.0110 · Cited by 36 · see citing works
Effects of Rosemary (Rosmarinus officinalis) on Lipid Profile of Diabetic Rats
Aljamal, A., & Alqadi, T. (2011) · Cited by 35 · see citing works
Incretins, Diabetes, Pancreatitis and Pancreatic Cancer: What the GI specialist needs to know
Forsmark, C. E. (2015) · Pancreatology · doi:10.1016/j.pan.2015.11.009 · Cited by 33 · see citing works
Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation
Naimi, M., Vlavcheski, F., Murphy, B. A., Hudlický, T., & Tsiani, E. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12674 · Cited by 31 · see citing works
Self-citation
Effect of a Rosmarinus officinalis leave extract on plasma glucose levels in normoglycaemic and diabetic mice.
Erenmemişoğlu, A., Saraymen, R., & Ustun, S. (1997) · PubMed · Cited by 30 · see citing works
Beneficial Effects of Endurance Exercise with Rosmarinus officinalis Labiatae Leaves Extract on Blood Antioxidant Enzyme Activities and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats
Nazem, F., Farhangi, N., & Neshat-Gharamaleki, M. (2015) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2014.11.003 · Cited by 27 · see citing works
Carnosic Acid Inhibits Lipid Accumulation in 3T3-L1 Adipocytes Through Attenuation of Fatty Acid Desaturation
Park, M.-Y., & Sung, M. (2015) · Journal of Cancer Prevention · doi:10.15430/jcp.2015.20.1.41 · Cited by 26 · see citing works
Effect of rosmarinic acid on insulin sensitivity, glyoxalase system and oxidative events in liver of fructose-fed mice.
Vanithadevi, B., & Anuradha, C. V. (2019) · International Journal of Diabetes and Metabolism · doi:10.1159/000497651 · Cited by 26 · see citing works
Short Review of Extracts of Rosemaryas a Food Additive
Raadt, P., Röttger-Wirtz, S., Vos, E., & Verhagen, H. (2015) · European Journal of Nutrition & Food Safety · doi:10.9734/ejnfs/2015/10404 · Cited by 25 · see citing works
Effect of Rosmarinus Officinalis Extract on some Cardiac Enzymes of Streptozotocin-induced Diabetic Rats
Alnahdi, H. S. (2012) · Journal of Health Science · doi:10.5923/j.health.20120204.03 · Cited by 24 · see citing works
Phenolic Diterpenes from Rosemary Suppress cAMP Responsiveness of Gluconeogenic Gene Promoters
Yun, Y. S., Noda, S., Shigemori, G., Kuriyama, R., Takahashi, S., Umemura, M., Takahashi, Y. K., & Inoue, H. (2012) · Phytotherapy Research · doi:10.1002/ptr.4794 · Cited by 21 · see citing works
Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody
Jung, D.-Y., Kim, E. Y., Joo, S.-Y., Park, J. B., Moon, C., Kim, S. H., Sim, E.-Y., Joh, J., Kwon, C. H. D., Kwon, G.-Y., et al. (2008) · Experimental & Molecular Medicine · doi:10.3858/emm.2008.40.1.1 · Cited by 20 · see citing works
Empagliflozin: A new treatment option for patients with type 2 diabetes mellitus
DAILEY, G. E. (2015) · Drugs of today · doi:10.1358/dot.2015.51.9.2368554 · Cited by 12 · see citing works
Effect of Rosmarinus Officinalis on Lipid Profile of Streptozotocin-induced Diabetic Rats
Soliman, G. Z. A. (2013) · The Egyptian Journal of Hospital Medicine · doi:10.12816/0001643 · Cited by 10 · see citing works
POM Analyses of Constituents of Rosmarinus officinalis and Their Synergistic Effect in Experimental Diabetic Rats
ElSawy, E. H. N. (2015) · Journal of Bioanalysis & Biomedicine · doi:10.4172/1948-593x.1000118 · Cited by 7 · see citing works
Phenolic Diterpenes from Rosemary and Sage
Schwarz, K. (2002) · Functional foods & nutraceuticals series · doi:10.1201/9781420012873.ch6 · Cited by 5 · see citing works

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Pang, G., Li, F.-X., Yan, Y., Zhang, Y., Kong, L., Pu, Z., Wang, K., Zhang, F., Liu, B., & Lu, C. C. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000006 · Cited by 121 · see citing works
The medicinal and aromatic plants as ingredients in functional beverage production
Maleš, I., Pedišić, S., Zorić, Z., Garofulić, I. E., Repajić, M., You, L., Vladimir‐Knežević, S., Butorac, D., & Dragović‐Uzelac, V. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105210 · Cited by 127 · see citing works
Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies
Hartogh, D. J. D., Gabriel, A., & Tsiani, E. (2019) · Nutrients · doi:10.3390/nu12010058 · Cited by 100 · see citing works
Self-citation
Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies
Hartogh, D. J. D., Gabriel, A., & Tsiani, E. (2020) · Nutrients · doi:10.3390/nu12010118 · Cited by 96 · see citing works
Self-citation
Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome
Bagetta, D., Maruca, A., Lupia, A., Mesiti, F., Catalano, R., Romeo, I., Moraca, F., Ambrosio, F. A., Costa, G., Artese, A., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111903 · Cited by 100 · see citing works
Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review
Ansari, P., Khan, J. T., Chowdhury, S., Reberio, A. D., Kumar, S., Seidel, V., Abdel‐Wahab, Y. H. A., & Flatt, P. R. (2024) · Nutrients · doi:10.3390/nu16213709 · Cited by 106 · see citing works
Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Salvia aurita Constituents
Etsassala, N. G. E. R., Badmus, J. A., Marnewick, J. L., Iwuoha, E. I., Nchu, F., & Hussein, A. A. (2020) · Antioxidants · doi:10.3390/antiox9111149 · Cited by 91 · see citing works
Environmentally Friendly Techniques and Their Comparison in the Extraction of Natural Antioxidants from Green Tea, Rosemary, Clove, and Oregano
Calderón‐Oliver, M., & Ponce‐Alquicira, E. (2021) · Molecules · doi:10.3390/molecules26071869 · Cited by 80 · see citing works
A review on prevention of glycation of proteins: Potential therapeutic substances to mitigate the severity of diabetes complications
Sarmah, S., & Roy, A. S. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.12.041 · Cited by 71 · see citing works
Carnosol Increases Skeletal Muscle Cell Glucose Uptake via AMPK-Dependent GLUT4 Glucose Transporter Translocation
Vlavcheski, F., Baron, D. C., Vlachogiannis, I. A., MacPherson, R. E. K., & Tsiani, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051321 · Cited by 67 · see citing works
Self-citation
Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence
O’Neill, E. J., Hartogh, D. J. D., Azizi, K., & Tsiani, E. (2020) · Antioxidants · doi:10.3390/antiox9100961 · Cited by 61 · see citing works
Self-citation
Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1‐mediated Nrf2/ HO ‐1 activation
Ji, R., Jia, F., Chen, X., Gao, Y., & Yang, J. (2023) · Phytotherapy Research · doi:10.1002/ptr.7749 · Cited by 61 · see citing works
Antioxidant and Antiproliferative Activities of Bioactive Compounds Contained in Rosmarinus officinalis Used in the Mediterranean Diet
Bourhia, M., Laasri, F. E., Aourik, H., Boukhris, A., Ullah, R., Bari, A., Ali, S. S., Mzibri, M. E., Benbacer, L., & Gmouh, S. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/7623830 · Cited by 54 · see citing works
Antidiabetic Effects and Mechanisms of Rosemary (Rosmarinus officinalisL.) and its Phenolic Components
Bao, T.-Q., Li, Y., Qu, C., Zheng, Z., Yang, H. Q., & Li, P. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500664 · Cited by 52 · see citing works
Rosmarinus officinalis essential oil modulates renal toxicity and oxidative stress induced by potassium dichromate in rats
El-Demerdash, F. M., El-Sayed, R. A., & Abdel‐Daim, M. M. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126791 · Cited by 46 · see citing works
Chemical Profile, Antioxidant, Anti-Inflammatory, and Anti-Cancer Effects of Italian Salvia rosmarinus Spenn. Methanol Leaves Extracts
Brindisi, M., Bouzidi, C., Frattaruolo, L., Loizzo, M. R., Tundis, R., Dugay, A., Deguin, B., Cappello, A. R., & Cappello, M. S. (2020) · Antioxidants · doi:10.3390/antiox9090826 · Cited by 45 · see citing works
Impact of Rosmarinus officinalis cold-pressed oil on health, growth performance, intestinal bacterial populations, and immunocompetence of Japanese quail
Mahgoub, S. A., El-Hack, M. E. A., Saadeldin, I. M., Hussein, M., Swelum, A. A., & Alagawany, M. M. (2018) · Poultry Science · doi:10.3382/ps/pey568 · Cited by 41 · see citing works
Chemical profiling, antioxidant, enzyme inhibitory and in silico modeling of Rosmarinus officinalis L. and Artemisia herba alba Asso. essential oils from Algeria
Benabdallah, A., Bencharif‐Betina, S., Bouchentouf, S., Boumendjel, M., Bechkri, S., Bensouıcı, C., Nicolì, F., Vergine, M., Negro, C., & Bellis, L. D. (2022) · South African Journal of Botany · doi:10.1016/j.sajb.2022.02.012 · Cited by 40 · see citing works
Biosynthesis of palladium, platinum, and their bimetallic nanoparticles using rosemary and ginseng herbal plants: evaluation of anticancer activity
Alinaghi, M., Mokarram, P., Ahmadi, M., & Bozorg-Ghalati, F. (2024) · Scientific Reports · doi:10.1038/s41598-024-56275-z · Cited by 39 · see citing works
In-silico reverse docking and in-vitro studies identified curcumin, 18α-glycyrrhetinic acid, rosmarinic acid, and quercetin as inhibitors of α-glucosidase and pancreatic α-amylase and lipid accumulation in HepG2 cells, important type 2 diabetes targets
Tshiyoyo, K. S., Bester, M. J., Serem, J. C., & Apostolides, Z. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.133492 · Cited by 38 · see citing works
Advance in dietary polyphenols as dipeptidyl peptidase-IV inhibitors to alleviate type 2 diabetes mellitus: aspects from structure-activity relationship and characterization methods
Jia, Y., Cai, S., Muhoza, B., Qi, B., & Li, Y. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1989659 · Cited by 34 · see citing works
Optimization extraction of rosemary essential oils using hydrodistillation with extraction kinetics analysis
Chen, H., Gu, Z., Yang, L., Yang, R., Ji, Y., Zeng, Q., Xiao, F., & Huang, P. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2549 · Cited by 33 · see citing works
The Potential of High Voltage Discharges for Green Solvent Extraction of Bioactive Compounds and Aromas from Rosemary (Rosmarinus officinalis L.)—Computational Simulation and Experimental Methods
Nutrizio, M., Kljusurić, J. G., Marijanović, Z., Dubrović, I., Viskić, M., Mikolaj, E., Chemat, F., & Jambrak, A. . (2020) · Molecules · doi:10.3390/molecules25163711 · Cited by 33 · see citing works
Hepatoprotective potential of Rosmarinus officinalis essential oil against hexavalent chromium-induced hematotoxicity, biochemical, histological, and immunohistochemical changes in male rats
El-Demerdash, F. M., El-Sayed, R. A., & Abdel‐Daim, M. M. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-12126-8 · Cited by 33 · see citing works
Honest nutraceuticals, cosmetics, therapies, and foods (NCTFs): standardization and safety of natural products
Sadgrove, N. J. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1874286 · Cited by 32 · see citing works
Dietary rosemary extract modulated gut microbiota and influenced the growth, meat quality, serum biochemistry, antioxidant, and immune capacities of broilers
Liu, Y., Li, C., Huang, X., Zhang, X., Deng, P., Jiang, G., & Dai, Q. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1024682 · Cited by 32 · see citing works
Potential Application of Some Lamiaceae Species in the Management of Diabetes
Etsassala, N. G. E. R., Hussein, A. A., & Nchu, F. (2021) · Plants · doi:10.3390/plants10020279 · Cited by 31 · see citing works
Attenuation of Free Fatty Acid-Induced Muscle Insulin Resistance by Rosemary Extract
Vlavcheski, F., & Tsiani, E. (2018) · Nutrients · doi:10.3390/nu10111623 · Cited by 31 · see citing works
Self-citation
Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response
Cai, G., Lin, F., Wu, D., Lin, C., Chen, H., Wei, Y., Weng, H., Chen, Z., Wu, M., Huang, E., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.859978 · Cited by 30 · see citing works
Carnosic Acid Attenuates the Free Fatty Acid-Induced Insulin Resistance in Muscle Cells and Adipocytes
Hartogh, D. J. D., Vlavcheski, F., Giacca, A., MacPherson, R. E. K., & Tsiani, E. (2022) · Cells · doi:10.3390/cells11010167 · Cited by 30 · see citing works
Self-citation
The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice
Ruiz‐Malagón, A. J., Rodríguez‐Sojo, M. J., Hidalgo‐Garcia, L., Molina‐Tijeras, J. A., García, F., Pischel, I., Romero, M., Duarte, J., Diez‐Echave, P., Rodríguez‐Cabezas, M. E., et al. (2022) · Antioxidants · doi:10.3390/antiox11061073 · Cited by 31 · see citing works
Thiacloprid Induced Developmental Neurotoxicity via ROS-Oxidative Injury and Inflammation in Chicken Embryo: The Possible Attenuating Role of Chicoric and Rosmarinic Acids
Farag, M. R., Khalil, S. R., Zaglool, A. W., Hendam, B. M., Moustafa, A. A., Cocco, R., Cerbo, A. D., & Alagawany, M. M. (2021) · Biology · doi:10.3390/biology10111100 · Cited by 27 · see citing works
Nutraceuticals and Diet-based Phytochemicals in Type 2 Diabetes Mellitus: From Whole Food to Components with Defined Roles and Mechanisms
Onaolapo, A. Y., & Onaolapo, O. J. (2018) · Current Diabetes Reviews · doi:10.2174/1573399814666181031103930 · Cited by 26 · see citing works
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance
Shamshoum, H., Vlavcheski, F., MacPherson, R. E. K., & Tsiani, E. (2021) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-0592 · Cited by 25 · see citing works
Self-citation
In Vitro Antidiabetic Activity Affecting Glucose Uptake in HepG2 Cells Following Their Exposure to Extracts of Lauridia tetragona (L.f.) R.H. Archer
Odeyemi, S. W., & Dewar, J. B. (2019) · Processes · doi:10.3390/pr8010033 · Cited by 25 · see citing works
Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system
Geng, W., Long, S. L., Chang, Y., Saxton, A. M., Joyce, S. A., & Lin, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-61723-7 · Cited by 24 · see citing works
Optimizing Ethanol Extraction of Rosemary Leaves and Their Biological Evaluations
Yeddes, W., Hammami, M., Gadhoumi, H., Affes, T. G., Nait-Mohamed, S., Wannes, W. A., & Tounsi, M. S. (2022) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2022.00002 · Cited by 24 · see citing works
Nutritional composition, phytochemical profile, therapeutic potentials, and food applications of rosemary: A comprehensive review
Shankar, A., Ali, A., Abdullah, H. M., Balaji, J., Kaur, J., Saeed, F., Wasiq, M., Imran, A., Jibraeel, H., Raheem, M. S., et al. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.106688 · Cited by 21 · see citing works
Use of dietary rosemary ( Rosmarinus officinalis L.) extract as a growth promotor and immunostimulant in common carp
Dezfoulnejad, M. C., & Molayemraftar, T. (2021) · Aquaculture Research · doi:10.1111/are.15690 · Cited by 21 · see citing works
Effect of rosemary leaf powder with weight loss diet on lipid profile, glycemic status, and liver enzymes in patients with nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial
Akbari, S., Sohouli, M. H., Ebrahimzadeh, S., Mansour‐Ghanaei, F., Hosseini, A. F., & Aryaeian, N. (2022) · Phytotherapy Research · doi:10.1002/ptr.7446 · Cited by 21 · see citing works
Gold nanoparticles (AuNPs) and Rosmarinus officinalis extract and their potentials to prompt apoptosis and arrest cell cycle in HT-29 colon cancer cells
Alshahrani, M. Y., & Ibrahim, E. H. (2022) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2022.102304 · Cited by 19 · see citing works
Muscle Cell Insulin Resistance Is Attenuated by Rosmarinic Acid: Elucidating the Mechanisms Involved
Hartogh, D. J. D., Vlavcheski, F., & Tsiani, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065094 · Cited by 18 · see citing works
Self-citation
Carnosic Acid against Lung Cancer: Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling
O’Neill, E. J., Sze, S. K., MacPherson, R. E. K., & Tsiani, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25041950 · Cited by 18 · see citing works
Self-citation
The Rosmarinus Bioactive Compound Carnosic Acid Is a Novel PPAR Antagonist That Inhibits the Browning of White Adipocytes
Colson, C., Batrow, P.-L., Gautier, N., Rochet, N., Ailhaud, G. P., Peiretti, F., & Amri, E. (2020) · Cells · doi:10.3390/cells9112433 · Cited by 18 · see citing works
Optimization of cultivation conditions of Salvia viridis L. shoots in the Plantform bioreactor to increase polyphenol production
Grzegorczyk-Karolak, I., Staniewska, P., Lebelt, L., & Piotrowska, D. G. (2021) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-021-02168-2 · Cited by 18 · see citing works
Alginate Microbeads for Trapping Phenolic Antioxidants in Rosemary (Rosmarinus officinalis L.): Multivariate Optimization Based on Bioactive Properties and Morphological Measurements
Toprakçı, G., Toprakçı, İ., & Şahin, S. (2025) · Gels · doi:10.3390/gels11030172 · Cited by 17 · see citing works
Diet Supplementation with Rosemary (Rosmarinus officinalis L.) Leaf Powder Exhibits an Antidiabetic Property in Streptozotocin-Induced Diabetic Male Wistar Rats
Kabubii, Z. N., Mbaria, J. M., Mathiu, P. M., Wanjohi, J. M., & Nyaboga, E. N. (2024) · Diabetology · doi:10.3390/diabetology5010002 · Cited by 21 · see citing works
Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake
El‐Huneidi, W., Anjum, S., Saleh, M. A., Bustanji, Y. K., Abu‐Gharbieh, E., & Taneera, J. (2022) · Molecules · doi:10.3390/molecules27072102 · Cited by 17 · see citing works
Natural Products for the Management of Diabetes
(2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64179-3.00010-4 · Cited by 17 · see citing works
Prevention of 4-hydroxynonenal-induced lipolytic activation by carnosic acid is related to the induction of glutathione S-transferase in 3T3-L1 adipocytes
Liu, K., Kuo, W.-C., Lin, C., Lii, C., Liu, Y., Cheng, Y.-H., & Tsai, C.-W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.04.567 · Cited by 16 · see citing works
Properties and use of rosemary (Rosmarinus officinalis L.)
Pawłowska, K., Janda, K., & Jakubczyk, K. (2020) · Pomeranian Journal of Life Sciences · doi:10.21164/pomjlifesci.722 · Cited by 16 · see citing works
Inhibition of tumor growth in CT-26 colorectal cancer-bearing mice with alcoholic extracts of Curcuma longa and Rosmarinus officinalis
Makaremi, S., Ganji, A., Ghazavi, A., & Mosayebi, G. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.101006 · Cited by 15 · see citing works
Thymus serpyllum Exhibits Anti-Diabetic Potential in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice: A Combined Biochemical and In Vivo Study
Azhar, J., John, P. C. L., & Bhatti, A. (2022) · Nutrients · doi:10.3390/nu14173561 · Cited by 15 · see citing works
Study on the Chemical Composition, Enzyme Inhibition and Antioxidant Activity of Ziziphora taurica subsp. cleonioides
Sarıkürkçü, C., Kakouri, E., Sarikurkcu, R. T., & Tarantilis, P. Α. (2019) · Applied Sciences · doi:10.3390/app9245515 · Cited by 14 · see citing works
Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells
Zappalà, A., Vicario, N., Calabrese, G., Turnaturi, R., Pasquinucci, L., Montenegro, L., Spadaro, A., Parenti, R., & Parenti, C. (2019) · Natural Product Research · doi:10.1080/14786419.2019.1587428 · Cited by 13 · see citing works
Critical review on biological effect and mechanisms of diterpenoids in Rosmarinus officinalis
Liang, H., Guan, M., Li, T., Li, S., Ma, C., & Li, C. (2024) · Food & medicine homology. · doi:10.26599/fmh.2025.9420021 · Cited by 12 · see citing works
Assessment of Effects of Rosemary Essential Oil on the Kidney Pathology of Diabetic Adult Male Albino Rats
Fareed, S. A., Yousef, E. M., & El-Moneam, S. M. A. (2023) · Cureus · doi:10.7759/cureus.35736 · Cited by 11 · see citing works
Rosemary extract increases neuronal cell glucose uptake and activates AMPK
Baron, D. C., Marko, D. M., Tsiani, E., & MacPherson, R. E. K. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-0014 · Cited by 10 · see citing works
Self-citation
Endothelial Function and Postprandial Glucose Control in Response to Test-Meals Containing Herbs and Spices in Adults With Overweight/Obesity
Huang, Y., Tsai, M.-F., Thorat, R. S., Xiao, D., Zhang, X., Sandhu, A. K., Edirisinghe, I., & Burton‐Freeman, B. M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.811433 · Cited by 10 · see citing works
Oxidative Stress and DNA Lesion Reduction of a Polyphenolic Enriched Extract of Thymus marschallianus Willd. in Endothelial Vascular Cells Exposed to Hyperglycemia
Ielciu, I., Filip, G. A., Oniga, I., Oláh, N.-K., Bâldea, I., Olteanu, D. E., BURTESCU, R. F., Turcuș, V., Sevastre-Berghian, A., Benedec, D., et al. (2021) · Plants · doi:10.3390/plants10122810 · Cited by 8 · see citing works
Cassia fistula nutrition rich flower tea derived biotic nanoparticles synthesis, characterization and their antioxidant and anti-hyperglycaemic properties
Veeramani, C., Newehy, A. S. E., Alsaif, M. A., & Al‐Numair, K. S. (2022) · African Health Sciences · doi:10.4314/ahs.v22i1.47 · Cited by 8 · see citing works
Applicability of ChatGPT 3.5 in the development of new analytical procedures
Kalyniukova, A., Várfalvyová, A., & Andruch, V. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.110787 · Cited by 7 · see citing works
Active Packaging Films from PBAT/PLA with Rosmarinus officinalis L. Extract: Antioxidant, UV-Shielding, and Compostable Properties
He, X., Tang, L., & Huang, R. (2026) · Molecules · doi:10.3390/molecules31020217 · Cited by 7 · see citing works
Employing Machine Learning Models to Predict Potential α-Glucosidase Inhibitory Plant Secondary Metabolites Targeting Type-2 Diabetes and Their In Vitro Validation
Jamir, L., & Hariprasad, P. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c00955 · Cited by 7 · see citing works
Evaluation of Antidiabetic Activity of Rosmarinus officinalis var. prostratus Growing in Syria in Alloxan Diabetic Rats
Malek, A., Sadaka, M. W. M., Hamo, S., & Al-Mahbashi, H. M. (2020) · Current Bioactive Compounds · doi:10.2174/1573407216999200426235739 · Cited by 7 · see citing works
A New HPLC Method with UV Detection for the Determination of Carnosol in Human Plasma and Application to a Pharmacokinetic Study
Ceylan, B., Tırıs, G., & Tekkeli, Ş. E. K. (2021) · Chromatographia · doi:10.1007/s10337-021-04069-0 · Cited by 6 · see citing works
Ameliorative effects of aqueous extract from rosemary on oxidative stress and inflammation pathways caused by a high-fat diet in C57BL/6 mice
Silva, A. M. D. O. E., Pereira, R. O., Oliveira, A. K. D. S., Harris, F. S., de Melo, I. L. P., Almeida-Souza, T. H., Yoshime, L. T., Melo, C. D. S., dos Santos, J. L., de Andrade-Wartha, E. R. S., et al. (2023) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2023-0157 · Cited by 6 · see citing works
Rosmarinus Officinalis L, Eriobotrya Japonica and Olea Europaea L Attenuate Adipogenesis in 3T3-L1-Derived Adipocytes and Inflammatory Response in LPS-Induced THP-1-Derived Macrophages
(2022) · Biointerface Research in Applied Chemistry · doi:10.33263/briac134.343 · Cited by 5 · see citing works
Bioassay guided isolation and compounds identification of the anti-diabetic fractions of (rosemary) Rosmarinus officinalis leaves extract
Kabubii, Z. N., Mbaria, J. M., Mathiu, P. M., Wanjohi, J. M., & Nyaboga, E. N. (2024) · Clinical Phytoscience · doi:10.1186/s40816-024-00378-7 · Cited by 5 · see citing works
Phytochemical Screening and in Vitro Antimicrobial and Anticancer Activities of Different Extracts of Rosmarinus officinalis (Rosemary): A Comparative Study
Ali, N. M. (2021) · Advances in Pharmacology and Pharmacy · doi:10.13189/app.2021.090302 · Cited by 5 · see citing works
Mapping Protein Targets of Carnosol, a Molecule Identified in Rosmarinus officinalis: In Silico Docking Studies and Network Pharmacology
Taboada-Alquerque, M., Pajaro-Valenzuela, D., Caballero-Gallardo, K., Cifuentes, A., Ibáñez, E., Ahumedo, M., Stashenko, E. E., & Olivero‐Verbel, J. (2023) · Scientia Pharmaceutica · doi:10.3390/scipharm91020019 · Cited by 4 · see citing works
Herbal Candies: A Potential Source of Health Benefits
Kailey, R., Rasane, P., Singh, J., Kaur, S., Gunjal, M., Kaur, J., Bhadariya, V., & Avinashe, H. A. (2023) · Current Nutrition & Food Science · doi:10.2174/0115734013250026231016140631 · Cited by 5 · see citing works
Carnosic Acid (CA) Induces a Brown Fat-like Phenotype, Increases Mitochondrial Biogenesis, and Activates AMPK in 3T3-L1 Adipocytes
Vlavcheski, F., MacPherson, R. E. K., Fajardo, V. A., Sze, N., & Tsiani, E. (2024) · Biomedicines · doi:10.3390/biomedicines12071569 · Cited by 4 · see citing works
Self-citation
Rosmarinus officinalis L.
Mersin, B., & Çitoğlu, G. S. (2022) · Springer eBooks · doi:10.1007/978-3-031-07753-1_34 · Cited by 4 · see citing works
Formulation of a novel anti-lung cancer drug: Vanadium nanoparticles containing Salvia officinalis
Liu, Z., Zhang, Z., Du, X., Liu, Y., & Zhang, Z. (2023) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2023.110520 · Cited by 4 · see citing works
PROTECTIVE EFFECT OF ROSMARINUS OFFICINALIS EXTRACT ON THE NEPHROTOXICITY CAUSED BY NICKEL CHLORIDE IN WISTAR RATS
Saker, H., Boussekine, S., Gasmi, S., Benkhedir, A., Benali, Y., & Bensouıcı, C. (2023) · Journal of Microbiology Biotechnology and Food Sciences · doi:10.55251/jmbfs.9764 · Cited by 4 · see citing works
Rosemary extract modulates stress resistance and accumulation of reactive oxygen species in the model organism Caenorhabditis elegans
Saier, C., Storbeck, S., Baier, S., Dietz, H., & Wätjen, W. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100233 · Cited by 3 · see citing works
Physicochemical and Microbiological Properties of Common Carp (Cyprinus carpio) Fillets Marinated with Rosemary and Laurel Essential Oils
Şevik, R., Denizkara, A. J., Akarca, G., Atik, A., & Atik, İ. (2022) · Journal of Aquatic Food Product Technology · doi:10.1080/10498850.2022.2120790 · Cited by 3 · see citing works
Comprehensive Review on the Development of Phytonanomedicines for Cancer Treatment
Fernandes, D. A. (2025) · Biomedical Materials & Devices · doi:10.1007/s44174-025-00280-x · Cited by 3 · see citing works
Biological functions and applications of rosemary extracts in animal production
Liu, Z., Xia, T., Jiang, A., Zhou, C., Lukuyu, B. A., & Tan, Z. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.10.002 · Cited by 2 · see citing works
Evaluation of antidiabetic activity of aqueous extract of Origanum floribundum Munby leaves in alloxan induced diabetic rats wistar
Nasri, M., Zaouani, M., Mimoune, N., Hani, F. A., Mahdid, M., & Toumi, M. (2021) · Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale · doi:10.4081/jbr.2020.9141 · Cited by 2 · see citing works
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Semwal, B. C., Chauhan, N. S., Jyot, V., Kumar, A., Sonia, S., & Bhupendra, S. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230727093911 · Cited by 2 · see citing works
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mohapatra, S., Ranjit, S. K., Pattnaik, G., Parida, P., Dutta, S., Ghosh, G., Rath, G., & Kar, B. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328331153240918093157 · Cited by 2 · see citing works
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Feng, X., Wu, X., Wu, Y., Zhao, Z., Xiang, C., Bai, X., Liu, X., Zhao, J., Takeda, S., & Qing, Y. (2020) · Cell Biology International · doi:10.1002/cbin.11357 · Cited by 2 · see citing works
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McGrowder, D. A., Miller, F. G., Nwokocha, C. R., Wilson-Clarke, C. F., Anderson, M., Anderson-Jackson, L., Williams, L., & Alexander-Lindo, R. L. (2020) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-7998-4808-0.ch003 · Cited by 2 · see citing works
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Abbas, Q., Al-Thawadi, S. M., & Perna, S. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839165498-00128 · Cited by 2 · see citing works
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Qiang</p>, <. (2022) · The Frontiers of Society Science and Technology · doi:10.25236/fsst.2022.040312 · Cited by 2 · see citing works
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Xu, R. (2022) · doi:10.22541/au.166857482.26607149/v1 · Cited by 2 · see citing works
Preparation of Ultrasound-Assisted Herbal Coffee Infusion, Bioaccessibility of Phenolic Compounds and Their Antioxidant, Anti-diabetic, and Anti-Alzheimer PotentialPreprint
Ali, A. (2024) · Preprints.org · doi:10.20944/preprints202402.1189.v1 · Cited by 2 · see citing works
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Almowallad, S. J., Alanazi, S. S., Obidan, A., Alsulami, S. O., Younis, F. A., & Alwabsi, H. A. (2025) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-025-00541-9 · Cited by 1 · see citing works
Changes in the reactivity of the vertebrobasilar arteries when using glucose-electrolyte drink with antioxidant plant extracts during submaximal exercise test
Сергеевна, Т. Н., Birukova, E. A., Хусаинов, Д. Р., Петрович, М. Н., Нагаева, Е. И., Burtseva, E. V., & Kushnir, S. K. (2023) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2023-8.1.10 · Cited by 1 · see citing works
Rosemary (Rosmarinus officinalis L.) improves biochemical outcomes in diabetes mellitus: a systematic review and meta-analysis of animal studies
Oliveira, V. M., Silveira, L. R., Bunnel, K. T., Domingueti, C. P., Baldoni, A. O., Baldoni, N. R., & do Couto, R. O. (2024) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-024-00742-5 · Cited by 1 · see citing works
Influência da adesão ao Padrão Alimentar Mediterrânico na saúde ao longo do Ciclo de Vida
João, D. R., Mateus, M. P., & Braz, N. M. D. A. R. (2022) · Acta Portuguesa de Nutrição · doi:10.21011/apn.2022.2808 · Cited by 1 · see citing works
Antioxidant Potential of Quercetin and Rosemary Extract as Components of Nanometric Apatite Biopolymer Materials for OsteoplastyPreprint
Sukhodub, L. F., Bozhko, N. V., Kumeda, M. O., & Sukhodub, L. B. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4793147 · Cited by 1 · see citing works

Propiedades Terapéuticas del Romero (Rosmarinus officinalis L.) en el Manejo de la Diabetes Mellitus 2, Perspectivas Metabólicas y Clínicas: Una Revisión Bibliográfica
Lazalde Ramos, B. P., Rodríguez, J. M., Galván-Valencia, M., & Quirarte-Báez, S. M. (2025) · Dialnet (Universidad de la Rioja)
Antidiabetic Effects and Mechanisms of Rosemary (Rosmarinus officinalisL.) and its Phenolic Components
Bao, T.-Q., Li, Y., Qu, C., Zheng, Z., Yang, H. Q., & Li, P. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500664 · Cited by 52 · see citing works
Exploring the anti-hyperglycemic potential of Rosemary (Rosmarinus officinalis) tea in type 2 diabetic individuals
Zahid, S., Mukhtar, S., & Ali, M. (2022) · doi:10.54117/iajnfms.v1i1.11 · Cited by 1 · see citing works
Aktivitas Antidiabetes Tanaman Rosemary (Rosmarinus officinalis L.)
Nurmala, N., Lukmayani, Y., & Syafnir, L. (2024) · Bandung Conference Series Pharmacy · doi:10.29313/bcsp.v4i2.13616
Anti-hyperglycemic effects of volatile oils extracted from Rosmarinus officinalis and Artemisia cinae in diabetic rats.
Benkhayal, F. A., El-Ageeli, W. H., Ramesh, S. R., & Farghamd, M. (2009) · Tamilnadu Journal of Veterinary and Animal Sciences · Cited by 1 · see citing works

Authors: Naimi, M., Vlavcheski, F., Shamshoum, H., & Tsiani, E.
Affiliations: Brock University (CA)
Corresponding author: Tsiani, Evangelia
ORCID: Vlavcheski, Filip
Shamshoum, Hesham
Tsiani, Evangelia
Venue: Nutrients
Publisher: MDPI AG
Published: 2017-09-01
Volume: 9
Issue: 9
Pages: 968
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu9090968
PMC: PMC5622728
OpenAlex: W2751672023
Cited by: 119
References: 76
Citations by year: 2026: 4 · 2025: 10 · 2024: 16 · 2023: 11 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 10 · 2018: 8
FWCI: 1.44
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Brock University Digital Repository (Brock University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Brock University
Natural Sciences and Engineering Research Council of Canada
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: rosemary extract, antidiabetic activity, type 2 diabetes, insulin resistance, polyphenols, nutraceuticals, functional foods, antioxidant activity, anti-inflammatory activity, antidiabetic mechanism
MeSH terms: Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Insulin Resistance, Plant Extracts, Rosmarinus

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Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives

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