Cited by 119Natural Antidiabetic Agents StudiesMedicinal Plant ResearchPhytochemicals and Antioxidant Activities

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Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives

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Naimi, Madina, Vlavcheski, Filip, Shamshoum, Hesham, Tsiani, Evangelia·2017·Nutrients

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Abstract

Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic burden to health care systems around the globe, results from defects in insulin action (termed insulin resistance) combined with impaired insulin secretion. Current methods of prevention and treatments for insulin resistance and T2DM are lacking in number and efficacy and, therefore, there is a need for new preventative measures and targeted therapies. In recent years, chemicals found in plants/herbs have attracted attention for their use as functional foods or nutraceuticals for preventing and treating insulin resistance and T2DM. Rosemary is an evergreen shrub indigenous to the Mediterranean region and South America, which contains various polyphenols. Rosemary extract and its polyphenolic constituents have been reported to have antioxidant, anti-inflammatory, anticancer, and anti-hyperglycemic properties. The current review summarizes the existing in vitro and in vivo studies examining the anti-diabetic effects of rosemary extract and its polyphenolic components and highlights the known mechanism of action.

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Authors: Naimi, M., Vlavcheski, F., Shamshoum, H., & Tsiani, E.
Affiliations: Brock University (CA)
Corresponding author: Tsiani, Evangelia
ORCID: Vlavcheski, Filip
Shamshoum, Hesham
Tsiani, Evangelia
Venue: Nutrients
Publisher: MDPI AG
Published: 2017-09-01
Volume: 9
Issue: 9
Pages: 968
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu9090968
PMC: PMC5622728
OpenAlex: W2751672023
Cited by: 119
References: 76
Citations by year: 2026: 4 · 2025: 10 · 2024: 16 · 2023: 11 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 10 · 2018: 8
FWCI: 1.44
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Brock University Digital Repository (Brock University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Brock University
Natural Sciences and Engineering Research Council of Canada
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: rosemary extract, antidiabetic activity, type 2 diabetes, insulin resistance, polyphenols, nutraceuticals, functional foods, antioxidant activity, anti-inflammatory activity, antidiabetic mechanism
MeSH terms: Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Insulin Resistance, Plant Extracts, Rosmarinus

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Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives

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