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Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives
Open accessAbstract
Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic burden to health care systems around the globe, results from defects in insulin action (termed insulin resistance) combined with impaired insulin secretion. Current methods of prevention and treatments for insulin resistance and T2DM are lacking in number and efficacy and, therefore, there is a need for new preventative measures and targeted therapies. In recent years, chemicals found in plants/herbs have attracted attention for their use as functional foods or nutraceuticals for preventing and treating insulin resistance and T2DM. Rosemary is an evergreen shrub indigenous to the Mediterranean region and South America, which contains various polyphenols. Rosemary extract and its polyphenolic constituents have been reported to have antioxidant, anti-inflammatory, anticancer, and anti-hyperglycemic properties. The current review summarizes the existing in vitro and in vivo studies examining the anti-diabetic effects of rosemary extract and its polyphenolic components and highlights the known mechanism of action.
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“According to Naimi et al. [34], rosemary contains a large amount of polyphenols, especially carnosic acid, rosmarinic acid and carnosol.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [34]
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Metadata
- Authors
- Naimi, M., Vlavcheski, F., Shamshoum, H., & Tsiani, E.
- Affiliations
- Brock University (CA)
- Corresponding author
- Tsiani, Evangelia
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-09-01
- Volume
- 9
- Issue
- 9
- Pages
- 968
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5622728
- OpenAlex
- W2751672023
- Cited by
- 119
- References
- 76
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 16 · 2023: 11 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 10 · 2018: 8
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Brock University Digital Repository (Brock University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Brock University
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- rosemary extract, antidiabetic activity, type 2 diabetes, insulin resistance, polyphenols, nutraceuticals, functional foods, antioxidant activity, anti-inflammatory activity, antidiabetic mechanism
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Insulin Resistance, Plant Extracts, Rosmarinus
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