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Cited by 190

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Fighting Hypoxia to Improve PDT

Open access
Larue, Ludivine, Myrzakhmetov, Bauyrzhan, Ben-Mihoub, Amina, Moussaron, Albert, Thomas, Noémie, Arnoux, Philippe, Baros, Francis, Vanderesse, Régis, Acherar, Samir, Frochot, Céline·2019·Pharmaceuticals

Abstract

Photodynamic therapy (PDT) has drawn great interest in recent years mainly due to its low side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for oxygen to induce a photodynamic effect. Tumours often have low oxygen concentrations, related to the abnormal structure of the microvessels leading to an ineffective blood distribution. Moreover, PDT consumes O2. In order to improve the oxygenation of tumour or decrease hypoxia, different strategies are developed and are described in this review: (1) The use of O2 vehicle; (2) the modification of the tumour microenvironment (TME); (3) combining other therapies with PDT; (4) hypoxia-independent PDT; (5) hypoxia-dependent PDT and (6) fractional PDT.

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Crossref · 10.3390/ph12040163

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Metadata

Authors
Larue, L., Myrzakhmetov, B., Ben-Mihoub, A., Moussaron, A., Thomas, N., Arnoux, P., Baros, F., Vanderesse, R., Acherar, S., & Frochot, C.
Venue
Pharmaceuticals
Publisher
MDPI AG
Published
2019-10-30
Volume
12
Issue
4
Pages
163
ISSN
1424-8247 (ISSN-L)
OpenAlex
W2982513294
Cited by
190
References
8
FWCI
12.68
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Fighting Hypoxia to Improve PDT. https://app.cochat.ai/papers/10.3390/ph12040163
The paper
Larue, L., Myrzakhmetov, B., Ben-Mihoub, A., Moussaron, A., Thomas, N., Arnoux, P., Baros, F., Vanderesse, R., Acherar, S., & Frochot, C. (2019). Fighting Hypoxia to Improve PDT. Pharmaceuticals. https://doi.org/10.3390/ph12040163

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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