CoChat
Sign Up
Cited by 36

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles

Iglesias, Guillermo R., Jabalera, Ylenia, Peigneux, Ana, Checa Fernández, Blanca Luna, Delgado, Ángel V., Jimenez-Lopez, Concepcion·2019·Pharmaceutics
DOI 10.3390/pharmaceutics11060273PMC PMC6631210
Open this paper in CoChat — free account

Abstract

In this work we report on the synthesis and characterization of magnetic nanoparticles of two distinct origins, one inorganic (MNPs) and the other biomimetic (BMNPs), the latter based on a process of bacterial synthesis. Each of these two kinds of particles has its own advantages when used separately with biomedical purposes. Thus, BMNPs present an isoelectric point below neutrality (around pH 4.4), while MNPs show a zero-zeta potential at pH 7, and appear to be excellent agents for magnetic hyperthermia. This means that the biomimetic particles are better suited to be loaded with drug molecules positively charged at neutral pH (notably, doxorubicin, for instance) and releasing it at the acidic tumor environment. In turn, MNPs may provide their transport capabilities under a magnetic field. In this study it is proposed to use a mixture of both kinds of particles at two different concentrations, trying to get the best from each of them. We study which mixture performs better from different points of view, like stability and magnetic hyperthermia response, while keeping suitable drug transport capabilities. This composite system is proposed as a close to ideal drug vehicle with added enhanced hyperthermia response.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/pharmaceutics11060273

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Diameter histograms (A,C) and TEM pictures (B,D) of biomimetic (BMNPs) and purely inorganic (MNPs) magnetic nanoparticles. The scale bar in B, D is 200 nm.
Figure 1 Diameter histograms (A,C) and TEM pictures (B,D) of biomimetic (BMNPs) and purely inorganic (MNPs) magnetic nanoparticles. The scale bar in B, D is 200 nm.CC BY · PubMed Central
Figure 2 The XRD diffraction patterns of purely inorganic (MNPs) and biomimetic magnetic nanoparticles (BMNPs). The positions and intensities of crystallographically-pure magnetite are labeled as M, and those of goethite as G.
Figure 2 The XRD diffraction patterns of purely inorganic (MNPs) and biomimetic magnetic nanoparticles (BMNPs). The positions and intensities of crystallographically-pure magnetite are labeled as M, and those of goethite as G.CC BY · PubMed Central
Figure 3 Magnetization cycles of MNPs (■), BMNPs (●), and 25 B + 75 M (♦) at 5 K (top), and 300 K (bottom). Magnifications of the low-field region are also plotted.
Figure 3 Magnetization cycles of MNPs (■), BMNPs (●), and 25 B + 75 M (♦) at 5 K (top), and 300 K (bottom). Magnifications of the low-field region are also plotted.CC BY · PubMed Central
Figure 4 Zero field cooling-field cooling (ZFC-FC) curves at 40 kA/m of MNPs (■), BMNPs (●) and 25 B + 75 M (♦).
Figure 4 Zero field cooling-field cooling (ZFC-FC) curves at 40 kA/m of MNPs (■), BMNPs (●) and 25 B + 75 M (♦).CC BY · PubMed Central
Figure 5 Zeta potential of purely inorganic MNPs (■) and biomimetic magnetic nanoparticles BMNPs (●).
Figure 5 Zeta potential of purely inorganic MNPs (■) and biomimetic magnetic nanoparticles BMNPs (●).CC BY · PubMed Central
Figure 6 Height of the sedimented volume relative to its initial value as a function of time for MNPs (■), BMNPs (●), 60 B + 40 M (▲), and 25 B + 75 M (♦). Inset: Short-time detail.
Figure 6 Height of the sedimented volume relative to its initial value as a function of time for MNPs (■), BMNPs (●), 60 B + 40 M (▲), and 25 B + 75 M (♦). Inset: Short-time detail.CC BY · PubMed Central
Figure 7 Time evolution of the temperature of the MNP suspensions, for different frequencies: 197 kHz (●), 236 kHz (▲), and 280 kHz (♦). Field strength: H0 = 18 kA/m. Sample volume 0.5 mL; particle concentration: 25 mg/mL.
Figure 7 Time evolution of the temperature of the MNP suspensions, for different frequencies: 197 kHz (●), 236 kHz (▲), and 280 kHz (♦). Field strength: H0 = 18 kA/m. Sample volume 0.5 mL; particle concentration: 25 mg/mL.CC BY · PubMed Central
Figure 8 Frequency dependence of (a) SAR and (b) ILP, for the investigated systems. MNPs (■), BMNPs (●), 60 B + 40 M (▲), and 25 B + 75 M (♦). Magnetic field strength: 18 kA/m; particle concentration: 25 mg/mL.
Figure 8 Frequency dependence of (a) SAR and (b) ILP, for the investigated systems. MNPs (■), BMNPs (●), 60 B + 40 M (▲), and 25 B + 75 M (♦). Magnetic field strength: 18 kA/m; particle concentration: 25 mg/mL.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 56

  1. Rezayan, 2016, Monodisperse magnetite (Fe3O4) nanoparticles modified with water soluble polymers for the diagnosis of breast cancer by MRI method, J. Magn. Magn. Mater., 420, 210, 10.1016/j.jmmm.2016.07.003 · DOI
  2. Argibay, 2016, Multicore magnetic Fe3O4@C beads with enhanced magnetic response for MRI in brain biomedical applications, IEEE Trans. Magn., 52, 1
  3. Portillo, 2017, Magnetic nanoparticles as a redispersing additive in magnetorheological fluid, J. Nanomater., 2017, 8, 10.1155/2017/9026219 · DOI
  4. Cardoso, 2018, Advances in magnetic nanoparticles for biomedical applications, Adv. Healthc. Mater., 7, 1700845, 10.1002/adhm.201700845 · DOI
  5. Ghazi, 2018, Rietveld refinement, morphology analysis, optical and magnetic properties of magnesium-zinc ferrite nanofibers, J. Magn. Magn. Mater., 468, 132, 10.1016/j.jmmm.2018.07.084 · DOI
  6. Lisjak, 2018, Anisotropic magnetic nanoparticles: A review of their properties, syntheses and potential applications, Prog. Mater. Sci., 95, 286, 10.1016/j.pmatsci.2018.03.003 · DOI
  7. Muhlberger, 2019, Functionalization of T lymphocytes for magnetically controlled immune therapy: Selection of suitable superparamagnetic iron oxide nanoparticles, J. Magn. Magn. Mater., 473, 61, 10.1016/j.jmmm.2018.10.022 · DOI
  8. Danilushkina, 2018, Influence of magnetic nanoparticles stabilized with polyelectrolytes on 2D and 3D cell cultures formation, Hum. Gene Ther., 29, A71
  9. Chen, 2016, Influence of magnetoplasmonic gamma-Fe2O3/Au core/shell nanoparticles on low-field nuclear magnetic resonance, Sci. Rep., 6, 35477, 10.1038/srep35477 · DOI
  10. Wang, 2016, A magnetic nanoparticles relaxation sensor for protein-protein interaction detection at ultra-low magnetic field, Biosens. Bioelectron., 80, 661, 10.1016/j.bios.2016.02.037 · DOI
  11. Angelakeris, 2018, Magnetic nanoparticles: A multifunctional vehicle for modern theranostics, Biochim. Biophys. Acta Gen. Subj., 1861, 1642, 10.1016/j.bbagen.2017.02.022 · DOI
  12. Winter, A., Engels, S., Reinhardt, L., Wasylow, C., Gerullis, H., and Wawroschek, F. (2017). Magnetic marking and intraoperative detection of primary draining lymph nodes in high-risk prostate cancer using superparamagnetic iron oxide nanoparticles: Additional diagnostic value. Molecules, 22. · DOI
  13. Duran, 2008, Magnetic colloids as drug vehicles, J. Pharm. Sci., 97, 2948, 10.1002/jps.21249 · DOI
  14. Patitsa, 2017, Magnetic nanoparticles coated with polyarabic acid demonstrate enhanced drug delivery and imaging properties for cancer theranostic applications, Sci. Rep., 7, 775, 10.1038/s41598-017-00836-y · DOI
  15. Gao, 2018, A theranostic nanocomposite system based on radial mesoporous silica hybridized with Fe3O4 nanoparticles for targeted magnetic field responsive chemotherapy of breast cancer, Rsc Adv., 8, 4321, 10.1039/C7RA12446E · DOI
  16. Moskvin, 2018, Biological evaluation of surface-modified magnetic nanoparticles as a platform for colon cancer cell theranostics, Colloids Surf. B Biointerfaces, 161, 35, 10.1016/j.colsurfb.2017.10.034 · DOI
  17. Semkina, 2018, Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer, Nanomed. Nanoechnol., 14, 1733, 10.1016/j.nano.2018.04.019 · DOI
  18. Vakilinezhad, 2018, Fabrication and in vitro evaluation of magnetic PLGA nanoparticles as a potential Methotrexate delivery system for breast cancer, J. Drug Deliv. Sci. Technol., 44, 467, 10.1016/j.jddst.2018.01.002 · DOI
  19. Obaidat, 2015, Magnetic properties of magnetic nanoparticles for efficient hyperthermia, Nanomaterials (Basel), 5, 63, 10.3390/nano5010063 · DOI
  20. Balidemaj, 2016, Hyperthermia treatment planning for cervical cancer patients based on electrical conductivity tissue properties acquired in vivo with EPT at 3 T MRI, Int. J. Hyperth., 32, 558, 10.3109/02656736.2015.1129440 · DOI
  21. Walter, 2016, Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia, Nanomedicine (Lond), 11, 1889, 10.2217/nnm-2016-5001 · DOI · Paper page
  22. Iglesias, 2016, Magnetic hyperthermia with magnetite nanoparticles: Electrostatic and polymeric stabilization, Colloid Polym. Sci., 294, 1541, 10.1007/s00396-016-3918-3 · DOI
  23. Sato, 2016, Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles, Sci. Rep., 6, 24629, 10.1038/srep24629 · DOI
  24. Hedayatnasab, 2017, Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application, Mater. Des., 123, 174, 10.1016/j.matdes.2017.03.036 · DOI
  25. Nemati, 2017, Superparamagnetic iron oxide nanodiscs for hyperthermia therapy: Does size matter?, J. Alloy. Compd., 714, 709, 10.1016/j.jallcom.2017.04.211 · DOI
  26. Vamvakidis, 2018, Magnetic hyperthermia efficiency and MRI contrast sensitivity of colloidal soft/hard ferrite nanoclusters, J. Colloid Interface Sci., 511, 101, 10.1016/j.jcis.2017.10.001 · DOI
  27. Pankhurst, 2003, Applications of magnetic nanoparticles in biomedicine, J. Phys. D, 36, R167, 10.1088/0022-3727/36/13/201 · DOI
  28. Soares, 2012, Application of hyperthermia for cancer treatment: Recent patents review, Recent Pat. Anticancer Drug Discov., 7, 64, 10.2174/157489212798358038 · DOI
  29. Alphandery, 2011, Chains of magnetosomes extracted from AMB-1 magnetotactic bacteria for application in alternative magnetic field cancer therapy, Acs Nano, 5, 6279, 10.1021/nn201290k · DOI
  30. 2018, Magnetic iron oxide nanoparticles as drug carriers: Preparation, conjugation and delivery, Nanomedicine (Lond), 13, 929, 10.2217/nnm-2017-0320 · DOI
  31. Prozorov, 2015, Size control of in vitro synthesized magnetite crystals by the MamC protein of Magnetococcus marinus strain MC-1, Appl. Microbiol. Biotechnol., 99, 5109, 10.1007/s00253-014-6326-y · DOI · Paper page
  32. Peigneux, 2018, pH-dependent adsorption release of doxorubicin on MamC-biomimetic magnetite nanoparticles, Langmuir, 34, 13713, 10.1021/acs.langmuir.8b03109 · DOI · Paper page
  33. Lacroix, 2009, Magnetic hyperthermia in single-domain monodisperse FeCo nanoparticles: Evidences for Stoner-Wohlfarth behavior and large losses, J. Appl. Phys., 105, 023911, 10.1063/1.3068195 · DOI
  34. Carrey, 2011, Simple models for dynamic hysteresis loop calculations of magnetic single-domain nanoparticles: Application to magnetic hyperthermia optimization, J. Appl. Phys., 110, 083921, 10.1063/1.3551582 · DOI
  35. Mehdaoui, 2011, Optimal size of nanoparticles for magnetic hyperthermia: A combined theoretical and experimental study, Adv. Funct. Mater., 21, 4573, 10.1002/adfm.201101243 · DOI
  36. Stoner, 1991, A mechanism of magnetic hysteresis in heterogeneous alloys, IEEE Trans. Magn., 27, 3475, 10.1109/TMAG.1991.1183750 · DOI
  37. Pankhurst, 2009, Progress in applications of magnetic nanoparticles in biomedicine, J. Phys. D Appl. Phys., 42, 224001, 10.1088/0022-3727/42/22/224001 · DOI
  38. 2013, Magnetic hyperthermia, Nanoscience: Nanostructures through Chemistry, Volume 1, 60
  39. Surowiec, 2017, Investigation of magnetite Fe3O4 nanoparticles for magnetic hyperthermia, Nukleonika, 62, 183, 10.1515/nuka-2017-0028 · DOI
  40. Coffey, 1995, Constant-magnetic-field effect in Néel relaxation of single-domain ferromagnetic particles, Phys. Rev. B Condens. Matter., 51, 15947, 10.1103/PhysRevB.51.15947 · DOI
  41. Hergt, 2010, Validity limits of the Neel relaxation model of magnetic nanoparticles for hyperthermia, Nanotechnology, 21, 015706, 10.1088/0957-4484/21/1/015706 · DOI
  42. Bakoglidis, 2012, Size-Dependent mechanisms in AC magnetic hyperthermia response of iron-oxide nanoparticles, IEEE Trans. Magn., 48, 1320, 10.1109/TMAG.2011.2173474 · DOI
  43. Dutz, 2013, Magnetic nanoparticle heating and heat transfer on a microscale: Basic principles, realities and physical limitations of hyperthermia for tumour therapy, Int. J. Hyperth., 29, 790, 10.3109/02656736.2013.822993 · DOI
  44. Dutz, 2014, Magnetic particle hyperthermia-a promising tumour therapy?, Nanotechnology, 25, 452001, 10.1088/0957-4484/25/45/452001 · DOI
  45. Guibert, 2015, Hyperthermia of magnetic nanoparticles: Experimental study of the role of aggregation, J. Phys. Chem. C, 119, 28148, 10.1021/acs.jpcc.5b07796 · DOI
  46. Fortin, 2007, Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia, J. Am. Chem. Soc., 129, 2628, 10.1021/ja067457e · DOI
  47. 2011, Inorganic magnetite precipitation at 25 °C: A low-cost inorganic coprecipitation method, J. Supercond. Nov. Magn., 24, 549, 10.1007/s10948-010-0999-y · DOI
  48. Gas, P., and Kurgan, E. (2017, January 25–30). Cooling effects inside water-cooled inductors for magnetic fluid hyperthermia. Proceedings of the 2017 Progress in Applied Electrical Engineering (PAEE), Koscielisko, Poland. · DOI
  49. Gas, P., and Miaskowski, A. (2015, January 17–19). Specifying the ferrofluid parameters important from the viewpoint of Magnetic Fluid Hyperthermia. Proceedings of the 2015 Selected Problems of Electrical Engineering and Electronics (WZEE), Kielce, Poland. · DOI
  50. Wildeboer, 2014, On the reliable measurement of specific absorption rates and intrinsic loss parameters in magnetic hyperthermia materials, J. Phys. D Appl. Phys., 47, 495003, 10.1088/0022-3727/47/49/495003 · DOI
  51. Muniz, 2016, The Scherrer equation and the dynamical theory of X-ray diffraction, Acta Crystallogr. A Found. Adv., A72, 385, 10.1107/S205327331600365X · DOI
  52. Zarivach, 2017, Magnetite nanoparticles biomineralization in the presence of the magnetosome membrane protein MamC: Effect of protein aggregation and protein atructure on magnetite formation, Cryst. Growth Des., 17, 1620, 10.1021/acs.cgd.6b01643 · DOI · Paper page
  53. Fonseca, 2002, Superparamagnetism and magnetic properties of Ni nanoparticles embedded in SiO2, Phys. Rev. B, 66, 104406, 10.1103/PhysRevB.66.104406 · DOI
  54. Obrien, 1978, Electrophoretic mobility of a spherical colloidal particle, J. Chem. Soc. Faraday Trans. 2, 74, 1607, 10.1039/f29787401607 · DOI
  55. Nudelman, 2016, Structure-function studies of the magnetite-biomineralizing magnetosome-associated protein MamC, J. Struct. Biol., 194, 244, 10.1016/j.jsb.2016.03.001 · DOI
  56. Jabalera, 2019, Protein conservation method affects MamC-mediated biomineralization of magnetic nanoparticles, Cryst. Growth Des., 19, 1064, 10.1021/acs.cgd.8b01590 · DOI

Cited by

Sorted by citations

See all 36

Metadata

Authors
Iglesias, G. R., Jabalera, Y., Peigneux, A., Checa Fernández, B. L., Delgado, Á. V., & Jimenez-Lopez, C.
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2019-06-11
Volume
11
Issue
6
Pages
273
ISSN
1999-4923
DOI
10.3390/pharmaceutics11060273
PMC
PMC6631210
Cited by
36
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles. https://app.cochat.ai/papers/10.3390/pharmaceutics11060273
The paper
Iglesias, G. R., Jabalera, Y., Peigneux, A., Checa Fernández, B. L., Delgado, Á. V., & Jimenez-Lopez, C. (2019). Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles. Pharmaceutics. https://doi.org/10.3390/pharmaceutics11060273