The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Gene Therapy in Cancer Treatment: Why Go Nano?
Open accessAbstract
The proposal of gene therapy to tackle cancer development has been instrumental for the development of novel approaches and strategies to fight this disease, but the efficacy of the proposed strategies has still fallen short of delivering the full potential of gene therapy in the clinic. Despite the plethora of gene modulation approaches, e.g., gene silencing, antisense therapy, RNA interference, gene and genome editing, finding a way to efficiently deliver these effectors to the desired cell and tissue has been a challenge. Nanomedicine has put forward several innovative platforms to overcome this obstacle. Most of these platforms rely on the application of nanoscale structures, with particular focus on nanoparticles. Herein, we review the current trends on the use of nanoparticles designed for cancer gene therapy, including inorganic, organic, or biological (e.g., exosomes) variants, in clinical development and their progress towards clinical applications.
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Cites
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Cited by
Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy
Sharifi-Rad, J., Quispe, C., Patra, J. K., Singh, Y. D., Panda, M. K., Das, G., Adetunji, C. O., Michael, O. S., Sytar, O., Polito, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3687700 · Cited by 298
Drug Delivery with polymeric nanocarriers-cellular uptake mechanisms
Nelemans, L. C., & Gurevich, L. (2020) · Materials · doi:10.3390/ma13020366 · Cited by 173
MicroRNA as an Important Target for Anticancer Drug Development
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Metadata
- Authors
- Roma-Rodrigues, C., Rivas-García, L., Baptista, P. V., & Fernandes, A. R.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2020-03-05
- Volume
- 12
- Issue
- 3
- Pages
- 233
- ISSN
- 1999-4923 (ISSN-L)
- OpenAlex
- W3010381651
- Cited by
- 220
- References
- 17
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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