Cited by 200Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsNanoparticle-Based Drug Delivery

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Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

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Teleanu, Raluca Ioana, Preda, Manuela Daniela, Niculescu, Adelina-Gabriela, Vladâcenco, Oana, Radu, Crina Ioana, Grumezescu, Alexandru Mihai, Teleanu, Daniel Mihai·2022·Pharmaceutics

DOI 10.3390/pharmaceutics14050987PMC PMC9145636

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Abstract

The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB. The BBB is disturbed in specific pathological illnesses such as stroke, diabetes, seizures, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The goal of this study is to offer a general overview of current brain medication delivery techniques and associated topics from the last five years. It is anticipated that this review will stimulate readers to look into new ways to deliver medications to the brain. Following an introduction of the construction and function of the BBB in both healthy and pathological conditions, this review revisits certain contested questions, such as whether nanoparticles may cross the BBB on their own and if medications are selectively delivered to the brain by deliberately targeted nanoparticles. Current non-nanoparticle options are also discussed, including drug delivery via the permeable BBB under pathological circumstances and the use of non-invasive approaches to improve brain medication absorption.

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Authors: Teleanu, R. I., Preda, M. D., Niculescu, A.-G., Vladâcenco, O., Radu, C. I., Grumezescu, A. M., & Teleanu, D. M.
Affiliations: Carol Davila University of Medicine and Pharmacy (RO)
Universitatea Națională de Știință și Tehnologie Politehnica București (RO)
Bucharest Emergency University Hospital (RO)
University of Bucharest (RO)
Corresponding author: Grumezescu, Alexandru Mihai
ORCID: Teleanu, Raluca Ioana
Preda, Manuela Daniela
Niculescu, Adelina-Gabriela
Vladâcenco, Oana
Grumezescu, Alexandru Mihai
Teleanu, Daniel Mihai
Venue: Pharmaceutics
Publisher: MDPI AG
Published: 2022-05-04
Volume: 14
Issue: 5
Pages: 987
ISSN: 1999-4923 (ISSN-L)
DOI: 10.3390/pharmaceutics14050987
PMC: PMC9145636
OpenAlex: W4229057365
Cited by: 200
References: 189
Citations by year: 2026: 33 · 2025: 72 · 2024: 57 · 2023: 26 · 2022: 12
FWCI: 4.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Pharmaceutics (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: blood-brain barrier, brain drug delivery, nanoparticles, blood-brain barrier disruption, targeted drug delivery, non-invasive drug delivery, blood-brain barrier permeability, neurological disorders, Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke

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