New developments in liposomal drug delivery
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNew Developments in Liposomal Drug DeliveryBhushan S. Pattni†, Vladimir V. Chupin‡, and Vladimir P. Torchilin*†§View Author Information† Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, United States‡ Laboratory for Advanced Studies of Membrane Proteins, Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia§ Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia*Tel.: (617) 373-3206. E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 19, 10938–10966Publication Date (Web):May 26, 2015Publication History Received23 January 2015Published online26 May 2015Published inissue 14 October 2015https://pubs.acs.org/doi/10.1021/acs.chemrev.5b00046https://doi.org/10.1021/acs.chemrev.5b00046review-articleACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views20991Altmetric-Citations1149LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cancer,Drug delivery,Encapsulation,Lipids,Vesicles Get e-Alerts
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nanoliposomes form a protective barrier that protects molecules from degradation by enzymes in the mouth and stomach, digestive juices, bile acid, and intestinal microorganisms.
“NL forms a protective barrier that protects the molecules from degradation by enzymes in the mouth and stomach, digestive juices, bile acid, and intestinal microorganisms [41,42].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [42]
Liposomes can improve drug delivery to solid tumors.
“Since liposomes can improve drug delivery to solid tumors, we explored their potential as an enabling technology for echinomycin in solid tumors26.”
From Liposomal Formulation of HIF-1α Inhibitor Echinomycin Eliminates Established Metastases of Triple-negative Breast Cancer (2020) · cites this paper as [26]
Cites
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282 · see citing works
Self-citationDoxil® — The first FDA-approved nano-drug: Lessons learned
Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792 · see citing works
Diffusion of univalent ions across the lamellae of swollen phospholipids
Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664 · see citing works
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558 · see citing works
Fang, J. Q., Nakamura, H., & Maeda, H. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.04.009 · Cited by 3,573 · see citing works
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., & Jain, R. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4607 · Cited by 2,438 · see citing works
Self-citationSzoka, F. C., & Papahadjopoulos, D. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4194 · Cited by 2,333 · see citing works
Treatment of Age-related Macular Degeneration With Photodynamic Therapy (TAP) Study Group (1999) · Archives of Ophthalmology · doi:10.1001/archopht.117.10.1329 · Cited by 2,192 · see citing works
Hope, M. J., Bally, M. B., Webb, G., & Cullis, P. R. (1985) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(85)90521-8 · Cited by 2,082 · see citing works
Tumor delivery of macromolecular drugs based on the EPR effect
Torchilin, V. P. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.011 · Cited by 2,032 · see citing works
Self-citationAmphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030 · see citing works
Self-citationHyperthermia in combined treatment of cancer
Wust, P., Hildebrandt, B., Sreenivasa, G., Rau, B., Gellermann, J., Riess, H. B., FELIX, R., & Schlag, P. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00818-5 · Cited by 2,002 · see citing works
Filipe, V., Hawe, A., & Jiskoot, W. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0073-2 · Cited by 1,885 · see citing works
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995) · PubMed · Cited by 1,706 · see citing works
Self-citationMultifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
Torchilin, V. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4333 · Cited by 1,674 · see citing works
Self-citationPhysical principles of membrane organization
Israelachvili, J. N., Marĉelja, S., & Horn, R. G. (1980) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500001645 · Cited by 1,406 · see citing works
Single bilayer liposomes prepared without sonication
Batzri, S., & Korn, E. D. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90408-2 · Cited by 1,360 · see citing works
Thermoresponsive Polymers for Biomedical Applications
Ward, M. A., & Georgiou, T. K. (2011) · Polymers · doi:10.3390/polym3031215 · Cited by 1,165 · see citing works
Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.
Gabizón, A., & Papahadjopoulos, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6949 · Cited by 1,134 · see citing works
Kirpotin, D. B., Drummond, D. C., Shao, Y., Shalaby, M. R., Hong, K., Nielsen, U. B., Marks, J. D., Benz, C. C., & Park, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4199 · Cited by 1,129 · see citing works
Magnetic nanoparticles for theragnostics
Shubayev, V. I., Pisanic, T. R., & Jin, S. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.007 · Cited by 1,029 · see citing works
Cell-Penetrating Peptides: Design, Synthesis, and Applications
Copolovici, D. M., Langel, K., Eriste, E., & Langel, Ü. (2014) · ACS Nano · doi:10.1021/nn4057269 · Cited by 967 · see citing works
Trends and Developments in Liposome Drug Delivery Systems
Lian, T., & Ho, R. J. Y. (2001) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.1023 · Cited by 910 · see citing works
Liposomal Drug Delivery Systems: An Update Review
Samad, A., Sultana, Y., & Aqil, M. (2007) · Current Drug Delivery · doi:10.2174/156720107782151269 · Cited by 909 · see citing works
Novel applications of liposomes
Lasiç, D. D. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(98)01220-7 · Cited by 865 · see citing works
Cell‐penetrating peptides: 20 years later, where do we stand?
Bechara, C., & Sagan, S. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.04.031 · Cited by 859 · see citing works
PET versus SPECT: strengths, limitations and challenges
Rahmim, A., & Zaidi, H. (2008) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e3282f3a515 · Cited by 843 · see citing works
Yeh, M., Chang, H., & Cheng, M.-Y. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s26766 · Cited by 801 · see citing works
The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer
Farhood, H., Serbina, N. V., & Huang, L. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)80016-9 · Cited by 799 · see citing works
Batist, G., Tulpule, A., Sinha, B. K., Katki, A. G., Myers, C. E., & Cowan, K. H. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66748-1 · Cited by 790 · see citing works
Needham, D., Anyarambhatla, G., Kong, G., & Dewhirst, M. W. (2000) · PubMed · Cited by 746 · see citing works
Preparation, Characterization and Applications of Liposomes: State of the Art
Laouini, A., Jaafar‐Maalej, C., Limayem-Blouza, I., et al. (2012) · Journal of Colloid Science and Biotechnology · doi:10.1166/jcsb.2012.1020 · Cited by 693 · see citing works
Nanoliposomes and Their Applications in Food Nanotechnology
Mozafari, M. R., Johnson, C. J., Hatziantoniou, S., & Demetzos, C. (2008) · Journal of Liposome Research · doi:10.1080/08982100802465941 · Cited by 687 · see citing works
Liposomes as immunological adjuvants
Allison, A. C., & Gregoriadis, G. C. (1974) · Nature · doi:10.1038/252252a0 · Cited by 676 · see citing works
Formation and properties of thin‐walled phospholipid vesicles
Reeves, J. P., & Dowben, R. M. (1969) · Journal of Cellular Physiology · doi:10.1002/jcp.1040730108 · Cited by 670 · see citing works
Current Trends in The Use of Liposomes for Tumor Targeting
Deshpande, P. P., Biswas, S., & Torchilin, V. P. (2013) · Nanomedicine · doi:10.2217/nnm.13.118 · Cited by 663 · see citing works
Self-citationAnti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery.
Park, J. W., Hong, K., Kirpotin, D. B., Colbern, G. T., Shalaby, R., Baselga, J. M., Shao, Y. Y., Nielsen, U. B., Marks, J. D., Moore, D. H., et al. (2002) · PubMed · Cited by 647 · see citing works
The Carrier Potential of Liposomes in Biology and Medicine
Gregoriadis, G. C. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609232951305 · Cited by 595 · see citing works
Kirby, C. J., Clarke, J., & Gregoriadis, G. (1980) · Biochemical Journal · doi:10.1042/bj1860591 · Cited by 592 · see citing works
Li, W. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.041 · Cited by 588 · see citing works
Andresen, T. L., Jensen, S. S., & Jørgensen, K. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2004.12.001 · Cited by 580 · see citing works
Liposomes from ionic, single-chain amphiphiles
Hargreaves, W. R., & Deamer, D. W. (1978) · Biochemistry · doi:10.1021/bi00611a014 · Cited by 576 · see citing works
Liposomal Nanocapsules in Food Science and Agriculture
Taylor, T. M., Weiß, J., Davidson, P. M., & Bruce, B. D. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390591001135 · Cited by 569 · see citing works
Preparation and characterization of liposomes as therapeutic delivery systems: a review
Vemuri, S., & Rhodes, C. T. (1995) · Pharmaceutica Acta Helvetiae · doi:10.1016/0031-6865(95)00010-7 · Cited by 566 · see citing works
An overview of liposome lyophilization and its future potential
Chen, C., Han, D., Cai, C., & Tang, X. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.024 · Cited by 547 · see citing works
Osmotic properties and water permeability of phospholipid liquid crystals
Bangham, A. D., de Gier, J., & Greville, G. D. (1967) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(67)90030-8 · Cited by 546 · see citing works
Controlled Vesicle Self-Assembly in Microfluidic Channels with Hydrodynamic Focusing
Jahn, Α., Vreeland, W. N., Gaitan, M., & Locascio, L. E. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0318030 · Cited by 539 · see citing works
Glantz, M., Jaeckle, K. A., Chamberlain, M. C., Phuphanich, S., Recht, L. D., Swinnen, L. J., Maria, B., LaFollette, S., Schumann, G. B., Cole, B. F., et al. (1999) · PubMed · Cited by 529 · see citing works
Liposomes as vaccine delivery systems: a review of the recent advances
Schwendener, R. A. (2014) · Therapeutic Advances in Vaccines · doi:10.1177/2051013614541440 · Cited by 524 · see citing works
Miller, C. R., Bondurant, B., McLean, S. D., McGovern, K. A., & O’Brien, D. F. (1998) · Biochemistry · doi:10.1021/bi980096y · Cited by 523 · see citing works
Juliano, R. L., & Stamp, D. (1975) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(75)80433-5 · Cited by 523 · see citing works
Senior, J. H., Delgado, C., Fisher, D., Tilcock, C., & Gregoriadis, G. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90337-8 · Cited by 521 · see citing works
Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide.
Kellogg, E. W., & Fridovich, I. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39909-x · Cited by 509 · see citing works
Oral delivery of anticancer drugs: Challenges and opportunities
Thanki, K., Gangwal, R. P., Sangamwar, A. T., & Jain, S. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.04.020 · Cited by 499 · see citing works
Silverman, J. A., & Deitcher, S. R. (2012) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-012-2042-4 · Cited by 474 · see citing works
Liposome-based drug delivery in breast cancer treatment
Park, J. W. (2002) · Breast Cancer Research · doi:10.1186/bcr432 · Cited by 469 · see citing works
Allen, T. M., Hansen, C., & Rutledge, J. M. (1989) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(89)90078-3 · Cited by 467 · see citing works
Kirpotin, D. B., Park, J. W., Hong, K., et al. (1997) · Biochemistry · doi:10.1021/bi962148u · Cited by 440 · see citing works
Nagayasu, A., Uchiyama, K., & Kiwada, H. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00041-1 · Cited by 438 · see citing works
Gill, P. S., Wernz, J., Scadden, D. T., Cohen, P., Mukwaya, G., Roenn, J. H. V., Jacobs, M., Kempin, S. J., Silverberg, I. J., Gonzales, G., et al. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.8.2353 · Cited by 438 · see citing works
Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles
Mayer, L. D., Hope, M. J., Cullis, P. R., & Janoff, A. S. (1985) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(85)90084-7 · Cited by 436 · see citing works
Microfluidic Mixing and the Formation of Nanoscale Lipid Vesicles
Jahn, Α., Stavis, S. M., Hong, J. S., Vreeland, W. N., DeVoe, D. L., & Gaitan, M. (2010) · ACS Nano · doi:10.1021/nn901676x · Cited by 434 · see citing works
Targeted Liposomal Drug Delivery to Monocytes and Macrophages
Kelly, C., Jefferies, C. A., & Cryan, S. (2010) · Journal of Drug Delivery · doi:10.1155/2011/727241 · Cited by 426 · see citing works
Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes
Torchilin, V. P., Levchenko, T. S., Rammohan, R., Volodina, N., Papahadjopoulos‐Sternberg, B., & D’Souza, G. G. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0435906100 · Cited by 419 · see citing works
Self-citationp H-Sensitive Liposomes: Possible Clinical Implications
Yatvin, M. B., Kreutz, W., Horwitz, B. A., & Shinitzky, M. (1980) · Science · doi:10.1126/science.7434025 · Cited by 415 · see citing works
Thermosensitive liposomes for localized delivery and triggered release of chemotherapy
Ta, T., & Porter, T. M. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.03.036 · Cited by 404 · see citing works
Amstad, E., Kohlbrecher, J., Müller, E., Schweizer, T., Textor, M., & Reimhult, E. (2011) · Nano Letters · doi:10.1021/nl2001499 · Cited by 397 · see citing works
Deformable liposomes and ethosomes: Mechanism of enhanced skin delivery
Elsayed, M. M. A., Abdallah, O. Y., Naggar, V. F., et al. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.05.027 · Cited by 384 · see citing works
Microfluidic methods for forming liposomes
van Swaay, D., & deMello, A. J. (2012) · Lab on a Chip · doi:10.1039/c2lc41121k · Cited by 382 · see citing works
Challenges in Development of Targeted Liposomal Therapeutics
Sawant, R. R., & Torchilin, V. P. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9330-0 · Cited by 382 · see citing works
Self-citationStructures of lipid–DNA complexes: supramolecular assembly and gene delivery
Safinya, C. R. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00230-x · Cited by 374 · see citing works
Pharmaceutical nanotechnology for oral delivery of anticancer drugs
Mei, L., Zhang, Z., Zhao, L., Huang, L., Yang, X., Tang, J., & Feng, S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.11.005 · Cited by 372 · see citing works
Campbell, R. B., Fukumura, D., Brown, E. B., Mazzola, L. M., Izumi, Y., Jain, R. K., Torchilin, V. P., & Munn, L. L. (2002) · PubMed · Cited by 372 · see citing works
Self-citationKuntsche, J., Horst, J. C., & Bunjes, H. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.02.001 · Cited by 363 · see citing works
Oxygen Radical-Mediated Pulmonary Toxicity Induced by Some Cationic Liposomes
Dokka, S., Toledo, D., Shi, X., Castranova, V., & Rojanasakul, Y. (2000) · Pharmaceutical Research · doi:10.1023/a:1007504613351 · Cited by 349 · see citing works
Liposomes as carriers of antigens and adjuvants
Alving, C. R. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90120-5 · Cited by 346 · see citing works
Torchilin, V. P. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.031 · Cited by 342 · see citing works
Self-citationZhang, J. A., Anyarambhatla, G., Ma, L., Ugwu, S. O., Xuan, T., Sardone, T., & Ahmad, I. N. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.06.009 · Cited by 335 · see citing works
Effect of cholesterol and ethanol on dermal delivery from DPPC liposomes
López-Pinto, J. M., González-Rodrı́guez, M. L., & Rabasco, A. M. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.02.021 · Cited by 335 · see citing works
Nanopreparations to overcome multidrug resistance in cancer
Patel, N. R., Pattni, B. S., Abouzeid, A. H., & Torchilin, V. P. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.004 · Cited by 334 · see citing works
Self-citationChattopadhyay, A. (1990) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(90)90128-e · Cited by 328 · see citing works
Phospholipids and Lipid-Based Formulations in Oral Drug Delivery
Fricker, G., Kromp, T., Wendel, A., Blume, A., Zirkel, J., Rebmann, H., Setzer, C., Quinkert, R., Martin, F. J., & Müller-Goymann, C. C. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0130-x · Cited by 327 · see citing works
Bacterial inactivation by using near- and supercritical carbon dioxide
Dillow, A. K., Dehghani, F., Hrkach, J. S., Foster, N. R., & Langer, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10344 · Cited by 323 · see citing works
Watson, D. S., Endsley, A. N., & Huang, L. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.070 · Cited by 322 · see citing works
The Carrier Potential of Liposomes in Biology and Medicine
Gregoriadis, G. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609302951406 · Cited by 321 · see citing works
Thermosensitive polymer-modified liposomes
Kono, K. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00204-6 · Cited by 303 · see citing works
Application of Nanotechnology in Cosmetics
Li, M., & Sprando, R. L. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0139-1 · Cited by 297 · see citing works
Lukyanov, A. N., ElBayoumi, T. A., Chakilam, A. R., & Torchilin, V. P. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.007 · Cited by 294 · see citing works
Self-citationComplexes between cationic liposomes and DNA visualized by cryo-TEM
Gustafsson, J., Arvidson, G., Karlsson, G., & Almgren, M. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)80018-b · Cited by 290 · see citing works
Kruyff, B. D., DEMEL, R. A., & DEENEN, L. L. M. (1972) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(72)90032-6 · Cited by 285 · see citing works
Cationic liposome-mediated delivery of siRNAs in adult mice
Sioud, M., & Sørensen, D. R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.057 · Cited by 283 · see citing works
Torchilin, V. P. (2008) · Peptide Science · doi:10.1002/bip.20989 · Cited by 283 · see citing works
Self-citationBlume, G., Cevc, G., Crommelin, M. D. J. A., Bakker‐Woudenberg, I. A. J. M., Kluft, C., & Storm, G. (1993) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(93)90039-3 · Cited by 282 · see citing works
Biswas, S., Dodwadkar, N. S., Deshpande, P. P., & Torchilin, V. P. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.009 · Cited by 281 · see citing works
Self-citationLandon, C. D. (2011) · The Open Nanomedicine Journal · doi:10.2174/1875933501103010038 · Cited by 279 · see citing works
Yang, Z., Li, J., Wang, Z.-Z., Dong, D., & Qi, X. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.017 · Cited by 267 · see citing works
Maruyama, K., 知子, 滝., Yuda, T., Kennel, S. J., Huang, L., & Iwatsuru, M. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)00263-o · Cited by 265 · see citing works
Berger, N., Sachse, A., Bender, J., Schubert, R., & Brandl, M. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00721-9 · Cited by 258 · see citing works
Stimulus-responsive nanopreparations for tumor targeting
Zhu, L., & Torchilin, V. P. (2012) · Integrative Biology · doi:10.1039/c2ib20135f · Cited by 258 · see citing works
Self-citationMatsumura, Y., Gotoh, M., Muro, K., Yamada, Y., Shirao, K., Shimada, Y., Okuwa, M., Matsumoto, S., Miyata, Y., Ohkura, H., et al. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh092 · Cited by 253 · see citing works
Liposomal systems as drug delivery vehicles for dermal and transdermal applications
Pierre, M. B. R., & Costa, I. D. S. M. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1166-4 · Cited by 249 · see citing works
Matanović, M. R., Kristl, J., & Grabnar, P. A. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.06.029 · Cited by 249 · see citing works
Serisier, D. J., Bilton, D., Soyza, A. D., Thompson, P. J., Kolbe, J., Greville, H. W., Cipolla, D. C., Bruinenberg, P., Gonda, I., & the ORBIT-2 investigators (2013) · Thorax · doi:10.1136/thoraxjnl-2013-203207 · Cited by 249 · see citing works
Liposomal amphotericin B (AmBisome): safety data from a phase II/III clinical trial
Meunier, F., Prentice, H. G., & Ringdén, O. T. H. (1991) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/28.suppl_b.83 · Cited by 247 · see citing works
van Dissel, J. T., Joosten, S. A., Hoff, S. T., Soonawala, D., Prins, C., Hokey, D. A., O’Dee, D. M., Graves, A. J., Thierry-Carstensen, B., Andreasen, L. V., et al. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.10.036 · Cited by 245 · see citing works
Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases
Andrade, F., Rafael, D., Videira, M., Ferreira, D., Sosnik, A., & Sarmento, B. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.020 · Cited by 245 · see citing works
Mamot, C., Ritschard, R., WICKI, A. N., Stehle, G., Dieterle, T., Bubendorf, L., Hilker, C., Deuster, S., Herrmann, R., & Rochlitz, C. F. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70476-x · Cited by 244 · see citing works
Mills, J. K., & Needham, D. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.08.007 · Cited by 238 · see citing works
Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy
Ryu, J. H., Koo, H., Sun, I., Yuk, S. H., Choi, K., Kim, K., & Kwon, I. C. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.06.012 · Cited by 235 · see citing works
Drug targeting and tumor heterogeneity
Bae, Y. H. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.09.074 · Cited by 234 · see citing works
Maruyama, K., Yuda, T., Okamoto, A., Kojima, S., Suginaka, A., & Iwatsuru, M. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90255-t · Cited by 230 · see citing works
Sum, A. K., Faller, R., & de Pablo, J. J. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74706-7 · Cited by 230 · see citing works
Formation and properties of 1000-A-diameter, single-bilayer phospholipid vesicles.
Enoch, H. G., & Strittmatter, P. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.145 · Cited by 229 · see citing works
Hong, R. L., Huang, C. J., Tseng, Y., Pang, V. F., Chen, S.-T., Liu, J. J., & Chang, F. (1999) · PubMed · Cited by 227 · see citing works
Spray Drying Technique: II. Current Applications in Pharmaceutical Technology
Sołłohub, K., & Cal, K. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21963 · Cited by 226 · see citing works
Lipoplatin Formulation Review Article
Stathopoulos, G. P., & Boulikas, T. (2012) · Journal of Drug Delivery · doi:10.1155/2012/581363 · Cited by 224 · see citing works
Park, E.-J., Zhang, Y., Vykhodtseva, N. I., & McDannold, N. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.09.007 · Cited by 223 · see citing works
Phase II studies of nebulised Arikace in CF patients withPseudomonas aeruginosainfection
Clancy, J. P., Dupont, L., Konstan, M. W., et al. (2013) · Thorax · doi:10.1136/thoraxjnl-2012-202230 · Cited by 222 · see citing works
Hybrid polymer/lipid vesicles: state of the art and future perspectives
Meins, J. L., Schatz, C., Lecommandoux, S., & Sandre, O. (2013) · Materials Today · doi:10.1016/j.mattod.2013.09.002 · Cited by 220 · see citing works
Tagami, T., Foltz, W. D., Ernsting, M. J., Lee, C. M., Tannock, I. F., May, J. P., & Li, S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.029 · Cited by 213 · see citing works
Incorporation of Lysozyme into Liposomes
Sessa, G., & Weissmann, G. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62994-1 · Cited by 202 · see citing works
Effective terminal sterilization using supercritical carbon dioxide
White, A., Burns, D., & Christensen, T. W. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.12.033 · Cited by 202 · see citing works
Terada, T., Iwai, M., Kawakami, S., Yamashita, F., & Hashida, M. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.12.023 · Cited by 197 · see citing works
Yuba, E., Harada, A., Sakanishi, Y., Watarai, S., & Kono, K. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.12.031 · Cited by 196 · see citing works
Biotinylated liposomes as potential carriers for the oral delivery of insulin
Zhang, X., Qi, J., Lü, Y., He, W., Li, X., & Wu, W. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.07.011 · Cited by 194 · see citing works
Development of a New Preparation Method of Liposomes Using Supercritical Carbon Dioxide
Otake, K., Imura, T., Sakai, H., et al. (2001) · Langmuir · doi:10.1021/la010122k · Cited by 193 · see citing works
Applications of Liposomes in Ophthalmology
Ebrahim, S. A., Peyman, G. A., & Lee, P. J. (2005) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2004.12.006 · Cited by 193 · see citing works
Ultrasonic Irradiation of Some Phospholipid Sols
Saunders, L. J., Perrin, J. H., & Gammack, D. B. (1962) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1962.tb11141.x · Cited by 190 · see citing works
Inflexal®V a trivalent virosome subunit influenza vaccine: production
Mischler, R., & Metcalfe, I. C. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00512-1 · Cited by 183 · see citing works
Interaction of the Disaccharide Trehalose with a Phospholipid Bilayer: A Molecular Dynamics Study
Pereira, C. S., Lins, R. D., Chandrasekhar, I., et al. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74285-x · Cited by 182 · see citing works
Enhanced oral absorption of insulin-loaded liposomes containing bile salts: A mechanistic study
Niu, M., Tan, Y., Guan, P., Hovgaard, L., Lü, Y., Qi, J., Lian, R., Li, X., & Wu, W. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.028 · Cited by 182 · see citing works
Harrington, K. J., Lewanski, C. R., Northcote, A. D., et al. (2001) · Annals of Oncology · doi:10.1023/a:1011199028318 · Cited by 182 · see citing works
Kastner, E., Kaur, R., Lowry, D., Moghaddam, B., Wilkinson, A., & Perrie, Y. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.10.030 · Cited by 180 · see citing works
Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro and in vivo studies
Goren, D., Horowitz, A. T., Zalipsky, S., Woodle, M. C., Yarden, Y., & Gabizón, A. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.625 · Cited by 179 · see citing works
Edwards, K. A., & Baeumner, A. J. (2005) · Talanta · doi:10.1016/j.talanta.2005.08.031 · Cited by 179 · see citing works
In vivo comparison of various liposome formulations for cosmetic application☆
Betz, G., AEPPLI, A., Menshutina, N. V., & Leuenberger, H. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.02.032 · Cited by 172 · see citing works
Preparation of Liposomes Using an Improved Supercritical Reverse Phase Evaporation Method
Otake, K., Shimomura, T., Goto, T., Imura, T., Furuya, T., Yoda, S., Takebayashi, Y., Sakai, H., & Abe, M. (2006) · Langmuir · doi:10.1021/la051654u · Cited by 171 · see citing works
Niederer, F., Ospelt, C., Brentano, F., Hottiger, M. O., Gay, R. E., Gay, S., Detmar, M. J., & Kyburz, D. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.148957 · Cited by 171 · see citing works
ElBayoumi, T. A., & Torchilin, V. P. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2392 · Cited by 170 · see citing works
Self-citationChen, K., Chuang, E., Wey, S., Lin, K., Cheng, F., Lin, C.-C., Liu, H.-L., Tseng, H., Liu, C.-P., Wei, M.-C., et al. (2014) · ACS Nano · doi:10.1021/nn501162x · Cited by 170 · see citing works
Rahimpour, Y., & Hamishehkar, H. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.666968 · Cited by 167 · see citing works
Tagami, T., Ernsting, M. J., & Li, S. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.02.009 · Cited by 166 · see citing works
Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes
Hatakeyama, H., Akita, H., Ishida, E., Hashimoto, K., Kobayashi, H., Aoki, T., Yasuda, J., Obata, K., Kikuchi, H., Ishida, T., et al. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.04.037 · Cited by 165 · see citing works
A new adjuvant delivery system ‘cyclic di-GMP/YSK05 liposome’ for cancer immunotherapy
Miyabe, H., Hyodo, M., Nakamura, T., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.004 · Cited by 165 · see citing works
Li, X., Zhao, Y. L., Sun, M., Shi, J., Ju, R.-J., Zhang, C.-X., Li, X., Zhao, W., Mu, L.-M., Zeng, F., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.049 · Cited by 163 · see citing works
Efficient cytoplasmic delivery of a fluorescent dye by pH-sensitive immunoliposomes.
Connor, J., & Huang, L. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.2.582 · Cited by 162 · see citing works
Ko, A. H., Tempero, M. A., Shan, Y.-S., Su, W., Lin, Y.-L., Dito, E., Ong, A., Wang, Y.-W., Yeh, C. G., & Chen, L.-T. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.408 · Cited by 160 · see citing works
Zong, T., Mei, L., Gao, H., Cai, W., Zhu, P., Shi, K., Chen, J., Wang, Y., Gao, F., & He, Q. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500057n · Cited by 160 · see citing works
Ehmann, F., Sakai‐Kato, K., Duncan, R., de la Ossa, D. H. P., Pita, R., Vidal, J.-M., Kohli, A., Tóthfalusi, L., Sanh, A., Tinton, S. A., et al. (2013) · Nanomedicine · doi:10.2217/nnm.13.68 · Cited by 160 · see citing works
Tardi, P. G., CHOICE, E., Masin, D., Redelmeier, T. E., Bally, M. B., & Madden, T. D. (2000) · PubMed · Cited by 160 · see citing works
Kale, A. A., & Torchilin, V. P. (2007) · Journal of drug targeting · doi:10.1080/10611860701498203 · Cited by 159 · see citing works
Self-citationNanotechnology and human health: risks and benefits
Cattaneo, A. G., Gornati, R., Sabbioni, E., Chiriva‐Internati, M., Cobos, E., Jenkins, M., & Bernardini, G. (2010) · Journal of Applied Toxicology · doi:10.1002/jat.1609 · Cited by 158 · see citing works
Liu, Q., & Boyd, B. J. (2012) · The Analyst · doi:10.1039/c2an36140j · Cited by 156 · see citing works
Laouini, A., Jaafar‐Maalej, C., Sfar, S. H., Charcosset, C., & Fessi, H. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.05.034 · Cited by 154 · see citing works
Photodynamic therapy with verteporfin (Visudyne): impact on ophthalmology and visual sciences.
Bressler, N. M., & Bressler, S. B. (2000) · PubMed · Cited by 152 · see citing works
Manconi, M., Caddeo, C., Sinico, C., et al. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.12.010 · Cited by 151 · see citing works
Yarmolenko, P., Zhao, Y., Landon, C. D., Spasojević, I., Yuan, F., Needham, D., Viglianti, B. L., & Dewhirst, M. W. (2010) · International Journal of Hyperthermia · doi:10.3109/02656731003789284 · Cited by 150 · see citing works
The effect of charge and cholesterol on the size and thickness of sonicated phospholipid vesicles
Johnson, S. M. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90022-9 · Cited by 148 · see citing works
Gambling, D. R., Hughes, T., Martin, G., Horton, W., & Manvelian, G. Z. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000145009.03574.78 · Cited by 148 · see citing works
Baek, S. E., Lee, K. H., Park, Y. S., Oh, D., Oh, S., Kim, K., & Kim, D. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.10.018 · Cited by 148 · see citing works
Remote loading of preencapsulated drugs into stealth liposomes
Sur, S., Fries, A. C., Kinzler, K. W., Zhou, S., & Vogelstein, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324135111 · Cited by 147 · see citing works
Yan, Z., Wang, F., Wen, Z., Zhan, C., Feng, L., Liu, Y., Wei, X., Xie, C., & Lu, W. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.07.034 · Cited by 144 · see citing works
Edwards, K. A., & Baeumner, A. J. (2005) · Talanta · doi:10.1016/j.talanta.2005.08.044 · Cited by 143 · see citing works
Toh, M.-R., & Chiu, G. N. C. (2013) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2013.07.011 · Cited by 143 · see citing works
du Plessis, J., Ramachandran, C., WEINER, N., et al. (1996) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(95)04281-4 · Cited by 142 · see citing works
Design of Folate-Linked Liposomal Doxorubicin to its Antitumor Effect in Mice
Yamada, A., Taniguchi, Y., Kawano, K., Honda, T., Hattori, Y., & Maitani, Y. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0159 · Cited by 141 · see citing works
Factors affecting the stability of dry liposomes
Crowe, J. H., & Crowe, L. M. (1988) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(88)90077-6 · Cited by 140 · see citing works
Woodle, M. C. (1993) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(93)90069-f · Cited by 140 · see citing works
Comparison of ethosomes and liposomes for skin delivery of psoralen for psoriasis therapy
Zhang, Y., Shen, L., Wu, Z., Zhao, J., & Feng, N. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.06.001 · Cited by 139 · see citing works
Some aspects of the phase behaviour of charged lipids
Hauser, H. (1984) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(84)90515-7 · Cited by 138 · see citing works
Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats
Gradauer, K., Barthelmes, J., Vonach, C., Almer, G., Mangge, H., Teubl, B. J., Roblegg, E., Dünnhaupt, S., Fröhlich, E., Bernkop‐Schnürch, A., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.011 · Cited by 137 · see citing works
Allen, T. M., & Everest, J. M. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21638-x · Cited by 137 · see citing works
Preparation of submicron unilamellar liposomes by freeze-drying double emulsions
Wang, T., Deng, Y., Geng, Y., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.01.023 · Cited by 135 · see citing works
The use of liposomal daunorubicin (DaunoXome) in acute myeloid leukemia
Fassas, Α., & Anagnostopoulos, Α. (2005) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190500052438 · Cited by 135 · see citing works
Liposome-based co-delivery of siRNA and docetaxel for the synergistic treatment of lung cancer
Qu, M., Zeng, R., Fang, S., Dai, Q., Li, H., & Long, J. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.08.019 · Cited by 134 · see citing works
The role of liposomes in analytical processes
Gómez‐Hens, A., & Fernández-Romero, J. M. (2004) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2004.07.017 · Cited by 132 · see citing works
Ruozi, B., Tosi, G., Forni, F., et al. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.01.020 · Cited by 131 · see citing works
Antibody-targeted liposomes in cancer therapy and imaging
Sofou, S., & Sgouros, G. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.2.189 · Cited by 129 · see citing works
Muthu, M. S., & Feng, S. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.729576 · Cited by 128 · see citing works
Lipid-enveloped hybrid nanoparticles for drug delivery
Tan, S., Li, X., Guo, Y., & Zhang, Z. (2012) · Nanoscale · doi:10.1039/c2nr32880a · Cited by 128 · see citing works
Yavlovich, A., Singh, A., Blumenthal, R. P., & Puri, A. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.07.030 · Cited by 127 · see citing works
Nobuto, H., Sugita, T., Kubo, T., Shimose, S., Yasunaga, Y., Murakami, T., & Ochi, M. (2004) · International Journal of Cancer · doi:10.1002/ijc.20035 · Cited by 126 · see citing works
Balbino, T. A., Aoki, N. T., Malfatti-Gasperini, A. A., et al. (2013) · Chemical Engineering Journal · doi:10.1016/j.cej.2013.04.053 · Cited by 126 · see citing works
Alhajlan, M. M. A., Alhariri, M., & Omri, A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00235-13 · Cited by 125 · see citing works
Liposomes as targetable drug carriers.
Vp, T. (1985) · PubMed · Cited by 125 · see citing works
Selection of high efficient transdermal lipid vesicle for curcumin skin delivery
Zhao, Y., Lu, C., Zhang, Y., Xiao, J., Zhao, Y., Tian, J., Xu, Y., Feng, Z., & Xu, C. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.06.052 · Cited by 124 · see citing works
Roy, A. C., Park, S. R., Cunningham, D., Kang, Y., Chao, Y., Chen, L., Rees, C., Lim, H. Y., Tabernero, J. M., Ramos, F. J., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt002 · Cited by 123 · see citing works
THE CROSSFLOW INJECTION TECHNIQUE: AN IMPROVEMENT OF THE ETHANOL INJECTION METHOD
Wagner, A., Vorauer‐Uhl, K., Kreismayr, G., & Katinger, H. W. D. (2002) · Journal of Liposome Research · doi:10.1081/lpr-120014761 · Cited by 122 · see citing works
Mo, R., Sun, Q., Li, N., & Zhang, C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.030 · Cited by 121 · see citing works
Lesoin, L., Crampon, C., Boutin, O., et al. (2011) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2011.01.006 · Cited by 121 · see citing works
Isoniazid Proliposome Powders for Inhalation—Preparation, Characterization and Cell Culture Studies
Rojanarat, W., Changsan, N., Tawithong, E., Pinsuwan, S., Chan, H., & Srichana, T. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12074414 · Cited by 120 · see citing works
Bao, A., Goins, B., Klipper, R. W., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.059535 · Cited by 120 · see citing works
Stimuli-responsive liposome-nanoparticle assemblies
Preiss, M. R., & Bothun, G. D. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.584868 · Cited by 119 · see citing works
Small angle X-ray scattering: possibilities and limitations in characterization of vesicles
Bouwstra, J. A., Gooris, G. S., Bras, W., et al. (1993) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(93)90059-c · Cited by 119 · see citing works
Skin penetration behaviour of liposomes as a function of their composition
Gillet, A., Lecomte, F., Hubert, P., et al. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.01.011 · Cited by 118 · see citing works
A new method for liposome preparation using a membrane contactor
Jaafar‐Maalej, C., Charcosset, C., & Fessi, H. (2010) · Journal of Liposome Research · doi:10.3109/08982104.2010.517537 · Cited by 118 · see citing works
Gabizón, A., Tzemach, D., Gorin, J., et al. (2009) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-1132-4 · Cited by 117 · see citing works
Banno, B., Ickenstein, L. M., Chiu, G. N. C., et al. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21988 · Cited by 117 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221 · see citing works
Liu, P., Chen, G., & Zhang, J. (2022) · Molecules · doi:10.3390/molecules27041372 · Cited by 1,334 · see citing works
Preparation and application of pH-responsive drug delivery systems
Ding, H., Tan, P., Fu, S., Tian, X., Zhang, H., Ma, X., Gu, Z., & Luo, K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.056 · Cited by 645 · see citing works
Alzheimer's Disease: Treatment Strategies and Their Limitations.
Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 592 · see citing works
“With the lower volume of hydration in the liposome core, hydrophilic molecules are entrapped with a lower efficiency than hydrophobic molecules [42].”
BackgroundPatel, S., Ashwanikumar, N., Robinson, E., Xia, Y., Mihai, C., Griffith, J. P., Hou, S., Esposito, A. A., Ketova, T., Welsher, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14527-2 · Cited by 601 · see citing works
Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer
Gurunathan, S., Kang, M.-H., Qasim, M., & Kim, J.-H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103264 · Cited by 367 · see citing works
Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M. (2018) · Small Methods · doi:10.1002/smtd.201700375 · Cited by 332 · see citing works
Physicochemical characterization of drug nanocarriers
Berbel Manaia, E., Paiva Abuçafy, M., Chiari-Andréo, B. G., Lallo Silva, B., Oshiro-Júnior, J. A., & Chiavacci, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s133832 · Cited by 207 · see citing works
Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier
Teleanu, R. I., Preda, M. D., Niculescu, A.-G., Vladâcenco, O., Radu, C. I., Grumezescu, A. M., & Teleanu, D. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14050987 · Cited by 200 · see citing works
Extracellular vesicles in cancer nanomedicine
Tarasov, V. V., Svistunov, A. A., Chubarev, V. N., Dostdar, S. A., Sokolov, A. V., Brzecka, A., Sukocheva, O., Neganova, M. E., Klochkov, S. G., Somasundaram, S. G., et al. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.017 · Cited by 97 · see citing works
Reconstituting Natural Cell Elements in Synthetic Cells
Gaut, N. J., & Adamala, K. P. (2021) · Advanced Biology · doi:10.1002/adbi.202000188 · Cited by 92 · see citing works
Axial pharmaceutical properties of liposome in cancer therapy: Recent advances and perspectives
Kiaie, S. H., Mojarad-Jabali, S., Khaleseh, F., Allahyari, S., Taheri, E., Zakeri-Milani, P., & Valizadeh, H. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119269 · Cited by 87 · see citing works
Current advances in non‐viral gene delivery systems: Liposomes versus extracellular vesicles
Belhadj, Z., Qie, Y., Carney, R. P., Li, Y., & Nie, G. (2023) · BMEMat · doi:10.1002/bmm2.12018 · Cited by 79 · see citing works
Bailey, C. M., Liu, Y., Peng, G., Zhang, H., He, M., Sun, D., Zheng, P., Liu, Y., & Wang, Y. (2020) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2020.102278 · Cited by 44 · see citing works
Shiridokht, F., Kehtari, P., Eskandani, M., Farajollahi, A., & Vandghanooni, S. (2025) · International Journal of Pharmaceutics: X · doi:10.1016/j.ijpx.2025.100419 · Cited by 4 · see citing works
- Authors
- Pattni, B. S., Chupin, V. V., & Torchilin, V. P.
- Affiliations
- Northeastern University (US)
- Moscow Institute of Physics and Technology (RU)
- Corresponding author
- Torchilin, Vladimir P.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-05-26
- Volume
- 115
- Issue
- 19
- Pages
- 10938-10966
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2300671107
- Cited by
- 1,600
- References
- 425
- Citations by year
- 2026: 95 · 2025: 132 · 2024: 141 · 2023: 142 · 2022: 155 · 2021: 191 · 2020: 195 · 2019: 170 · 2018: 150 · 2017: 135 · 2016: 83 · 2015: 11
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (5U54CA151881)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- liposomal drug delivery, liposomes, liposome encapsulation, lipids, vesicle membrane composition, targeted drug delivery, tumor targeting, liposome biodistribution, liposome clearance, liposome toxicity, liposome surface modification
- MeSH terms
- Animals, Drug Carriers, Pharmaceutical Preparations, Humans, Liposomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review