Cited by 585biodegradable polymer synthesis and propertiesHydrogels: synthesis, properties, applicationsPolymer Surface Interaction Studies

Natural and Synthetic Polymers for Biomedical and Environmental Applications

Open access
Satchanska, Galina, Davidova, Slavena, Petrov, Petar D.·2024·Polymers

Abstract

Natural and synthetic polymers are a versatile platform for developing biomaterials in the biomedical and environmental fields. Natural polymers are organic compounds that are found in nature. The most common natural polymers include polysaccharides, such as alginate, hyaluronic acid, and starch, proteins, e.g., collagen, silk, and fibrin, and bacterial polyesters. Natural polymers have already been applied in numerous sectors, such as carriers for drug delivery, tissue engineering, stem cell morphogenesis, wound healing, regenerative medicine, food packaging, etc. Various synthetic polymers, including poly(lactic acid), poly(acrylic acid), poly(vinyl alcohol), polyethylene glycol, etc., are biocompatible and biodegradable; therefore, they are studied and applied in controlled drug release systems, nano-carriers, tissue engineering, dispersion of bacterial biofilms, gene delivery systems, bio-ink in 3D-printing, textiles in medicine, agriculture, heavy metals removal, and food packaging. In the following review, recent advancements in polymer chemistry, which enable the imparting of specific biomedical functions of polymers, will be discussed in detail, including antiviral, anticancer, and antimicrobial activities. This work contains the authors’ experimental contributions to biomedical and environmental polymer applications. This review is a vast overview of natural and synthetic polymers used in biomedical and environmental fields, polymer synthesis, and isolation methods, critically assessessing their advantages, limitations, and prospects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/polym16081159

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 98

  1. [1]Puertas-Bartolomé M. Mora-Boza A. García-Fernández L. Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications Polymers 2021 13 1209 10.3390/polym13081209 33918049 PMC8069319 · DOI
  2. [2]Aravamudhan A. Ramos D.M. Nada A.A. Kumbar S.G. Chapter 4—Natural Polymers: Polysaccharides and Their Derivatives for Biomedical Applications Natural and Synthetic Biomedical Polymers Elsevier Amsterdam, The Netherlands 2014 67 89 Available online: https://www.sciencedirect.com/science/article/abs/pii/B9780123969835000041 (accessed on 15 March 2024)
  3. [3]Schultz B. Snow E.S. Walker S. Mechanism of D-Alanine Transfer to Teichoic Acids Shows How Bacteria Acylate Cell Envelope Polymers Nat. Microbiol. 2023 8 1318 1329 10.1038/s41564-023-01411-0 37308592 PMC10664464 · DOI
  4. [4]Caillol S. Special Issue “Natural Polymers and Biopolymers II” Molecules 2020 26 112 10.3390/molecules26010112 33383720 PMC7796038 · DOI
  5. [5]Rajeswari S. Natural Polymers: A Recent Review World J. Pharm. Pharm. Sci. 2017 6 472 494 10.20959/wjpps20178-9762 · DOI
  6. [6]Silva A.C.Q. Silvestre A.J.D. Vilela C. Freire C.S.R. Natural Polymers-Based Materials: A Contribution to a Greener Future Molecules 2022 27 94 10.3390/molecules27010094 PMC8747056 35011326 · DOI
  7. [7]Silva S.S. Gomes J.M. Rodrigues L.C. Reis R.L. Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications Mar. Drugs 2020 18 346 10.3390/md18070346 32629815 PMC7401240 · DOI
  8. [8]Zhang Y. Yu X. Cheng Z. Research on the Application of Synthetic Polymer Materials in Contemporary Public Art Polymers 2022 14 1208 10.3390/polym14061208 35335537 PMC8954564 · DOI
  9. [9]Shrivastava A. Introduction to Plastics Engineering William Andrew Publishing Boston, MA, USA 2018 1 16 Available online: https://www.sciencedirect.com/science/article/pii/B9780323395007000010 (accessed on 15 March 2024)
  10. [10]D’Alvise T.M. Sunder S. Hasler R. Moser J. Knoll W. Synatschke C.V. Harvey S. Weil T. Preparation of Ultrathin and Degradable Polymeric Films by Electropolymerization of 3-Amino-L-Tyrosine Macromol. Rapid Commun. 2022 44 202200332 10.1002/marc.202200332 35689352 · DOI
  11. [11]Cao S. Ivanov T. de Souza Melchiors M. Landfester K. Caire da Silva L. Controlled Membrane Transport in Polymeric Biomimetic Nanoreactors ChemBioChem 2023 24 202200718 10.1002/cbic.202200718 36715701 · DOI
  12. [12]Hunter A. Moghimi S.M. Therapeutic Synthetic Polymers: A Game of Russian Roulette? Drug Discov. Today 2002 7 998 1001 10.1016/S1359-6446(02)02444-3 12546917 · DOI
  13. [13]PubMed Available online: https://pubmed.ncbi.nlm.nih.gov/?db=pubmed (accessed on 4 April 2024)
  14. [14]Zhang H. Lin X. Cao X. Wang Y. Wang J. Zhao Y. Developing Natural Polymers for Skin Wound Healing Bioact. Mater. 2024 33 355 376 10.1016/j.bioactmat.2023.11.012 38282639 PMC10818118 · DOI
  15. [15]Zhao L. Zhou Y. Zhang J. Liang H. Chen X. Tan H. Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications Pharmaceutics 2023 15 2514 10.3390/pharmaceutics15102514 37896274 PMC10610124 · DOI
  16. [16]Long S. Xie C. Lu X. Natural Polymer-Based Adhesive Hydrogel for Biomedical Applications Biosurface Biotribology 2022 8 69 94 10.1049/bsb2.12036 · DOI
  17. [17]Jao D. Xue Y. Medina J. Hu X. Protein-Based Drug-Delivery Materials Materials 2017 10 517 10.3390/ma10050517 28772877 PMC5459032 · DOI
  18. [18]Birajdar M.S. Joo H. Koh W.-G. Park H. Natural Bio-Based Monomers for Biomedical Applications: A Review Biomater. Res. 2021 25 1 14 10.1186/s40824-021-00208-8 33795019 PMC8015023 · DOI
  19. [19]Snetkov P. Zakharova K. Morozkina S. Olekhnovich R. Uspenskaya M. Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer Polymers 2020 12 1800 10.3390/polym12081800 32796708 PMC7464276 · DOI
  20. [20]Teixeira-Costa B.E. Andrade C.T. Natural Polymers Used in Edible Food Packaging—History, Function and Application Trends as a Sustainable Alternative to Synthetic Plastic Polysaccharides 2022 3 32 58 10.3390/polysaccharides3010002 · DOI
  21. [21]Mantha S. Pillai S. Khayambashi P. Upadhyay A. Zhang Y. Tao O. Pham H.M. Tran S.D. Smart Hydrogels in Tissue Engineering and Regenerative Medicine Materials 2019 12 3323 10.3390/ma12203323 31614735 PMC6829293 · DOI
  22. [22]Bharadwaz A. Jayasuriya A.C. Recent Trends in the Application of Widely Used Natural and Synthetic Polymer Nanocomposites in Bone Tissue Regeneration Mater. Sci. Engineering. C Mater. Biol. Appl. 2020 110 110698 10.1016/j.msec.2020.110698 PMC7433904 32204012 · DOI
  23. [23]Ciolacu D.E. Nicu R. Ciolacu F. Natural Polymers in Heart Valve Tissue Engineering: Strategies, Advances and Challenges Biomedicines 2022 10 1095 10.3390/biomedicines10051095 35625830 PMC9139175 · DOI
  24. [24]Cardoso L.M.d.F. Barreto T. Gama J.F.G. Alves L.A. Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy Polymers 2022 14 2641 10.3390/polym14132641 35808686 PMC9268758 · DOI
  25. [25]Devi N. Singh S. Manickam S. Cruz-Martins N. Kumar V. Verma R. Kumar D. Itaconic Acid and Its Applications for Textile, Pharma and Agro-Industrial Purposes Sustainability 2022 14 13777 10.3390/su142113777 · DOI
  26. [27]González-López M.E.S. Gradilla-Hernández M.S. Barajas-Álvarez P. Current Trends in Biopolymers for Food Packaging: A Review Front. Sustain. Food Syst. 2023 7 1225371 10.3389/fsufs.2023.1225371 · DOI
  27. [28]Ponnusamy P.G. Mani S. Material and Environmental Properties of Natural Polymers and Their Composites for Packaging Applications—A Review Polymers 2022 14 4033 10.3390/polym14194033 36235981 PMC9573536 · DOI
  28. [29]Wypij M. Trzcińska-Wencel J. Golińska P. Avila-Quezada G.D. Ingle A.P. Rai M. The Strategic Applications of Natural Polymer Nanocomposites in Food Packaging and Agriculture: Chances, Challenges, and Consumers’ Perception Front. Chem. 2023 10 1106230 10.3389/fchem.2022.1106230 36704616 PMC9871319 · DOI
  29. [30]Lu H. Zhang S. Wang J. Chen Q. A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems Front. Nutr. 2021 8 783831 10.3389/fnut.2021.783831 34926557 PMC8671830 · DOI
  30. [31]Acquavia M.A. Pascale R. Martelli G. Bondoni M. Bianco G. Natural Polymeric Materials: A Solution to Plastic Pollution from the Agro-Food Sector Polymers 2021 13 158 10.3390/polym13010158 33406618 PMC7796273 · DOI
  31. [32]Ngwuluka N.C. Ochekpe N.A. Aruoma O.I. Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery Polymers 2014 6 1312 1332 10.3390/polym6051312 · DOI
  32. [33]Akbari A. Bigham A. Rahimkhoei V. Sharifi S. Jabbari E. Antiviral Polymers: A Review Polymers 2022 14 1634 10.3390/polym14091634 35566804 PMC9101550 · DOI
  33. [34]Kamatar A. Gunay G. Acar H. Natural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroids Polymers 2020 12 2506 10.3390/polym12112506 33126468 PMC7692845 · DOI
  34. [35]Li Y. Meng Q. Chen S. Ling P. Kuss M.A. Duan B. Wu S. Advances, Challenges, and Prospects for Surgical Suture Materials Acta Biomater. 2023 168 78 112 10.1016/j.actbio.2023.07.041 37516417 · DOI
  35. [36]Reddy M.S.B. Ponnamma D. Choudhary R. Sadasivuni K.K. A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds Polymers 2021 13 1105 10.3390/polym13071105 33808492 PMC8037451 · DOI · Paper page
  36. [37]McMahan S. Taylor A. Copeland K.M. Pan Z. Liao J. Hong Y. Current Advances in Biodegradable Synthetic Polymer Based Cardiac Patches J. Biomed. Mater. Res. Part A 2020 108 972 983 10.1002/jbm.a.36874 31895482 PMC7030941 · DOI
  37. [38]Liu F. Wang X. Synthetic Polymers for Organ 3D Printing Polymers 2020 12 1765 10.3390/polym12081765 32784562 PMC7466039 · DOI
  38. [39]Kalirajan C. Dukle A. Nathanael A.J. Oh T.-H. Manivasagam G. A Critical Review on Polymeric Biomaterials for Biomedical Applications Polymers 2021 13 3015 10.3390/polym13173015 34503054 PMC8433665 · DOI
  39. [40]Thadepalli S. Review of Multifarious Applications of Polymers in Medical and Health Care Textiles Mater. Today Proc. 2021 55 330 336 10.1016/j.matpr.2021.07.513 · DOI
  40. [41]Vallejos S. Trigo-López M. Arnaiz A. Miguel Á. Muñoz A. Mendía A. García J.M. From Classical to Advanced Use of Polymers in Food and Beverage Applications Polymers 2022 14 4954 10.3390/polym14224954 36433081 PMC9699061 · DOI
  41. [42]Kadhem A.J. Gentile G.J. Fidalgo de Cortalezzi M.M. Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review Molecules 2021 26 6233 10.3390/molecules26206233 34684813 PMC8540986 · DOI
  42. [43]Zhao X. Lv L. Pan B. Zhang W. Zhang S. Zhang Q. Polymer-Supported Nanocomposites for Environmental Application: A Review Chem. Eng. J. 2011 170 381 394 10.1016/j.cej.2011.02.071 · DOI
  43. [44]Shoukat H. Buksh K. Noreen S. Pervaiz F. Maqbool I. Hydrogels as Potential Drug-Delivery Systems: Network Design and Applications Ther. Deliv. 2021 12 375 396 10.4155/tde-2020-0114 33792360 · DOI
  44. [45]Ravula T. Hardin N.Z. Ramamoorthy A. Polymer Nanodiscs: Advantages and Limitations Chem. Phys. Lipids 2019 219 45 49 10.1016/j.chemphyslip.2019.01.010 30707909 PMC6497063 · DOI
  45. [46]Chi J. Zhang X. Chen C. Shao C. Zhao Y. Wang Y. Antibacterial and Angiogenic Chitosan Microneedle Array Patch for Promoting Wound Healing Bioact. Mater. 2020 5 253 259 10.1016/j.bioactmat.2020.02.004 32128464 PMC7044469 · DOI
  46. [47]García M.A. Hensler G. Al-Gousous J. Pielenhofer J. Wagner M. Lennernäs H. Langguth P. Novel Food Drug Interaction Mechanism Involving Acyclovir, Chitosan and Endogenous Mucus Drug Metab. Pharmacokinet. 2023 49 100491 10.1016/j.dmpk.2023.100491 36805824 · DOI
  47. [48]Zhang H. Zhang Z. Zhang H. Chen C. Zhang D. Zhao Y. Protein-Based Hybrid Responsive Microparticles for Wound Healing ACS Appl. Mater. Interfaces 2021 13 18413 18422 10.1021/acsami.0c19884 33856190 · DOI
  48. [49]Shao J. Wang B. Li J. Jansen J.A. Walboomers X.F. Yang F. Antibacterial Effect and Wound Healing Ability of Silver Nanoparticles Incorporation into Chitosan-Based Nanofibrous Membranes Mater. Sci. Eng. C 2019 98 1053 1063 10.1016/j.msec.2019.01.073 30812989 · DOI
  49. [50]Ho T.-C. Chang C.-C. Chan H.-P. Chung T.-W. Shu C.-W. Chuang K.-P. Duh T.-H. Yang M.-H. Tyan Y.-C. Hydrogels: Properties and Applications in Biomedicine Molecules 2022 27 2902 10.3390/molecules27092902 35566251 PMC9104731 · DOI
  50. [51]Stickdorn J. Czysch C. Medina-Montano C. Stein L. Xu L. Scherger M. Schild H. Grabbe S. Nuhn L. Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses Int. J. Mol. Sci. 2023 24 15417 10.3390/ijms242015417 37895096 PMC10607756 · DOI
  51. [52]Nordin N.N. Aziz N.K. Naharudin I. Anuar N.K. Effects of Drug-Free Pectin Hydrogel Films on Thermal Burn Wounds in Streptozotocin-Induced Diabetic Rats Polymers 2022 14 2873 10.3390/polym14142873 35890648 PMC9316922 · DOI
  52. [53]Kamenova K. Prancheva A. Stoyanova S. Radeva L. Tibi I.P.-E. Yoncheva K. Ravutsov M.A. Marinova M.K. Simeonov S.P. Mitova S. Functional Hydrogels for Delivery of the Proteolytic Enzyme Serratiopeptidase Gels 2024 10 156 10.3390/gels10030156 38534574 PMC10970136 · DOI
  53. [54]Wang R. Yu Y. Gai M. Mateos‐Maroto A. Morsbach S. Xia X. He M. Fan J. Peng X. Landfester K. Liposomal Enzyme Nanoreactors Based on Nanoconfinement for Efficient Anti-Tumor Therapy Angew. Chem. Int. Ed. 2023 62 202308761 10.1002/anie.202308761 37496129 · DOI
  54. [55]Ali M. Brocchini S. Synthetic Approaches to Uniform Polymers Adv. Drug Deliv. Rev. 2006 58 1671 1687 10.1016/j.addr.2006.10.002 17125883 · DOI
  55. [56]Alleva N. Eigen K. Ng D.Y. Weil T. A Versatile and Efficient Method to Isolate DNA–Polymer Conjugates ACS Macro Lett. 2023 12 1257 1263 10.1021/acsmacrolett.3c00371 37656875 PMC10515633 · DOI
  56. [57]Tong X. Pan W. Su T. Zhang M. Dong W. Qi X. Recent Advances in Natural Polymer-Based Drug Delivery Systems React. Funct. Polym. 2020 148 104501 10.1016/j.reactfunctpolym.2020.104501 · DOI
  57. [58]Giliopoulos D. Zamboulis A. Giannakoudakis D. Bikiaris D. Triantafyllidis K. Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications Molecules 2020 25 185 10.3390/molecules25010185 31906398 PMC6983263 · DOI
  58. [59]Krauhausen I. Coen C. Spolaor S. Gkoupidenis P. van de Burgt Y. Brain-Inspired Organic Electronics: Merging Neuromorphic Computing and Bioelectronics Using Conductive Polymers Adv. Funct. Mater. 2023 34 202307729 10.1002/adfm.202307729 · DOI
  59. [60]Zhang N. Kohn D.H. Using Polymeric Materials to Control Stem Cell Behavior for Tissue Regeneration Birth Defects Res. C Embryo Today Rev. 2012 96 63 81 10.1002/bdrc.21003 22457178 PMC5538808 · DOI
  60. [61]Kraemer M. Bellion M. Kissmann A.-K. Herberger T. Synatschke C.V. Bozdogan A. Andersson J. Rodriguez A. Ständker L. Wiese S. Aptamers as Novel Binding Molecules on an Antimicrobial Peptide-Armored Composite Hydrogel Wound Dressing for Specific Removal and Efficient Eradication of Pseudomonas aeruginosa Int. J. Mol. Sci. 2023 24 4800 10.3390/ijms24054800 36902270 PMC10002764 · DOI
  61. [62]Ter Horst B. Moiemen N.S. Grover L.M. Natural Polymers Biomaterials for Skin Repair and Regeneration Woodhead Publishing Cambridge, UK 2019 151 192 10.1016/b978-0-08-102546-8.00006-6 · DOI
  62. [63]Belluati A. Harley I. Lieberwirth I. Bruns N. An Outer Membrane-Inspired Polymer Coating Protects and Endows Escherichia Coli with Novel Functionalities Small 2023 19 202303384 10.1002/smll.202303384 37452438 · DOI
  63. [64]Gasperini L. Mano J.F. Reis R.L. Natural Polymers for the Microencapsulation of Cells J. R. Soc. Interface 2014 11 20140817 10.1098/rsif.2014.0817 25232055 PMC4191114 · DOI
  64. [65]Papadopoulos L. Malletzidou L. Patsiaoura D. Magaziotis A. Psochia E. Terzopoulou Z. Chrissafis K. Markessini C. Papadopoulou E. Bikiaris D.N. Synthesis and Characterization of Unsaturated Succinic Acid Biobased Polyester Resins Appl. Sci. 2021 11 896 10.3390/app11030896 · DOI
  65. [66]Kim H.J. Koo J.M. Kim S.H. Hwang S.Y. Im S.S. Synthesis of Super Absorbent Polymer Using Citric Acid as a Bio-Based Monomer Polym. Degrad. Stab. 2017 144 128 136 10.1016/j.polymdegradstab.2017.07.031 · DOI
  66. [67]Sabbah M. Di Pierro P. Ruffo F. Schiraldi C. Alfano A. Cammarota M. Porta R. Glutamic Acid as Repeating Building Block for Bio-Based Films Polymers 2020 12 1613 10.3390/polym12071613 32698496 PMC7407828 · DOI
  67. [68]Scelsi E. Angelini A. Pastore C. Deep Eutectic Solvents for the Valorisation of Lignocellulosic Biomasses towards Fine Chemicals Biomass 2021 1 29 59 10.3390/biomass1010003 · DOI
  68. [69]Hussein H.S. Shaarawy H.H. Hussien N.H. Hawash S.I. Preparation of Nano-Fertilizer Blend from Banana Peels Bull. Natl. Res. Cent. 2019 43 26 10.1186/s42269-019-0058-1 · DOI · Paper page
  69. [70]Wang J. Emmerich L. Wu J. Vana P. Zhang K. Hydroplastic Polymers as Eco-Friendly Hydrosetting Plastics Nat. Sustain. 2021 4 877 883 10.1038/s41893-021-00743-1 · DOI
  70. [71]Bashir K. Aggarwal M. Physicochemical, Structural and Functional Properties of Native and Irradiated Starch: A Review J. Food Sci. Technol. 2019 56 513 523 10.1007/s13197-018-3530-2 30906009 PMC6400748 · DOI
  71. [72]Gamage A. Thiviya P. Mani S. Ponnusamy P.G. Manamperi A. Evon P. Merah O. Madhujith T. Environmental Properties and Applications of Biodegradable Starch-Based Nanocomposites Polymers 2022 14 4578 10.3390/polym14214578 36365571 PMC9656360 · DOI
  72. [73]Jacob J. Gopi S. Isolation and Physicochemical Characterization of Biopolymers Biopolymers and Their Industrial Applications Elsevier Amsterdam, The Netherlands 2021 45 79 10.1016/b978-0-12-819240-5.00003-1 · DOI
  73. [74]Biswas D. Das S. Mohanto S. Mantry S. Extraction, Modification, and Characterization of Natural Polymers used in Transdermal Drug Delivery System: An updated review Asian J. Pharm. Clin. Res. 2020 13 10 20 10.22159/ajpcr.2020.v13i7.37756 · DOI
  74. [75]Liu R. Suárez J.M. Weisblum B. Gellman S.H. McBride S.M. Synthetic Polymers Active against Clostridium Difficile Vegetative Cell Growth and Spore Outgrowth J. Am. Chem. Soc. 2014 136 14498 14504 10.1021/ja506798e 25279431 PMC4210120 · DOI
  75. [76]Zhang C. Yang X. Yu L. Chen X. Zhang J. Zhang S. Wu S. Electrospun Polyasparthydrazide Nanofibrous Hydrogel Loading with In-Situ Synthesized Silver Nanoparticles for Full-Thickness Skin Wound Healing Application Mater. Des. 2024 239 112818 10.1016/j.matdes.2024.112818 · DOI
  76. [77]Mejía S.P. Marques R.d.C. Landfester K. Orozco J. Mailänder V. Effect of Protein Corona on the Specificity and Efficacy of Nanobioconjugates to Treat Intracellular Infections Macromol. Biosci. 2024 24 e2300197 10.1002/mabi.202300197 37639236 · DOI
  77. [78]Petrov P.D. Yoncheva K. Gancheva V. Konstantinov S. Trzebicka B. Multifunctional Block Copolymer Nanocarriers for Co-Delivery of Silver Nanoparticles and Curcumin: Synthesis and Enhanced Efficacy against Tumor Cells Eur. Polym. J. 2016 81 24 33 10.1016/j.eurpolymj.2016.05.010 · DOI
  78. [79]Wang J. Luo Y. Wu H. Cao S. Abdelmohsen L.K. Shao J. van Hest J.C. Inherently Fluorescent Peanut-Shaped Polymersomes for Active Cargo Transportation Pharmaceutics 2023 15 1986 10.3390/pharmaceutics15071986 37514172 PMC10385398 · DOI
  79. [80]Kim P.-H. Cho J.-Y. Myocardial Tissue Engineering Using Electrospun Nanofiber Composites BMB Rep. 2016 49 26 36 10.5483/BMBRep.2016.49.1.165 26497579 PMC4914209 · DOI
  80. [81]Kamenova K. Haladjova E. Grancharov G. Kyulavska M. Tzankova V. Aluani D. Yoncheva K. Pispas S. Petrov P. Co-Assembly of Block Copolymers as a Tool for Developing Novel Micellar Carriers of Insulin for Controlled Drug Delivery Eur. Polym. J. 2018 104 1 9 10.1016/j.eurpolymj.2018.04.039 · DOI
  81. [82]Borisova D. Haladjova E. Kyulavska M. Petrov P. Pispas S. Stoitsova S. Paunova-Krasteva T. Application of Cationic Polymer Micelles for the Dispersal of Bacterial Biofilms Eng. Life Sci. 2018 18 943 948 10.1002/elsc.201800040 32624888 PMC6999407 · DOI
  82. [83]Haladjova E. Toncheva-Moncheva N. Apostolova M.D. Trzebicka B. Dworak A. Petrov P. Dimitrov I. Rangelov S. Tsvetanov C.B. Polymeric Nanoparticle Engineering: From Temperature-Responsive Polymer Mesoglobules to Gene Delivery Systems Biomacromolecules 2014 15 4377 4395 10.1021/bm501194g 25320910 · DOI
  83. [84]Kaygisiz K. Rauch-Wirth L. Iscen A. Hartenfels J. Kremer K. Münch J. Synatschke C.V. Weil T. Peptide Amphiphiles as Biodegradable Adjuvants for Efficient Retroviral Gene Delivery Adv. Healthc. Mater. 2023 13 e2301364 10.1002/adhm.202301364 37947246 PMC11468294 · DOI
  84. [85]Mohanty A.K. Wu F. Mincheva R. Hakkarainen M. Raquez J.-M. Mielewski D.F. Narayan R. Netravali A.N. Misra M. Sustainable Polymers Nat. Rev. Methods Primers 2022 2 1 27 10.1038/s43586-022-00124-8 · DOI
  85. [86]Chang C. Ginn B. Livingston N.K. Yao Z. Slavin B. King M.W. Chung S. Mao H.-Q. 1.4.6—Medical Fibers and Biotextiles Biomaterials Science Academic Press Cambridge, MA, USA 2020 575 600 Available online: https://www.sciencedirect.com/science/article/pii/B9780128161371000386 (accessed on 15 March 2024)
  86. [87]Grethe T. Biodegradable Synthetic Polymers in Textiles– What Lies beyond PLA and Medical Applications? A Review Tekstilec 2021 64 33 47 10.14502/Tekstilec2021.64.32-46 · DOI
  87. [88]Sikder A. Pearce A.K. Parkinson S.J. Napier R. O’Reilly R.K. Recent Trends in Advanced Polymer Materials in Agriculture Related Applications ACS Appl. Polym. Mater. 2021 3 1203 1217 10.1021/acsapm.0c00982 · DOI
  88. [89]Austin H.P. Allen M.D. Donohoe B.S. Rorrer N.A. Kearns F.L. Silveira R.L. Pollard B.C. Dominick G. Duman R. El Omari K. Characterization and Engineering of a Plastic-Degrading Aromatic Polyesterase Proc. Natl. Acad. Sci. USA 2018 115 E4350 E4357 10.1073/pnas.1718804115 29666242 PMC5948967 · DOI
  89. [90]Ma S. Fu S. Yang H. He P. Sun Z. Duan X. Jia D. Colombo P. Zhou Y. Exploiting Bifunctional 3D-Printed Geopolymers for Efficient Cesium Removal and Immobilization: An Approach for Hazardous Waste Management J. Clean. Prod. 2024 437 140599 10.1016/j.jclepro.2024.140599 · DOI
  90. [91]Satchanska G. Topalova Y. Dimkov R. Groudeva V. Petrov P. Tsvetanov C. Selenska-Pobell S. Golovinsky E. Phenol Degradation by Environmental Bacteria Entrapped in Cryogels Biotechnol. Biotechnol. Equip. 2015 29 514 521 10.1080/13102818.2015.1009167 · DOI
  91. [92]Schöpfer L. Schnepf U. Marhan S. Brümmer F. Kandeler E. Pagel H. Hydrolyzable Microplastics in Soil—Low Biodegradation but Formation of a Specific Microbial Habitat? Biol. Fertil. Soils 2022 58 471 486 10.1007/s00374-022-01638-9 · DOI
  92. [93]Sander M. Kohler H.-P.E. McNeill K. Assessing the Environmental Transformation of Nanoplastic through 13C-Labelled Polymers Nat. Nanotechnol. 2019 14 301 303 10.1038/s41565-019-0420-3 30944423 · DOI
  93. [94]Boaventura N.F. Sousa T.F.d.P. Casagrande M.D.T. The Application of an Eco-Friendly Synthetic Polymer as a Sandy Soil Stabilizer Polymers 2023 15 4626 10.3390/polym15244626 38139878 PMC10747516 · DOI
  94. [95]Nelson T.F. Baumgartner R. Jaggi M. Bernasconi S.M. Battagliarin G. Sinkel C. Künkel A. Kohler H.-P.E. McNeill K. Sander M. Biodegradation of Poly (Butylene Succinate) in Soil Laboratory Incubations Assessed by Stable Carbon Isotope Labelling Nat. Commun. 2022 13 5691 10.1038/s41467-022-33064-8 36171185 PMC9519748 · DOI
  95. [96]Eubeler J.P. Zok S. Bernhard M. Knepper T.P. Environmental Biodegradation of Synthetic Polymers I. Test Methodologies and Procedures TrAC Trends Anal. Chem. 2009 28 1057 1072 10.1016/j.trac.2009.06.007 · DOI · Paper page
  96. [97]Choubey R. Sonker N. Bajpai J. Jain P. Singh A. Synthesis of Polymer Nanomaterials, Mechanisms, and Their Structural Control Advances in Polymeric Nanomaterials for Biomedical Applications Elsevier Amsterdam, The Netherlands 2021 41 63 10.1016/b978-0-12-814657-6.00004-5 · DOI
  97. [98]McDonald S.M. Yang Q. Hsu Y.-H. Nikam S.P. Hu Z. Wang Z. Asheghali D. Yen T. Dobrynin A.V. Rogers J.A. Resorbable Barrier Polymers for Flexible Bioelectronics Nat. Commun. 2023 14 7299 10.1038/s41467-023-42775-5 37949871 PMC10638316 · DOI
  98. [99]Feist J.D. Lee D.C. Xia Y. A Versatile Approach for the Synthesis of Degradable Polymers via Controlled Ring-Opening Metathesis Copolymerization Nat. Chem. 2022 14 53 58 10.1038/s41557-021-00810-2 34795434 · DOI

Cited by

Sorted by citations

Authors
Satchanska, G., Davidova, S., & Petrov, P. D.
Affiliations
  • New Bulgarian University (BG)
  • Bulgarian Academy of Sciences (BG)
Corresponding author
Satchanska, Galina
Venue
Polymers
Publisher
MDPI AG
Published
2024-04-20
Volume
16
Issue
8
Pages
1159
ISSN
2073-4360 (ISSN-L)
OpenAlex
W4395004493
Cited by
585
References
1
Citations by year
2026: 257 · 2025: 270 · 2024: 58
FWCI
15.85
Type
journal article
Language
en
Open access
Locations
  • Polymers (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Central Fund for Strategic Development, New Bulgarian University, Sofia, Bulgaria (NBU-CFSR-1837/2024)
  • Bulgarian Ministry of Education and Science (NBU-CFSR-1837/2024)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
natural polymers, synthetic polymers, biomaterials, polysaccharides, alginate, hyaluronic acid, collagen, bacterial polyesters, biodegradable polymers, drug delivery, tissue engineering, wound healing, regenerative medicine, food packaging, heavy metal removal, gene delivery, bioinks, 3D printing, antimicrobial polymers, antiviral polymers, polymer synthesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review