Cited by 68Substance Abuse Treatment and OutcomesYouth, Drugs, and ViolenceGambling Behavior and Treatments

A Multi-Level Analysis of Biological, Social, and Psychological Determinants of Substance Use Disorder and Co-Occurring Mental Health Outcomes

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Belfiore, Cecilia Ilaria, Galofaro, Valeria, Cotroneo, Deborah, Lopis, Alessia, Tringali, Isabella, Denaro, Valeria, Casu, Mirko·2024·Psychoactives

Abstract

We explored the intricate interplay of biological, social, and psychological factors contributing to substance use disorder (SUD) and co-occurring psychiatric symptoms. Drug misuse is a global concern, with increasing prevalence rates affecting mental well-being and safety. The spectrum of SUD includes polysubstance users, posing challenges for treatment and associated health outcomes. Various psychoactive substances like cannabis, hallucinogens, opioids, and stimulants impact addiction vulnerability, with marijuana being widely used globally. Gender differences in SUD prevalence have narrowed, with women escalating drug consumption rapidly once initiated. Age disparities in substance use highlight regional variations among adolescents. Comorbidities with psychiatric symptoms are common, with mood and anxiety disorders frequently observed. This study aimed to analyze factors influencing SUD development and maintenance to inform prevention strategies and treatment recommendations. By conducting a systematic search of databases, sixty articles were reviewed, revealing diverse methodologies and geographic locations. Biological factors, including neurotransmitter systems like endocannabinoid and dopaminergic systems, play a significant role in addiction. Genetic and neurobiological factors contribute to cannabis addiction susceptibility. Social factors such as childhood experiences and parenting styles influence substance use behaviors. Psychological factors like personality traits and mental health conditions interact with SUD development. Understanding these multifaceted interactions is crucial for designing effective interventions to address the complexities of SUD and co-occurring psychiatric symptoms.

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Crossref · 10.3390/psychoactives3020013

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  • Multi-level evidence links fragmented addiction and mental health systems to reduced psychological resilience over time.

    “while multi‐level evidence links fragmented addiction and mental health systems to reduced psychological resilience over time [54].”

    From Treatment Experiences of Individuals With Co-Occurring Mental Health and Substance Use Disorders and Perspectives of Mental Health Workers in Ashanti Region, Ghana (2026) · cites this paper as [54]

    The Discussion describes biological, psychological, and social influences on addiction and calls for comprehensive treatment, but does not link fragmented addiction and mental health systems to declining psychological resilience. Searches for fragmentation, resilience, and related service terms found no passage establishing that relationship over time; the paper’s copy provides no page numbers for these sections. (LLM, conf=0.77)

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  1. Skewes, M.C.; Gonzalez, V.M. The Biopsychosocial Model of Addiction. In Principles of Addiction; Elsevier: Amsterdam, The Netherlands, 2013; pp. 61-70; ISBN 978-0-12-398336-7.
  2. Bukowski, W.M.; Laursen, B.; Rubin, K.H. (Eds.) Handbook of Peer Interactions, Relationships, and Groups, 2nd ed.; The Guilford Press: New York, NY, USA, 2018; ISBN 978-1-4625-2501-0.

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Authors
Belfiore, C. I., Galofaro, V., Cotroneo, D., Lopis, A., Tringali, I., Denaro, V., & Casu, M.
Affiliations
  • APA Association for Psychoanalysis Applied to Clinics, Research and Teaching, Via Trieste 13, 95127 Catania, Italy
  • University of Catania (IT)
  • Associazione Amici di San Patrignano Sicilia, Via Rametta 47, 95124 Catania, Italy
  • University of Padua (IT)
Corresponding author
  • Belfiore, Cecilia Ilaria
  • Casu, Mirko
Venue
Psychoactives
Publisher
MDPI AG
Published
2024-04-08
Volume
3
Issue
2
Pages
194-214
ISSN
2813-1851 (ISSN-L)
OpenAlex
W4394610842
Cited by
67
References
53
Citations by year
2026: 29 · 2025: 32 · 2024: 6
FWCI
20.44
Type
journal article
Language
en
Open access
Locations
  • Psychoactives (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Demography › Youth, Drugs, and Violence
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords
substance use disorders, polydrug use, cannabis use disorder, opioid use, stimulant use, hallucinogens, psychiatric comorbidity, mood disorders, anxiety disorders, endocannabinoid system, dopaminergic system, genetic susceptibility, childhood experiences, parenting styles, personality traits, gender differences in substance use, age differences in substance use, adolescents, addiction vulnerability, prevention

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