Development of a Nafion/MWCNT-SPCE-Based Portable Sensor for the Voltammetric Analysis of the Anti-Tuberculosis Drug Ethambutol
Open accessAbstract
Herein we describe the development, characterization and application of an electrochemical sensor based on the use of Nafion/MWCNT-modified screen-printed carbon electrodes (SPCEs) for the voltammetric detection of the anti-tuberculosis (anti-TB) drug ethambutol (ETB). The electrochemical behaviour of the drug at the surface of the developed Nafion/MWCNT-SPCEs was studied through cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques. Electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM) were employed to characterize the modified surface of the electrodes. Results showed that, compared to both unmodified and MWCNTs-modified SPCEs, negatively charged Nafion/MWCNT-SPCEs remarkably enhanced the electrochemical sensitivity and selectivity for ETB due to the synergistic effect of the electrostatic interaction between cationic ETB molecules and negatively charged Nafion polymer and the inherent electrocatalytic properties of both MWCNTs and Nafion. Nafion/MWCNT-SPCEs provided excellent biocompatibility, good electrical conductivity, low electrochemical interferences and a high signal-to-noise ratio, providing excellent performance towards ETB quantification in microvolumes of human urine and human blood serum samples. The outcomes of this paper confirm that the Nafion/MWCNT-SPCE-based device could be a potential candidate for the development of a low-cost, yet reliable and efficient electrochemical portable sensor for the low-level detection of this antimycobacterial drug in biological samples.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The development of electrochemical transducers has been especially promising due to their low cost, simplicity, and portability.
“The development of electrochemical transducers has been especially promising due to their low cost, simplicity, and portability.7,8”
From Wearable sensors for monitoring the physiological and biochemical profile of the athlete (2019) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Advanced Carbon Electrode Materials for Molecular Electrochemistry
McCreery, R. L. (2008) · Chemical Reviews · doi:10.1021/cr068076m · Cited by 2,737 · see citing works
Electrochemical Sensors and Biosensors Based on Nanomaterials and Nanostructures
Zhu, C., Yang, G., Li, H., Du, D., & Lin, Y. (2014) · Analytical Chemistry · doi:10.1021/ac5039863 · Cited by 1,754 · see citing works
Biosensors: sense and sensibility
Turner, A. P. F. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35528d · Cited by 1,690 · see citing works
Nanomaterials based electrochemical sensors for biomedical applications
Chen, A., & Chatterjee, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35518g · Cited by 959 · see citing works
Advances in the development of new tuberculosis drugs and treatment regimens
Zumla, A. I., Nahid, P., & Cole, S. T. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4001 · Cited by 895 · see citing works
Voltammetric techniques for the assay of pharmaceuticals—A review
Gupta, V. K., Jain, R., Radhapyari, K., et al. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.09.027 · Cited by 505 · see citing works
Role of carbon nanotubes in electroanalytical chemistry
Agüı́, L., Yáñez‐Sedeño, P., & Pingarrón, J. M. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.05.070 · Cited by 498 · see citing works
Disposable Screen Printed Electrochemical Sensors: Tools for Environmental Monitoring
Hayat, A., & Marty, J. (2014) · Sensors · doi:10.3390/s140610432 · Cited by 433 · see citing works
Gao, C., Guo, Z., Liu, J., et al. (2012) · Nanoscale · doi:10.1039/c2nr11757f · Cited by 424 · see citing works
Electrochemical Sensors Based on Carbon Nanotubes
Ahammad, A. J. S., Lee, J., & Rahman, M. A. (2009) · Sensors · doi:10.3390/s90402289 · Cited by 374 · see citing works
New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects
Zumla, A. I., Gillespie, S. H., Höelscher, M., Philips, P. P. J., Cole, S. T., Abubakar, I., McHugh, T. D., Schito, M. L., Maeurer, M. J., & Nunn, A. J. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70328-1 · Cited by 341 · see citing works
Couto, R. A. S., Lima, J. L. F. C., & Quinaz, M. B. (2015) · Talanta · doi:10.1016/j.talanta.2015.06.011 · Cited by 263 · see citing works
Self-citationZumla, A. I., Chakaya, J. M., Centis, R., D’Ambrosio, L., Mwaba, P., Bates, M., Kapata, N., Nyirenda, T. E., Chanda, D. M., Mfinanga, S., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00063-6 · Cited by 221 · see citing works
Human genetics of tuberculosis: a long and winding road
Abel, L., Baghdadi, J. E., Bousfiha, A. A., Casanova, J., & Schurr, E. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0428 · Cited by 191 · see citing works
Hong, S. A., Kwon, J. S., Kim, D., & Yang, S. H. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.09.025 · Cited by 129 · see citing works
Evaluation of nafion based double layer capacitors by electrochemical impedance spectroscopy
Lufrano, F., Staiti, P., & Minutoli, M. (2003) · Journal of Power Sources · doi:10.1016/s0378-7753(03)00589-5 · Cited by 111 · see citing works
Ku, S., Palanisamy, S., & Chen, S. (2013) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2013.08.029 · Cited by 108 · see citing works
Xue, Y., Bo, X., & Guo, L. (2011) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2011.01.058 · Cited by 86 · see citing works
Rooney, M. B., Coomber, D. C., & Bond, A. M. (2000) · Analytical Chemistry · doi:10.1021/ac991464m · Cited by 80 · see citing works
Mishra, G. K., Sharma, A., & Bhand, S. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.09.033 · Cited by 62 · see citing works
Cheemalapati, S., Chen, S., Ali, M. A., et al. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.06.035 · Cited by 62 · see citing works
Contribution of Nafion loading to the activity of catalysts and the performance of PEMFC
Lai, C.-M., Lin, J.-C., Ting, F.-P., Chyou, S., & Hsueh, K. (2008) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2008.05.074 · Cited by 60 · see citing works
Thapliyal, N. B., Karpoormath, R. V., & Goyal, R. N. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2014.09.054 · Cited by 49 · see citing works
Colorimetric and titrimetric assay of isoniazid
El-Brashy, A. M., & El‐Ashry, S. M. (1992) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/0731-7085(92)80060-z · Cited by 49 · see citing works
Zhou, Z., Wu, X.-B., Wei, Q., et al. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7049-0 · Cited by 47 · see citing works
Hee, D. K.-H., Seo, J. J., & Lee, L. (2014) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2014.09.019 · Cited by 43 · see citing works
Chemiluminescence detection of isoniazid using Ru(phen)32+–isoniazid–Ce(IV) system
Xi, J., Shi, B., Ai, X., et al. (2004) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2004.05.021 · Cited by 40 · see citing works
Screen-printed back-to-back electroanalytical sensors
Metters, J. P., Randviir, E. P., & Banks, C. E. (2014) · The Analyst · doi:10.1039/c4an01501k · Cited by 40 · see citing works
Liu, Y., Fu, Z., & Wang, L. (2010) · Luminescence · doi:10.1002/bio.1243 · Cited by 40 · see citing works
Ngece, R. F., West, N., Ndangili, P. M., et al. (2011) · International Journal of Electrochemical Science · doi:10.1016/s1452-3981(23)18149-1 · Cited by 32 · see citing works
Feng, Y., & Dong, C. (2004) · Journal of Chromatographic Science · doi:10.1093/chromsci/42.9.474 · Cited by 31 · see citing works
Pan, X., Wang, L., Gründemann, D., & Sweet, D. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01255-13 · Cited by 30 · see citing works
Determination of ethambutol by a sensitive fluorescent probe
Wu, W., Yang, J., Du, L., et al. (2011) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2011.02.045 · Cited by 29 · see citing works
Determination of antitubercular drugs by micellar electrokinetic capillary chromatography (MEKC)
Acedo‐Valenzuela, M., Espinosa-Mansilla, A., de la Peña, A. M., et al. (2002) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-002-1494-5 · Cited by 28 · see citing works
García-González, R., Fernández-Abedul, M. T., & Costa‐García, A. (2013) · Talanta · doi:10.1016/j.talanta.2013.01.034 · Cited by 27 · see citing works
Burke, A. M., & Gorodetsky, A. A. (2012) · Nature Chemistry · doi:10.1038/nchem.1418 · Cited by 26 · see citing works
Wang, F., Zhou, J., Liu, Y., et al. (2011) · The Analyst · doi:10.1039/c1an15372b · Cited by 24 · see citing works
Gennaro, M. C., Calvino, R., & Abrigo, C. (2001) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(01)00037-8 · Cited by 20 · see citing works
Ng, K., Zhou, H., Zhang, Y. L., Hybertson, B. M., Randolph, T. W., & Christians, U. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.10.008 · Cited by 20 · see citing works
Abolhasani, J., & Hassanzadeh, J. (2014) · Luminescence · doi:10.1002/bio.2659 · Cited by 19 · see citing works
Perantoni, C. B., Carbogim, L. G. S., Semaan, F. S., et al. (2011) · Electroanalysis · doi:10.1002/elan.201100195 · Cited by 14 · see citing works
Kawde, A.-N. M., Temerk, Y. M., & Farhan, N. (2014) · PubMed · Cited by 14 · see citing works
Lima, A. E. B., Júnior, G. E. D. L., Batista, N. C., et al. (2015) · Electroanalysis · doi:10.1002/elan.201500600 · Cited by 13 · see citing works
Perantoni, C. B., Azevedo, A., Vaz, F. A. S., et al. (2013) · Open Chemistry · doi:10.2478/s11532-013-0301-9 · Cited by 7 · see citing works
Determination of ethambutol at glassy carbon electrode modified with multiwall carbon nanotubes
Shao, C., Wei, Y., Li, S.-M., et al. (2008) · Chemia Analityczna · Cited by 5 · see citing works
[Colorimetric determination of isoniazid in aqueous solutions and biological fluids].
Csiba, A. (1989) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wearable sensors for monitoring the physiological and biochemical profile of the athlete
Seshadri, D. R., Li, R. T., Voos, J. E., Rowbottom, J. R., Alfes, C. M., Zorman, C. A., & Drummond, C. K. (2019) · npj Digital Medicine · doi:10.1038/s41746-019-0150-9 · Cited by 537 · see citing works
- Authors
- Couto, R., & Quinaz, M.
- Affiliations
- Universidade do Porto (PT)
- Corresponding author
- Quinaz, Maria
- ORCID
- Couto, Rosa
- Venue
- Sensors
- Publisher
- MDPI AG
- Published
- 2016-06-30
- Volume
- 16
- Issue
- 7
- Pages
- 1015
- ISSN
- 1424-8220 (ISSN-L)
- PMC
- PMC4970065
- OpenAlex
- W2460692629
- Cited by
- 28
- References
- 46
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 3
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Sensors (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Union (FEDER funds) (POCI/01/0145/FEDER/007265)
- National funds (FCT/MEC, Fundação para a Ciência e Tecnologia and Ministério da Educação e Ciência) (PT2020 UID/QUI/50006/2013)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Electrocatalysts for Energy Conversion
- Keywords
- ethambutol, electrochemical sensor, screen-printed carbon electrode, multi-walled carbon nanotubes, Nafion, antitubercular agents, portable sensors, electrocatalysis, electrostatic interactions, low-cost biosensor
- MeSH terms
- Antitubercular Agents, Electrodes, Ethambutol, Fluorocarbon Polymers, Humans, Hydrogen-Ion Concentration, Oxidation-Reduction, Printing, Solutions, Nanotubes, Carbon, Electrochemical Techniques, Dielectric Spectroscopy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
