The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development
Open accessAbstract
Aflatoxins are fungal metabolites found in feeds and foods. When the ruminants eat feedstuffs containing Aflatoxin B1 (AFB1), this toxin is metabolized and Aflatoxin M1 (AFM1) is excreted in milk. International Agency for Research on Cancer (IARC) classified AFB1 and AFM1 as human carcinogens belonging to Group 1 and Group 2B, respectively, with the formation of DNA adducts. In the last years, some epidemiological studies were conducted on cancer patients aimed to evaluate the effects of AFB1 and AFM1 exposure on cancer cells in order to verify the correlation between toxin exposure and cancer cell proliferation and invasion. In this review, we summarize the activation pathways of AFB1 and AFM1 and the data already reported in literature about their correlation with cancer development and progression. Moreover, considering that few data are still reported about what genes/proteins/miRNAs can be used as damage markers due to AFB1 and AFM1 exposure, we performed a bioinformatic analysis based on interaction network and miRNA predictions to identify a panel of genes/proteins/miRNAs that can be used as targets in further studies for evaluating the effects of the damages induced by AFB1 and AFM1 and their capacity to induce cancer initiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Global burden of aflatoxin-induced hepatocellular carcinoma: A risk assessment
Liu, Y., & Wu, F. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901388 · Cited by 1,224
Mechanisms of Aflatoxin Carcinogenesis
Eaton, D. L., & Gallagher, E. P. (1994) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.34.040194.001031 · Cited by 774
Toxic effects of mycotoxins in humans.
Peraica, M., Radić, B., Lucić, A., & Pavlović, M. (1999) · Europe PMC (PubMed Central) · Cited by 764
On the occurrence of aflatoxin M1 in milk and dairy products
Prandini, A., Tansini, G., Sigolo, S., Filippi, L., Laporta, M., & Piva, G. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.10.005 · Cited by 494
Aflatoxin in food and feed: occurrence, legislation and inactivation by physical methods
Rustom, I. Y. S. (1997) · Food Chemistry · doi:10.1016/s0308-8146(96)00096-9 · Cited by 489
The toxicology of aflatoxins as a basis for public health decisions
Wild, C. P. (2002) · Mutagenesis · doi:10.1093/mutage/17.6.471 · Cited by 475
Modification of immune function through exposure to dietary aflatoxin in Gambian children.
Turner, P. C., Moore, S. E., Hall, A. J., Prentice, A. M., & Wild, C. P. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5753 · Cited by 471
Jard, G., Liboz, T., Mathieu, F., Guyonvarc’h, A., & Lebrihi, A. (2011) · Food Additives & Contaminants: Part A · doi:10.1080/19440049.2011.595377 · Cited by 324
Aflatoxins as risk factors for hepatocellular carcinoma in humans.
Wogan, G. N. (1992) · PubMed · Cited by 280
Gallagher, E. P., Kunze, K. L., Stapleton, P. L., & Eaton, D. L. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0326 · Cited by 267
Cited by
Aflatoxin Contamination, Its Impact and Management Strategies: An Updated Review
Shabeer, S., Asad, S., Jamal, A., & Ali, A. (2022) · Toxins · doi:10.3390/toxins14050307 · Cited by 327
Al-Shaarani, A. A. Q. A., & Pecoraro, L. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1428415 · Cited by 50
Synergism in actions of HBV with aflatoxin in cancer development
Jin, J., Kouznetsova, V. L., Kesari, S., & Tsigelny, I. F. (2023) · Toxicology · doi:10.1016/j.tox.2023.153652 · Cited by 43
Metadata
- Authors
- Marchese, S., Polo, A., Ariano, A., Velotto, S., Costantini, S., & Severino, L.
- Venue
- Toxins
- Publisher
- MDPI AG
- Published
- 2018-05-24
- Volume
- 10
- Issue
- 6
- Pages
- 214
- ISSN
- 2072-6651 (ISSN-L)
- OpenAlex
- W2804189517
- Cited by
- 594
- References
- 78
- FWCI
- 32.16
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development. https://app.cochat.ai/papers/10.3390/toxins10060214
- The paper
- Marchese, S., Polo, A., Ariano, A., Velotto, S., Costantini, S., & Severino, L. (2018). Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development. Toxins. https://doi.org/10.3390/toxins10060214
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
