The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies
Open accessAbstract
Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and humans have been completed over the last two decades. We conducted a systematic review of safety and toxicity data associated with phage therapy in both animals and humans reported in English language publications from 2008–2021. Overall, 69 publications met our eligibility criteria including 20 animal studies, 35 clinical case reports or case series, and 14 clinical trials. After summarizing safety and toxicity data from these publications, we discuss potential approaches to optimize safety and toxicity monitoring with the therapeutic use of phage moving forward. In our systematic review of the literature, we found some adverse events associated with phage therapy, but serious events were extremely rare. Comprehensive and standardized reporting of potential toxicities associated with phage therapy has generally been lacking in the published literature. Structured safety and tolerability endpoints are necessary when phages are administered as anti-infective therapeutics.
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Cites
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Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria
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Phage Therapy in the Postantibiotic Era
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Phage therapy: From biological mechanisms to future directions
Strathdee, S. A., Hatfull, G. F., Mutalik, V. K., & Schooley, R. T. (2023) · Cell · doi:10.1016/j.cell.2022.11.017 · Cited by 817
Laxminarayan, R., Impalli, I., Rangarajan, R., Cohn, J., Ramjeet, K., Trainor, B. W., Strathdee, S., Sumpradit, N., Berman, D., Wertheim, H., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00878-x · Cited by 111
(2023) · doi:10.3390/vaccines11050919 · Cited by 50
Bacteriophages as Solid Tumor Theragnostic Agents
Veeranarayanan, S., Azam, A. H., Kiga, K., Watanabe, S., & Cui, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010402 · Cited by 39
Mutalik, V. K., & Arkin, A. P. (2022) · iScience · doi:10.1016/j.isci.2022.104121 · Cited by 32
Metadata
- Authors
- Liu, D., Van Belleghem, J. D., de Vries, C. R., Burgener, E., Chen, Q., Manasherob, R., Aronson, J. R., Amanatullah, D. F., Tamma, P. D., & Suh, G. A.
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2021-06-29
- Volume
- 13
- Issue
- 7
- Pages
- 1268
- ISSN
- 1999-4915 (ISSN-L)
- OpenAlex
- W3175417702
- Cited by
- 268
- References
- 111
- FWCI
- 20.56
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, D., Van Belleghem, J. D., de Vries, C. R., Burgener, E., Chen, Q., Manasherob, R., Aronson, J. R., Amanatullah, D. F., Tamma, P. D., & Suh, G. A. (2021). The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies. Viruses. https://doi.org/10.3390/v13071268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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