A New Role for the HTLV-1 p8 Protein: Increasing Intercellular Conduits and Viral Cell-to-Cell Transmission
Open accessAbstract
Retroviruses like HIV-1 and HTLV-1 can be transmitted efficiently by direct contact between infected and target cells. For HIV-1, various modes of cell-to-cell transfer have been reported, including virological synapses, polysynapses, filopodial bridges, and nanotube-like structures. So far, only synapses and biofilms have been described for HTLV-1 transmission. Recently, Van Prooyen et al. [1] identified an additional mode of HTLV-1 transmission through cellular conduits induced by the viral accessory protein p8.
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p8 and Nef both localize at the IS, suppress TCR function, induce conduit/TNT formation, translocate to recipient cells via TNTs, causing cell anergy and viral escape from immune surveillance.
“Based on HIV and HTLV TNT studies, an analogy can be drawn between the p8 protein from HTLV-1, and Nef from HIV-1. Both proteins localize at the IS, suppress TCR function, and induce conduit/TNT formation. They translocate to recipient cells via TNTs, causing cell anergy and viral escape from immune surveillance [118].”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [118]
The Abstract (page not provided) says p8 colocalizes with the immune synapse and down-regulates TCR expression; it also reports that p8 and Nef form intercellular conduits and can transfer to other cells. But it says Nef probably does not induce nanotubes, and describes protection from immune recognition after p8 transfer as a proposed model. It does not establish that transfer by both proteins causes recipient-cell anergy and viral escape. (LLM, conf=0.88)
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Cites
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Research works printed but not linked: 21
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HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread
Kalinichenko, S., Komkov, D., & Mazurov, D. (2022) · Viruses · doi:10.3390/v14010152 · Cited by 68 · see citing works
“They translocate to recipient cells via TNTs, causing cell anergy and viral escape from immune surveillance [118].”
Background
- Authors
- Malbec, M., Roesch, F., & Schwartz, O.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Schwartz, Olivier
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2011-03-09
- Volume
- 3
- Issue
- 3
- Pages
- 254-259
- ISSN
- 1999-4915 (ISSN-L)
- PMC
- PMC3185692
- OpenAlex
- W1980633901
- Cited by
- 21
- References
- 2
- Citations by year
- 2024: 4 · 2022: 3 · 2021: 2 · 2020: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Viruses (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- HTLV-1, p8 protein, virological synapse, nanotubes, filopodia, viral accessory proteins
- MeSH terms
- Cell Line, Humans, Human T-lymphotropic virus 1, HTLV-I Infections, Viral Regulatory and Accessory Proteins
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