HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits
Open accessAbstract
Contact-dependent communication between immune cells generates protection but also facilitates viral spread. Here we found that macrophages formed long-range actin-propelled conduits in response to negative factor (Nef), a human immunodeficiency virus type 1 (HIV-1) protein with immunosuppressive functions. Conduits attenuated immunoglobulin G2 (IgG2) and IgA class switching in systemic and intestinal lymphoid follicles by shuttling Nef from infected macrophages to B cells through a guanine-exchange factor-dependent pathway involving the amino-terminal anchor, central core and carboxy-terminal flexible loop of Nef. By showing stronger virus-specific IgG2 and IgA responses in patients with Nef-deficient virions, our data suggest that HIV-1 exploits intercellular 'highways' as a 'Trojan horse' to deliver Nef to B cells and evade humoral immunity systemically and at mucosal sites of entry.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nef mediates formation of TNTs in infected macrophages via M-sec and by enhancing production of myosin-X; Nef translocates from HIV-1-infected macrophages to B cells through nanotubes, inhibiting production of antiviral IgG2 and IgA.
“The HIV accessory protein, Nef, has been reported to mediate the formation of TNTs in infected macrophages via the cellular protein M-sec [113], and by enhancing the production of the motor protein myosin-X [114]. Moreover, Nef is capable of translocating from HIV-1-infected macrophages to B cells through nanotubes, where it exerts anti-immune activity by inhibiting the production of antiviral IgG”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [115]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
RETRACTED ARTICLE: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Litinskiy, M. B., Nardelli, B., Hilbert, D. M., He, B., Schaffer, A., Casali, P., & Cerutti, A. (2002) · Nature Immunology · doi:10.1038/ni829 · Cited by 1,252 · see citing works
Self-citationRetractedQiao, X., He, B., Chiu, A., Knowles, D. M., Chadburn, A., & Cerutti, A. (2006) · Nature Immunology · doi:10.1038/ni1302 · Cited by 199 · see citing works
Self-citationRetractedNanotubular Highways for Intercellular Organelle Transport
Rustom, A., Saffrich, R., Markovic, I., Walther, P., & Gerdes, H.-H. (2004) · Science · doi:10.1126/science.1093133 · Cited by 2,038 · see citing works
Lane, H. C., Masur, H., Edgar, L. C., Whalen, G., Rook, A. H., & Fauci, A. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308253090803 · Cited by 1,600 · see citing works
Importance of the nef gene for maintenance of high virus loads and for development of AIDS
Kestier, H. W., Ringler, D. J., Mori, K., Panicali, D., Sehgal, P. K., Daniel, M. D., & Desrosiers, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90097-i · Cited by 1,593 · see citing works
Shaffer, A. L., Lin, K., Kuo, T. C., Yu, X., Hurt, E. M., Rosenwald, A., Giltnane, J. M., Yang, L., Zhao, H., Calame, K. L., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00335-7 · Cited by 1,048 · see citing works
Moir, S. L., Ho, J., Malaspina, A., Wang, W., DiPoto, A. C., O’Shea, M. A., Roby, G. A., Kottilil, S., Arthos, J. A., Proschan, M. A., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072683 · Cited by 894 · see citing works
Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., et al. (2007) · Nature · doi:10.1038/nature06287 · Cited by 846 · see citing works
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
Klein, U., Casola, S. S., Cattoretti, G., Shen, Q. “., Lia, M., Mo, T., Ludwig, T. E., Rajewsky, K., & Dalla‐Favera, R. (2006) · Nature Immunology · doi:10.1038/ni1357 · Cited by 802 · see citing works
HIV vaccine design and the neutralizing antibody problem
Burton, D. R., Desrosiers, R. C., Doms, R. W., Koff, W. C., Kwong, P. D., Moore, J. P., Nabel, G. J., Sodroski, J., Wilson, I. A., & Wyatt, R. T. (2004) · Nature Immunology · doi:10.1038/ni0304-233 · Cited by 765 · see citing works
Sowinski, S., Jolly, C., Berninghausen, O., Purbhoo, M. A., Chauveau, A., Köhler, K., Oddos, S., Eissmann, P., Brodsky, F. M., Hopkins, C., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1682 · Cited by 754 · see citing works
He, B., Xu, W., Santini, P. A., Polydorides, A. D., Chiu, A., Estrella, J. S., Shan, M., Chadburn, A., Villanacci, V., Plebani, A., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.014 · Cited by 748 · see citing works
Self-citationB cells in HIV infection and disease
Moir, S. L., & Fauci, A. S. (2009) · Nature reviews. Immunology · doi:10.1038/nri2524 · Cited by 702 · see citing works
Aiken, C., Konner, J. A., Landau, N. R., Lenburg, M. E., & Trono, D. (1994) · Cell · doi:10.1016/0092-8674(94)90360-3 · Cited by 694 · see citing works
Antibodies, viruses and vaccines
Burton, D. R. (2002) · Nature Reviews Immunology · doi:10.1038/nri891 · Cited by 637 · see citing works
HIV disease: fallout from a mucosal catastrophe?
Brenchley, J. M., Price, D. A., & Douek, D. C. (2006) · Nature Immunology · doi:10.1038/ni1316 · Cited by 579 · see citing works
Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission
Sherer, N. M., Lehmann, M. J., Jimenez-Soto, L. F., Horensavitz, C., Pypaert, M., & Mothes, W. (2007) · Nature Cell Biology · doi:10.1038/ncb1544 · Cited by 432 · see citing works
Functional Connectivity between Immune Cells Mediated by Tunneling Nanotubules
Watkins, S. C., & Salter, R. D. (2005) · Immunity · doi:10.1016/j.immuni.2005.08.009 · Cited by 400 · see citing works
Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection
Wiley, R. D., & Gummuluru, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507995103 · Cited by 311 · see citing works
Milito, A. D., Nilsson, A., Titanji, K., Thorstensson, R., Reizenstein, E., Narita, M., Grützmeier, S., Sönnerborg, A. B., & Chiodi, F. (2003) · Blood · doi:10.1182/blood-2003-07-2375 · Cited by 311 · see citing works
Xu, W., He, B., Chiu, A., Chadburn, A., Shan, M., Buldys, M., Ding, A. H., Knowles, D. M., Santini, P. A., & Cerutti, A. (2007) · Nature Immunology · doi:10.1038/ni1434 · Cited by 305 · see citing works
Self-citationHIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway
Blagoveshchenskaya, A. D., Thomas, L., Feliciangeli, S. F., Hung, C., & Thomas, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01162-5 · Cited by 305 · see citing works
Greenberg, M. E., Iafrate, A. J., & Skowronski, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.10.2777 · Cited by 300 · see citing works
Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection
Titanji, K. (2006) · Blood · doi:10.1182/blood-2005-11-013383 · Cited by 290 · see citing works
Davis, D. M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2020 · Cited by 288 · see citing works
Cytonemes and tunneling nanotubules in cell–cell communication and viral pathogenesis
Sherer, N. M., & Mothes, W. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.07.003 · Cited by 242 · see citing works
Activation of Vav by Nef Induces Cytoskeletal Rearrangements and Downstream Effector Functions
Fackler, O., Luo, W., Geyer, M., Alberts, A. S., & Peterlin, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(01)80005-8 · Cited by 237 · see citing works
Greenberg, M. E., DeTulleo, L., Rapoport, I., Skowroński, J., & Kirchhausen, T. L. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00518-0 · Cited by 230 · see citing works
Greenberg, M. E., Bronson, S., Lock, M. W., Neumann, M., Pavlakis, G. N., & Skowroński, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.6964 · Cited by 222 · see citing works
He, B., Qiao, X., Klasse, P. J., Chiu, A., Chadburn, A., Knowles, D. M., Moore, J. P., & Cerutti, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3931 · Cited by 218 · see citing works
Self-citationSchröfelbauer, B., Yu, Q., Zeitlin, S. G., & Landau, N. R. (2005) · Journal of Virology · doi:10.1128/jvi.79.17.10978-10987.2005 · Cited by 216 · see citing works
Mechanism of Nef‐induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes
Piguet, V., Chen, Y., Mangasarian, A., Foti, M., Carpentier, J., & Trono, D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2472 · Cited by 209 · see citing works
Human Immunodeficiency Virus Type-1 Infection Impairs the Formation of the Immunological Synapse
Thoulouze, M., Sol‐Foulon, N., Blanchet, F. P., Dautry‐Varsat, A., Schwartz, O., & Alcover, A. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.016 · Cited by 192 · see citing works
Qiao, X., He, B., Chiu, A., Knowles, D. M., Chadburn, A., & Cerutti, A. (2016) · Nature Immunology · doi:10.1038/ni1016-1235a · Cited by 189 · see citing works
Self-citationHart, M., Steel, A., Clark, S. A., Moyle, G. J., Nelson, M. R., Henderson, D., Wilson, R., Gotch, F. M., Gazzard, B., & Kelleher, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.8212 · Cited by 177 · see citing works
Binley, J. Μ., Klasse, P. J., Cao, Y., Jones, I. M., Markowitz, M. H., Ho, D. D., & Moore, J. P. (1997) · Journal of Virology · doi:10.1128/jvi.71.4.2799-2809.1997 · Cited by 176 · see citing works
Hide, shield and strike back: how HIV-infected cells avoid immune eradication
Peterlin, B. M., & Trono, D. (2003) · Nature reviews. Immunology · doi:10.1038/nri998 · Cited by 176 · see citing works
Popovič, M., Tenner‐Racz, K., Pelser, C. B., Stellbrink, H., van Lunzen, J., Lewis, G. K., Kalyanaraman, V. S., Gallo, R. C., & Rácz, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506857102 · Cited by 164 · see citing works
Soluble Nef antigen of HIV‐1 is cytotoxic for human CD4+ T cells
Fujii, Y. R., Otake, K., Tashiro, M., & Adachi, A. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00859-9 · Cited by 135 · see citing works
Modulation of the immunological synapse: a key to HIV-1 pathogenesis?
Fackler, O., Alcover, A., & Schwartz, O. (2007) · Nature reviews. Immunology · doi:10.1038/nri2041 · Cited by 131 · see citing works
Martinez, V., Costagliola, D. G., Bonduelle, O., Ngo‐Giang‐Huong, N., Schnuriger, A., Theodorou, I. D., Clauvel, J., Sicard, D., Agut, H., Debré, P., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/430320 · Cited by 124 · see citing works
Mestecky, J. F., Jackson, S., Moldoveanu, Z., Nesbit, L. R., Kulhavy, R., Prince, S. J., Sabbaj, S., Mulligan, M. J., & Goepfert, P. (2004) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2004.20.972 · Cited by 113 · see citing works
Dyer, W. B., Ogg, G. S., Demoitié, M., Jin, X., Geczy, A. F., Rowland‐Jones, S., McMichael, A. J., Nixon, D. F., & Sullivan, J. S. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.436-443.1999 · Cited by 103 · see citing works
Self-citationPerturbations in B cell responsiveness to CD4 + T cell help in HIV-infected individuals
Moir, S. L., Ogwaro, K. M., Malaspina, A., Vasquez, J., Donoghue, E. T., Hallahan, C. W., Liu, S., Ehler, L. A., Planta, M. A., Kottilil, S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730819100 · Cited by 89 · see citing works
Evidence for a Pathogenic Determinant in HIV-1 Nef Involved in B Cell Dysfunction in HIV/AIDS
Swingler, S., Zhou, J. T., Swingler, C., Dauphin, A., Greenough, T. C., Jolicoeur, P., & Stevenson, M. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.015 · Cited by 82 · see citing works
Poudrier, J., Weng, X., Kay, D., Paré, G., Calvo, E., Hanna, Z., Kosco-Vilbois, M., & Jolicoeur, P. (2001) · Immunity · doi:10.1016/s1074-7613(01)00177-7 · Cited by 78 · see citing works
Calcineurin and vacuolar-type H + -ATPase modulate macrophage effector functions
Conboy, I. M., Manoli, D. S., Mhaiskar, V., & Jones, P. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6324 · Cited by 76 · see citing works
Prost, S., Dantec, M. L., Augé, S., Grand, R. L., Derdouch, S., Aurégan, G., Déglon, N., Relouzat, F., Aubertin, A.-M., Maillère, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33037 · Cited by 67 · see citing works
Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1
da Costa, L. J., Chen, N., dos Santos, A. L., Aguiar, R. S., Tanuri, A., Plemenitaš, A., & Peterlin, B. M. (2006) · Retrovirology · doi:10.1186/1742-4690-3-33 · Cited by 59 · see citing works
Plasma levels of B-lymphocyte stimulator increase with HIV disease progression
Rodriguez, B. A., Valdez, H., Freimuth, W. W., Butler, T., Asaad, R. J., & Lederman, M. M. (2003) · AIDS · doi:10.1097/00002030-200309050-00018 · Cited by 50 · see citing works
Schäfer, F., Kewenig, S., Stolte, N., Stahl-Hennig, C., Stallmach, A., Kaup, F.-J., Zeitz, M., & Schneider, T. (2002) · Gut · doi:10.1136/gut.50.5.608 · Cited by 48 · see citing works
Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination
Begum, N. A., Izumi, N., Nishikori, M., Nagaoka, H., Shinkura, R., & Honjo, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607439200 · Cited by 47 · see citing works
Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation
Peng, B., & Robert-Guroff, M. (2001) · Immunology Letters · doi:10.1016/s0165-2478(01)00250-4 · Cited by 45 · see citing works
Muratori, C., Sistigu, A., Ruggiero, E., Falchi, M., Bacigalupo, I., Palladino, C., Toschi, E., & Federico, M. (2007) · Journal of Virology · doi:10.1128/jvi.00675-07 · Cited by 21 · see citing works
Santa‐Marta, M., Aires‐da‐Silva, F., Fonseca, A. M., Rato, S., & Gonçalves, J. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.02.005 · Cited by 19 · see citing works
Mann, J., Patrick, C. N., Cragg, M. S., Honeychurch, J., Mann, D. A., & Harris, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6560 · Cited by 15 · see citing works
Régulier, E. G., Panemangalore, R., Richardson, M. W., DeFranco, J. J., Kocieda, V., Gordon-Lyles, D. C., Silvera, P. M., Khalili, K., Zagury, J., Lewis, M. G., et al. (2005) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000173702.05308.c4 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
Mabbott, N. A., Donaldson, D. S., Ohno, H., Williams, I. R., & Mahajan, A. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.30 · Cited by 721 · see citing works
Extracellular vesicles and viruses: Are they close relatives?
Hoen, E. N. M. N., Cremer, T., Gallo, R. C., & Margolis, L. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605146113 · Cited by 495 · see citing works
Lou, E., Fujisawa, S., Morozov, A., Barlas, A., Romin, Y., Dogan, Y., Gholami, S., Moreira, A. L., Manova-Todorova, K., & Moore, M. A. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033093 · Cited by 420 · see citing works
M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex
Hase, K., Kimura, S., Takatsu, H., Ohmae, M., Kawano, S., Kitamura, H., Ito, M., Watarai, H., Hazelett, C. C., Yeaman, C., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1990 · Cited by 402 · see citing works
Microvesicles and Viral Infection
Meckes, D. G., & Raab‐Traub, N. (2011) · Journal of Virology · doi:10.1128/jvi.05853-11 · Cited by 389 · see citing works
Wiring through tunneling nanotubes--from electrical signals to organelle transfer
Abounit, S., & Zurzolo, C. (2012) · Journal of Cell Science · doi:10.1242/jcs.083279 · Cited by 386 · see citing works
Intestinal IgA production and its role in host-microbe interaction
Gutzeit, C., Magri, G., & Cerutti, A. (2014) · Immunological Reviews · doi:10.1111/imr.12189 · Cited by 332 · see citing works
Self-citationZomer, A., Vendrig, T., Hopmans, E. S., van Eijndhoven, M. A. J., Middeldorp, J. M., & Pegtel, D. M. (2010) · Communicative & Integrative Biology · doi:10.4161/cib.3.5.12339 · Cited by 329 · see citing works
Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses
Kirchhoff, F. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.06.004 · Cited by 318 · see citing works
Viral effects on the content and function of extracellular vesicles
Raab‐Traub, N., & Dittmer, D. P. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.60 · Cited by 264 · see citing works
Function of Mucosa-Associated Lymphoid Tissue in Antibody Formation
Brandtzæg, P. (2010) · Immunological Investigations · doi:10.3109/08820131003680369 · Cited by 240 · see citing works
Verweij, F. J., van Eijndhoven, M. A. J., Hopmans, E. S., Vendrig, T., Würdinger, T., Cahir-McFarland, E. D., Kieff, E. D., Geerts, D., van der Kant, R., Neefjes, J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.123 · Cited by 230 · see citing works
The role of extracellular vesicles in COVID-19 virus infection
Hassanpour, M., Rezaie, J., Nouri, M., & Panahi, Y. (2020) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2020.104422 · Cited by 229 · see citing works
HIV-exposed uninfected children: a growing population with a vulnerable immune system?
Afran, L., Garcia-Knight, M., Nduati, E. W., Urban, B. C., Heyderman, R. S., & Rowland‐Jones, S. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12251 · Cited by 219 · see citing works
Mechanisms for Cell-to-Cell Transmission of HIV-1
Bracq, L., Xie, M., Bénichou, S., & Bouchet, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00260 · Cited by 192 · see citing works
Tunneling Nanotubes: Intimate Communication between Myeloid Cells
Dupont, M., Souriant, S., Lugo‐Villarino, G., Maridonneau‐Parini, I., & Vérollet, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00043 · Cited by 182 · see citing works
The Role of Extracellular Vesicles in Viral Infection and Transmission
Urbanelli, L., Buratta, S., Tancini, B., Sagini, K., Delo, F., Porcellati, S., & Emiliani, C. (2019) · Vaccines · doi:10.3390/vaccines7030102 · Cited by 179 · see citing works
Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission
Van Prooyen, N., Gold, H., Andresen, V., Schwartz, O., Jones, K., Ruscetti, F., Lockett, S., Gudla, P., Venzon, D., & Franchini, G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009635107 · Cited by 178 · see citing works
The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis
Hanna, S. J., McCoy-Simandle, K., Miskolci, V., Guo, P., Cammer, M., Hodgson, L., & Cox, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-08950-7 · Cited by 169 · see citing works
Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein*
Jaworski, E., Narayanan, A., Duyne, R. V., Shabbeer-Meyering, S., Iordanskiy, S., Saifuddin, M., Das, R., Afonso, P. V., Sampey, G., Chung, M., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.549659 · Cited by 167 · see citing works
B‐cell responses to HIV infection
Moir, S. L., & Fauci, A. S. (2017) · Immunological Reviews · doi:10.1111/imr.12502 · Cited by 163 · see citing works
Vaccination Strategies to Promote Mucosal Antibody Responses
Chen, K., & Cerutti, A. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.013 · Cited by 155 · see citing works
Self-citationParallel Epigenomic and Transcriptomic Responses to Viral Infection in Honey Bees (Apis mellifera)
Galbraith, D. A., Yang, X., Niño, E. L., Yi, S. V., & Grozinger, C. M. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004713 · Cited by 153 · see citing works
Pathways of cell-cell transmission of HTLV-1
Pique, C., & Jones, K. S. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00378 · Cited by 148 · see citing works
Insights into B cells and HIV ‐specific B‐cell responses in HIV ‐infected individuals
Moir, S. L., & Fauci, A. S. (2013) · Immunological Reviews · doi:10.1111/imr.12067 · Cited by 144 · see citing works
Tunneling Nanotubes and Tumor Microtubes in Cancer
Roehlecke, C., & Schmidt, M. H. H. (2020) · Cancers · doi:10.3390/cancers12040857 · Cited by 141 · see citing works
A Temporal Model of Human IgE and IgG Antibody Function
Collins, A. M., & Jackson, K. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00235 · Cited by 140 · see citing works
Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages
Hashimoto, M., Bhuyan, F., Hiyoshi, M., Noyori, O., Nasser, H., Miyazaki, M., Saito, T., Kondoh, Y., Osada, H., Kimura, S., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1500845 · Cited by 138 · see citing works
Tunneling nanotubes, a novel mode of tumor cell–macrophage communication in tumor cell invasion
Hanna, S. J., McCoy-Simandle, K., Leung, E., Genna, A., Condeelis, J. S., & Cox, D. (2019) · Journal of Cell Science · doi:10.1242/jcs.223321 · Cited by 133 · see citing works
Extracellular Vesicles and Their Convergence with Viral Pathways
Wurdinger, T. D., Gatson, N. T., Balaj, L., Kaur, B., Breakefield, X. O., & Pegtel, D. M. (2012) · Advances in Virology · doi:10.1155/2012/767694 · Cited by 130 · see citing works
Role of Secretory Immunoglobulin a and Secretory Component in the Protection of Mucosal Surfaces
Corthésy, B. (2010) · Future Microbiology · doi:10.2217/fmb.10.39 · Cited by 128 · see citing works
Pathogen manipulation of B cells: the best defence is a good offence
Nothelfer, K., Sansonetti, P., & Phalipon, A. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3415 · Cited by 94 · see citing works
Souriant, S., Balboa, L., Dupont, M., Pingris, K., Kviatcovsky, D., Cougoule, C., Lastrucci, C., Bah, A., Gasser, R., Poincloux, R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.091 · Cited by 103 · see citing works
Lou, E., Fujisawa, S., Barlas, A., Romin, Y., Manova-Todorova, K. O., Moore, M. A. S., & Subramanian, S. (2012) · Communicative & Integrative Biology · doi:10.4161/cib.20569 · Cited by 120 · see citing works
Exosomes and nanotubes: Control of immune cell communication
McCoy-Simandle, K., Hanna, S. J., & Cox, D. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.12.006 · Cited by 113 · see citing works
Haas, A., Zimmermann, K., & Oxenius, A. (2011) · Journal of Virology · doi:10.1128/jvi.05607-11 · Cited by 105 · see citing works
The Role of BAFF System Molecules in Host Response to Pathogens
Sakai, J., & Akkoyunlu, M. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-17 · Cited by 109 · see citing works
Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells
Thayanithy, V., Babatunde, V., Dickson, E. L., Wong, P., Oh, S., Ke, X., Barlas, A., Fujisawa, S., Romin, Y., Moreira, A. L., et al. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.01.014 · Cited by 104 · see citing works
Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications
Mittal, R., Karhu, E., Wang, J., Delgado, S., Zukerman, R. J., Mittal, J., & Jhaveri, V. M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27072 · Cited by 107 · see citing works
Innate control of B cell responses
Cerutti, A., Puga, I., & Cols, M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.02.004 · Cited by 105 · see citing works
Self-citationSpecialized Intercellular Communications via Cytonemes and Nanotubes
Yamashita, Y. M., Inaba, M., & Buszczak, M. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062932 · Cited by 105 · see citing works
Banerjee, K., Klasse, P. J., Sanders, R. W., Pereyra, F., Michael, E., Lu, M., Walker, B. D., & Moore, J. P. (2010) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2009.0223 · Cited by 103 · see citing works
Self-citationKadiu, I., & Gendelman, H. E. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9298-z · Cited by 100 · see citing works
HIV-1 Nef Inhibits Ruffles, Induces Filopodia, and Modulates Migration of Infected Lymphocytes
Nobile, C., Rudnicka, D., Hasan, M., Aulner, N., Porrot, F., Machu, C., Renaud, O., Prévost, M., Hivroz, C., Schwartz, O., et al. (2009) · Journal of Virology · doi:10.1128/jvi.02230-09 · Cited by 100 · see citing works
Tiede, L. M., Cook, E. A., Morsey, B., & Fox, H. S. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.128 · Cited by 99 · see citing works
Nikolic, D. S., Lehmann, M., Felts, R. L., Garcia, E., Blanchet, F. P., Subramaniam, S., & Piguet, V. (2011) · Blood · doi:10.1182/blood-2010-09-305417 · Cited by 99 · see citing works
Extracellular Vesicles in Viral Infections: Two Sides of the Same Coin?
Martins, S. D. T., & Alves, L. R. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.593170 · Cited by 98 · see citing works
Intercellular communication in malignant pleural mesothelioma: properties of tunneling nanotubes
Ady, J., Desir, S., Thayanithy, V., Vogel, R. I., Moreira, A. L., Downey, R. J., Fong, Y., Manova-Todorova, K. O., Moore, M. A. S., & Lou, E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00400 · Cited by 95 · see citing works
Bridging the Gap: Virus Long-Distance Spread via Tunneling Nanotubes
Jansens, R. J. J., Tishchenko, A., & Favoreel, H. W. (2020) · Journal of Virology · doi:10.1128/jvi.02120-19 · Cited by 88 · see citing works
HIV-1 reprograms the migration of macrophages
Vérollet, C., Souriant, S., Bonnaud, E. M., Jolicoeur, P., Raynaud‐Messina, B., Kinnaer, C., Fourquaux, I., Imle, A., Bénichou, S., Fackler, O., et al. (2014) · Blood · doi:10.1182/blood-2014-08-596775 · Cited by 93 · see citing works
Mukerji, J., Olivieri, K. C., Misra, V., Agopian, K. A., & Gabuzda, D. H. (2012) · Retrovirology · doi:10.1186/1742-4690-9-33 · Cited by 92 · see citing works
Mazzolini, J., Herit, F., Bouchet, J., Benmerah, A., Bénichou, S., & Niedergang, F. (2010) · Blood · doi:10.1182/blood-2009-12-259473 · Cited by 88 · see citing works
The Role of Exosomes in Infectious Diseases
Hosseini, H. M., Fooladi, A. A. I., Nourani, M. R., & Ghanezadeh, F. (2013) · Inflammation & Allergy - Drug Targets · doi:10.2174/1871528111312010005 · Cited by 89 · see citing works
Porcine Reproductive and Respiratory Syndrome Virus Utilizes Nanotubes for Intercellular Spread
Guo, R., Katz, B. B., Tomich, J. M., Gallagher, T., & Fāng, Y. (2016) · Journal of Virology · doi:10.1128/jvi.00036-16 · Cited by 90 · see citing works
Rezaie, J., Aslan, C., Ahmadi, M., Zolbanin, N. M., Kashanchi, F., & Jafari, R. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00537-0 · Cited by 88 · see citing works
Dynamic roles for NF‐κB in HTLV‐I and HIV‐1 retroviral pathogenesis
Chan, J. K., & Greene, W. C. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01094.x · Cited by 87 · see citing works
Macrophage Bridging Conduit Trafficking of HIV-1 Through the Endoplasmic Reticulum and Golgi Network
Kadiu, I., & Gendelman, H. E. (2011) · Journal of Proteome Research · doi:10.1021/pr200262q · Cited by 85 · see citing works
Barone, F., Vossenkämper, A., Boursier, L., Su, W., Watson, A., John, S., Dunn‐Walters, D. K., Fields, P., Wijetilleka, S., Edgeworth, J. D., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.12.005 · Cited by 80 · see citing works
Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice
Hur, E. M., Patel, S. N., Shimizu, S., Rao, D. S., Gnanapragasam, P. N. P., An, D. S., Yang, L., & Baltimore, D. (2012) · Blood · doi:10.1182/blood-2012-04-422303 · Cited by 79 · see citing works
Zhu, X., Guo, Y., Yao, S., Yan, Q., Xue, M., Hao, T., Zhou, F., Zhu, J., Qin, D., & Lu, C. (2013) · Oncogene · doi:10.1038/onc.2013.136 · Cited by 79 · see citing works
The molecular basis of induction and formation of tunneling nanotubes
Kimura, S., Hase, K., & Ohno, H. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1518-1 · Cited by 78 · see citing works
Mechanisms of HIV-1 Nef Function and Intracellular Signaling
Foster, J. L., Denial, S. J., Temple, B. R. S., & Garcia, J. V. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9262-y · Cited by 76 · see citing works
HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo
Stolp, B., Imle, A., Coelho, F. M., Hons, M., Gorina, R., Lyck, R., Stein, J. V., & Fackler, O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204322109 · Cited by 76 · see citing works
How HIV Takes Advantage of the Cytoskeleton in Entry and Replication
Stolp, B., & Fackler, O. (2011) · Viruses · doi:10.3390/v3040293 · Cited by 76 · see citing works
Transfer of Intracellular HIV Nef to Endothelium Causes Endothelial Dysfunction
Wang, T., Green, L. A., Gupta, S. K., Kim, C., Wang, L., Almodóvar, S., Flores, S. C., Prudovsky, I. A., Jolicoeur, P., Liu, Z., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091063 · Cited by 74 · see citing works
Yates, N. L., Stacey, A., Nolen, T. L., Vandergrift, N., Moody, M. A., Montefiori, D. C., Weinhold, K. J., Blattner, W. A., Borrow, P., Shattock, R. J., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2012.107 · Cited by 73 · see citing works
Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection
Haas, A., Zimmermann, K., Graw, F., Slack, E. M. C., Rusert, P., Ledergerber, B., Bossart, W., Weber, R. K., Thurnheer, M. C., Battegay, M., et al. (2011) · Gut · doi:10.1136/gut.2010.224774 · Cited by 71 · see citing works
Dikeakos, J. D., Thomas, L., Kwon, G. J., Elferich, J., Shinde, U. P., & Thomas, G. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-11-0928 · Cited by 70 · see citing works
Adding new dimensions: towards an integrative understanding of HIV-1 spread
Fackler, O., Murooka, T. T., Imle, A., & Mempel, T. R. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3309 · Cited by 69 · see citing works
Novel mechanisms of central nervous system damage in HIV infection
Hazleton, J. E., Berman, J. W., & Eugenin, E. (2010) · HIV/AIDS · doi:10.2147/hiv.s9186 · Cited by 22 · see citing works
HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread
Kalinichenko, S., Komkov, D., & Mazurov, D. (2022) · Viruses · doi:10.3390/v14010152 · Cited by 68 · see citing works
“Moreover, Nef is capable of translocating from HIV-1infected macrophages to B cells through nanotubes, where it exerts anti-immune activity by inhibiting the production of antiviral IgG2 and IgA [115].”
BackgroundTunneling nanotubes: emerging view of their molecular components and formation mechanisms.
Kimura, S., Hase, K., & Ohno, H. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.05.013 · Cited by 63 · see citing works
Lock, J. T., Parker, I., & Smith, I. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.06.004 · Cited by 61 · see citing works
den Broeke, C. V., Jacob, T., & Favoreel, H. W. (2014) · Small GTPases · doi:10.4161/sgtp.28318 · Cited by 63 · see citing works
Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles
Sanada, T., Hirata, Y., Naito, Y., Yamamoto, N., Kikkawa, Y., Ishida, Y., Yamasaki, C., Tateno, C., Ochiya, T., & Kohara, M. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.10.003 · Cited by 62 · see citing works
Emerging Concepts on the Role of Innate Immunity in the Prevention and Control of HIV Infection
Ackerman, M. E., Dugast, A., & Alter, G. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-050310-085221 · Cited by 60 · see citing works
An emerging role for p21-activated kinases (Paks) in viral infections
den Broeke, C. V., Radu, M., Chernoff, J., & Favoreel, H. W. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.12.005 · Cited by 60 · see citing works
Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
Laguette, N., Brégnard, C., Bénichou, S., & Basmaciogullari, S. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.05.003 · Cited by 61 · see citing works
Macrophage Cell-Cell Interactions Promoting HIV-1 Infection
Dupont, M., & Sattentau, Q. J. (2020) · Viruses · doi:10.3390/v12050492 · Cited by 55 · see citing works
Stolp, B., Abraham, L., Rudolph, J. M., & Fackler, O. (2010) · Journal of Virology · doi:10.1128/jvi.02467-09 · Cited by 58 · see citing works
Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes
Uhl, J., Gujarathi, S., Waheed, A. A., Gordon, A., Freed, E. O., & Gousset, K. (2019) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-018-0493-z · Cited by 57 · see citing works
Regulation of mucosal IgA responses: lessons from primary immunodeficiencies
Cerutti, A., Cols, M., Gentile, M., Cassis, L., Barra, C., He, B., Puga, I., & Chen, K. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06266.x · Cited by 57 · see citing works
Self-citationSilva, R., Moir, S. L., Kardava, L., DeBell, K. E., Simhadri, V. R., Ferrando‐Martínez, S., Leal, M., Peña, J., Coligan, J. E., & Borrego, F. (2011) · Blood · doi:10.1182/blood-2010-09-310318 · Cited by 57 · see citing works
A Murid Gamma-Herpesviruses Exploits Normal Splenic Immune Communication Routes for Systemic Spread
Frederico, B., Chao, B. N., May, J. S., Belz, G. T., & Stevenson, P. G. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.03.010 · Cited by 54 · see citing works
Mechanisms of HIV Neuropathogenesis: Role of Cellular Communication Systems
Malik, S., & Eugenin, E. A. (2016) · Current HIV Research · doi:10.2174/1570162x14666160324124558 · Cited by 56 · see citing works
Innate Signaling Networks in Mucosal IgA Class Switching
Chorny, A., Puga, I., & Cerutti, A. (2010) · Advances in immunology · doi:10.1016/b978-0-12-381300-8.00002-2 · Cited by 55 · see citing works
Self-citationDemberg, T., Brocca‐Cofano, E., Xiao, P., Venzon, D. J., Vargas‐Inchaustegui, D. A., Lee, E. M., Kalisz, I., Kalyanaraman, V. S., DiPasquale, J., McKinnon, K. M., et al. (2012) · Journal of Virology · doi:10.1128/jvi.00298-12 · Cited by 55 · see citing works
Why Cells and Viruses Cannot Survive without an ESCRT
Calistri, A., Reale, A., Palù, G., & Parolin, C. (2021) · Cells · doi:10.3390/cells10030483 · Cited by 53 · see citing works
Ohno, H., Hase, K., & Kimura, S. (2010) · Communicative & Integrative Biology · doi:10.4161/cib.3.3.11242 · Cited by 24 · see citing works
HIV trafficking in host cells: motors wanted!
Gaudin, R., de Alencar, B. C., Arhel, N. J., & Benaroch, P. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.09.004 · Cited by 52 · see citing works
Chelvanambi, S., Bogatcheva, N. V., Bednorz, M., Agarwal, S., Maier, B., Alves, N. J., Li, W., Syed, F., Saber, M. M., Dahl, N., et al. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0089oc · Cited by 50 · see citing works
How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission
Lehmann, M., Nikolic, D. S., & Piguet, V. (2011) · Viruses · doi:10.3390/v3091757 · Cited by 48 · see citing works
Mestecky, J. F., Wright, P. F., Lopalco, L., Staats, H. F., Kozlowski, P. A., Moldoveanu, Z., Alexander, R. C., Kulhavy, R., Pastori, C., Maboko, L., et al. (2010) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2010.0169 · Cited by 48 · see citing works
Targeting HIV-1 Envelope Glycoprotein Trimers to B Cells by Using APRIL Improves Antibody Responses
Melchers, M., Bontjer, I., Tong, T., Chung, N. P. Y., Klasse, P. J., Eggink, D., Montefiori, D. C., Gentile, M., Cerutti, A., Olson, W. C., et al. (2011) · Journal of Virology · doi:10.1128/jvi.06259-11 · Cited by 48 · see citing works
Self-citationAdy, J., Thayanithy, V., Mojica, K. M., Wong, P., Carson, J. S., Rao, P., Fong, Y., & Lou, E. (2016) · Molecular Therapy — Oncolytics · doi:10.1038/mto.2016.29 · Cited by 48 · see citing works
Kumar, A., Kodidela, S., Tadrous, E., Cory, T. J., Walker, C. M., Smith, A. M., Mukherjee, A., & Kumar, S. (2020) · Viruses · doi:10.3390/v12080887 · Cited by 48 · see citing works
Immunologic characteristics of HIV ‐infected individuals who make broadly neutralizing antibodies
Borrow, P., & Moody, M. A. (2017) · Immunological Reviews · doi:10.1111/imr.12504 · Cited by 47 · see citing works
How do PrPSc Prions Spread between Host Species, and within Hosts?
Mabbott, N. A. (2017) · Pathogens · doi:10.3390/pathogens6040060 · Cited by 46 · see citing works
HIV-1 Trans Infection of CD4 + T Cells by Professional Antigen Presenting Cells
Rinaldo, C. R. (2013) · Scientifica · doi:10.1155/2013/164203 · Cited by 46 · see citing works
Mangino, G., Percario, Z. A., Fiorucci, G., Vaccari, G., Acconcia, F., Chiarabelli, C., Leone, S., Noto, A., Horenkamp, F. A., Manrique, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022982 · Cited by 46 · see citing works
- Authors
- Xu, W., Santini, P. A., Sullivan, J. S., He, B., Shan, M., Ball, S. C., Dyer, W. B., Ketas, T. J., Chadburn, A., Cohen-Gould, L., Knowles, D. M., Chiu, A., Sanders, R. W., Chen, K., & Cerutti, A.
- Affiliations
- Cornell University (US)
- The University of Sydney (AU)
- Icahn School of Medicine at Mount Sinai (US)
- Northwestern University (US)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Cerutti, Andrea
- ORCID
- Venue
- Nature Immunology
- Published
- 2009-08-02
- Volume
- 10
- Issue
- 9
- Pages
- 1008-1017
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC2784687
- OpenAlex
- W1968201178
- Cited by
- 302
- References
- 57
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 14 · 2023: 11 · 2022: 11 · 2021: 14 · 2020: 20 · 2019: 13 · 2018: 15 · 2017: 16 · 2016: 14 · 2015: 18 · 2014: 21 · 2013: 18 · 2012: 32
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI074378, R01AI057653-S1, AI 07621, T32AI007621, R01AI057653)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Keywords
- HIV-1, Nef protein, macrophages, B cells, IgG2, IgA, class switch recombination, guanine nucleotide exchange factor, mucosal immunity
- MeSH terms
- Actins, B-Lymphocytes, Cell Communication, Humans, Immunoglobulin A, Immunoglobulin G, Macrophages, HIV Antibodies, HIV-1, HIV Core Protein p24, Immunoglobulin Class Switching, Germinal Center, CD40 Antigens, U937 Cells, nef Gene Products, Human Immunodeficiency Virus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review