The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Pattern Recognition Receptors and the Innate Immune Response to Viral Infection
Open accessAbstract
The innate immune response to viral pathogens is critical in order to mobilize protective immunity. Cells of the innate immune system detect viral infection largely through germline-encoded pattern recognition receptors (PRRs) present either on the cell surface or within distinct intracellular compartments. These include the Toll-like receptors (TLRs), the retinoic acid-inducble gene I-like receptors (RLRs), the nucleotide oligomerization domain-like receptors (NLRs, also called NACHT, LRR and PYD domain proteins) and cytosolic DNA sensors. While in certain cases viral proteins are the trigger of these receptors, the predominant viral activators are nucleic acids. The presence of viral sensing PRRs in multiple cellular compartments allows innate cells to recognize and quickly respond to a broad range of viruses, which replicate in different cellular compartments. Here, we review the role of PRRs and associated signaling pathways in detecting viral pathogens in order to evoke production of interferons and cytokines. By highlighting recent progress in these areas, we hope to convey a greater understanding of how viruses activate PRR signaling and how this interaction shapes the anti-viral immune response.
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Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×
“deoxycytidylate-phosphate-deoxyguanylate (CpG) motifs in viral and bacterial DNA [49].”
BackgroundSpecies-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
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IRF-7 is the master regulator of type-I interferon-dependent immune responses
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Recognition of single-stranded RNA viruses by Toll-like receptor 7
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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
Kurt-Jones, E. A., Popova, L., Kwinn, L., Haynes, L. M., Jones, L. P., Tripp, R. A., Walsh, E. E., Freeman, M. W., Golenbock, D. T., Anderson, L. J., et al. (2000) · Nature Immunology · doi:10.1038/80833 · Cited by 1,683
Self-citationPlasmacytoid dendritic cells in immunity
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Hornung, V., Guenthner-Biller, M., Bourquin, C., Ablasser, A., Schlee, M., Uematsu, S., Noronha, A., Manoharan, M., Akira, S., de Fougerolles, A., et al. (2005) · Nature Medicine · doi:10.1038/nm1191 · Cited by 1,232
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
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Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
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Cited by
The COVID-19 Cytokine Storm; What We Know So Far
Ragab, D., Salah Eldin, H., Taeimah, M., Khattab, R., & Salem, R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01446 · Cited by 1,622
Imamura, K., Imamachi, N., Akizuki, G., Kumakura, M., Kawaguchi, A., Nagata, K., Kato, A., Kawaguchi, Y., Sato, H., Yoneda, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.009 · Cited by 678
Sterile inflammation in the liver
Kubes, P., & Mehal, W. Z. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.008 · Cited by 666
Jensen, S., & Thomsen, A. R. (2012) · Journal of Virology · doi:10.1128/jvi.05738-11 · Cited by 604
Endosomal escape: A bottleneck for LNP-mediated therapeutics
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Metadata
- Authors
- Thompson, M. R., Kaminski, J. J., Kurt-Jones, E. A., & Fitzgerald, K. A.
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2011-06-23
- Volume
- 3
- Issue
- 6
- Pages
- 920-940
- ISSN
- 1999-4915 (ISSN-L)
- OpenAlex
- W2135143264
- Cited by
- 845
- References
- 58
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- gold
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