The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry
Open accessAbstract
Influenza A viruses (IAVs) cause seasonal pandemics and epidemics with high morbidity and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of influenza virus plays a crucial role in the initial stage of virus infection, making it a potential target for anti-influenza therapeutics development. Here we found that quercetin inhibited influenza infection with a wide spectrum of strains, including A/Puerto Rico/8/34 (H1N1), A/FM-1/47/1 (H1N1), and A/Aichi/2/68 (H3N2) with half maximal inhibitory concentration (IC50) of 7.756 ± 1.097, 6.225 ± 0.467, and 2.738 ± 1.931 μg/mL, respectively. Mechanism studies identified that quercetin showed interaction with the HA2 subunit. Moreover, quercetin could inhibit the entry of the H5N1 virus using the pseudovirus-based drug screening system. This study indicates that quercetin showing inhibitory activity in the early stage of influenza infection provides a future therapeutic option to develop effective, safe and affordable natural products for the treatment and prophylaxis of IAV infections.
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Cites
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Cited by
Plant Flavonoids: Chemical Characteristics and Biological Activity
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Flavonoids: Promising Natural Compounds against Viral Infections
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Colunga Biancatelli, R. M. L., Berrill, M., Catravas, J. D., & Marik, P. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01451 · Cited by 512
Metadata
- Authors
- Wu, W., Li, R., Li, X., He, J., Jiang, S., Liu, S., & Yang, J.
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2015-12-25
- Volume
- 8
- Issue
- 1
- Pages
- 6
- ISSN
- 1999-4915 (ISSN-L)
- OpenAlex
- W2217790406
- Cited by
- 425
- References
- 45
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wu, W., Li, R., Li, X., He, J., Jiang, S., Liu, S., & Yang, J. (2015). Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses. https://doi.org/10.3390/v8010006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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