Flavonoids: Promising Natural Compounds against Viral Infections
Open accessAbstract
Flavonoids are widely distributed as secondary metabolites produced by plants and play important roles in plant physiology, having a variety of potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activity. Different flavonoids have been investigated for their potential antiviral activities and several of them exhibited significant antiviral properties in in vitro and even in vivo studies. This review summarizes the evidence for antiviral activity of different flavonoids, highlighting, where investigated, the cellular and molecular mechanisms of action on viruses. We also present future perspectives on therapeutic applications of flavonoids against viral infections.
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The broadness of the O-H band suggests strong hydrogen bonding interactions characteristic of phenolic compounds.
“The broadness of this band suggests strong hydrogen bonding interactions, which are characteristic of phenolic compounds [37,38].”
From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [37]
The Chemistry of flavonoids section describes flavonoid structures and substitutions, but does not discuss an O–H spectral band or its broadness. Searches for hydrogen bonding, FTIR, and O–H stretching found no passage connecting a broad band to hydrogen bonding in phenolic compounds. (LLM, conf=0.74)
Experimental — accuracy not yet measuredA broad IR band at 3338 cm−1 extending from 3042 to 3600 cm−1 is indicative of O-H stretching vibrations associated with hydroxyl groups in phenolic compounds, flavonoids, and other hydroxylated molecules.
“Furthermore, a broad band at 3338 cm−1, extending from 3042 to 3600 cm−1, is indicative of O-H stretching vibrations, commonly associated with hydroxyl groups in phenolic compounds, flavonoids, and other hydroxylated molecules.”
From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [37]
The Introduction’s ‘Chemistry of flavonoids’ section discusses flavonoid structures and modification by hydroxylases, but does not interpret infrared bands. Searches for 3338 cm−1, the 3042–3600 cm−1 range, and FTIR/O–H stretching found no passage addressing the claimed band assignment; page numbers were not available in our copy. (LLM, conf=0.76)
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Antimicrobial Activities of Natural Bioactive Polyphenols
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- Authors
- Zakaryan, H., Arabyan, E., Oo, A., & Zandi, K.
- Affiliations
- Institute of Molecular Biology (AM)
- University of Malaya (MY)
- Emory University (US)
- Corresponding author
- Zakaryan, Hovakim
- Venue
- Archives of Virology
- Published
- 2017-05-25
- Volume
- 162
- Issue
- 9
- Pages
- 2539-2551
- ISSN
- 0003-9012 (ISSN-L)
- 0304-8608
- 1432-8798
- PMC
- PMC7087220
- OpenAlex
- W2618085212
- Cited by
- 534
- References
- 159
- Citations by year
- 2026: 40 · 2025: 41 · 2024: 44 · 2023: 80 · 2022: 107 · 2021: 113 · 2020: 82 · 2019: 14 · 2018: 11 · 2017: 2
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Archives of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- RA MES State Committee of Science (15RF-081, 16YR-1F064)
- Topics
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Pharmacology › Synthesis of Organic Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- flavonoids, antiviral activity, viral infection, natural compounds, plant secondary metabolites, mechanism of action, antioxidant activity, anti-inflammatory activity, anticancer activity, antibacterial activity, antifungal activity, antiviral drug discovery
- MeSH terms
- Animals, Antiviral Agents, Flavonoids, Humans, Plants, Virus Diseases, Molecular Structure
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