The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis
Open accessAbstract
Exosomes, membrane vesicles of 40–100 nm in diameter, are derived from endosomes in various cells. The bioactive molecules specifically packed into exosomes can be horizontally transferred into recipient cells changing their biological properties, by which tumour cells continuously modify their surrounding microenvironment and distant target cells favouring cancer metastasis. It has been suspected for a long time that exosomes participate in the whole process of tumour metastasis. Although there is much unknown and many controversies in the role of cancer exosome, the major contribution of tumour‐associated exosomes to different steps of cancer metastasis are demonstrated in this review. Mainly because these exosomes are easily accessible and capable of representing their parental cells, exosomes draw much attention as a promising biomarker for tumour screening, diagnosis and prognosis. Currently, researchers have found numerous biomarkers in exosomes with great potential to be utilized in personalized medicine. In this article, we summarize the roles of biomarkers, which are validated by clinical samples. Even though many conundrums remain, such as exosome extraction, large multicentre validation of biomarkers and data interpretation, exosomes are certain to be used in clinical practice in the near future as the field rapidly expands.
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Cites
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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
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Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis
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Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
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Self-citationExosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
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“Promote cell protrusion and invasive migration Fibroblast Wnt/PCP activated by CD81 Breast cancer cell (27)”
BackgroundHypoxic enhancement of exosome release by breast cancer cells
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Crossing the endothelial barrier during metastasis
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Exosomes are released by cultured cortical neurones
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Cited by
Nishida-Aoki, N., Tominaga, N., Takeshita, F., Sonoda, H., Yoshioka, Y., & Ochiya, T. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.10.009 · Cited by 208
The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited
Dzobo, K., Senthebane, D. A., & Dandara, C. (2023) · Cancers · doi:10.3390/cancers15020376 · Cited by 146
Extracellular vesicles as personalized medicine
Beetler, D. J., Di Florio, D. N., Bruno, K. A., Ikezu, T., March, K. L., Cooper, L. T., Wolfram, J., & Fairweather, D. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101155 · Cited by 101
Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools
Palazzolo, S., Memeo, L., Hadla, M., Duzagac, F., Steffan, A., Perin, T., Canzonieri, V., Tuccinardi, T., Caligiuri, I., & Rizzolio, F. (2020) · Cancers · doi:10.3390/cancers12113165 · Cited by 34
Tang, Z., Tang, C., Sun, C., Ying, X., & Shen, R. (2022) · Aging · doi:10.18632/aging.204200 · Cited by 26
Liu, Y., Xia, Y., Smollar, J., Mao, W., & Wan, Y. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188539 · Cited by 23
Metadata
- Authors
- An, T., Qin, S., Xu, Y., Tang, Y., Huang, Y., Situ, B., Inal, J. M., & Zheng, L.
- Venue
- Journal of Extracellular Vesicles
- Publisher
- Wiley
- Published
- 2015-01
- Volume
- 4
- Issue
- 1
- Pages
- 27522-27522
- ISSN
- 2001-3078 (ISSN-L)
- OpenAlex
- W1937665132
- Cited by
- 282
- References
- 13
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- gold
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