Growth hormone, inflammation and aging
Open accessAbstract
Mutant animals characterized by extended longevity provide valuable tools to study the mechanisms of aging. Growth hormone and insulin-like growth factor-1 (IGF-1) constitute one of the well-established pathways involved in the regulation of aging and lifespan. Ames and Snell dwarf mice characterized by GH deficiency as well as growth hormone receptor/growth hormone binding protein knockout (GHRKO) mice characterized by GH resistance live significantly longer than genetically normal animals. During normal aging of rodents and humans there is increased insulin resistance, disruption of metabolic activities and decline of the function of the immune system. All of these age related processes promote inflammatory activity, causing long term tissue damage and systemic chronic inflammation. However, studies of long living mutants and calorie restricted animals show decreased pro-inflammatory activity with increased levels of anti-inflammatory adipokines such as adiponectin. At the same time, these animals have improved insulin signaling and carbohydrate homeostasis that relate to alterations in the secretory profile of adipose tissue including increased production and release of anti-inflammatory adipokines. This suggests that reduced inflammation promoting healthy metabolism may represent one of the major mechanisms of extended longevity in long-lived mutant mice and likely also in the human.
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Growth hormone was made responsible for the chronic smoldering inflammation during aging, which can be studied in growth hormone pathway-deficient mice that demonstrate less inflammation and increased longevity.
“Growth hormone was made responsible for the chronic smoldering inflammation during aging, which can be studied in growth hormone pathway-deficient mice that demonstrate less inflammation and increased longevity [119].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [119]
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“Growth hormone was made responsible for the chronic smoldering inflammation during aging, which can be studied in growth hormone pathway-deficient mice that demonstrate less inflammation and increased longevity [119].”
BackgroundLong-term p110α PI3K inactivation exerts a beneficial effect on metabolism
Foukas, L. C., Bilanges, B., Bettedi, L., Pearce, W., Ali, K., Sancho, S., Withers, D. J., & Vanhaesebroeck, B. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201953 · Cited by 91 · see citing works
- Authors
- Masternak, M. M., & Bartke, A.
- Affiliations
- SIU Medicine (US)
- ORCID
- Bartke, Andrzej
- Venue
- Pathobiology of Aging & Age-related Diseases
- Publisher
- Informa UK Limited
- Published
- 2012-01
- Volume
- 2
- Issue
- 1
- Pages
- 17293
- ISSN
- 2001-0001 (ISSN-L)
- PMC
- PMC3417471
- OpenAlex
- W2040740730
- Cited by
- 89
- References
- 63
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 10 · 2013: 8 · 2012: 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Pathobiology of Aging & Age-related Diseases (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG019899, R01AG032290, P01AG031736, U19AG023122)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- growth hormone, insulin-like growth factor I, aging, longevity, inflammation, insulin resistance, adiponectin, adipokines, caloric restriction, Ames dwarf mice, Snell dwarf mice, growth hormone receptor knockout, immunosenescence, metabolic homeostasis, anti-inflammatory activity
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