Growth hormone, inflammation and aging
Open accessAbstract
Mutant animals characterized by extended longevity provide valuable tools to study the mechanisms of aging. Growth hormone and insulin-like growth factor-1 (IGF-1) constitute one of the well-established pathways involved in the regulation of aging and lifespan. Ames and Snell dwarf mice characterized by GH deficiency as well as growth hormone receptor/growth hormone binding protein knockout (GHRKO) mice characterized by GH resistance live significantly longer than genetically normal animals. During normal aging of rodents and humans there is increased insulin resistance, disruption of metabolic activities and decline of the function of the immune system. All of these age related processes promote inflammatory activity, causing long term tissue damage and systemic chronic inflammation. However, studies of long living mutants and calorie restricted animals show decreased pro-inflammatory activity with increased levels of anti-inflammatory adipokines such as adiponectin. At the same time, these animals have improved insulin signaling and carbohydrate homeostasis that relate to alterations in the secretory profile of adipose tissue including increased production and release of anti-inflammatory adipokines. This suggests that reduced inflammation promoting healthy metabolism may represent one of the major mechanisms of extended longevity in long-lived mutant mice and likely also in the human.
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Growth hormone was made responsible for the chronic smoldering inflammation during aging, which can be studied in growth hormone pathway-deficient mice that demonstrate less inflammation and increased longevity.
“Growth hormone was made responsible for the chronic smoldering inflammation during aging, which can be studied in growth hormone pathway-deficient mice that demonstrate less inflammation and increased longevity [119].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [119]
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1 retracted
Bonkowski, M. S., Dominici, F. P., Arum, O., Rocha, J. S., Al-Regaiey, K., Westbrook, R., Spong, A., Panici, J. A., Masternak, M. M., Kopchick, J. J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004567 · Cited by 125 · see citing works
Self-citationRetractedObesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works
Broken Limits to Life Expectancy
Oeppen, J., & Vaupel, J. W. (2002) · Science · doi:10.1126/science.1069675 · Cited by 2,819 · see citing works
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733 · see citing works
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606 · see citing works
Subcutaneous and visceral adipose tissue: Structural and functional differences
Ibrahim, M. M. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00623.x · Cited by 2,238 · see citing works
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Bastard, J., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., & Fève, B. (2006) · PubMed · Cited by 2,069 · see citing works
Inflammation as a Cardiovascular Risk Factor
Willerson, J. T., & Ridker, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000129535.04194.38 · Cited by 1,304 · see citing works
Dwarf mice and the ageing process
Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091 · see citing works
Self-citationHuman growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911 · see citing works
Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826 · see citing works
Zhou, Y., Xu, B. C., Maheshwari, H., He, L., Reed, M. A., Lozykowski, M. G., Okada, S., Cataldo, L. R., Coschigamo, K., Wagner, T. E., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13215 · Cited by 802 · see citing works
Inflammatory Exposure and Historical Changes in Human Life-Spans
Finch, C., & Crimmins, E. (2004) · Science · doi:10.1126/science.1092556 · Cited by 763 · see citing works
Guevara‐Aguirre, J., Balasubramanian, P., Guevara‐Aguirre, M., Wei, M., Madia, F., Cheng, C., Hwang, D., Martín‐Montalvo, A., Saavedra, J., Ingles, S. A., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001845 · Cited by 735 · see citing works
Functionally significant insulin-like growth factor I receptor mutations in centenarians
Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705467105 · Cited by 703 · see citing works
Aging and proinflammatory cytokines
Bruunsgaard, H., Pedersen, M., & Pedersen, B. K. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200105000-00001 · Cited by 690 · see citing works
Coschigano, K. T., Holland, A. N., Riders, M. E., List, E. O., Flyvbjerg, A., & Kopchick, J. J. (2003) · Endocrinology · doi:10.1210/en.2003-0374 · Cited by 510 · see citing works
Inflamm‐ageing and lifelong antigenic load as major determinants of ageing rate and longevity
Martinis, M. D., Franceschi, C., Monti, D., & Ginaldi, L. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.02.055 · Cited by 488 · see citing works
Infection, inflammation, height, and longevity
Crimmins, E. M., & Finch, C. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501470103 · Cited by 468 · see citing works
Reduced insulin/IGF‐1 signalling and human longevity
van Heemst, D., Beekman, M., Mooijaart, S. P., Heijmans, B. T., Brandt, B. W., Zwaan, B. J., Slagboom, P. E., & Westendorp, R. G. J. (2005) · Aging Cell · doi:10.1111/j.1474-9728.2005.00148.x · Cited by 338 · see citing works
A role for preadipocytes as macrophage‐like cells
Cousin, B., Muñoz, O., André, M., Fontanilles, A. M., Dani, C., Cousin, J. L., Laharrague, P. F., Casteilla, L., & Pénicaud, L. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.2.305 · Cited by 320 · see citing works
Bonkowski, M. S., Rocha, J. S., Masternak, M. M., Al-Regaiey, K., & Bartke, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600161103 · Cited by 311 · see citing works
Self-citationIkeno, Y., Bronson, R. T., Hubbard, G. B., Lee, S., & Bartke, A. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.4.b291 · Cited by 298 · see citing works
Self-citationIkeno, Y., Hubbard, G. B., Lee, S., Cortez, L. A., Lew, C. M., Webb, C. R., Berryman, D. E., List, E. O., Kopchick, J. J., & Bartke, A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp017 · Cited by 238 · see citing works
Self-citationAl-Regaiey, K., Masternak, M. M., Bonkowski, M. S., Sun, L. Y., & Bartke, A. (2004) · Endocrinology · doi:10.1210/en.2004-1120 · Cited by 235 · see citing works
Self-citationSpaulding, C. C., Walford, R. L., & Effros, R. B. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01824-6 · Cited by 224 · see citing works
Can Growth Hormone (GH) Accelerate Aging? Evidence from GH-Transgenic Mice
Bartke, A. (2003) · Neuroendocrinology · doi:10.1159/000073704 · Cited by 180 · see citing works
Self-citationInflammation, heat shock proteins, and type 2 diabetes
Hooper, P. L., & Hooper, P. L. (2008) · Cell Stress and Chaperones · doi:10.1007/s12192-008-0073-x · Cited by 133 · see citing works
Murphy, W. J., Durum, S. K., & Longo, D. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.12.3851 · Cited by 127 · see citing works
Fabris, Ν., Pierpaoli, W., & Sorkin, E. (1971) · PubMed · Cited by 122 · see citing works
Georges, J., Rupprecht, H. J., Blankenberg, S., Poirier, O., Bickel, C., Hafner, G., Nicaud, V., Meyer, J., Cambien, F., & Tiret, L. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00717-3 · Cited by 119 · see citing works
Metabolic effects of intra‐abdominal fat in GHRKO mice
Masternak, M. M., Bartke, A., Wang, F., Spong, A., Gesing, A., Fang, Y., Salmon, A. B., Hughes, L. F., Liberati, T. A., Boparai, R. K., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00763.x · Cited by 108 · see citing works
Self-citationAdipocytokines and Lipid Levels in Ames Dwarf and Calorie-Restricted Mice
Wang, Z., Al-Regaiey, K., Masternak, M. M., & Bartke, A. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.4.323 · Cited by 100 · see citing works
Self-citationVeldhuis, J. D. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.12.005 · Cited by 98 · see citing works
Insulin Sensitivity as a Key Mediator of Growth Hormone Actions on Longevity
Masternak, M. M., Panici, J. A., Bonkowski, M. S., Hughes, L. F., & Bartke, A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp024 · Cited by 97 · see citing works
Self-citationFernandes, G., Venkatraman, J. T., Turturro, A., Attwood, V. G., & Hart, R. W. (1997) · Journal of Clinical Immunology · doi:10.1023/a:1027344730553 · Cited by 91 · see citing works
Baroni, C. D., Fabris, Ν., & Bertoli, G. (1969) · PubMed · Cited by 91 · see citing works
Wang, Z., Masternak, M. M., Al-Regaiey, K., & Bartke, A. (2007) · Endocrinology · doi:10.1210/en.2006-1313 · Cited by 89 · see citing works
Self-citationOliveira, J. L. M., Marques-Santos, C., Barreto‐Filho, J. A., Ximenes, R., Britto, A. V. D. O., Souza, A. H. O., Prado, C. M., Oliveira, C. R. P., Pereira, R. M. C., Vicente, T. A. R., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2571 · Cited by 88 · see citing works
Spaulding, C. C., Walford, R. L., & Effros, R. B. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01808-8 · Cited by 82 · see citing works
Adipose tissue changes in obesity
Coppack, S. W. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331049 · Cited by 74 · see citing works
Immunodeficiency of the Thymus-Dependent System of the Ames Dwarf Mouse
Duquesnoy, R. J. (1972) · The Journal of Immunology · doi:10.4049/jimmunol.108.6.1578 · Cited by 73 · see citing works
Bonkowski, M. S., Pamenter, R. W., Rocha, J. S., Masternak, M. M., Panici, J. A., & Bartke, A. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.562 · Cited by 69 · see citing works
Self-citationDefective B cell development in Snell dwarf (dw/dw) mice can be corrected by thyroxine treatment
Montecino‐Rodriguez, E., Clark, R. T., Johnson, A. H., Collins, L., & Dorshkind, K. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.8.3334 · Cited by 62 · see citing works
Deepak, D. S., Daousi, C., Javadpour, M., Clark, D. J., PERRY, Y. S., Pinkney, J. H., & MacFarlane, I. A. (2010) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2010.02.002 · Cited by 61 · see citing works
Caloric restriction and immunosenescence: a current perspective
Mohammad, A. P. (2000) · Frontiers in bioscience · doi:10.2741/pahlavani · Cited by 58 · see citing works
Immunologic disparity in the hypopituitary dwarf mouse
Cross, R. J., Bryson, J. S., & Roszman, T. L. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.5.1347 · Cited by 52 · see citing works
T and B lymphocytes in pituitary dwarf Snell-Bagg mice.
Dumont, F. J., Robert, F., & Bischoff, P. (1979) · PubMed · Cited by 47 · see citing works
Influence of caloric restriction on aging immune system.
Pahlavani, M. A. (2004) · PubMed · Cited by 45 · see citing works
Pahlavani, M. A., & Vargas, D. M. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22322.x · Cited by 39 · see citing works
Ectopic pituitary transplants restore immunocompetence in Ames dwarf mice
Esquifino, A. I., Villanúa, M. A., Szary, A., et al. (1991) · European Journal of Endocrinology · doi:10.1530/acta.0.1250067 · Cited by 39 · see citing works
Schneider, G. (1976) · American Journal of Anatomy · doi:10.1002/aja.1001450306 · Cited by 34 · see citing works
Masternak, M. M., Panici, J. A., Wang, F., Wang, Z., & Spong, A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp172 · Cited by 33 · see citing works
Self-citationEffects of Growth Hormone and Thyroxine Replacement Therapy on Insulin Signaling in Ames Dwarf Mice
Louis, A., Bartke, A., & Masternak, M. M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq018 · Cited by 27 · see citing works
Self-citationCheng, Y., Cao, Y., Mao, S. H., Liu, H., Ji, L. L., Xu, S., Zhang, M., & Huang, Y. (2009) · Inflammation Research · doi:10.1007/s00011-009-0056-0 · Cited by 24 · see citing works
Dhahbi, J. M., Li, X., Tran, T. Q., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.04.004 · Cited by 23 · see citing works
Involvement of sensory nerves in the protective effect of growth hormone on acute pancreatitis
Jaworek, J. M., Leja‐Szpak, A., DEMBINSKI, A. B., et al. (2009) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2009.06.001 · Cited by 15 · see citing works
Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice
Coschigano, K. T., Wetzel, A., Obichere, N., et al. (2010) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2010.06.001 · Cited by 15 · see citing works
Sashinami, H., & Nakane, A. (2010) · Cytokine · doi:10.1016/j.cyto.2009.12.005 · Cited by 13 · see citing works
Frost, R. A., Pereyra, E., & Lang, C. H. (2010) · Endocrinology · doi:10.1210/en.2010-0248 · Cited by 12 · see citing works
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Obesity and related consequences to ageing
Jura, M., & Kozak, L. P. (2016) · AGE · doi:10.1007/s11357-016-9884-3 · Cited by 473 · see citing works
Justice, J. N., Ferrucci, L., Newman, A. B., Aroda, V. R., Bahnson, J. L., Divers, J., Espeland, M. A., Marcovina, S., Pollak, M. N., Kritchevsky, S. B., et al. (2018) · GeroScience · doi:10.1007/s11357-018-0042-y · Cited by 359 · see citing works
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“Growth hormone was made responsible for the chronic smoldering inflammation during aging, which can be studied in growth hormone pathway-deficient mice that demonstrate less inflammation and increased longevity [119].”
BackgroundLong-term p110α PI3K inactivation exerts a beneficial effect on metabolism
Foukas, L. C., Bilanges, B., Bettedi, L., Pearce, W., Ali, K., Sancho, S., Withers, D. J., & Vanhaesebroeck, B. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201953 · Cited by 91 · see citing works
- Authors
- Masternak, M. M., & Bartke, A.
- Affiliations
- SIU Medicine (US)
- ORCID
- Bartke, Andrzej
- Venue
- Pathobiology of Aging & Age-related Diseases
- Publisher
- Informa UK Limited
- Published
- 2012-01
- Volume
- 2
- Issue
- 1
- Pages
- 17293
- ISSN
- 2001-0001 (ISSN-L)
- PMC
- PMC3417471
- OpenAlex
- W2040740730
- Cited by
- 89
- References
- 63
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 10 · 2013: 8 · 2012: 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Pathobiology of Aging & Age-related Diseases (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG019899, R01AG032290, P01AG031736, U19AG023122)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- growth hormone, insulin-like growth factor I, aging, longevity, inflammation, insulin resistance, adiponectin, adipokines, caloric restriction, Ames dwarf mice, Snell dwarf mice, growth hormone receptor knockout, immunosenescence, metabolic homeostasis, anti-inflammatory activity
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