Guidelines for Lupus Anticoagulant Testing in South Africa
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However, the LA is a misnomer since it is associated with thrombosis in vivo, and most commonly is detected as an incidental, transient laboratory finding associated with conditions such as autoimmune diseases, infections and even in healthy individuals.Repeatedly positive LA testing in the setting of thrombotic and/or obstetric complications is required to diagnose the antiphospholipid syndrome (APS).This review intends to provide clarity on LA testing in the South African context and to provide a national guideline in order to standardise LA testing, interpretation and reporting of results.
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Clotting times of screening, mixing, and confirmatory procedures are prone to inter- and intra-assay variability; therefore, it is recommended to normalize these clotting times by generating a ratio between test clotting time and NPP clotting time.
“Clotting times of screening, mixing, and confirmatory procedures are prone to inter- (between same-principle tests offered by different manufacturers) and intra-assay (between batches of the same reagent) variability [25]; for this reason, it is recommended to normalize a screening, mixing, and confirmatory clotting time, generating a ratio between test clotting time and NPP clotting time [9,36,48”
From Lupus Anticoagulant Detection under the Magnifying Glass (2023) · cites this paper as [54]
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Cites
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Lupus Anticoagulant Detection under the Magnifying Glass
Molinari, A. C., Martini, T., Banov, L., Ierardi, A., Leotta, M., Strangio, A., & Santoro, R. C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206654 · Cited by 9 · see citing works
- Authors
- Bailly, J., Louw, S. (., De Koker, A. (., Potgieter, J. J. C., Coetzee, M. J., Chapanduka, Z. C. (. C., & Opie, J. J.
- Affiliations
- University of Cape Town (ZA)
- University of the Witwatersrand
- University of Cape Town
- University of Pretoria (ZA)
- University of the Free State (ZA)
- Stellenbosch University (ZA)
- ORCID
- Venue
- The Journal of Medical Laboratory Science and Technology of South Africa
- Publisher
- AOSIS
- Published
- 2020-01
- Volume
- 2
- Issue
- 1
- Pages
- 6-12
- ISSN
- 2664-2549 (ISSN-L)
- OpenAlex
- W3042381477
- Cited by
- 3
- References
- 5
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Medical Laboratory Science & Technology of South Africa (publishedVersion, cc-by-nc-nd)
- SUNScholar (Stellenbosch University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- lupus anticoagulant, antiphospholipid syndrome, thrombosis, pregnancy complications, South Africa
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