Centella asiatica extract cream inhibited microphthalmia-associated transcription factor (MITF) expression and prevented melanin amount increase in Guinea pig skin exposed to ultraviolet-B
Open accessAbstract
Background: Centella asiatica has been popularly used in cosmetic products, especially due to its antioxidant benefits in soothing and healing wounds. However, the inhibition of melanogenesis in the content of Centella asiatica has not been widely studied. This study aimed to prove the effectiveness of 10% Centella asiatica cream on male Guinea pig ( Cavia porcellus ) skin exposed to UVB. Methods: The randomized posttest-only control group study was conducted on 36 Guinea pigs aged 3-months, body weight 300-350 grams with a healthy skin condition. They were randomly divided into two groups; each consists of 18 Guinea pigs. The first group was a control group given base cream 20-minutes before and 4-hours after UVB exposure, 3-times-a-week for two weeks. The second group was the treatment group given 10% Centella asiatica cream and expose to UVB with the same procedure. The histopathological preparations were made using a punch biopsy after intervention was completed. Immunohistochemical staining was performed to measure the expression of microphthalmia-associated-transcription-factor (MITF) and Masson-Fontana to measure the amount of melanin. Data analysis was conducted to compare the results in both groups. Results: The treatment group had a significantly lower mean MITF expression (13.61 ± 5.36 vs. 27.24 ± 6.50%) and melanin amount (5.95 ± 3.81 vs. 16.59 ± 5.77%) (p < 0.001) compared to the control group. Conclusion: The administration of cream consists of Centella asiatica extract 10% effectively inhibits the expression of MITF and prevented the increase of melanin amount in male guinea pigs ( Cavia porcellus ) exposed to UVB.
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C. asiatica extract cream inhibited MITF expression and prevented an increase in melanin levels in Guinea pig skin exposed to UVB.
“The study found that the cream was able to inhibit the expression of MITF, a key regulator of melanin production, and prevent an increase in melanin levels in the skin.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [41]
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Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23 · see citing works
“The study conducted by Idana et al. 41 titled “ C. asiatica extract cream inhibited microphthalmia-associated transcription factor (MITF) expression and prevented melanin amount increase in Guinea pig skin exposed to ultraviolet-B” investigates the effects of C. asiatica extract cream on melanin…”
MethodChutoprapat, R., Witarat, J., Jongpanyangarm, P., Mang Sung Thluai, L., Khankaew, P., & Wah Chan, L. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.123980 · Cited by 11 · see citing works
Seo, J., Jeong, C., Oh, S., Lee, S.-Y., Park, H., Seo, D., Yoo, D., Sim, W.-J., Lim, T.-G., Park, J. H. Y., et al. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5454 · Cited by 6 · see citing works
Ningsih, Z., Muchtaromah, B., Duhita, M. R., Adawıyah, R., Maulahibati, F. F., Hayati, A., & Sharmin, T. (2023) · Advances in engineering research/Advances in Engineering Research · doi:10.2991/978-94-6463-148-7_45
Wongso, D. K., Wiraguna, A. A. G. P., Winarti, N. W., Pangkahila, W. I., Aman, I. G. M., & Iswari, I. S. (2023) · International Journal of Research Publications · doi:10.47119/ijrp1001261620225006
Self-citationKim, Y., Lee, J. H., & Cho, E. (2026) · Bioresources and Bioprocessing · doi:10.1186/s40643-026-01121-5
“Extracts of C. asiatica influence melanocyte activity, exerting skin-whitening effects (Idana et al. 2022; Seo et al. 2025).”
- Authors
- Idana, F., Anak Agung Gde Putra, W., & Winarti, N. W.
- Affiliations
- Udayana University (ID)
- Department of Dermatology and Venerology, Faculty of Medicine Udayana University, Bali, Indonesia
- ORCID
- Winarti, Ni Wayan
- Venue
- Neurologico Spinale Medico Chirurgico
- Published
- 2022-03
- Volume
- 5
- Issue
- 1
- Pages
- 27-31
- ISSN
- 2621-2064 (ISSN-L)
- OpenAlex
- W4404558380
- Cited by
- 6
- References
- 0
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Neurologico Spinale Medico Chirurgico (publishedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- Centella asiatica, MITF, melanogenesis, skin cream, photoprotection, melanin content, guinea pig skin, topical herbal extract
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